• 치과방사선
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• 제29권2호
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• pp.407-410
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• 1999

Purpose; To find out the best imaging parameters for the diagnosis of disc in MRI imaging. Materials and methods; The diagnostic quality of the disc among the Tl, PD and T2 images of same patients02 joints, 223 images) was compared by visual(I-IV grades) and gray level measurement (pre- and infra-discal area) method. Results; PD images showed best results with 43.7％ of the images belonging to grade III (good) and with statistically significant higher difference of the gray levels at pre- and infra-discal areas. But there were no grade N (excellent) images. Conclusions; PD images are best method among Tl. PD and T2 images in diagnosing the disc but since there were no excellent images further imaging parameters should be studied for better images.

• Radiation Oncology Journal
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• 제2권2호
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• pp.177-184
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• 1984

A retrospective analysis of survival data of i2 cases with brain astrocytomas was presented. All patients received post·operative radiotherapy in the period of $1973\~1983$ at YUMC, Yonsei Cancer Center. There were 24 patients with Grade II, 12 patients with Grade III and 16 patients with Grade IV astrocytomas. Survival rates o ere analyzed according to histologic grade of malignancy, age, tumor location, radiation dose and extent of surgical tumor resection. 5year actuarial survival for patients with Grade II astrocytomas was $32.9\%$ and Grade III was $42.9\%$. The 1 year and 2 year survival rate of Grade astrocytomas were $46.7\%$ and $0\%$. Histologic grade of tumor was important prognostic factor in brain astrocytomas. Age and extent of surgical resection were significant prognostic (actors in all grades of astrocytomas and tumor location and radiation dose were significant in Grade f astrocytomas.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7187-7191
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• 2013

Most of the exogenous and endogenous chemical compounds are metabolized by enzymes of xenobiotic processing pathways, including the phase I cytochrome p450 species. Carcinogens and their metabolites are generally detoxified by phase II enzymes like glutathione-S-transferases (GST). The balance of enzymes determines whether metabolic activation of pro-carcinogens or inactivation of carcinogens occurs. Under certain conditions, deregulated expression of xenobiotic enzymes may also convert endogenous substrates to metabolites that can facilitate DNA adduct formation and ultimately lead to cancer development. In this study, we aimed to test the association between deregulation of metabolizing genes and brain tumorigenesis. The expression profile of metabolizing genes CYP1A1 and GSTP1 was therefore studied in a cohort of 36 brain tumor patients and controls using Western blotting. In a second part of the study we analyzed protein expression of GSTs in the same study cohort by ELISA. CYP1A1 expression was found to be significantly high (p<0.001) in brain tumor as compared to the normal tissues, with ~4 fold (OR=4, 95%CI=0.43-37) increase in some cases. In contrast, the expression of GSTP1 was found to be significantly low in brain tumor tissues as compared to the controls (p<0.02). This down regulation was significantly higher (OR=0.05, 95%CI=0.006-0.51; p<0.007) in certain grades of lesions. Furthermore, GSTs levels were significantly down-regulated (p<0.014) in brain tumor patients compared to controls. Statistically significant decrease in GST levels was observed in the more advanced lesions (III-IV, p<0.005) as compared to the early tissue grades (I-II). Thus, altered expression of these xenobiotic metabolizing genes may be involved in brain tumor development in Pakistani population. Investigation of expression of these genes may provide information not only for the prediction of individual cancer risk but also for the prevention of cancer.

• Journal of Korean Neurosurgical Society
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• 제63권2호
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• pp.210-217
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• 2020

Objective : To analyze the accuracy of iliac screws using freehand technique performed by the same surgeon. We also analyzed how the breach of iliac screws was related to the clinical symptoms resulting in revision surgery. Methods : From January 2009 to November 2015, 100 patients (193 iliac screws) were analyzed using postoperative computed tomography scans. The breaches were classified based on the superior, inferior, lateral, and medial iliac wall violation by the screw. According to the length of screw extrusion, the classification grades were as follows : grade 1, screw extrusion <1 cm; grade II, 1 cm ≤ screw extrusion <2 cm; grade III, 2 cm ≤ screw extrusion <3 cm; and grade IV, 3 cm ≤ screw extrusion. We also reviewed the revision surgery associated with iliac screw misplacement. Results : Of the 193 inserted screws, 169 were correctly located and 24 were misplaced screws. There were eight grade I, six grade II, six grade III, and four grade IV screw breaches, and 11, 8, 2, and 3 screws violated the medial, lateral, superior, and inferior walls, respectively. Four revision surgeries were performed for the grade III or IV iliac screw breaches in the lateral or inferior direction with respect to its related symptoms. Conclusion : In iliac screw placement, 12.4% breaches developed. Although most breaches were not problematic, symptomatic violations (2.1%) could result in revision surgery. Notably, the surgeon should keep in mind that lateral or inferior wall breaches longer than 2 cm can be risky and should be avoided.

• 한국환경복원기술학회지
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• 제7권1호
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• pp.116-127
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• 2004

The objectives of this study are to build up the concept of Environment-Oriented Land Suitability Assessment(EOLSA) and to develop the EOLSA mapping system by applying the EOLSA criteria to the case study area. In order to draw out the EOLSA critera, this study adopted the Delphi method including the experts' awareness survey to urban planners as well as environmental researchers in May and June 2001. As a result, the concept of EPLSA was defined as a process of land use planning to scientifically assess the physical and environmental value of land and to classify conservation aptitude into several grades for the sustainable management of environmental resources. With an outcome of applying the EOLSA criteria with five degrees to the Seoul Metropolitan Area (SMA), Grade I, indicating the highest conservation value, accounted for 57.76% of the SMA. Then, Grade II reached up to 15.06%, Grade III 3.12%, Grade IV 15.92%, and Grade V, the lowest conservation value, 7.99% respectively. And also, the case analysis showed that the share of Grade I area was the highest in Gapyong county and Yangpyong county, Pochon county, Yeonchon county, Yongin city in the order and the lowest in Kwangmyong city, Osan city, Kunpo city, Kuri city, and Buchon city.

• 대한핵의학회지
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• 제16권2호
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• pp.29-36
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• 1982

Quantification of the regurgitation amount is important before and after valvular replacement surgery. Until now cardiac catheterization with cineventriculography, echocardiography have been used to measure the regurgitation amount, but also have many limitations. EKG gated cardiac blood pool scan provides a simple, non-invasive -method for quantify the regurgitation amount. By calculating the ratio of left ventricular to right ventricular stroke counts (stroke volume ratio) in gated bood pool scan, we measured the left ventricular regurgitation amount in 28 cases of valvular regurgitation and 25 cases of normal group. 1. Stroke volume ratio was higher in cases of valvular regurgitation $(2.11{\pm}0.58)$ than in cases of normal control $(1.15{\pm}0.31)$. (p<0.01). 2. Stroke volume ratio was classified by regurgitation grade using X-ray cineventriculography. In grades of mild regurgitation $(Grade\;I{\sim}II)$, stroke volume ratio was $2.02{\pm}0.29$, and in grades of severe regurgitation $(Grade\;III{\sim}IV)$, stroke volume ratio was $2.55{\pm}0.34$, so stroke volume ratio was well correlated with the grade of X-ray cineventriculography. 3. Stroke volume ratio was classfied by functional class made in New York Heart Association. In classes of mild regurgitation $(class\;I{\sim}II)$, stroke volume ratio was $2.08{\pm}0.26$, and in classes of severe regurgitation $(class\;III{\sim}IV)$, stroke volume ratio was $2.55{\pm}0.38$, Stroke volume ratio well represented the functional class. 4. After aortic and mitral valve replacement in 28 patients, the stroke volume ratio, decreased from $2.11{\pm}0.58\;to\;1.06{\pm}0.26$. Gated blood pool scan provides a noninvasive method of qnantifying valvular regurgitation and assessing the result of surgical interventions.

• Journal of Animal Science and Technology
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• 제54권1호
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• pp.29-33
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• 2012

본 연구는 충남 대단위 양돈장 5개에서 도체등급판정을 받은 26,983두를 대상으로 성별, 사료급여량별, 등지방두께별, 도체중별에 따른 돼지 도체의 육질등급을 조사 분석하여 고급돈육 생산에 필요한 기초적 자료를 얻고자 실시하였다. 성별 육질 등급 간에는 통계적으로 유의한 차이(p<0.01)를 보였다. 암컷은 $1^+$ 등급(76.7%) 출현율이 가장 많았으나, 거세돈은 1등급 출현율(56.5%)이 가장 높았다. 도체중은 사료급여량 그룹간에는 유의한 차이(p<0.05)를 보였는데, 사료급여량을 가장 적게 급여한 그룹 I의 경우 평균 도체중이 85.8 kg으로 가장 가벼웠으나, 가장 많이 급여한 그룹 IV는 89.5 kg으로 가장 무거운 것으로 나타났다. 육질등급은 등지방 두께간 유의한 차이(p<0.001)를 보였는데, 15 mm 이하 등지방 두께 그룹에서는 2등급(67.5%)의 출현율이 높았으나, 15~19 mm 등지방 두께 그룹은 1등급(89.3%) 출현율이 가장 높았다. 도체중간 육질등급은 유의한 차이(p<0.05)를 보였는데, 도체중 85 kg 이상 그룹은 2등급(54.3%) 출현율이 가장 높았으나, 78~84 kg 그룹은 1등급(62.1%)이 가장 높게 출현 되었다. 이와 같이 도체중, 등지방 두께 등은 육질등급 판정의 중요한 요인으로 작용됨으로 비육돈에 최적사양관리 시스템개발로 고급돈육 생산에 이바지해야 할 것으로 생각된다.

• Journal of Trauma and Injury
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• 제26권3호
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• pp.131-138
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• 2013

Purpose: The aim of this study is to present a retrospective review of patients who had a sudden onset of facial palsy after trauma and who underwent facial nerve decompression. Methods: The cases of 25 patients who had traumatic facial palsy were reviewed. Facial nerve function was graded according to the House-Brackmann grading scale. According to facial nerve decompression, patients were categorized into the surgical (decompression) group, with 7 patients in the early decompression subgroup and 2 patients in the late decompression subgroup, and the conservative group(16 patients). Results: The facial nerve decompression group included 8 males and 1 female, aged 2 to 86 years old, with a mean age of 40.8. In early facial nerve decompression subgroup, facial palsy was H-B grade I to III in 6 cases (66.7%); H-B grade IV was observed in 1 case(11.1%). In late facial nerve decompression subgroup, 1 patient (11.1%) had no improvement, and the other patient(11.1%) improved to H-B grade III from H-B grade V. A comparison of patients who underwent surgery within 2 weeks to those who underwent surgery 2 weeks later did not show any significant difference in improvement of H-B grades (p>0.05). The conservative management group included 15 males and 1 female, aged 6 to 66 years old, with a mean age of 36. At the last follow up, 15 patients showed H-B grades of I to III(93.7%), and only 1 patient had an H-B grade of IV(6.3%). Conclusion: Generally, we assume that early facial nerve decompression can lead to some recovery from traumatic facial palsy, but a prospective controlled study should and will be prepared to compare of conservative treatment to late decompression.

• 한국습지학회지
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• 제6권3호
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• pp.83-93
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• 2004

본 연구의 목적은 하천환경의 정량적 평가기법을 통해 하천 관리 전략의 틀을 개발하는데 있다. 연구 대상지는 경남 진주시를 관통하여 남강으로 유입되는 6개의 지방 하천이다. 하천환경 평가는 세 가지의 현장 조사를 통해 수행되었다. 첫째, 대상 하천의 제방선으로부터 좌우 50m, 길이 500m 간격을 단위구간으로 하여 20개의 평가항목에 대해서 하천 자연도를 조사하여 5등급으로 평가하였다. 둘째, 수질 및 유량을 8회 조사하여 5등급으로 평가하였다. 셋째, 해당 하천 유역의 토지이용도를 주거지 비율을 따라 5등급으로 평가하였다. 이상의 하천환경의 세 가지 부문인자인 자연도, 수질 그리고 토지이용도를 통합하여 다시 5등급으로 분류하여 최종적인 하천 환경을 평가하였으며 그 결과에 따라 각 하천별 관리 전략을 제시하였다. 하천별 적용 결과를 살펴보면, 판문천과 가좌천은 적극적인 환경복원이 필요한 IV등급으로 평가되었고, 나불천과 용아천은 부분적 복원이 필요한 II등급으로 평가되었으며, 영천강과 독산천은 현 상태 유지가 바람직한 I등급으로 평가되었다. 이상의 대상 하천별 환경 평가는 향후 하천관리 계획수립이나 하천 복원을 위해 중요한 참고자료가 될 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3355-3360
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• 2015

Background: Zinc transporters have been considered as essential regulators in many cancers; however, their mechanisms remain unknown, especially in gliomas. Isocitrate dehydrogenase 1(IDH1) mutation is crucial to glioma. This study aimed to investigate whether zinc transporters are correlated with glioma grade and IDH1 mutation status. Materials and Methods: IDH1 mutation status and mRNA expression of four zinc transporters (ZIP4, ZIP9, ZIP11, and ZnT9) were determined by subjecting a panel of 74 glioma tissue samples to quantitative real-time PCR and pyrosequencing. The correlations between the expression levels of these zinc transporter genes and the grade of glioma, as well as IDH1 mutation status, were investigated. Results: Among the four zinc transporter genes, high ZIP4 expression and low ZIP11 expression were significantly associated with higher grade (grades III and IV) tumors compared with lower grade (grades I and II) counterparts (p<0.0001). However, only ZIP11 exhibited weak correlation with IDH1 mutation status (p=0.045). Samples with mutations in IDH1 displayed higher ZIP11 expression than those without IDH1 mutations. Conclusions: This finding indicated that zinc transporters may interact with IDH1 mutation by direct modulation or action in some shared pathways or genes to promote the development of glioma. Zinc transporters may play an important role in glioma. ZIP4 and ZIP11 are promising molecular diagnostic markers and novel therapeutic targets. Nevertheless, the detailed biological function of zinc transporters and the mechanism of the potential interaction between ZIP11 and IDH1 mutation in gliomagenesis should be further investigated.