• Journal of Powder Materials
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• v.25 no.2
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• pp.104-108
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• 2018

Grain-growth behavior in the $95Na_{1/2}Bi_{1/2}TiO_3-5BaTiO_3$ (mole fraction, NBT-5BT) system has been investigated with the addition of $Na_2CO_3$. When $Na_2CO_3$ is added to NBT-5BT, the growth rate is higher than desired and grains are already impinging each other during the initial stage of sintering. The grain size decreases as the sintering temperature increases. With the addition of $Na_2CO_3$, a liquid phase infiltrates the interfaces between grains during sintering. The interface structure can be changed to be more faceted and the interface migration rate can increase due to fast material transport through the liquid phase. As the sintering temperature increases, the impingement of abnormal grains increases because the number of abnormal grains increases. Therefore, the average grain size of abnormal grains can be decreased as the temperature increases. The phenomenon can provide evidence that grain coarsening in NBT-5BT with addition of $Na_2CO_3$ is governed by the growth of facet planes, which would occur via mixed control.

• Journal of Microbiology and Biotechnology
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• v.23 no.11
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• pp.1586-1597
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• 2013

Energy-efficient metabolic responses were often noted in high-productive cultures. To better understand these metabolic responses, an investigation into the relationship between metabolic responses and energy regulation was conducted via a comparative analysis among cultures with different energy source supplies. Both glycolysis and glutaminolysis were studied through the kinetic analyses of major extracellular metabolites concerning the fast and slow cell growth stages, respectively, as well as the time-course profiles of intracellular metabolites. In three cultures showing distinct antibody productivities, the amino acid metabolism and energy state were further examined. Both the transition of lactate from production to consumption and steady intracellular pools of pyruvate and lactate were observed to be correlated with efficient energy regulation. In addition, an efficient utilization of amino acids as the replenishment for the TCA cycle was also found in the cultures with upregulated energy metabolism. It was further revealed that the inefficient energy regulation would cause low cell productivity based on the comparative analysis of cell growth and productivity in cultures having distinct energy regulation.

• BMB Reports
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• v.47 no.7
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• pp.399-404
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• 2014

B7-H4 is a member of B7 family of co-inhibitory molecules and B7-H4 protein is found to be overexpressed in many human cancers and which is usually associated with poor survival. In this study, we developed a therapeutic vaccine made from a fusion protein composed of a tetanus toxoid (TT) T-helper cell epitope and human B7-H4IgV domain (TT-rhB7-H4IgV). We investigated the anti-tumor effect of the TT-rhB7-H4IgV vaccine in BALB/c mice and SP2/0 myeloma growth was significantly suppressed in mice. The TT-rhB7-H4IgV vaccine induced high-titer specific antibodies in mice. Further, the antibodies induced by TT-rhB7-H4IgV vaccine were capable of depleting SP2/0 cells through complement-dependent cytotoxicity (CDC) in vitro. On the other hand, the poor cellular immune response was irrelevant to the therapeutic efficacy. These results indicate that the recombinant TT-rhB7-H4IgV vaccine might be a useful candidate of immunotherapy for the treatment of some tumors associated with abnormal expression of B7-H4.

• Journal of Environmental Impact Assessment
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• v.28 no.1
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• pp.49-62
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• 2019

Environmental changes can affect life-history traits, such as growth rate and reproduction, and organisms adapt on a given environmental condition to maximize ecological fitness. This study shows the effects of water temperature and dissolved oxygen level on early growth and accumulated damage in fish using a dynamic-state-dependent model. I have hypothesized that the level of foraging activity is related to growth and stress and so the optimal level can maximize reproductive success - ultimately, fitness. The critical temperature and dissolved oxygen (DO) is also defined as inducing the maximum growth rate at the level. So, the model predicts the highest growth rate at oxygen saturation and lower growth rate at lower or higher level of DO in water. Lower DO (i.e., hypoxia) causes slower growth rate through higher amount of accumulated stress whereas higher DO (i.e., hyperoxia) induces faster growth rate, but smaller body size. In addition, I show that there is lower impact when considering simple or independent environmental factors on environmental assessment. My findings suggest that multiple environmental factors as physiological ecology approach should be considered to improve impact assessment in environmental changes and a further study is needed to develop advanced assessment tools considering multiple environmental factors.

• Journal of Contemporary Eastern Asia
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• v.16 no.2
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• pp.82-92
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• 2017

The Korean state evolved as a distinct entity in a region of major power convergence and conflict. All states, as human constructions, seek sovereignty and life security of their subjects/citizens, and are rotted in organic society. In the Republic of Korea, constitutional order has provided a framework for political action and a succession of regimes - authoritarianism, military dictatorship, and constitutional democracy. Since 1960 two paradigms have undergone a cycle of growth and decline, and a third, since the 2016 candlelight demonstrations in Gwanghwamun, may be the beginnning of a third generation paradigm - populist constitutionalism.

• Bulletin of the Korean Mathematical Society
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• v.59 no.4
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• pp.961-977
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• 2022

In this paper, we consider the following Kirchhoff type equation on the whole space $$\{-(a+b{\displaystyle\smashmargin{2}{\int\nolimits_{{\mathbb{R}}^3}}}\;{\mid}{\nabla}u{\mid}^2dx){\Delta}u=u^5+{\lambda}k(x)g(u),\;x{\in}{\mathbb{R}}^3,\\u{\in}{\mathcal{D}}^{1,2}({\mathbb{R}}^3),$$ where λ > 0 is a real number and k, g satisfy some conditions. We mainly investigate the existence of ground state solution via variational method and concentration-compactness principle.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.7
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• pp.251-260
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• 2020

The purpose of this paper is to investigate the impact of total factor productivity (TFP), institutional quality, and interactive variable between them on economic growth in 13 low-middle income countries in Asia for the period 2000-2018. The paper uses the difference Generalized Method of Moments (GMM) to explore the dataset provided by the World Bank. The empirical results show that TFP and the interactive variable positively impact on the economic growth, while the institutional determinants have a negative influence. The negative effect is explained by the weak institutions in these low-middle income countries. The findings of the study suggest two points. First, the government should continue to improve TFP, which is associated with the application of technical advances, technological innovations, improvement of management methods, and skilled workers. Second, far more important, is that the authorities should pay special attention to implement institutional reform and strengthen the governance in the future. The successful experiences from Japan, Korea and Singapore will help other governments in Asian low-middle income countries to build developmental state. Probably, the developmental state actively interfere in the market to promote and realize the development goals. By doing so, these economies might overcome the so-called "middle-income trap".

• ALGAE
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• v.21 no.2
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• pp.229-234
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• 2006

For the test organism of algal growth potential (AGP), the diatom in the genus Stephanodiscus which cause blooms in the Nakdong River was used instead of generally used strains of Selenastrum, Microcystis, or Anabaena. AGP results indicated that all the samples in the Nakdong River except for that from the Nakdan Bridge site were eutrophic state. Furthermore, the sample from Kumho River site was hypertrophic state. In the main stream Nakdong River, the value of AGP was lowest at the upstream Nakdan Bridge site and was highest at Koryoung Bridge site which is just downstream of Kumho River confluent point indicating the seriousness of pollution contributed by the Kumho River to the Nakdong River. Changes in the concentration of nutrients before and after the AGP tests and inter-relationship among the nutrients indicated that the growth of the Stephanodiscus in the AGP tests were mostly affected by the nitrate, silicate and phosphate. The limiting nutrient was identified by the nutrient addition experiments and the results showed that phosphate was the limiting nutrient for the growth of Stephanodiscus in the tested samples.

• Computers and Concrete
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• v.24 no.4
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• pp.283-293
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• 2019

The limited availability of raw materials and increasing service demands for pavements pose a unique challenge in terms of pavement design and concrete material selection. The self-compacting rubberized concrete (SCRC) can be used in pavement design. The SCRC pavement slab has advantages of excellent toughness, anti-fatigue and convenient construction. On the premise of satisfying the strength, the SCRC can increase the ductility of pavement slab. The aim of this investigation is proposing a new method to predict the crack growth and flexural capacity of large-scale SCRC slabs. The mechanical properties of SCRC are obtained from experiments on small-scale SCRC specimens. With the increasing of the specimen depth, the bearing capacity of SCRC beams decreases at the same initial crack-depth ratio. By constructing extended finite element method (XFEM) models, crack growth and flexural capacity of large-scale SCRC slabs with different fracture types and force conditions can be predicted. Considering the diversity of fracture types and force conditions of the concrete pavement slab, the corresponding test was used to verify the reliability of the prediction model. The crack growth and flexural capacity of SCRC slabs can be obtained from XFEM models. It is convenient to conduct the experiment and can save cost.

• Archives of Pharmacal Research
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• v.23 no.4
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• pp.267-282
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• 2000

Cytochrome P45O (CYP) 2E1 catalyzes the metabolism of a wide variety of therapeutic agents, procarcinogens, and low molecular weight solvents. CYP2E1-catalyzed metabolism may cause toxicity or DNA damage through the production of toxic metabolites, oxygen radicals, and lipid peroxidation. CYP2E1 also plays a role in the metabolism of endogenous compounds including fatty acids and ketone bodies. The regulation of CYP2E1 expression is complex, and involves transcriptional, post-transcriptional, translational, and post-translational mechanisms. CYP2E1 is transcriptionally activated in the first few hours after birth. Xenobiotic inducers elevate CYP2E1 protein levels through both increased translational efficiency and stabilization of the protein from degradation, which appears to occur primarily through ubiquitination and proteasomal degradation. CYP2E1 mRNA and protein levels are altered in response to pathophysiologic conditions by hormones including insulin, glucagon, growth hormone, and leptin, and growth factors including epidermal growth factor and hepatocyte growth factor, providing evidence that CYP2E1 expression is under tight homeostatic control.