• Investigative Magnetic Resonance Imaging
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• v.6 no.1
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• pp.41-46
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• 2002

The Fourier transform arteriography (FTA) exploits the periodic variation of arterial flow velociety of arterial flow velocity in stnchronized with cardiac cycles. This technique is intrinsically unique compared to other modern techniques. This technique separates the arteries from the veins using the pulsatile arterial flow without using the presaturation RF pulses. Therefore, it has less RF deposition and is free from the dark band artifacts that can arise from retrograde flow and curved arteries. Furthermore, it is free from the artifacts induced by eddy currents. However, there are some drawbacks such as a single projection view and the saturation of arteries at the end of an imaging slab. These drawbacks are circumvented by applying recently developed techniques. The fast gradient switching capability of modern MRI systems enabled us to incorporate dual projection views into the conventional FTA sequence without increasing the repetition time. In addition, signals from the distal arteries were enhanced by use of a ramped RF pulse and therefore the distal arteries were less saturated. By use of the FTA sequence with dual projection views and the ramped RF pulse, we acquired the sagittal and coronal projection views of femoral arteriograms simultaneously with more enhanced signals of distal arteries than the conventional FTA.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.3
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• pp.173-184
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• 2013

A multi-level design optimization framework for aerodynamic design of rotary wing such as propeller and helicopter rotor blades is presented in this study. Strategy of the proposed framework is to enhance aerodynamic performance by sequentially applying the planform and sectional design optimization. In the first level of a planform design, we used a genetic algorithm and blade element momentum theory (BEMT) based on two-dimensional aerodynamic database to find optimal planform variables. After an initial planform design, local flow conditions of blade sections are analyzed using high-fidelity CFD methods. During the next level, a sectional design optimization is conducted using two dimensional Navier-Stokes analysis and a gradient based optimization algorithm. When optimal airfoil shape is determined at the several spanwise locations, a planform design is performed again. Through this iterative design process, not only an optimal flow condition but also an optimal shape of an EAV propeller blade is obtained. To validate the optimized propeller-blade design, it is tested in wind-tunnel facility with different flow conditions. An efficiency, which is slightly less than the expected improvement of 7% predicted by our proposed design framework but is still satisfactory to enhance the aerodynamic performance of EAV system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.31 no.6_1
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• pp.431-437
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• 2013

Landslides are caused by earthquakes or heavy rains. Recently the incidence of landslides has been increased. However, it is impossible to predict the occurrence of landslide exactly. The purpose of this research is that subdivide the classes of elements in the landslide management system by using spatial analysis technique and AHP method. The existing landslide management system is only comprised of weighted value the slope elements without weighted value about the slop direction elements. For the accuracy improvement in landslide occurrence point, weighted value about the slope direction should be considered. This research is focused on segmentation in slope direction three categories. If the direction of landslide does not affect the structure, I do not think the subject is worth considerating. Based on these results will discuss the improvements in Landslides management systems. Analysis results, segmentation on the slope and the slope direction are needed. Segmented categories about topography elements will be increase the accuracy of landslides management system. Also, since topography of the elements is only considered, segmentation of different elements is needed.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.1
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• pp.119-131
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• 1998

It has been reported that the glycoprotein extracted from Aloe has strong anti-inflammatory response. However, there has been no research report yet about the effect of Aloe on allergic hypersensitivity reactivity. By using guinea pig lung mast cells, this study aimed to examine the effects of Aloe glycoprotein (NY945) on the mediator releases caused by mast cell activation, and also aimed to assess the effects of NY945 on the mechanism of mediator releases in the mast cell activation. We partially purified mast cell from guinea pig lung tissues by using the enzyme digestion, the rough and the discontinuous density percoll gradient method. Mast cells were sensitized with IgG1 (anti-OA) and challenged with ovalbumin. Histamine was assayed by fluorometric analyzer, leukotrienes by radioimmunoassay. The phospholipase D activity was assessed by the production of labeled phosphatidylalcohol. The amount of mass 1, 2-diacylglycerol (DAG) was measured by the $[^3H]DAG$ produced when prelabeled with $[^3H]myristic$ acid. The phospholipid methylation was assessed by measuring the incorporation of the $[^3H]methyl$ moiety into phospholipids of cellular membranes. Pretreatment of NY945 (10 ${\mu}g$) significantly decreased histamine and leukotrienes releases during mast cell activation. The decrease of histamine release was stronger than that of leukotriene during mast cell activation. The phospholipase D activity increased by the mast cell activation was decreased by the dose-dependent manner in the pretreatment of NY945. The amount of DAG produced by PLC activity was decreased by NY945 pretreatment. The amount of mass 1, 2-diacylglycerol produced by activation of mast cells was decreased in the pretreatment of NY945. NY945 pretreatment strongly inhibited the incorporation of the $[^3H]methyl$ moiety into phospholipids. The data suggest that NY945 purified from Aloe inhibits in part an increase of 1, 2-diacylglycerol which is produced by activating mast cells with antigen-antibody reactions, which is mediated via phosphatidylcholine-phospholipase D and phosphatidylinositol-phospholipase C systems, and then followed by the inhibition of histamine release. Furthermore, NY945 reduces the production of phosphatidylcholine by inhibiting the methyltransferase I and II, which decreases the conversion of phosphatidylcholine into arachidonic acid and inhibits the production of leukotrienes.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.1
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• pp.92-100
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• 2018

Vortical systems are considered a main feature to sustain turbulence in a boundary layer through interaction. Such turbulent structures result in frictional drag and erosion or vibration in engineering applications. Research for controlling turbulent flow has been actively carried out, but in order to show the effect of vortices in a turbulent boundary layer, it is necessary to clarify the mechanism by which turbulent energy is transferred. For this purpose, it is convenient to demonstrate and capture phenomena in a laminar boundary layer. Therefore, in this study, the interactions of disturbed flow around a hemisphere on a flat plate in laminar flow were analyzed. In other words, a street of hairpin vortices was generated following a wake region formed after flow separation occurred over a hemisphere. Necklace vortices surrounding the hemisphere also appeared due to a strong adverse pressure gradient that brought high momentum fluid into the wake region thereby leading to an increase in the frequency of hairpin vortices. To mitigate the effect of these necklace vortices, local suction control was applied through a hole in front of the hemisphere. Flow visualization was recorded to qualitatively determine flow modifications, and hot-film measurements quantitatively supported conclusions on how much the power of the hairpin vortices was reduced by local wall suction.

• Journal of the Korea Society of Computer and Information
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• v.18 no.7
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• pp.23-35
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• 2013

This paper proposes an effective technique that is used to automatically extract feature vectors from vibration signals for fault classification systems. Conventional mel-frequency cepstral coefficients (MFCCs) are sensitive to noise of vibration signals, degrading classification accuracy. To solve this problem, this paper proposes spectral envelope cepstral coefficients (SECC) analysis, where a 4-step filter bank based on spectral envelopes of vibration signals is used: (1) a linear predictive coding (LPC) algorithm is used to specify spectral envelopes of all faulty vibration signals, (2) all envelopes are averaged to get general spectral shape, (3) a gradient descent method is used to find extremes of the average envelope and its frequencies, (4) a non-overlapped filter is used to have centers calculated from distances between valley frequencies of the envelope. This 4-step filter bank is then used in cepstral coefficients computation to extract feature vectors. Finally, a multi-layer support vector machine (MLSVM) with various sigma values uses these special parameters to identify faulty types of induction motors. Experimental results indicate that the proposed extraction method outperforms other feature extraction algorithms, yielding more than about 99.65% of classification accuracy.

• Animal cells and systems
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• v.2 no.4
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• pp.483-488
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• 1998

We previously found that a potent gonadotropin-releasing hormone (GnRH) agonist, buserelin, decreases GnRH promoter activity together with GnRH mRNA level, providing evidence for an autoregulatory mechanism operating at the level of GnRH gene transcription in immortalized GT1-1 neuronal cells. To examine whether agonist-induced decrease in GnRH mRNA level requires the continuous presence of buserelin, we performed a pulse-chase experiment of buserelin treatment. Short-term exposure (15 min) of GT1-1 neuronal cells to buserelin ($10{\mu}M$) was able to decrease GnRH mRNA levels when determined 24 h later. When GT1-1 cells were treated with buserelin ( $10{\mu}M$) for 30 min and then incubated for 1, 3, 6, 12, 24, and 48 h after buserelin removal, a significant decrease in GnRH mRNA levels was observed after the 12 h incubation period. These data indicate that inhibitory signaling upon buserelin treatment may occur rapidly, but requires a long time (at least 12 h) to significantly decrease the GnRH mRNA level. To examine the possible involvement of de novo synthesis and/or mRNA stability in buserelin-induced decrease in GnRH gene expression, actinomycin D ($5{\mu}m/ml$), a potent RNA synthesis blocker, was co-treated with buserelin. Actinomycin D alone failed to alter basal GnRH mRNA Revel, but blocked the buserelin-induced decrease in GnRH mRNA level at 12 h of post-treatment. These data suggest that buserelin may exert its inhibitory action by altering the stability of GnRH mRNA. Moreover, a polvsomal RNA separation by sucrose gradient centrifugation demonstrated that buserelin decreased the translational efficiency of the transcribed GnRH mRNA. Taken together, these results clearly indicate that GnRH agonist buserelin acts as an inhibitory signal at multiple levels such as transcription mRNA stability, and translation.

• Journal of KIISE:Computer Systems and Theory
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• v.36 no.5
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• pp.404-411
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• 2009

We introduce in this paper a new method for smooth foldover-free warping of images, based on the vector field deformation technique proposed by Von Funck et al. It allows users to specify the constraints in two different ways: positional constraints to constrain the position of a point in the image and gradient constraints to constrain the orientation and scaling of some parts of the image. From the user-specified constraints, it computes in the image domain a C1-continuous velocity vector field, along which each pixel progressively moves from its original position to the target. The target positions of the pixels are obtained by solving a set of partial derivative equations with the 4th order Runge-Kutta method. We show how our method can be useful for texture mapping with hard constraints. We start with an unconstrained planar embedding of a target mesh using a previously known method (Least Squares Conformal Map). Then, in order to obtain a texture map that satisfies the given constraints, we use the proposed warping method to align the features of the texture image with those on the unconstrained embedding. Compared to previous work, our method generates a smoother texture mapping, offers higher level of control for defining the constraints, and is simpler to implement.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.4
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• pp.445-456
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• 1997

We previously reported that some components of ginsenosides decreased mediator releases evoked by the activation of mast cells with specific antigen-antibody reactions. This study aimed to assess the effects of ginsenosides ($Rb_2$, Re) on the mechanism of histamine release in the mast cell activation. We partially purified guinea pig lung mast cells by using enzyme digestion, the rough and the discontinuous percoll density gradient method. Mast cells were sensitized with $IgG_1$ and challenged with ovalbumin (OA). Histamine was assayed by fluorometric analyzer, leukotrienes by radioimmunoassay. Phospholipase D (PLD) activity was assessed more directly by the production of $[^3H]phosphatidylbutanol$ (PBut) which was produced by PLD-mediated transphosphatidylation in the presence of butanol. The amount of 1,2- diacylglycerol (DAG) were measured by the $[^3H]DAG$ labeled with $[^3H]palmitic$ acid or $[^3H]myristic$ acid. Pretreatment of $Rb_2$ ($300\;{\mu}g$) significantly decreased histamine release by 60%, but Re ($300\;{\mu}g$) increased histamine release by 34%. Leukotrienes release in $Rb_2$ was decreased by 40%, Re was not affected in the leukotrienes release during mast cell activations. An increasing PLD activity during mast cell activation was decreased by the dose-dependent manner in the pretreatment of $Rb_2$, but Re pretreatment facilitated the increased PLD activity during mast cell activation. The amount of DAG produced by phospholipase C (PLC) activity was decreased by $Rb_2$ pretreatment, but Re pretreatment was not affected. The amount of mass DAG was decreased by $Rb_2$ and Re pretreatment during mast cell activation. The data suggest that $Rb_2$ purified from Korean Red Ginseng Radix inhibits the DAG which is produced by the activation of mast cells with antigen-antibody reactions via both phosphatidylinositide-PLC and phosphatidylcholine-PLD systems, and then followed by the inhibition of histamine release. However, Re increases histamine release by stimulation of DAG production, which is mediated by phosphatidylcholine-PLD system rather than by phosphatidylinositide-PLC system, but inhibits the mass DAG production. Thus, it could be inferred that other mechanisms play a role in the increase of histamine release during mast cell activation.

• The Journal of Engineering Geology
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• v.24 no.4
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• pp.487-499
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• 2014

While the vertical open type of heat exchanger is more effective in areas of abundant groundwater, and is becoming more widely used, the heat exchanger most commonly used in geothermal heating and cooling systems in Korea is the vertical closed loop type. In this study, we performed numerical simulations of the optimal utilization of geothermal energy based on the hydrogeological and thermal properties to evaluate the efficiency of the vertical open type in areas of abundant groundwater supply. The first simulation indicated that the vertical open type using groundwater directly is more efficient than the vertical closed loop type in areas of abundant groundwater. Furthermore, a doublet system with separated injection and extraction wells was more efficient because the temperature difference (${\Delta}$) between the injection and extraction water generated by heat exchange with the ground is large. In the second simulation, we performed additional numerical simulations of the optimal utilization of geothermal energy that incorporated heat transfer, distance, flow rate, and groundwater hydraulic gradient targeting a single well, SCW (standing column well), and doublet. We present a flow diagram that can be used to select the optimal type of heat exchanger based on these simulation results. The results of this study indicate that it is necessary to examine the adequacy of the geothermal energy utilization system based on the hydrogeological and thermal properties of the area concerned, and also on a review of the COP (coefficient of performance) of the geothermal heating and cooling system.