• The Korean Journal of Nuclear Medicine
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• v.18 no.2
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• pp.17-23
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• 1984

For nearly a century it has been known that chemical activity accompanies mental activity, but only recently has it been possible to begin to examine its exact nature. Positron-emitting radioactive tracers have made it possible to study the chemistry of the human mind in health and disease, using chiefly cyclotron-produced radionuclides, carbon-11, fluorine-18 and oxygen-15. It is now well established that measurable increases in regional cerebral blood flow, glucose and oxygen metabolism accompany the mental functions of perception, cognition, emotion and motion. On May 25, 1983 the first imaging of a neuroreceptor in the human brain was accomplished with carbon-11 methyl spiperone, a ligand that binds preferentially to dopamine-2 receptors, 80% of which are located in the caudate nucleus and putamen. Quantitative imaging of serotonin-2, opiate, benzodiazapine and muscarinic cholinergic receptors has subsequently been accomplished. In studies of normal men and women, it has been found that dopamine and serotonin receptor activity decreases dramatically with age, such a decrease being more pronounced in men than in women and greater in the case of dopamine receptors than serotonin-2 receptors. Preliminary studies in patients with neuropsychiatric disorders suggests that dopamine-2 receptor activity is diminished in the caudate nucleus of patients with Huntington's disease. Positron tomography permits quantitative assay of picomolar quantities of neuro-receptors within the living human brain. Studies of patients with Parkinson's disease, Alzheimer's disease, depression, anxiety, schizophrenia, acute and chronic pain states and drug addiction are now in progress. The growth of any scientific field is based on a paradigm or set of ideas that the community of scientists accepts. The unifying principle of nuclear medicine is the tracer principle applied to the study of human disease. Nineteen hundred and sixty-three was a landmark year in which technetium-99m and the Anger camera combined to move the field from its latent stage into a second stage characterized by exponential growth within the framework of the paradigm. The third stage, characterized by gradually declining growth, began in 1973. Faced with competing advances, such as computed tomography and ultrasonography, proponents and participants in the field of nuclear medicine began to search for greener pastures or to pursue narrow sub-specialties. Research became characterized by refinements of existing techniques. In 1983 nuclear medicine experienced what could be a profound change. A new paradigm was born when it was demonstrated that, despite their extremely low chemical concentrations, in the picomolar range, it was possible to image and quantify the distribution of receptors in the human body. Thus, nuclear medicine was able to move beyond physiology into biochemistry and pharmacology. Fundamental to the science of pharmacology is the concept that many drugs and endogenous substances, such as neurotransmitters, react with specific macromolecules that mediate their pharmacologic actions. Such receptors are usually identified in the study of excised tissues, cells or cell membranes, or in autoradiographic studies in animals. The first imaging and quantification of a neuroreceptor in a living human being was performed on May 25, 1983 and reported in the September 23, 1983 issue of SCIENCE. The study involved the development and use of carbon-11 N-methyl spiperone (NMSP), a drug with a high affinity for dopamine receptors. Since then, studies of dopamine and serotonin receptors have been carried out in over 100 normal persons or patients with various neuropsychiatric disorders. Exactly one year later, the first imaging of opitate receptors in a living human being was performed [1].

• Korean Journal of Organic Agriculture
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• v.24 no.3
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• pp.435-451
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• 2016

The objective of the present study was to perform a comparative analysis of the chemical properties of the cultivation site soil and growth characteristics of organically and conventionally cultivated ginseng (Panax ginseng C. A. Meyer). Organically and conventionally cultivated ginseng samples (4-, 5-, and 6-year-old) were collected from 52 fields at 14 locations throughout Korea. The samples were collected over three years from 2013 to 2015, with the collection period between October and November of each year. In order to increase the yield of organically cultivated ginseng, the amount of nutrients was increased to match that of the conventional cultivation system, which highlights the need for proper management in accordance with the standards for chemical properties of soil. Growth duration of organic ginseng was ${\geq}60days$ shorter than that of conventional ginseng and its average yield per 1ha was 60% than that of conventional ginseng. Root weight of organically cultivated ginseng was approximately 54% that of conventionally cultivated ginseng. Rhizome diameter and body shape index of organically cultivated ginseng were lower than those of conventionally cultivated ginseng, indicating that organically cultivated ginseng was thinner and longer than conventionally cultivated ginseng. Root length was greater in 5-year-old conventionally cultivated ginseng with a low percentage of paddy-upland rotation fields. The number of rootlets was lower in 5- and 6-year-old organically cultivated ginseng with a high percentage of direct seeding cultivation. Dry weight was distinctly lower in 5- and 6-year-old organically cultivated ginseng with early defoliation than that of conventionally cultivated ginseng. Incidences of notched belly and root rot tended to be higher in conventional cultivation, with the incidence of notched belly being distinctly higher in 4- and 6-year-old roots and root rot being more prevalent in 5- and 6-year-old roots. Red discoloration and eelworm damage, which are highly affected by soil moisture, were most common in the organically cultivated 4-year-old roots. Organically cultivated ginseng showed early defoliation than conventionally cultivated ginseng, as a result, its yield and weight were low, while the incidence of physiological disorders was low. In order to increase the yield of organically cultivated ginseng, studies on cultivation technology that can overcome early defoliation, as well as soil moisture management that can minimize physiological disorders, are required.

• Journal of Bio-Environment Control
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• v.27 no.3
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• pp.191-198
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• 2018

The objective of this study was to determine the effects of combination of air temperature and soil water contents on growth, physiological disorder rate, and yield of garlic. This experiments has been carried out in the typical plastic house (one side open and other side installed ventilation fans) which was maintained gradient air temperature (maximum different value of air temperature : $6^{\circ}C$). The excessive irrigation (EI) set at $0.34m^3/m^3$ soil moisture contents. The significant differences found in the growth parameters of garlics as affected by air temperature and soil moisture conditions. The plant height of garlic with combination of ambient $(A)+6^{\circ}C$ and optimal irrigation (OI; set at $0.22m^3/m^3$ soil moisture contents) treatments represented 47.4 cm/plant, which was the highest among all the tested treatments. The leaf length and width showed the greatest, which were 16.1 and 2.4 cm/plant, respectively, in $A+6^{\circ}C-OI$. The physiological disorder ratio was higher as 12.9% at $A+6^{\circ}C-OI$ and was not occurred at ambient temperature with EI compared with OI treatment. The bulb and clove weight were dramatically decreased at $A+6^{\circ}C$ temperature treatment. The yields were decreased by 51% in OI at $A+6^{\circ}C$ and $A+3^{\circ}C$ temperature treatment. Those results indicated that yields were decreased and ratio of physiological disorders was increased by high temperature treatments.

• FLOWER RESEARCH JOURNAL
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• v.16 no.1
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• pp.36-43
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• 2008

This purpose of this study was to examine the effect of planting density, growing medium and strength of a nutrient solution (National Horticultural Research Institute's nutrient solution: HRI's) on the growth and development of Oriental hybrid lily 'Le Reve' in a box cultivation. The planting density with 14, 18 and 22 bulbs had sprouting one day earlier than other treatments. Planting density of 22 bulbs flowered first, while six bulbs flowered the last, indicating that higher planting densities led earlier flowering. The increasing planting density increased stem length of cut flowers. On the other hand, cut flower quality was improved when the planting density was lower. The incidence of physiological disorders such as blasting was more frequent in planting density of 22, 18, and 14, indicating that higher planting densities caused higher incidences of physiological disorders. All planting densities except 22 bulbs displayed superior results in width, weight, number, and scale weight of the bulbs. Greater planting densities led to inferior bulb enlargement and an increased decomposition rate. pH decreased in all treatments after the bulb enlargement and decreased more as the planting density increased. Contents of P, K, Ca, and Mg increased, while contents of K and Ca decreased, as the planting density increased. The rice hull+coir (1:1, v/v) treatment was better than others, but did not show that much of a difference. Moreover, in bulbs enlargement after cut flower harvest, lily medium and perlite+peat moss treatments showed superior results, and decomposition rate was the greatest in the rice hull+coir (1:1, v/v) treatment. In the HRI's solution strength treatment from the period of flower bud emergence to flower harvest, higher solution strengths gave better cut flower quality in terns of length, weight, and number of flowers. The non-treated control and one third strength of a HRI's solution hastened flowering, indicating that lower strengths led to earlier flowering. According to the results of leaf analysis as affected by solution strength during the flower harvest, absorption rates of N and K were greater when the strength was higher, and Ca and Mg showed the same tendency. On the other hand, the absorption rate of P was the lowest in all treatments.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4437-4441
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• 2014

SMAD7 has been identified as a functional candidate gene for colorectal cancer (CRC). SMAD7 protein is a known antagonist of the transforming growth factor beta ($TGF-{\beta}$) signaling pathway which is involved in tumorigenesis. Polymorphisms in SMAD7 may thus alter cancer risk. The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological features in an Iranian population. In total, 210 subjects including 105 patients with colorectal cancer and 105 healthy controls were recruited in our study. All samples were genotyped by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of colorectal cancer and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs2337107and the risk of colorectal cancer. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). Although there was not any association between genotypes and disorder, CT was the most common genotype in this population. This genotype prevalence was also higher in the patients with well grade (54.9%) and colon (72.0%) tumors. Our results provide the first evidence that this polymorphism is not a potential contributor to the risk of colorectal cancer and clinicopathological features in an Iranian population, and suggests the need of a large-scale case-control study to validate our results.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.3
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• pp.153-160
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• 2010

Objectives: The purpose of this study was to evaluate the prenatal, perinatal, and infancy history of children with autism spectrum disorder (ASD) as compared to unaffected siblings (SIB) and typically developing children (TC). Methods: Subjects with ASD, their SIB, and TC were recruited. All subjects were assessed using both the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) and were subsequently identified as affected or unaffected. Prenatal, perinatal, and infancy history was obtained from the primary caregivers and each facet was compared in those with ASD, the SIB, and the TC groups using SPSS ver. 17.0 (p<.05). Results: 70 individuals with ASD (63 males, 87.94${\pm}$37.8months), 53 SIB (27 males, 85.4087.94${\pm}$48.06 months), and 32 TC (19 males, 104.1987.94${\pm}$23.409 months) were analyzed. The ASD group showed significantly higher rates of insufficient vaccination as they aged age ($x^2$=15.54, p=.000). Among the scheduled vaccinations, the DPT vaccination ($x^2$=10.08, p=.006) was insufficient in ASD groups. The ASD group also showed higher rates of sleep disturbances from infancy. Differences in maternal/paternal age at conception, gestational age, and growth parameters at birth were not significantly difference among the three groups. Conclusion: These results do not support the previous controversies regarding the relationship between prenatal/perinatal complications and ASD. However, these results indicate that perinatal and prenatal factors may contribute to the development of ASD.

• Korean Journal of Food Science and Technology
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• v.6 no.3
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• pp.147-157
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• 1974

This study was undertaken to observe the effect of sesame in the diet of rats (Splague Dowley). Comparisons were made of weight gains, organ weights and the cholesterol, phospholipid and triglyceride content of the blood serum and liver tissue. Rats weighing 67-80 g were used for the study, while rats weighing 160-165 g were used in the study. In the both studies, the experimental animals were fed on sesame mixtures for 24 weeks. The study was conducted to determine the effect of sesame hulls which are known to contain a high proportion of oxalic acid and phytic acid, which are toxic substances causing various physical disorders. The rats were divided into four groups, a control group which was fed on a standard diet and three groups fed with 20%, 10% and 5% mixtures of sesame seed hulls respectively. The study was designed to observe the same effect, but in this case the rats were divided into two groups, one fed with a 5% mixture of whole sesame seeds and the other with a 5% mixture of dehulled seeds. The results are as follows: 1) An examination of weight gains showed that group I and II which were fed on 20% and 10% mixture of sesame hulls were significantly retarded in comparison with the control group(P<0. 05). 2) Comparisons of organ weights, group I (20% mixture) showed relatively lower weights(P<0.05). 3) The cholesterol content of the blood serum and liver tissue of group I (20% mixture) and group II (10% mixture) were significantly higher than that of the control. 4) The group fed on the whole sesame seed diet and that fed on the dehulled seed diet differed significantly from each other. 5) With the results stated above, the investigators could observe that a high content of sesame hulls in the diet caused retardation in growth and might be the cause of many physical disorders. Though these effects are not important in Korea at present, the increasing intake of sesame seeds and oils indicates that it may become an important problems.

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.2
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• pp.270-277
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• 2002

Since founded in 1959, it's well known that the KAPD has pioneered in the researches and clinical aspects of pediatric dentistry in Korea. It's official journal, the Journal of the KAPD, was first published in 1974 and has pressed total 956 articles up to now(March, 2001). In this study, all the articles pressed in this journal have been surveyed, focussing in their main theme, their chronological and thematic distribution. The thematic classification was made with the reference of the previous studies and renowned textbooks in pediatric dentistry. And we obtained the results as follows: 1. The researches on dental materials and dental equipments have shown continuous increase throughout the period. 2. The researches on dental caries, caries prevention and systemic disorders have occupied relatively high proportion consistently. 3. The researches on malocclusions and cysts/minor surgery have shown increasing tendency in the second period, but are decreasing in the third period. 4. The researches on craniofacial growth/development, tooth development/eruption, developmental disorders of teeth, management of eruption space have shown decreasing tendency. 5. The researches on behavioral research, oral habits, occlusion of primary-mixed dentition have shown very low proportion, reaching no more than 1% throughout the period.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.72-78
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• 2015

Objectives: The stomach is a sensitive digestive organ that is susceptible to exogenous pathogens from the diet. In response to such pathogens, the stomach induces oxidative stress, which might be related to the development of both gastric organic disorders such as gastritis, gastric ulcers, and gastric cancer, and functional disorders such as functional dyspepsia. This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. Methods: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. In this study, the modified ethanol gastritis model was used. The rats were administrated 56% ethanol orally every other day. The dose of ethanol was 8 g/kg body weight. The normal group received the same amount of normal saline instead of ethanol. The NP and the GLP groups were treated with injection of saline and GLP respectively. The control group received no treatment. Two local acupoints CV12 (中脘) and ST36 (足三里) were used. All laboratory rats underwent treatment for 15 days. On last day, the rats were sacrificed and their stomachs were immediately excised. Results: Ulcers of the gastric mucosa appeared as elongated bands of hemorrhagic lesions parallel to the long axis of the stomach. In the NP and GLP groups, the injuries to the gastric mucosal injuries were not as severe as they were in the control group. Wound healings of the chronic gastric ulcers was promoted by using GLP and significant alterations of the indices in the gastric mucosa were observed. Such protection was demonstrated by gross appearance, histology and immunehistochemistry staining for Bcl-2-associated X (BAX), B-cell lymphoma 2 (Bcl-2) and Transforming growth factor-beta 1 (TGF-${\beta}1$). Conclusion: These results suggest that GLP at CV12 and ST36 can provide significant protection to the gastric mucosa against an ethanol induced chronic gastric ulcer.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.1
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• pp.38-47
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• 2019

The most common cause of mouth breathing is obstacles caused by mechanical factors in upper airway. Mouth breathing could be consequently pathological cause of sleep-disordered breathing. Sleep-disordered breathing in children can cause growth disorders and behavioral disorders. The purpose of this study was to investigate relationship between upper airway and sleep-disordered breathing in children with mouth breathing. Twenty boys between 7 - 9 years old who reported to have mouth breathing in questionnaire were evaluated with clinical examination, questionnaires, lateral cephalometric radiographs, and portable sleep testing. This study assessed apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) for the evaluation of sleep-disordered breathing and was done to investigate the correlation between these values and the upper airway width measured by lateral cephalometric radiographs. There was no significant correlation with the size of the tonsils (p = 0.921), but the adenoid hypertrophy was higher in the abnormal group than in the normal group (p = 0.008). In the classification according to AHI and ODI, retropalatal and retroglossal distance showed a statistically significant decrease in the abnormal group compared to the normal group (p = 0.002, p = 0.001). As AHI and ODI increased, upper airway width tended to be narrower. This indicates that mouth breathing could affect the upper airway, which is related to sleep quality.