• Clinical and Experimental Pediatrics
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• 제49권10호
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• pp.1093-1099
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• 2006

목 적 : 호모시스테인은 성인에서 관상동맥 질환을 포함한 심혈관 질환의 독립적인 위험 인자로서, 혈관 내피세포 손상과 혈액 응고 촉진, 혈전 형성 등의 기전으로 동맥경화증의 위험을 증가시킨다고 알려져 있으나 이러한 호모시스테인이 소아에 미치는 영향은 아직까지 연구된 바가 없다. $TNF-{\alpha}$는 전염증성 사이토카인으로서 혈관 내피세포 손상과 관상동맥의 염증 반응을 초래한다. 본 연구에서는 호모시스테인이 가와사키병의 관상동맥 합병증에 미치는 영향과 $TNF-{\alpha}$의 연관성에 대해 알아보고자 하였다. 방 법 : 가와사키병 환아 24명(관상동맥 확장이 없는 군(1군) : 8명, 관상동맥 확장이 있는 군(2군) : 16명)에 대한 임상 양상과 면역글로불린 투여 전과 후, 회복기에서의 호모시스테인과 $TNF-{\alpha}$ 혈중 농도를 비교하였다. 대조군은 같은 시기에 내원한 열이 없는 정상 소아(3군 : 10명)와 열성 질환 소아(4군 : 11명)로 정하였다. 결 과 : 면역글로불린 투여 전의 호모시스테인은 1군($14.0{\pm}7.0{\mu}mol/L$)에서 3군($5.9{\pm}1.1{\mu}mol/L$)에 비해 유의하게 높았으며(P<0.05), 2군($17.4{\pm}8.0{\mu}mol/L$)에서는 3군($5.9{\pm}1.1{\mu}mol/L$)과 4군($9.2{\pm}2.0{\mu}mol/L$) 각각에 비해 유의하게 높았다(P<0.05). $TNF-{\alpha}$에서도 면역글로불린 투여 전 2군($858.4{\pm}934.0pg/mL$)이 3군($8.0{\pm}1.1pg/mL$)과 4군($54.1{\pm}146.3pg/mL$)에 비해 유의하게 높았다(P<0.05). 2군에서 시간 경과에 따른 호모시스테인과 $TNF-{\alpha}$를 비교해 보면 면역글로불린 투여 전에 각각 $17.4{\pm}8.0{\mu}mol/L$, $858.4{\pm}934.0pg/mL$로 가장 높았고, 면역글로불린 투여 후와 회복기로 갈수록 감소하였다. 또한 가와사키병 급성기에서 호모시스테인과 $TNF-{\alpha}$는 양의 상관관계를 가진다(r=0.488, P<0.05). 결 론 : 호모시스테인의 혈중 농도가 높을수록 가와사키병에서 관상동맥 병변이 발생할 가능성이 더 높았으며 $TNF-{\alpha}$와 같은 사이토카인도 관상동맥 병변의 형성에 중요한 역할을 할 것으로 생각된다.

• Imaging Science in Dentistry
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• 제47권3호
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• pp.175-180
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• 2017

Purpose: Pineal gland calcification has been proposed to play a role in the pathogenesis of Alzheimer disease. This study evaluated the prevalence and extent of pineal gland calcification in cone-beam computed tomography (CBCT) scans of patients referred for dental implant therapy who could possibly be a vulnerable group for this condition. Materials and Methods: A retrospective evaluation of 500 CBCT scans was conducted. Scans that showed the area where the pineal gland was located were included. The scans were initially screened by a single observer to record the prevalence and extent of calcification. Six weeks following the completion of the study, another investigator randomly reviewed and selected 50 scans to investigate inter-observer variation, which was evaluated using reliability analysis statistics. The prevalence and measurements of the calcifications were reported using descriptive statistics. The chi-square test was used to compare the prevalence between males and females. Results: The prevalence of pineal gland calcification was 58.8%. There was no statistically significant correlation between age and the extent of the calcification. The prevalence of calcification was 58.6% in females and 59.0% in males. The average anteroposterior measurement was $3.73{\pm}1.63mm$, while the average mediolateral measurement was $3.47{\pm}1.31mm$. The average total calcified area was $9.79{\pm}7.59mm^2$. Conclusion: The prevalence of pineal gland calcification was high in patients undergoing implant therapy. While not all pineal gland calcifications lead to neurodegenerative disorders, they should be strongly considered in the presence of any symptoms as a reason to initiate further investigations.

• The Journal of Korean Physical Therapy
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• 제19권4호
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• pp.53-64
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• 2007

Purpose: We investigated the effects of music on pain, blood pressure, and pulse in patients with chronic back pain. We tried to find some change of satisfaction of treatment and a sense. Method: We recruited total 30 patients with chronic back pain, who had pain from lumbago for more than six months. Subjects received electrotherapy and electrotherapy with music one at a time during me test, and subjects received one in the morning and the other one in the afternoon. We compared the test results between the electrotherapy and electrotherapy with music. Visual Analogue Scale was used to check the effect on pain. Blood pressure and pulse were checked, too. The gathered informatio was analyzed by t-test, independent sample t-test, and chi-square test. Results: There was statistically not significant difference between electrotherapy and electrotherapy with the music in VAS(Visual Analogue Scale)(p>0.05). There were statistically some significant differences between two groups in systolic pressure, diastolic pressure, and the pulse(p<0.05). Subject group showed statistically higher scores of satisfaction(p<0.05). There was significant difference between two groups(p<0.05) in the tingling and vibration sense. Conclusion: we found that the lumbago patients who are treated by electrotherapy with the music did not have additional difference in relief of pain, but electrotherapy with music can get better effects on their blood pressure, the pulse, satisfaction, and tingling-vibration sense. This means that the patients receive their treatment comfortably with rest. Therefore, We consider that it is desirable to play music to lumbago patients to offer the better treatment service to the patients.

• 한국환경생태학회지
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• 제30권5호
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• pp.908-914
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• 2016

우리나라 유아교육현장에서 자연친화 교육에 대한 관심이 높아지고 자연체험 프로그램에 대한 요구가 증가하고 있다. 본 연구에서는 숲이 가지고 있는 산림치유인자들과 요인들을 활용하는 숲에서의 오감체험활동이 유아의 자아효능감과 생명존중인식에 미치는 영향을 알아보고자 하였다. 실험대상은 청주시 OO동에 위치한 유아교육기관의 숲특별반을 주2회 참여하는 실험군과 통제군은 숲활동을 하지 않고 유아교육기관에서 운영하는 프로그램에 참여하는 만 5세 유아 남녀 각각 20명으로 하였으며 남자아이는 11명, 여자아이는 9명씩이었다. 실험기간은 2016년 8월08일부터 2016년 9월20일까지 매주 2회씩 12회기로 1시간 (60분)씩 실시하였다. 오감체험활동은 숲에서 유아들이 오감을 깨우고, 오감을 통해 계절의 변화를 알고, 자신의 자아를 확립하고 자연과 친해지는 활동이다. 프로그램 실시 전후에 유아를 대상으로 한 자아효능감 검사와 생명존중인식검사를 실시하고 그 자료는 SPSS 18.0 로 분석하였다. 그 결과 긍정적인 생각과 자신감을 나타내는 자아효능감, 자연과 함께 더불어 살아가며 생명을 존중하는 생명존중인식이 통계적으로 유의미하게 향상되었다(p<0.05). 오감체험활동을 통해 유아들은 온몸으로 자유롭게 자연을 마음껏 느낄 수 있었고, 교실에서 이루어지는 활동에 비해 자아효능감이나 생명존중인식에 긍정적인 영향을 주는 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1213-1217
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• 2015

Background: Gastric cancer is the second most common cause of cancer- related deaths worldwide and ranks $11^{th}$ or $14^{th}$ among all deaths. Patients with advanced disease require supportive care along with the medical and/or surgical treatment. Aim: To assess the need for palliative care for patients with advanced tumours along with standard clinical therapy. Materials and Methods: Eighty-four patients with metastatic (stage 4) gastric cancer, including both patients who had received surgical treatment or not, were followed up in Bagcilar Training and Research Hospital, Division of Medical Oncology between 2011 and 2014. They were categorised as supportive care (-) (Group 1, n=37) and (+) groups (Group 2, n=47) and evaluated retrospectively. Results: Demographic characteristics of the patients were as follows: mean age, Group 1, $65.2{\pm}10.5$ years, Group $2,63.7{\pm}11.3$ years; male/female ratio, Group 1, 21/16, Group 2, 28/19; distribution of Eastern Cooperative Oncology Group (ECOG) performance scores of 0 and 1, Group 1, ECOG 0 (n=9) and 1 (n=14), Group 2, ECOG 0 (34) and 1 (n=13) (p<0.0001); patients receiving second-line, Group 1 (n=7) and Group 2 (n=22) (p<0.008) or third - line chemotherapy,Group 2 (n=6) (p<0.02); mortality rates, Group 1, (n=28; 75.6%) and Group 2 (n=30; 63.8%); progression-free survival (PFS) rates, Group 1, $17.4{\pm}6$ weeks, Group 2, $28.3{\pm}16.2$ weeks; statistically significant overall survival rates, Group 1, $20.8{\pm}8.2$ weeks and Group 2, $28.3{\pm}162$ weeks (p<0.01). Conclusions: The supportive care team (medical oncologist, general surgeon, internal medicine specialist, algologist, psychiatrist and radiologist) can play a role in the treatment of metastatic gastric tumours, with improvements shown in terms of the performance status of cases, eligibility of patients to be on chemotherapy programmes for longer duration and overall survival rates in Turkey.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권4호
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• pp.278-305
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• 2016

Objective: The aim of this systematic literature review is to analyze the psychosocial interventions for children and adolescents after disasters. Methods: We conducted a review of the extant research literature from 1991 to 2015 via a comprehensive search of the MEDLINE, EMBASE, Cochrane CENTRAL, PubMed and PsyclNFO databases. The keywords employed in this research included: 'child', 'adolescent', 'youth', 'disaster', 'posttraumatic', 'psychosocial', 'therapy' and 'intervention'. The researchers followed the PRISMA guidelines. A total of 850 articles were screened for their eligibility and fifty-nine were found to meet the study criteria. The final data analysis was performed based on the disaster type, study design, type of intervention, sample size, age, school grade, number of sessions, setting of intervention delivery, providers, approach and parent involvement. Results: Countries worldwide have experienced various kinds of disasters, including earthquakes, hurricanes, vessel accidents, tornados, tsunamis, volcanic eruptions, war, fire, terrorism, and traffic accidents. The types of psychosocial intervention that were conducted after these disasters included: psychological first aid, psychological debriefing, psychoeducation, trauma focused cognitive behavior therapy, eye movement desensitization reprocessing, prolonged exposure therapy, group play therapy and arts therapy, project interventions, school-based interventions and web-based interventions. Conclusion: The findings of the systematic literature review suggest that an appropriate psychosocial intervention could be utilized as evidence-based mental health treatment for children and adolescents after disasters.

• 재활치료과학
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• 제12권4호
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• pp.53-65
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• 2023

목적 : 본 연구는 정신건강 분야에서 근무하는 작업치료사가 정신질환자에게 신체기능 향상 중재를 제공한 업무 경험 및 실태를 파악하고자 시도된 연구이다. 연구방법 : 2022년 11월 7일에서 11월 14일까지 정신건강 분야에서 근무하는 작업치료사를 대상으로 자료를 수집하였다. 이메일을 통해 설문지를 배포하여 응답을 수렴하였으며, 수집된 응답지 46부에 대해 기술통계 및 상관관계를 분석하였다. 결과 : 설문응답자는 여자(58.7%), 20~30대(84.8%)가 가장 많았고, 주로 정신건강복지센터(41.3%)에서 근무하였으며, 정신건강작업치료사 수련과정(91.3%)을 수료하였다. 정신건강분야 경력은 1년 이상 3년 미만(65.2%), 담당 업무는 프로그램(71.1%), 사례관리(62.2%), 행정업무(57.8%)가 가장 높았으며, 신체기능 향상을 위한 중재(73.9%)를 제공한 경험이 있었다. 자료 분석 결과 신체기능 중심 그룹 중재의 빈도는 주 1~2회(41.2%)가 많았고, 스트레칭, 유산소운동, 산책 순이었으며, 개별 중재의 빈도는 주 1~2회(38.1%)가 많았고, 산책, 스트레칭, 유산소운동 순으로 도출되었다. 결론 : 작업치료사는 정신건강 전문가로서 정신질환자의 다양한 작업과 일상생활활동에 균형 잡힌 참여를 가능하게 한다. 현재 다수의 작업치료사들이 정신건강 분야에서 정신질환자의 신체기능 향상을 위한 다양한 작업치료적 중재를 제공하고 있으나 이에 대한 연구는 아직 부족한 실정이다. 본 연구를 통해 정신건강작업치료의 중요성과 신체기능 향상 중재의 근거 기반 서비스 제공의 필요성을 확인하였다. 이를 통해 정신질환자들에게 더욱 효과적인 치료를 제공할 수 있는 기반이 마련될 것으로 기대한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제25권1호
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• pp.6-13
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• 2014

Objectives : The aim of this study is to assess the career paths and practice patterns of child and adolescent psychiatrists in South Korea. Methods : A survey on demographic data, work environment, opinion on fellowship training program, and current practice patterns was conducted in 76/223 (34.0%) of all child and adolescent psychiatrists (N=223) were from 1980 to 2008. The survey data from the responders were analyzed. Results : More than half of those surveyed were women. The mean age of survey participants was 40.8 years; most were married, and lived in the Seoul National Capital Area. In general, the responders were very satisfied with their work. They worked in private practice, public sector, group practice, and as consultants. Up to 87% of the patients treated were children and adolescents. The most common treatment modalities were medication and parent psychoeducation. Social skills training and play therapy were applied mainly for children aged 4 to 12 years old. Cognitive behavioral therapy and counseling were preferred in adolescents. Conclusion : The current study used a database approach in order to define current practice patterns. These data may be helpful in consideration of future training programs, workforce issues in child and adolescent psychiatry in South Korea, and also in collaboration with other mental health providers.

• The Journal of Korean Physical Therapy
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• 제21권3호
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• pp.95-102
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• 2009

Purpose: This study evaluates MCP-1 expression in the dorsal horn of a rat model of lumbar disc herniation by an autograft of the nucleus pulposus to the spinal nerve. Methods: After a coccygeal nucleus pulposus graft to the left $5^{th}$ lumbar spinal nerve, proximal to dorsal root ganglion, mechanical allodynia and thermal hyperalgesia were assessed 1 day before surgery, and 1, 10, 20, 30 days after surgery. The mRNA of MCP-1 in the dorsal horn was assessed by real time PCR to compare the temporal pattern of neuropathic pain of the lumbar disc herniation model. Results: In the ipsilateral side of the lumbar disc herniation models, mechanical allodynia and thermal hyperalgesia reached a maximum at 10 days after surgery with significant difference from the control group. Pain was also provoked in the contralateral side of the lumbar disc herniation models with less intensity than the ipsilateral side. The level of MCP-1 mRNA expression in the dorsal horn reached a peak at 20 days after surgery. Conclusion: Mechanical allodynia and thermal hyperalgesia was induced by nucleus pulposus in a rat lumbar disc herniation model, similar to a previously reported peripheral nerve injury model. The level of MCP-1 expression was higher in the dorsal horn of the ipsilateral and contralateral sides. These results suggest that MCP-1 might play a role in the maintenance of neuropathic pain.

• Clinical and Experimental Pediatrics
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• 제53권11호
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• pp.921-930
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• 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.