• 무역학회지
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• 제43권6호
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• pp.51-70
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• 2018

본 연구는 글로벌 해운기업의 목표부채비율 추정하고 자본구조와 시장점유율의 관계를 규명하고자 한다. 2010년부터 2017년까지 세계 상위 100대 해운기업을 대상으로 목표부채비율을 결정하는 요인과 부채비율이 해운시장의 시장점유율에 미치는 영향을 실증분석 하였다. 연구결과, 글로벌 해운기업은 목표부채비율을 62% 정도 조정하고 있으며, 수익성과 MB 비율은 음(+), 기업규모의 5년 만기 국고채 이자율은 양(+)의 영향을 미치는 것을 확인하였다. 전체 해운기업은 전략적으로 부채를 사용하여 시장점유율을 높이고 있는 것을 확인하였다. 그리고 해운기업을 물동량 중심과 운임 중심으로 비교분석 한 결과, 물동량 중심 기업은 부채비율을 높여 컨테이너 물동량을 늘리고, 운임 중심 기업도 전략적으로 부채를 사용하여 운임을 낮추어 시장점유율을 높이고 있었다. 특히 컨테이너 물동량 중심 기업은 운임 중심 기업보다 더 전략적 부채를 사용하여 물동량 증가를 통해 수익 증가 및 경쟁적 지위 획득을 통한 과점화 전략을 펼치고 있다. 또한 물동량 중심 기업과 운임 중심 기업을 고성장과 저성장 기업으로 비교한 결과, 고성장 기업일수록 부채비율이 시장점유율에 미치는 영향이 미흡하였다. 이는 고성장 해운기업의 경영자일수록 주식발행보다 부채발행을 통한 자산 투자 규모를 축소하는 과소투자 문제가 발생하고 있는 것을 확인하였다는 점에서 큰 의미를 갖는다. 연구결과는 해운기업의 자본구조가 시장점유율에 영향을 미치는 새로운 변수로 인정될 수 있으며, 이를 해운시장의 경쟁전략과 연계하여 관리할 필요가 있음을 시사한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2061-2068
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• 2015

Background: Tumors are largely unable to metabolize ketone bodies for energy due to various deficiencies in one or both of the key mitochondrial enzymes, which may provide a rationale for therapeutic strategies that inhibit tumor growth by administration of a ketogenic diet with average protein but low in carbohydrates and high in fat. Materials and Methods: Thirty-six male BALB/C nude mice were injected subcutaneously with tumor cells of the colon cancer cell line HCT116. The animals were then randomly split into three feeding groups and fed either a ketogenic diet rich in omega-3 fatty acids and MCT (MKD group; n=12) or lard only (LKD group; n=12) or a standard diet (SD group; n=12) ad libitum. Experiments were ended upon attainment of the target tumor volume of $600mm^3$ to $700mm^3$. The three diets were compared for tumor growth and survival time (interval between tumor cell injection and attainment of target tumor volume). Results: The tumor growth in the MKD and LKD groups was significantly delayed compared to that in the SD group. Conclusions: Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model. Further studies are needed to address the mechanism of this diet intervention and the impact on other tumor-relevant parameters such as invasion and metastasis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권3호
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• pp.177-185
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• 2010

Introduction: Epidermal growth factor receptor (EGFR) is expressed in human epithelial tumors including salivary cancers, and known to be correlated with tumor progression and poor clinical courses in some epithelial tumors. In this study, we determined the therapeutic effect of the anti-EGFR monoclonal antibody Erbitux (C225, cetuximab) in combination with the DNA topoisomerase I inhibitor irinotecan (CPT-11) on human salivary adenoid cystic carcinoma (SACC) cells growing in nude mice. Materials and Methods: At first, immunocytochemical analysis for the expression of EGFR and phosphorylated EGFR (pEGFR) on a human salivary ACC cell line (ACC3). To determine the in vivo effects of Erbitux and CPT-11, nude mice with orthotopic parotid tumors were randomized to receive intraperitoneal Erbitux (1 mg) two times per week, intraperitoneal Irinotecan (50 mg/kg) once per week, Erbitux plus CPT-11, or placebo. (control) Tumor volume and weight were measured. And mechanisms of in vivo activity of Erbitux and/or CPT-11 were determined by immunohistochemical/ immunofluorescent analyses. Results: Immunocytochemical staining of ACC3 demonstrated that EGFR was expressed and phosphorylated. CPT-11 inhibited ACC tumor growth in nude mice. Tumors of mice treated with CPT-11 and CPT-11 plus Erbitux exhibited increased tumor cell apoptosis and decreased microvessel density, which correlated with a decrease in the tumor volume in nude mice. But, CPT-11 seems not to be synergistic with Erbitux in our ACC3 model system. Conclusion: These results suggest that anti-EGFR monoclonal antibody and the DNA topoisomerase I inhibitor will be effective in the treatment of recurred or metastatic lesions of salivary ACC.

• 한국결정성장학회지
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• 제13권1호
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• pp.1-4
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• 2003

In the present work we consider morphological structure of the faces of BGO crystals grown by Czochralski technique under the conditions of low temperature gradient (0.1~1 deg/cm) and interconnection between the morphological features of faces at the crystallization front and the formation of defects within the crystal volume. It is demonstrated that the {112} faces retain stability while the growing surface deviates from the crystallographic (112) plane up to 1 degree. At larger deviation, the region of the stable facet growth passes either to the region of macrosteps or to the region of normal growth. depending on conditions.

• 대한기계학회논문집B
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• 제26권6호
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• pp.817-822
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• 2002

Sooting characteristics of counterflow ethylene/propane mixture flames have been experimentally studied to investigate the fuel structure effect on PHM and soot formation. Laser-induced incandescene and laser-induced fluorescene techniques were employed to measure soot volume fraction and polycyclic aromatic hydrocarbon (PAH) concentration, respectively. Importance of $C_{3-}$species on PAH growth as well as the H-abstraction-C$_2$ $H_2$addition (HACA) mechanism has been emphasized, considering that PAH growth rate is greater for with mixed fuel than fer pure fuel flames. It was also confirmed that HACA pathways are the dominant soot growth mechanism. A new PAH growth model including both $C_{2-}$ and $C_{3-}$growth mechanisms is proposed based on the experimental results.

• Journal of Welding and Joining
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• 제15권3호
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• pp.128-135
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• 1997

Reaction diffusion and formation of $Ni_3Al$phase with $L1_2$ structure have been studied in temperature range of 1432K to 1573K using the diffusion couple of (Ni-40, 5at%Al)/(Ni-14, 1at%Al) and (Ni-49, 2at%Al)/ (Nickel). The layer growth of Ni$_{3}$Al pyhase in the annealed diffusion couple was measured by optical microscope and electron probe microanalyzer (EPMA). The layer growth of $Ni_3Al$phase in diffusion zone obeyed the parabolic law without any indication of grain boundary effects. The layer growth of $Ni_3Al$phase in temperature range of 1423K to 1573K was mainly controlled by the volume diffusion mechanism. The rate of layer growth of $Ni_3Al$phase was found to be colsely related to the composition of intermetallic compound NiAl phase. The activation energy for layer growth of $Ni_3Al$phase was calculated to be 127kJ/mol.

• 한국세라믹학회지
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• 제32권5호
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• pp.587-593
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• 1995

Abnomal grain growth behavior of BaTiO3 ceramics was investigated with addition of seed grains. It was foudn that the nucleation rate of abnormal grain was constant and growth of abnormal grain was linearly increased with sitnering time, regardless of amount of seed grains. These facts were also confirmed by fitting of the volume fraction of abnormal grain vs. sintering time using Avrami type equation (n=4). It was suggested that seed grains did not change the nucleation rate or growth mechanism of abnormal grain but increase the number of abnormal grains at initial stage of sintering and then it led to fine microstructure of BaTiO3 ceramics.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.70-71
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• 2006

Growth behavior and kinetics of grains in a liquid matrix has been studied by computer simulation for various physical and processing conditions. The kinetics of growing and dissolving grains were considered to follow those of single crystals in a matrix. Depending on the shape of crystals, rounded or faceted, different kinetic equations were adopted for growing grains and an identical equation for dissolving grains. Effects of such critical parameters as step free energy, temperature, and liquid volume fraction were evaluated.

• 한국결정성장학회지
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• 제29권6호
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• pp.251-256
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• 2019

ZnO를 통상적인 소결온도 이상의 온도 1385℃에서 소결하는 과정에서 mm 크기로 거대 성장된 입자를 갖는 세라믹스를 제조하였다. 1400℃에서 8시간 소결하는 경우 성장에 참여하지 않은 입자의 크기는 30~40 ㎛이고 거대 성장된 입자는 1,000 ㎛에 달하여 부피비 최소 10,000배 이상의 급속한 성장이 이루어졌다. 이러한 급속한 성장의 원인으로 일차 입자 크기분포, 성형압 불균일 또는 불순물의 합입등을 고려하였으며, 이들 중 일차입자 크기 분포일 것으로 추정되나 확실한 증거를 확보하지 못하였다. 미세구조 관찰을 통해 거대입자 성장은 주변의 입자를 통째로 합치는 과정을 통해 성장하는 것으로 추정된다.

• Fisheries and Aquatic Sciences
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• 제26권7호
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• pp.447-454
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• 2023

Fast somatic growth is important considerations for successful and competitive aquaculture industry. In rainbow trout reared in South Korea, triploid induction was used to suppress negative influence of reproductive maturation to body growth. However, the effects of triploidy are visible in both mature fish and developing juvenile fish. Thus, it is also important to explicate the effect of triploid induction on growth during the early-life stages of rainbow trout-alevins and fry. Rainbow trout fertilized eggs were subjected to triploid induction and polyploidy was checked by flow cytometry. Diploid and triploid alevins and fry were reared separately in tanks with constant flow of freshwater through flow-through water system and growth measurements were done from zero days after hatching (DAH 0) until DAH 134. The egg-yolk morphometrics of alevins-yolk length, yolk height, yolk volume and yolk weight-were statistically similar (p > 0.05) in both genotypes from DAH 0 to DAH 22. The total length, body height, and body weight of alevins and fry were statistically better (p > 0.05) in both genotypes until DAH 92 but thereafter, triploid had a significantly better growth performance (p < 0.05) over diploid fish until the completion of study at DAH 134. With that, triploid induction did not influence alevin yolk regions and body growth and fry somatic growth until around 3 months after hatching, but considerable growth enhancement was subsequently apparent.