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Effects of Soyoligosaccharides on Blood glucose and Lipid Metabolism in Streptozotocin-Induced Diabetic Rats (대두올리고당이 당뇨 유발 흰쥐의 혈당 및 지질대상에 미치는 영향)

  • 김미현;김혜영;김우경;김지영;김숙희
    • Journal of Nutrition and Health
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    • v.34 no.1
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    • pp.3-13
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    • 2001
  • This study was conducted to investigate the effect of soyligosaccharides on improvement of diabetes mellitus. Sprague Dawley rats were divided into three groups. Control and one experimental group were fel AIN-93G diet(mixed diet) and the other experimental group was fed a similar diet containing 5% soyligosaccharides(oligosaccharide diet) for 6 weeks. Experimental groups were divided into two sub-groups after streptozotocin(STZ) injection and fed th mixed diet or the oligosaccharide diet for the next 2 weeks. Followings are final experimental and control groups: MM (mixed dietlongrightarrowSTZ injectionlongrightarrowmixed diet). MO(mixed dietlongrightarrowSTZ injectionlongrightarrowoligosaccharide diet), OM( oligosaccharide dietlongrightarrowSTZ injectionlongrightarrowmixed diet), OO(oligosaccharide dietlongrightarrowSTZ injectionlongrightarrowoligosaccharide diet), C(mixed dietlongrightarrowplacebo injectionlongrightarrowmixed diet). Blood glucose was analyzed at d1, d8 and d12 after streptozotocin injection. At the end of the experimental period, fecal bifidobacteria, plasma insulin, total lipid, triglyceride, cholesterol, and leptin concentrations was analyzed, After STZ injection, blood glucose level was significantly elevated in experimental group compared to a control group. Elevated blood glucose level declined faster in OO group compared to the other experimental groups. Meanwhile, insulin concentration decreased in all experimental groups compared to a control group. The number of bifidobacteria was significantly increased in oligosaccharide diet groups after STZ injection (MO and OO) than a mixed diet group(MM). Plasma cholesterol concentration significantly decreased in oligosaccharide diet groups(MO and OO) compared to mixed diet groups (MM and OM) after SZ injection. Plasma triglyceride and liver cholesterol concentrations significantly decreased in MO group compared to other experimental groups. Meanwhile, plasma leptin concentration was significantly lower in oligosaccharide diet groups after STZ injection(MO and OO) compared to a control group. The results in this study suggest that the dietary soyoligosaccharides has strong on reduction of reduction of blood glucose and lipid concentrations in streptozotoicin-induced diabetic rats. Thus, the use of soyoligosaccharides at a diet for IDDM patients may help to improve diabetes mellitus symptoms.(Korean J Nutrition 34(1) : 3-13, 2001)

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Effect of Dietary Oil Containing $\gamma$-Linolenic Acid on the Plasma Lipid Levels and Thrombotic Activity in Rats (감마-리놀렌산을 함유하는 식이지방이 흰쥐의 혈전작용 및 혈액지질 수준에 미치는 영향)

  • ;Zammit, A Victor
    • Journal of Nutrition and Health
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    • v.36 no.9
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    • pp.889-897
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    • 2003
  • This study was carried out to determine the effect of dietary ${\gamma}$-linolenic acid on decreasing the plasma lipid levels and the thrombotic activity in rats. Sprague-Dawley male rats (B.W 120 g) were fed a experimental diet containing 5% lard (46.05% saturated fatty acids) , corn oil (51.36% linoleic acid) , evening primrose oil (EPO,72.80% linoleic acid and 9.16% ${\gamma}$-linolenic acid) or borage oil (BO,40.29% linoleic acid and 24.25% ${\gamma}$-liolenic acid) for 30 days. Although there were no significant differences in the food intake among the groups, the body weight gain of the BO group was significantly lower than that of the other groups. The bleeding time of the BO group was significantly longer than that of the other groups. There were significantly differences in the whole blood clotting time among the groups except for the EPO and corn oil groups, where the whole blood clotting time of the BO group was the highest among the groups, and that of the lard group was the lowest. The plasma triacyglyceride (TAG) , total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations were the lowest in the BO group, but highest in the lard group, and there were significant differences among the groups. The plasma HDL-C concentrations were in the following order: BO, EPO, corn oil and lard groups and there were significant differences among the groups. The excretions of fecal neutial steroids and acidic steroids of the BO group were the highest among the groups, and there were significant differences compared to the other groups. The results suggest that dietary EPO and BO containing ${\gamma}$-linolenic acid has an antithrombotic activity, and inhibits the increasing of plasma TAG, TC and LDL-C concentrations compared to lard, which contains saturated fatty acids, or corn oil, which contains linoleic acid.

십전대보탕(十全大補湯) 와송(瓦松) 및 십전대보탕가와송(十全大補湯加瓦松)의 항암효과(抗癌效果)와 면역반응(免疫反應)에 관(關)한 연구(硏究)

  • Hwang, Gyu-Dong;Ryu, Bong-Ha;Park, Dong-Won;Ryu, Gi-Won
    • THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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    • v.2 no.1
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    • pp.1-23
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    • 1996
  • In order to research the effects of Shipjundaebotang(SDT) and Orostachys Herba(OH) on anti-tumor and immune response, the author performed this experimental study. Experimental groups are divided into five groups, which are solid extract of Orostachys Herba by water(OHW), solid extract of Orostachys Herba by ethanol(OHE), solid extract of Shipjundaebotang (SDT), solid extract of Shipjundaebotang added by solid extract of Orostachys Herba by water(SDT+OHW) and solid extract of Shipjundaebotang added by solid extract of Orostachys Herba by ethanol (SDT+OHE). In these experimental studies, extension of survival days for anti-tumor effect was observed, and de layed type hypersensitivity and rosette forming cell for cell-mediated immune response, hemagglutinin titers and hemolysin titers for humeral immune response, spleenic natural killer cell activity and carbon clearance (K-index) in vitro were measured with mice. The result were summerized as follows: I. SDT, SDT+OHW and SDT+OHE treated groups were significantly recognized to extend the survival days of tumor bearing mice as compared with the control group. 2. Delayed type hypersensitivity was significantly increased in SDT, SDT+OHW and SDT+OHE treated groups as compared with control group. 3. Hemagglutinin titer was increasred in all sample groups as compared with control group, but not significantly. 4. Hemolysin titers was significantly increased in SDT, SDT+OHW and SDT+OHE treated groups as compared with control group, and SDT+OHE treated group showed the increasing effect with significance as compared with the other sample groups. 5. For the effect of roselle forming cell quantitation, SDT, SDT+OHW and SDT+OHE treated groups showed the increasing effect with significance as compared with control group. 6. Natural killer cell activity was significantly increased in SDT+OHW as compared with comrol group, but the other groups, except OHW and SDT+OHW treated groups, revealed the increasing effect as compared with control group, but the significance was not admitted. 7. For the effect of K-index(Carbon clearance), SDT, SDT+OHW and SDT+OHE treated groups showed the increas ing effect with significance as compared with control group. 8. The study didn't show that Orostachys herba had any significance with survival days, anti-tumor effect and immune re sponse.

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Effects of zinc, vitamin and selenium additives for improving meat quality on the growth performance, carcass characteristics and economic efficiency of holstein steers (아연, 비타민과 셀레늄의 첨가가 홀스타인 거세우의 발육, 도체특성 및 경제성에 미치는 영향)

  • Cho, Won Mo;Lee, Sang Min
    • Korean Journal of Agricultural Science
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    • v.42 no.3
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    • pp.253-259
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    • 2015
  • This study was conducted to investigate the effect of different additives on the growth performance, feed efficiency and carcass characteristics in Holstein steers during 18month fattening periods. Twenty four Holstein steers, 5months of age and 176.6kg, were randomly allocated to 3 experimental groups 8 animals each for 18-months feeding trial. The groups were control (not additive), T1 (fed zinc, Vitamin C) and T2 (fed zinc, Vitamin C, Vitamin B6 and Selenium). According to feeding additives, final weight was not significantly different among the treatment groups, tended to be high at T2 group (827kg) compared to the other groups. Average daily gain was not different among the treatment groups during the experimental periods, but T2 group was significantly greater than T1 group in growing stage (p<0.05). The feed additives had no effects on DMI during experimental periods. Feed conversion ratio of T1 group in growing stage was significantly higher than those of other groups (p<0.05), average feed conversion ratio was tend to be decreased at T2 group rather compared with other groups. In the results of yield traits, carcass weight were relatively higher in T2 group than other groups (p<0.05). Rib-eye area, back fat thickness and yield index were similar between groups. In quality traits, marbling, meat color, fat color, texture and maturity were not significantly different among the groups. In economic efficiency, income was highest at T2 group as 91~393 thousand won among 3 groups.

An Analysis on Factors Related to Health Management & Disease Awareness of Industrial Workers (산업장 근로자들의 건강관리 및 질병에 대한 인식과 관련요인)

  • 전봉천;남철현
    • Korean Journal of Health Education and Promotion
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    • v.13 no.2
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    • pp.1-23
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    • 1996
  • This study was conducted to investigate health management and health awareness of industrial workers and use the information for the development of health education program and the guidline of health management for industrial workers. The survey was carried out on 1,200 workers who were selected from Incheon, Ulsan, Pohang, Masan, Changwon city from Oct. 2 to Oct. 31. 1995. The main results are summarized as follows. 1. With regard to health behavior after regular physical examination, 48.3% of subjests answered "consulting with medical doctors or health workers" and 7.9% answered "non action anything", 2. As for need of environmental control of work, of the total subjects, 96.1% answered "need". 3. As for participation of health education, 61.2% of the subjects were positive, which was higher in male, in higher age groups, in middle school graduates, in healthy group by self assessment than other groups respectively. 4. As for knowledge level of the disease, the average score was $4,97{\pm}1.41$ point to 7 point full mark (71 point to 100 point full mark), the score level was higher in male higher economic, in office workers, in higher education groups, in working period longer groups, in healthier groups, in higher age groups than other groups respectively. 5. As for attitude level of the disease, the average score was $4,70{\pm}1.25$ point to 7 point full mark (67.1 point to 100 point full mark), which was lower, in higher age group, in longer education level, in healthier groups in longer working period than other groups respectively, while the score was higher in male, in day-time workers, in urban residence than other groups respectively.han other groups respectively.

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An Analysis on the Level of Elementary Gifted Students' Argumentation in Scientific Inquiry (초등학교 영재 학생들의 탐구 활동에서 나타나는 논증 과정 평가 및 분석)

  • Lim, Jae-Keun;Song, Yun-Mi;Song, Mi-Sun;Yang, Il-Ho
    • Journal of Korean Elementary Science Education
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    • v.29 no.4
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    • pp.441-450
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    • 2010
  • The purpose of this study was to evaluate the level of elementary gifted students' argumentation and examine the special features of argumentation founded in scientific inquiry. 28 students were selected in the special education center for the gifted in K National University. They were organized 8 groups of 3~4 students and engaged in scientific inquiry activity. The researcher wasn't involved in students' inquiry activity and argumentation except for the guiding and introducing their activity. In the first session, each group carried out the experiment 'Putting a heated can in the water' and then, the students discussed to probe their experimental results and build their explanation. In the second session, each group presented their experiment results and evidence from their experiment justifying their claims, and had questions from other groups. The protocol data during 8 groups' argumentations were analyzed using 'Rubric for Scientific Argumentation Assessment' (Yang et al., 2009) in three domains- the form, content and attitude. As a result, in form domain, almost groups were rated 2 points due to their argument without rebuttal on the subcategory of 'composition', but they got a good grade above 3 points in subcategory such as 'claim', 'ground', and 'conclusion'. In content domain, almost groups got points above 3 points. In attitude domain, there were some striking contrast between each groups. Six groups got good score more than 4 points on the subcategory of openness, but two groups, they alleged and got score below 3 point. While the 6 groups of all got 4 points in the aspect of participation, 3 groups got 3 points lower than because they only just asserted and not interact with other groups. Throughout the argumentation, two features were found that; as time goes by, arguments were refined; Students tended to use their prior to knowledge rather than evidence such as experimental data in making claims and conclusions.

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The Effects of the Task-Oriented Trunk Training on Muscle Strength and Muscle Activity of Trunk, Balance and Gait in Stroke Patients (뇌졸중 환자의 과제지향몸통훈련이 몸통 근력과 근활성도, 균형 및 보행에 미치는 효과)

  • Oh, Gkubin;Lee, Hyojung
    • Journal of The Korean Society of Integrative Medicine
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    • v.8 no.1
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    • pp.203-217
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    • 2020
  • Purpose : This study aimed to determine whether task-oriented trunk training can improve muscle strength, muscle activity, balance, and gait in stroke patients. Methods : A total of 27 stroke patients who agreed to participate in the study were randomly divided into the following two groups: (1) experimental group 1, task-oriented training applied to the proximal part (n=14) and (2) experimental group 2, task-oriented training applied to the distal part (n=13). Thereafter, task-oriented trunk training was accordingly applied in each group for 60 minutes per session, 5 times per week for 6 weeks. Muscle power, muscle activity, balance, and gait were assessed using a digital dynamometer, surface electromyograph, Timed Up and Go (TUG) test, and gait analyzer (G-WALK), respectively, before and after training. Results : Trunk muscle strength significantly increased in both groups after training (p<.05). and there was a significant difference between the groups. Muscle activity in the stance phase during gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Muscle activity in the swing phase during gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. The TUG test values significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Conclusion : The results of this study show that task-oriented training can improve trunk muscle strength, muscle activity, balance, and gait in stroke patients.

Radiation Exposure Analysis of Female Nuclear Medicine Radiation Workers (여성 핵의학 방사선종사자의 관련 피폭요인 분석)

  • Lee, Juyoung;Kim, Ji-Hyeon;Park, Hoon-Hee
    • The Korean Journal of Nuclear Medicine Technology
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    • v.21 no.2
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    • pp.86-93
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    • 2017
  • Purpose In this study, radiation workers who work in nuclear medicine department were analyzed to find the cause of differences of radiation exposure from General Characteristic, Knowledge, Recognition and Conduct, especially females working on nuclear medicine radiation, in order to pave the way for positive defense against radiation exposure. Materials and Methods The subjects were 106 radiation workers who were divided into two groups of sixty-four males and forty-two females answered questions about their General Characteristic, Knowledge, Recognition, Conduct, and radiation exposure dose which was measured by TLD (Thermo Luminescence Dosimeter). Results The results of the analysis revealed that as the higher score of knowledge and conduct was shown, the radiation exposure decreased in female groups, and as the higher score of conduct was shown, the radiation exposure decreased in male groups. In the correlation analysis of female groups, the non-experienced in pregnancy showed decreasing amount of radiation exposure as the score of knowledge and conduct was higher and the experienced in pregnancy showed decreasing amount of radiation exposure as the score of recognition and conduct was higher. In the regression analysis on related factors of radiation exposure dose of nuclear medicine radiation workers, the gender caused the meaningful result and the amount of radiation exposure of female groups compared to male groups. In the regression analysis on related factors of radiation exposure dose of female groups, the factor of conduct showed a meaningful result and the amount of radiation exposure of the experienced in pregnancy was lower compared to the non-experienced. Conclusion The conclusion of this study revealed that radiation exposure of female groups was lower than that of male groups. Therefore, male groups need to more actively defend themselves against radiation exposure. Among the female groups, the experienced in pregnancy who have an active defense tendency showed a lower radiation exposure. Thus, those who have never been pregnant need to have a more active defensive conduct for the future possibility of pregnancy.

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A Study on the Preparation and Characterstics of Fermented fruit-Vegetable Juice (발효과채쥬스의 제조 및 특성에 관한 연구)

  • Kim, Yoo-Kyeong;Bai, Young-Hee;Yoon, Sun
    • Korean journal of food and cookery science
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    • v.6 no.4 s.13
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    • pp.59-68
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    • 1990
  • Juices prepared from carrots, apples, and mandarin oranges were fermented with Leuconostoc mesenteroides or along with Saccharomyces cerevisiae. The pH of the fermented juices was not found significantly different between the mixed and single-cultured groups. The juices containing 0.5% NaCl had lower pH than the groups without 0.5% NaCl. The final pH of the single-cultured gruops was the highest among the sample groups. However, reducing sugar content of the mixed-cultured groups was lower than that of the single-cultured groups. The viable cells of the mixed-cutured groups were remarkably increased until 3 days of storage, and after 6 days they were gradually decreased. The results of the sensory evaluation demonstrated acidic, salty and alcoholic flavors were significantly different among the groups. The single-cultured group without salt was significantly more acidic than the non-pasteurized control group. The mixed-cultured group with salt was significantly more alcoholic than the group without salt and control groups. The non-pasteurized control group was significantly more homogeneous than the mixed-cultured groups and single-cultured group with salt. Preference ranking test showed that flavor and overall acceptability of the fermented juices was significantly different among the groups. Flavor of the single-cultured group without salt was found significantly better than those of the groups with salt. With the respect of overall acceptability, the single-cultured group without salt was significantly more acceptable than the non-pasteurized control group and the mixed-cultured group with salt.

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The Effect of Dietary Fat Levels and Protein Source in Early Life on the Cholesterol and Lipid Metabolism in Adult Rats (흰쥐에서 태아 및 유아기에 섭취한 지방량과 단백질 급원의 변화가 성장후에 Cholesterol 및 지방대사에 미치는 영향)

  • Kim, Wha-Young;Park, Hyun-Suh
    • Journal of Nutrition and Health
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    • v.14 no.3
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    • pp.136-145
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    • 1981
  • This study was designed to observe the effects of both control and atherogenic diets on the cholesterol and triglyceride (TG) in serum and liver of adult rats fed diets supplying two levels of dietary fat and two different sources of dietary protein in early life. For the first experimental period, the rats were assigned into the four diet groups: High fat, casein (HC); High fat, gluten (HG); Low fat, casein (LC): Low fat, gluten (LG). Each group was subdivided into control and atherogenic groups for the second experimental period. Cholesterol and TG were determined in serum and liver after 7 hr fasting. The body weight gain was greater in the rats of the casein groups than those of the gluten groups tut not influenced by the level of the dietary fat. The difference in body weight from the quality of dietary protein in the first period was not disappeared even after the second period. After the first period, higher serum cholesterol was observed in the rats fed either casein or high fat diets. With the second experimental diet, rats fed atherogenic diet showed higher serum cholesterol concentration but lower serum TG levels compared to those fed control diet, regardless the diets fed in the first period. Serum cholesterol level of the rats of both groups which had been fed high fat diets in early life was increased compared to those of the low fat diet groups. This effect was more pronounced with the atherogenic diet groups than control groups. However, no differences were found in serum cholesterol levels resulted from the different types of dietary protein fed in the first period. Serum TG concentration was not influenced by the quality of protein and level of fat in the diet but seemed to be mere affected by the amount of carbohyrates in the diet. Liver cholesterol per unit weight was greater in the gluten diet groups than in the casein groups but total cholesterol was higher in casein fed rats. There were no differences in liver TG among the groups.

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