• Bulletin of the Korean Chemical Society
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• v.32 no.8
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• pp.2648-2656
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• 2011

A simple HPLC-DAD method was developed and validated to determine B group vitamin content (thiamine, riboflavin, nicotinamide, pantothenic acid, pyridoxine and folic acid) in supplemented food samples, i.e., infant formula, cereal, low-calorie food, a multi-vitamin pill and a vitamin drink. In this study, the most significant advantages were simultaneous determination of the six B group vitamins in various food matrices and a small number of sample treatment steps that required only an organic solvent, acetonitrile. Moreover, this method prevents reduction of column durability, because the mobile phase does not contain ion-pairing reagents. Analytes were separated on a Develosil RPAQUEOUS $C_{30}$ (4.6 mm ${\times}$ 250 mm, 5 ${\mu}M$ particle size) column with a gradient elution of acetonitrile and 20 mM phosphate buffer (pH 3.0) at a flow rate between 0.8 and 1.0 mL/min. Detection was performed at 275 nm, except for that of pantothenic acid (205 nm). The calibration curves for all six vitamins showed good linearity with correlation coefficients ($r^2$) higher than 0.995. The developed method was validated with respect to linearity, intra- and inter-day accuracy and precision, limit of quantification (LOQ), recovery and stability. The method showed good precision and accuracy, with intra- and inter-assay coefficients of variation less than 15% at all concentrations. The recovery was carried out according to the standard addition procedure, with yields ranging from 89.8 to 104.4%. This method was successfully applied to the determination of vitamin B groups in supplemented food products.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4347-4351
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• 2015

Background: Previous studies showed that genetic polymorphisms of glutathione S-transferase P1 (GSTP1) were involved in glutathione metabolism and genetic polymorphisms of ribonucleotide reductase (RRM1) were correlated with DNA synthesis. Here we explored the effects of these polymorphisms on the chemosensitivity and clinical outcome in Chinese non-small cell lung cancer (NSCLC) patients treated with gemcitabine-cisplatin regimens. Materials and Methods: DNA sequencing was used to evaluate genetic polymorphisms of GSTP1 Ile105Val and RRM1 C37A-T524C in 47 NSCLC patients treated with gemcitabine-cisplatin regimens. Clinical response was evaluated according to RECIST criteria after 2 cycles of chemotherapy and toxicity was assessed by 1979 WHO criteria (acute and subacute toxicity graduation criteria in chemotherapeutic agents). Results: There was no statistical significance between sensitive and non-sensitive groups regarding the genotype frequency distribution of GSTP1 Ile105Val polymorphism (p>0.05). But for RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009). And according to the joint detection of GSTP1 Ile105Val and RRM1 C37A-T524C polymorphisms, the proportion of type A (A/A + high effective genotype) was significantly higher in sensitive group than in non-sensitive group (p=0.009). Toxicity showed no correlation with the genotypes between two groups (p>0.05). Conclusions: Compared with single detection of genetic polymorphisms of GSTP1 Ile105Val or RRM1 C37A-T524C, joint detection of both may be more helpful for patients with NSCLC to receive gemcitabine-cisplatin regimens as the first-line chemotherapy. Especially, genetic polymorphism of RRM1 is more likely to be used as an important biomarker to predict the response and toxicity of gemcitabine-cisplatin combination chemotherapy in NSCLC.

• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.973-979
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• 2002

Purpose : Recently, a number of rapid antigen detection tests have been available to diagnose group A streptococcal pharyngotonsillitis. The purpose of this study was to determine the sensitivity, specificity and consistency of the two rapid antigen detection tests. Methods : Among the patients who visited our clinic from November 2001 to February 2002, 61 patients who had clinical findings of pharyngeal erythema or edema, pharyngeal exudates and soft palatine petechiae were enrolled in our study. A total of 61 patients were tested with rapid antigen detection tests and throat culture. BD $LINK2^{TM}$ Strep A(Becton, Dickinson & Company, U.S.A.) and $QuickVue^{(R)}$ $In-Line^{TM}$(Quidel Corporation, U.S.A.) were selected for rapid antigen detection tests. Results : Of the 61 patients tested, 22 patients were confirmed as group A streptococcal pharyngotonsillitis by throat culture. The BD $LINK2^{TM}$ Strep A had a sensitivity of 81.8% and a specificity 89.7%. The positive and negative predictive values were 81.8% and 89.7%, respectively. The $QuickVue^{(R)}$ $In-Line^{TM}$ had a sensitivity of 77.3% and a specificity of 100%. The positive and negative predictive values were 100% and 88.6%, respectively. The kappa values of BD $LINK2^{TM}$ Strep A and $QuickVue^{(R)}$ $In-Line^{TM}$ were 0.72 and 0.81, respectively. Conclusion : In addition to high sensitivity, specificity and consistency, both kits are easy to use and simple to interpret, and therefore have the potential to be used with backup throat culture for diagnosis of acute pharyngotonsillitis.

• The Korean Journal of Nuclear Medicine
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• v.33 no.6
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• pp.466-474
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• 1999

Purpose: The purpose of this study was to evaluate the diagnostic accuracy of [$^{18}F$]FDG PET in the diagnosis of recurrent head and neck cancer after the completion of surgery and radiotherapy in patients with head and neck cancers. Materials and Methods: In fifty-nine patients with head and neck cancers whole body [$^{18}F$]FDG PET studies were performed. According to the different therapeutic modalities, patients were divided into four groups (Group I; pre-treatment, Group II: surgery, Group III; radiotherapy, Group IV; both surgery and radiotherapy). [$^{18}F$]FDG PET images were compared with clinical, CT and histopathologic findings. Results: for detection of metastatic lymph nodes in 14 patients of pre-treatment group (group I), the sensitivity and specificity of PET were 100% (10/10) and 75% (3/4), and those of CT were 80% (8/10) and 100% (4/4). For detection of recurrence in 45 patients of post-treatment group, overall sensitivity and specificity of PET were 96.2% (25/26) and 78.9% (15/19) [(100% and 75% in group II, 80% and 10% in group III, and 100% and 100% in group IV)] without significant difference from pre-treatment group (P>0.1). In detecting recurrence, the sensitivity and specificity of [$^{18}F$]FDG PET were 90.9% (10/11) and 20% (1/5) in 16 patients who underwent [$^{18}F$]FDG PET within 2 months after the completion of treatment. The specificity of these patients was significantly lower than that of 29 patients (100% of sensitivity and specificity) who underwent [$^{18}F$]FDG PET 2 months after treatment (p<0.05). Conclusion: [$^{18}F$]FDG PET is an accurate diagnostic modality for the detection of recurrence in head and neck cancer. Post-therapy [$^{18}F$]FDG PET should be obtained at least 2 months after the completion of surgery or radiotherapy.

• Journal of the Korean Society for Nondestructive Testing
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• v.22 no.1
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• pp.1-8
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• 2002

The high frequency ultrasonic transducers using polyvinyliden fluoride(PVDF) and polyvinylidene fluoride trifluorethyylene(P(VDF-TrFE)) were developed. The characteristics of fabricated high frequency ultrasonic transducer such as beam diameter, high frequency ultrasonic detection field and amplitude of the first pulse echo signal from the test target in the water were analyzed. The high frequency ultrasonic detection field was affected by the length of coaxial cable between high frequency transducer and ultrasonic pulser/receiver. As the size of the test target increased, the high frequency detection field decreased and the amplitude of a reflection signal increased. The peak amplitude of the first pulse echo signal of P(VDF-TrFE) transducer was higher than that of PVDF transducer. The high frequency ultrasonic detection field of PVDF transducer was wider than that of P(VDF-TrFE) transducer. With C-scan testing, the developed high frequency ultrasonic transducer could detect the 30 to $100{\mu}m$ of hydrogen induced crack of steel specimen by C-scan testing.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1857-1859
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• 2004

It is widely known that the ultra high frequency (UHF) method that detects the electromagnetic wave of the PD pulses in the gas insulated space is one of the most competitive methods for its high sensitivity. From the above point of view, this paper describes the noise suppression methods and the PD measurement results of the in-service substation by the developed UHF PD measurement system which consists of the external UHF coupler, the UWB LNA and the digital storage oscilloscope. As results, it was found that the effect of the noise suppression methods were verified and that the developed external UHF coupler showed a better detection sensitivity than a conventional external coupler.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1860-1862
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• 2004

It is widely known that the ultra high frequency (UHF) method that detects the electromagnetic wave of the PD pulses in the gas insulated space is one of the most competitive methods for its high sensitivity. From the above point of view, this paper describes the characteristics of GIS PD signals measured with ultra wide band (UWB) GIS PD detecting system in which PD signals are detected into the dual UHF band. The UWB PD detection system consists of the UWB UHF coupler, the UWB low noise amplifier (LNA) and the oscilloscope. The dual bands for PD signals are 0.5-2GHz(full band) and 1-2GHz(high band). As results, it was found that the partial discharges of each defect have their own characteristic pattern and the ratio of High band to Full band increases with gas pressure.

• KIEE International Transactions on Power Engineering
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• v.4A no.1
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• pp.42-47
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• 2004

This paper presents the various application programs for the Distribution Automation System (DAS) of the Korea Electric Power Corporation (KEPCO)'s distribution system. These programs are developed to allow for optimal operation in the areas of feeder automation, relay coordination, loss minimization and so on. They are single line diagram auto creation programs for the feeder, service restoration program, protection coordination program, data error detection program, and optimal network reconfiguration program. The details of these programs are presented for validity and effectiveness.

• Proceedings of the KSRS Conference
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• 2007.03a
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• pp.167-170
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• 2007

연안 김 양식장의 효과적 관리를 위해서는 실제 시설량의 조사가 펼요하며 인공위성을 이용한 방법이 가장 효과적이다. 본 연구에서는 스펙트로미터에 의한 해수 및 김 양식장 시설에 대한 광 측정을 통하여 파장별 특성을 조사하였다 10m의 해상도를 갖고 있는 SPOT-5 다중분광영상을 사용하였으며，김 양식장의 자동탐지알고리듬의 개발을 위하여 경기도 화성시 제부도 남방해역에 대한 2005년도 영상을 사용하였다. 김 양식장을 추출하기 위하여 우선 3밴드 영상의 분광특성을 이용한 밴드차(Band difference) 영상을 작성하여，두 가지 방법(형태학적 처리기법 및 Canny 에지 탐지기법)으로 처리를 한 후，두 결과를 합성하여 라벨령함으로써 탐지율을 극대화하였다 양식장 시설 현황 조사 결과는，정부에서 전체 생산량을 조절할 수 있게 하며，양식업자가 좋은 수확을 달성하는데 도움이 될 수 있을 것이다.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.60.2-60.2
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• 2014

Hierarchical structure of star-forming regions is widespread and may be characteristic of all star formation. We studied the hierarchical structure of star-forming regions in the Local Group galaxies (M31, M33, Phoenix, Pegasus, Sextans A, Sextans B, WLM). The star-forming regions were selected from Galaxy Evolution Explorer (GALEX) far-UV imaging in various detection thresholds for investigating hierarchical structure. We examined the spatial distribution of the hot massive stars within star-forming regions from Hubble Space Telescope (HST) multi-band photometry. Small compact groups arranged within large complexes. The cumulative mass distribution follows a power law. The results allow us to understand the hierarchical structure of star formation and recent evolution of the Local Group galaxies.