• Kidney Research and Clinical Practice
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• 제37권4호
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• pp.404-413
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• 2018

Background: Dynapenic obesity and sarcopenic obesity increase cardiovascular disease (CVD) and mortality in nonuremic patients. The present study was designed to determine the prevalence of dynapenic obesity and sarcopenic obesity and their associations with CVD risk factors in peritoneal dialysis (PD) patients. Methods: All eligible PD patients in Tehran peritoneal dialysis centers were included in this cross-sectional study. Skeletal muscle mass and fat mass were assessed using bioelectrical impedance analysis. Muscle strength and physical performance were determined using hand grip strength and a 4-meter walk gait speed test, respectively. In addition, a 5-mL blood sample was obtained from each patient. Results: The prevalence of dynapenic obesity and sarcopenic obesity were 11.4% and 3.8% in PD patients, respectively. Serum high-sensitive C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1, triglyceride, total cholesterol, and low-density lipoprotein cholesterol were significantly higher in PD patients with dynapenic obesity than in dynapenic nonobese and nondynapenic nonobese patients. Similarly, serum concentrations of CVD risk factors in PD patients with sarcopenic obesity were higher than in nonsarcopenic nonobese patients, but these differences were statistically significant only for serum hs-CRP and triglyceride. In addition, muscle strength and skeletal muscle mass percentage were negatively associated with markers of inflammation and dyslipidemia, whereas body fat percentage was positively associated with these CVD risk factors. Conclusion: This study indicates that although the prevalence of dynapenic obesity and sarcopenic obesity are relatively low in PD patients, these disorders may be associated with CVD risk factors.

• Journal of Ginseng Research
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• 제43권3호
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• pp.475-481
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• 2019

Background: The ginsenoside Rg1 has been shown to exert various pharmacological activities with health benefits. Previously, we have reported that Rg1 promoted myogenic differentiation and myotube growth in C2C12 myoblasts. In this study, the in vivo effect of Rg1 on fiber-type composition and oxidative metabolism in skeletal muscle was examined. Methods: To examine the effect of Rg1 on skeletal muscle, 3-month-old mice were treated with Rg1 for 5 weeks. To assess muscle strength, grip strength tests were performed, and the lower hind limb muscles were harvested, followed by various detailed analysis, such as histological staining, immunoblotting, immunostaining, and real-time quantitative reverse transcription polymerase chain reaction. In addition, to verify the in vivo data, primary myoblasts isolated from mice were treated with Rg1, and the Rg1 effect on myotube growth was examined by immunoblotting and immunostaining analysis. Results: Rg1 treatment increased the expression of myosin heavy chain isoforms characteristic for both oxidative and glycolytic muscle fibers; increased myofiber sizes were accompanied by enhanced muscle strength. Rg1 treatment also enhanced oxidative muscle metabolism with elevated oxidative phosphorylation proteins. Furthermore, Rg1-treated muscles exhibited increased levels of anabolic S6 kinase signaling. Conclusion: Rg1 improves muscle functionality via enhancing muscle gene expression and oxidative muscle metabolism in mice.

• Journal of Acupuncture Research
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• 제38권1호
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• pp.72-78
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• 2021

Combined Western-Korean medicine treatments were given to a 67-year-old woman with late onset seizures who underwent surgical drainage of a subdural hematoma. Clonazepam and herbal medicine was prescribed. Acupuncture, moxibustion, cupping, chuna, and physical therapy were also performed. The frequency and intensity of seizures was assessed using the Chalfont Seizure Severity Scale. The seizure index score improved from 25 at admission to 0 at discharge. Pain in the right upper extremity reduced from 10 to 0 on the visual analogue scale and muscle strength increased from Grade 3 to 5 in Medical Research Council Scale for the Manual Muscle Test. At the time of hospitalization, the manual muscle strength tests for the affected shoulder, elbow, wrist, and grip strength were 30%, 60%, 10%, 5%, respectively, which improved almost 100% by discharge. Further studies using combined Western-Korean medicine for seizures after strokes are necessary to determine the most effective treatment.

• Journal of Ginseng Research
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• 제46권5호
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• pp.657-665
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• 2022

Background: Sarcopenia is a new and emerging risk factor aggravating the quality of life of elderly population. Because Korean Red Ginseng (RG) is known to have a great effect on relieving fatigue and enhancing physical performance, it is invaluable to examine its potential as an anti-sarcopenic drug. Methods: Anti-sarcopenic effect of non-saponin fraction of Korean Red Ginseng (RGNS) was evaluated in C2C12 myoblasts treated with C2-ceramide to induce senescence phenotypes, and 22-month-old mice fed with chow diet containing 2% RGNS (w/w) for 4 further months. Results: The RGNS treatment significantly alleviated cellular senescence indicated by intracellular lipid accumulation, increased amount of lysosomal β-galactosidase, and reduced proliferative capacity in C2C12 myoblasts. This effect was not observed with saponin fraction. In an aged mouse, the 4-month-RGNS diet significantly improved aging-associated loss of muscle mass and strength, assessed by the weights of hindlimb skeletal muscles such as tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (GN) and soleus (SOL), and the cross-sectional area (CSA) of SOL muscle, and the behaviors in grip strength and hanging wire tests, respectively. During the same period, an aging-associated shift of fast-to slow-twitch muscle in SOL muscle was also retarded by the RGNS treatment. Conclusions: These findings suggested that the long-term diet of RGNS significantly prevented aging-associated muscle atrophy and reduced physical performance, and thus RGNS has a strong potential to be developed as a drug that prevents or improves sarcopenia.

• Journal of Microbiology and Biotechnology
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• 제33권7호
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• pp.915-925
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• 2023

Sarcopenia is defined as loss of muscle mass and strength due to aging. Recent studies show that sarcopenia may improve via the gut-muscle axis, suggesting that gut health may affect muscle phenotypes. In this study, we aimed to investigate the ability of Lactobacillus rhamnosus JY02 as a probiotic strain isolated from kimchi to alleviate sarcopenia. L. rhamnosus JY02-conditioned medium (CM) reduced dexamethasone (DEX)-induced myotube diameter atrophy and expression of muscle degradation markers (MuRF1 and atrogin-1) in C2C12 cells. The amelioration of sarcopenia was investigated by measuring body composition (lean mass), hand grip strength, myofibril size (using histological analysis), and mRNA and protein expression of muscle-related factors in a DEX-induced mouse model. The results of these analyses showed that L. rhamnosus JY02 supplementation promoted the production of muscle-enhancement markers (MHC Iβ, MHC IIα, and Myo-D) and reduced both the production of muscle degradation markers and the symptoms of muscle atrophy (loss of lean mass and muscle strength). We also found decreased levels of pro-inflammatory cytokines (IL-6, IFN- γ) and increased levels of anti-inflammatory cytokines (IL-10) in the serum of DEX+JY02-administered mice compared to those in DEX-treated mice. Overall, these results suggest that L. rhamnosus JY02 is a potent probiotic supplement that prevents sarcopenia by suppressing muscle atrophy.

• 디지털융복합연구
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• 제20권1호
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• pp.361-368
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• 2022

이 연구에서는 새롭게 Asian Working Group for Sarcopenia에서 제시한 수정된 근감소증 진단 cut-off value를 이용하여 정상 집단과 근력이 저하된 possible sarcopenia(PS) 집단을 구분하였다. 국민건강영양조사 제 7기 자료를 토대로, 집단간 신체적 특성의 차이와 삶의 질, 유·무산소 운동 실천에 따른 교차비를 산출하였다. 대상자는 20세-80세까지를 포함하였다. 집단간 차이는 복합표본 독립 t-test와 logistic 회귀분석을 통해 확인하였다. 그 결과는 PS 집단은 나이가 더 많았으며, 신장, 체중, 체질량지수가 모두 낮았다. 허리둘레는 남성 PS 집단이 유의하게 낮았으나, 여성 PS 집단이 유의하게 높았다. 삶의 질의 영역 중 운동 능력에서 일상활동에 지장이 있는 경우가 남성에서는 8.28배, 여성에서는 15.52배 높았다. 유산소 운동의 실천 여부도 PS 집단에서 남녀 각각 19%, 26% 더 낮았으며, 근력 운동실천 여부도 남녀 각각 52%, 43% 더 낮았다.

• 대한한방내과학회지
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• 제44권6호
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• pp.1118-1138
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• 2023

Objectives: Sarcopenia is an age-associated skeletal muscle disorder that can profoundly impact the health of elderly people. However, the efficacy of herbal medicine in sarcopenia is uncertain. This review aims to investigate evidence of the effect of herbal medicine on sarcopenia. Methods: We systematically searched 12 electronic databases for relevant randomized controlled trials (RCTs). Only trials that met the inclusion criteria were selected, and the characteristics of the included studies were extracted and synthesized in a narrative manner. The quality of the included studies was assessed using Cochrane's Risk of Bias (RoB) 2.0 tool. Results: 7 RCTs involving 672 participants with sarcopenia met the inclusion criteria. The intervention combining herbal medicine and conventional treatment (i.e., exercise, nutritional support) had a significant therapeutic effect compared with the conventional treatment, showing improvement in muscle strength (i.e., grip strength), muscle mass (i.e., appendicular skeletal muscle mass index), and physical function (i.e., gait speed, short physical performance battery, and timed up and go test). However, the methodological quality of the included RCTs was relatively low due to their high RoB, making it difficult to evaluate the efficacy of herbal medicine in sarcopenia. In terms of safety, several adverse events were reported. Conclusion: This review suggests that herbal medicine has a positive effect on muscle strength, muscle mass, and physical performance in elderly patients with sarcopenia, but there is a clear need for further research in this area.

• 융합정보논문지
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• 제11권5호
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• pp.242-250
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• 2021

본 연구는 서울·경기에 위치하고 있는 노인복지관과 노인정에서 자발적으로 참여의사를 밝힌 65세 이상노인 514명을 대상으로 노인의 근력, 인지기능, 일상생활수행능력 및 우울의 통합적 인과관계를 분석하였다. 자료수집은 근력은 상·하지근력, 악력(좌,우), 인지기능은 간이 정신상태검사, 선로잇기검사, 숫자외우기검사, 스트룹검사를 실시하였으며, 일상생활수행능력 및 우울은 설문지를 이용하여 측정하였다. 그 결과 첫째, 노인의 근력과 인지기능, 일상생활수행능력 및 우울간에는 통계적으로 유의한 상관관계가 나타났다. 둘째, 노인의 근력과 인지기능, 일상생활수행능력 및 우울의 통합적 관계성에 대한 분석에 모든 변인 간에 통계적 유의성이 나타났다. 본 연구는 노인의 근력, 인지기능, 일상생활수행능력 및 우울의 관계성을 확인하여 노인의 성공적인 노화와 자립적인 노후생활을 위한 기초자료를 제공할 수 있을 것이다.

• 재활치료과학
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• 제3권2호
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• pp.71-81
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• 2014

목적: 본 연구의 목적은 CPM (Continuous Passive Motion)을 뇌졸중 환자의 손 기능 및 수부 근력 재활에 사용하고 그 영향을 살펴보는데 있다. 연구방법 : 본 연구의 대상자는 뇌졸중으로 인한 편마비 증상을 가진, Brunnstrom 4-6단계에 해당하는 치료후 18개월 이내의 급성기 환자 3명이다 연구방법은 3명의 대상자에 대하여 단일사례 (A-B) 실험설계를 사용하였으며 CPM의 영향을 검사하기 위해 젭슨수지기능, 퍼듀페그보드, 수부근력 세 가지를 측정하였다. CPM 적용기간은 3주였으며, 적용회수는 하루 2회, 매회 20분씩, 총 30회기였다. 연구결과: 수부근력 측정 중 손끝잡기에서 대상자 2명의 값이 변화가 없었다. 그 외의 젭슨수지기능, 퍼듀페그보드, 수부근력 검사에서는 CPM 적용 후의 검사 결과가 향상되었다. 결과의 유효성 검증을 위하여 비모수적 통계방법인 Wilcoxon signed ranks test를 실시한 결과 모든 항목에 대한 P-Value가 0. 05 보다 큰 값이 나와 처치 전 후 값의 차이가 통계적으로는 유의미하지 않다는 결과를 얻었다. 결론: 참여 대상자 수가 적고 프로그램 적용 기간이 짧은 제한점이 있으나, 수부 재활을 위해 실시한 CPM이 연구대상자 전원의 손 기능 및 근력 향상에 영향을 주었다는 것을 확인하였다. 이는 주로 하지 기능과 근력 향상을 위해 사용되는 CPM이 급성기 뇌졸중 환자의 수부 치료에도 유용하게 사용될 수 있음을 보여준다.

• 한국산학기술학회논문지
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• 제21권12호
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• pp.162-169
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• 2020

본 연구는 고등부 씨름 선수들을 대상으로 체급별 기초·전문체력의 차이를 알아보는데 목적이 있다. 측정기간은 2019년 11월 25일-12월4일이며, 총 28명의 고등부 씨름 선수(80kg이하 7명, 90kg이하 8명, 90kg이하 7명, 100kg이상 6명)를 대상으로 체급별 기초·전문 체력요인(근력, 근파워, 민첩성, 무산소성파워, 유산소능력, 유연성, 등속성근기능)을 측정하여 비교·분석하였다. 자료처리는 SPSS 23.0을 활용하여 one-way ANOVA와 Duncan을 실시하였다. 그 결과 첫째, 악력과 팔굽혀펴기, 서전트점프, 제자리멀리뛰기, 체후굴, 체전굴, 사이드스텝, 반응시간에서 체급별 차이가 나타나지 않았다. 둘째, 배근력에서 100kg 이하인 그룹이 100kg 이상인 장사급보다 유의하게 낮게 나타났으며, 윗몸일으키기와 20m 셔틀런에서 장사급보다 유의하게 높게 나타났다. 셋째, 무산소성 최고파워와 평균파워의 상대적인 값은 100kg 이하인 그룹이 100kg 이상인 장사급보다 유의하게 높게 나타났다. 넷째, 등속성근기능의 경우 허리 신전/굴곡력과 무릎 관절의 우측 신전근력, 그리고 좌우측 굴곡근력에서 체급별 차이가 없었다. 본 연구 결과에서 얻은 결론은 고등부 씨름 선수의 경우 근파워, 유연성, 민첩성 그리고, 체중당 무산소성 평균파워와 등속성 허리근력, 무릎굴근력에서 체급에 따른 차이가 없다는 것을 확인할 수 있었다.