• Title/Summary/Keyword: growth diagnosis

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Utility of VEGF and sVEGFR-1 in Bronchoalveolar Lavage Fluid for Differential Diagnosis of Primary Lung Cancer

  • Cao, Chao;Sun, Shi-Fang;Lv, Dan;Chen, Zhong-Bo;Ding, Qun-Li;Deng, Zai-Chun
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2443-2446
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    • 2013
  • Published data have shown that the levels of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1) in plasma and pleural effusion might be usefulness for lung cancer diagnosis. Here, we performed a prospective study to investigate the utility of VEGF and sVEGFR-1 in bronchoalveolar lavage fluid (BALF) for differential diagnosis of primary lung cancer. A total of 56 patients with solitary pulmonary massed by chest radiograph or CT screening were enrolled in this study. BALF and plasma samples were obtained from all patients and analyzed for VEGF and sVEGFR-1 using a commercially available sandwich ELISA kit. The results showed that the levels of VEGF in BALF were significantly higher in patients with a malignant pulmonary mass compared with patients with a benign mass (P < 0.001). However, no significant difference of sVEGFR-1 in BALF was found between malignant and non-malignant groups (P = 0.43). With a cut-off value of 214 pg/ml, VEGF showed a sensitivity and specificity of 81.8% and 84.2%, respectively, in predicting the malignant nature of a solitary pulmonary mass. Our study suggests that VEGF is significantly increased in BALF among patients with lung cancer than in benign diseases. Measurement of VEGF in BALF might be helpful for differential diagnosis of primary lung cancer.

A Study on the Clinical Characteristics of 4-Constitution Groups in 8-Constitution Medicine (8체질의학에서 목$\cdot$$\cdot$$\cdot$수 4체질군의 임상적 특징에 대한 연구)

  • Lee Sang-Beom;Choi Kyung-Mee;Park Young-Jae;Park Young-Bae
    • The Journal of Korean Medicine
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    • v.26 no.3 s.63
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    • pp.80-97
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    • 2005
  • Backgrounds : In recent years there has teen renewed interest in the importance of 8-constitution medicine as evidenced by growth of research in this field. Although diagnosis by 8-constitution depends on pulse types, it still is subjective and thus could be insignificant. Therefore, diagnosis based on objective characteristics is essential. Objectives : The purpose of this study was to find objective characteristics of the 4-constitution groups {木(Mok; hepatonia, cholecystonia), {土(To; pancreotonia, gastrotonia), {金(Gum; pulmotonia, colonotonia), {水(Soo; renotonia, vesicotonia)} in 8-constitution for further diagnosis and therapy. Also, some significant clinical tendencies of 4-constitution groups were studied. Methods : From Nov. 2001 to Apr. 2004, data were collected through a questionnaire given to 720 patients who were classified into one of 8 constitutions according to their pulse types and their responses to constitution-based acupuncture therapy. The questionnaire was composed of 80 items which were about personality, physical shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to various foods. The data were statistically analyzed by cross-tabulation and one-way analysis of variance, and SPSS V10.0.7PC was used. Results : The results are summarized as follows: 1) Among participants, proportions of hepatotonia, pancreotonia, and cholecystotonia were higher than those of vesicotonia, pulmotonia, colonotonia, renotonia, grstrotonia. 2) 52 items of 80 variances showed significant differences by gender, 3) 13 items were highly correlated with 4-constitution groups in males, and 26 items in fremales. 4) 22 items showed significant group differences among 4-constitution groups in males, and 41 items in females. Also, for each item 4-constitution groups were sorted according to their means, so that the constitutional tendencies were objectively figured out by personality, shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to foods. Conclusions : Most clinical characteristics of 4-constitution groups found in this study coincided with those from the previous ones in this fold. Thus, classifying patients into one of the 4-constitution groups based on significant objective characteristics is of great benefit to diagnosis and therapy. further study should be followed to improve proper therapy for each constitution.

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Applicability of Vegetation Index and SPAD Reading to Nondestructive Diagnosis of Rice Growth and Nitrogen Nutrition Status (식생지수와 SPAD를 이용한 벼 생육 및 질소영양상태의 비파괴적 진단 가능성 검토)

  • Kim Min-Ho;Shin Jin-Chul;Lee Byun-Woo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.6
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    • pp.369-377
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    • 2005
  • Precise application of topdressing nitrogen (N) fertilizer is indispensible for securing high yield and good quality of rice and minimizing N losses to the environment as well. For precise N management, growth and nitrogen nutrition status (NNS) should be diagnosed rapidly and accurately. The objective of the study was to evaluate the applicability of vegetation index (VI) calculated from hyperspectral canopy reflectance measurement and SPAD reading to nondestructive in situ diagnosis of growth and NNS of rice. Canopy reflectance, SPAD read­ing, growth parameters, and NNS characteristics were measured from various N treatments to evaluate the relationships among them for two cropping seasons from 2001 to 2002. The correlation coefficient of VIs with variables of growth and NNS increased positively as rice canopy became more closed. Regardless of growth stages, VIs had significantly high correlations with LAI, shoot dry weight (DW), shoot N content and nitrogen nutrition index (NNI). Those correlation coefficients increased steadily before heading stage as rice grew up. However, tiller number and leaf N concentration showed significantly high correlations with VIs only at and after panicle initiation stage (PIS). Among the VIs, RVIgreen had significantly higher correlation with the measured parameters than the other VIs: it showed correlation coefficients greater than 0.8 with leaf and shoot N concentration and DW, and much higher coefficients greater than 0.9 with LAI, shoot N content, and NNI. At LAI of below 2.5, VIs had non-significant or low correlations with the growth and NNS indicators due to the background effects. SPAD reading had significantly high correlation with leaf N concentration and NNI at each growth stage. In addition, it had significant correlations with variables of growth and NNS at PIS and booting stage, particularly, at booting stage. Though SPAD reading had a significantly high correlation value at a given growth stage in each year, it showed very weak relationship with variables of growth and NNS when pooled across growth stages and years. In conclusion, RVIgreen was found to be the most reliable VI to estimate the growth and NNS of rice around at PIS, but SPAD reading had much limitations.

Left Atrial Myxoma (좌심방 점액종 1례 보고)

  • 오세웅
    • Journal of Chest Surgery
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    • v.20 no.4
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    • pp.809-814
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    • 1987
  • Myxoma is a benign growth constituting nearly 50% of all primary cardiac tumors. It is important because in can be abolished by surgical therapy and is usually fatal if unrecognized and untreated. Primary cardiac tumors are uncommon in all age group. In contrast, tumors metastatic to the heart are significantly more common. The diagnosis is made by echocardiography and cardiac angiography. Recently a wider use of echocardiogram as the screening test of valve lesions can be expected to increase the number of myxomas found preoperatively. We report the two cases of left atrial myxomas which were removed successfully by surgery in the thoracic and cardiovascular surgery department, Marryknoll Hospital.

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Esophageal hemangioma-A case report (양성 식도 혈관종 -1례 보고-)

  • 김진국
    • Journal of Chest Surgery
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    • v.23 no.5
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    • pp.994-997
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    • 1990
  • We are reporting a case of esophageal hemangioma, which is a very rare disease with only 24 cases having been reported. A 31-year-old male with dysphagia was shown to have a hemangioma of the upper thoracic esophagus and resection of the lesion cured this problem. Once diagnosed in symptomatic patient, treatment should be instituted because of followings; 1. growth potency to large size, 2. possible complications such as hemorrhage and obstruction, and 3. exclusion diagnosis of malignancy. Surgery is the treatment of choice due to its effectiveness and safety, but endoscopic removal may be possible for small tumors and those on a pedicle.

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Ununited Anconeal Process (UAP) in Dog: A Case Report (견(犬)의 주돌기 융합부전증(融合不全症)의 수술치료예(手術治療例))

  • Cho, Kil Hyon
    • Korean Journal of Veterinary Research
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    • v.20 no.2
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    • pp.123-125
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    • 1980
  • Ununited Anconeal Process (UAP) is defined as a disease of young dogs due to developmental abnormality in which there is a seperation of the anconeal process from the diaphysis of the ulna, leading to a front leg lameness and secondary osteoarthritis. A six -year-old German Shepherd dog was presented because of intermittent right front leg lameness. Diagnosis was made of ununited anconeal process with moderate osteoarthritis by radiographic examination. Surgical removal of ununited anconeal process and curettage of osteoarthritic growth within the elbow joint relieved significant clinical signs despite of size and age of the dog.

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A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the $FGFR2$ gene

  • Lee, Min-Young;Jeon, Ga-Won;Jung, Ji-Mi;Sin, Jong-Beom
    • Clinical and Experimental Pediatrics
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    • v.53 no.7
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    • pp.774-777
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    • 2010
  • Pfeiffer syndrome is a rare autosomal dominant disorder characterized by coronal craniosynostosis, brachycephaly, mid-facial hypoplasia, and broad and deviated thumbs and great toes. Pfeiffer syndrome occurs in approximately 1:100,000 live births. Clinical manifestations and molecular genetic testing are important to confirm the diagnosis. Mutations of the fibroblast growth factor receptor 1 ($FGFR1$) gene or $FGFR2$ gene can cause Pfeiffer syndrome. Here, we describe a case of Pfeiffer syndrome with a novel c833_834GC>TG mutation (encoding Cys278Leu) in the $FGFR2$ gene associated with a coccygeal anomaly, which is rare in Pfeiffer syndrome.

Intraosseous ameloblastoma masquerading as exophytic growth: a case report

  • CJ, Sanjay;David, Chaya.M;Kaul, Rachna;BK, Ramnarayan;Ramachandra, Prashanth
    • Imaging Science in Dentistry
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    • v.41 no.2
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    • pp.89-93
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    • 2011
  • Intraosseous ameloblastoma is the most common and simple type of ameloblastoma prevalent among odontogenic tumors. Clinico-radiographically intraosseous ameloblastoma presents as slow, painless swelling or expansion of the jaws and described as multilocular expansile radiolucency that occurs most frequently in mandibular molar/ramus area. This article describes a case of follicular ameloblastoma involving 45 year old male which is different from the usual presentation, which includes-exophytic growth, different location and without expansion of the cortex.