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Background Breast Parenchymal Signal During Menstrual Cycle on Diffusion-Weighted MRI: A Prospective Study in Healthy Premenopausal Women

  • Yeon Soo Kim;Bo La Yun;A Jung Chu;Su Hyun Lee;Hee Jung Shin;Sun Mi Kim;Mijung Jang;Sung Ui Shin;Woo Kyung Moon
    • Korean Journal of Radiology
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    • v.25 no.6
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    • pp.511-517
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    • 2024
  • Objective: To prospectively investigate the influence of the menstrual cycle on the background parenchymal signal (BPS) and apparent diffusion coefficient (ADC) of the breast on diffusion-weighted MRI (DW-MRI) in healthy premenopausal women. Materials and Methods: Seven healthy premenopausal women (median age, 37 years; range, 33-49 years) with regular menstrual cycles participated in this study. DW-MRI was performed during each of the four phases of the menstrual cycle (four examinations in total). Three radiologists independently assessed the BPS visual grade on images with b-values of 800 sec/mm2 (b800), 1200 sec/mm2 (b1200), and a synthetic 1500 sec/mm2 (sb1500). Additionally, one radiologist conducted a quantitative analysis to measure the BPS volume (%) and ADC values of the BPS (ADCBPS) and fibroglandular tissue (ADCFGT). Changes in the visual grade, BPS volume (%), ADCBPS, and ADCFGT during the menstrual cycle were descriptively analyzed. Results: The visual grade of BPS in seven women varied from mild to marked on b800 and from minimal to moderate on b1200 and sb1500. As the b-value increased, the visual grade of BPS decreased. On b800 and sb1500, two of the seven volunteers showed the highest visual grade in the early follicular phase (EFP). On b1200, three of the seven volunteers showed the highest visual grades in EFP. The BPS volume (%) on b800 and b1200 showed the highest value in three of the six volunteers with dense breasts in EFP. Three of the seven volunteers showed the lowest ADCBPS in the EFP. Four of the seven volunteers showed the highest ADCBPS in the early luteal phase (ELP) and the lowest ADCFGT in the late follicular phase (LFP). Conclusion: Most volunteers did not exhibit specific BPS patterns during their menstrual cycles. However, the highest BPS and lowest ADCBPS were more frequently observed in EFP than in the other menstrual cycle phases, whereas the highest ADCBPS was more common in ELP. The lowest ADCFGT was more frequent in LFP.

A Clinical Analysis of the Correlation between Acne Distribution in the Jaw and Emmeniopathy (월경병과 하악부 면포 발생과의 관계에 대한 임상적 고찰)

  • Yu Hyun-jung;Lee Seung-deok;Choi In-hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.17 no.2
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    • pp.87-93
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    • 2004
  • Objective: We would like to find out the correlation between acne distribution in the jaw and the emmeniopathy. Methods: The clinical studies were made on 43 cases of acne vulgaris who visited to Department of Dermatology, Dongguk University Gangnam Oriental Medical Hospital during from August, 2002 to July, 2004. We divided the patients into two groups. A group had the emmeniopathy. B group didn't have the emmeniopathy. In the acne grade and the number of acne, we investigated the difference between A and B group statistically. We used the statical methods of student's t-test on the number of acne and wilcoxon rank sum test on acne grade. Results: The mean age was 25.8${\pm}$4.80 in A group and 27.6${\pm}$5.68 in B group. There were painful menstruation, quality of thickness, menstrual cycle disorder, menstrual amount disorder, dark purple color, premenstrual acne in A group with the emmeniopathy. The acne grade was 1.69${\pm}$1.28 in A group, 1.43${\pm}$1.28 in B group. The number of acne was 3.66${\pm}$3.15 in A group, 4.36${\pm}$4.07 in B group. P-value was 0.52 in acne grade and 0.25 in the number of acne. We investigated no difference between A and B group statistically on acne grade and the number of acne. Conclusions: We needed the further study about the factor which affect on acne distribution and emmeniopathy.

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Mastectomy Method according to the Breast Size in the Female to Male Transgenders (여성에서 남성 성전환자의 유방크기에 따른 유방절제방법)

  • Yang, Jin-Il;Park, Su-Sung;Lee, Keun-Cheol;Kim, Seok-Kwun
    • Archives of Plastic Surgery
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    • v.38 no.1
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    • pp.63-68
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    • 2011
  • Purpose: Mastectomy is one of the operative procedures of female to male transsexuals. It is aimed to excise all of breast tissues and to reconstruct male chest wall, areola, and nipple. Breast sizes are varied by developmental status and their hormonal therapy. There are several approaches for mastectomy. This study is aimed to suggest appropriate mastectomy methods according to breast size in the female to male transgenders. Methods: We retrospectively analysed 46 patients of female to male transgenders. Breast size was categorized by their inner wear size. In A cup size, mastectomy was done with periareolar approach. In C cup size, inframammary fold approach subcutaneous mastectomy was performed. In B cup size, periareolar approach was used for grade A or B ptosis patient, and inframammary fold approach was choosen for the patient with grade C ptosis. Results: Subcutaneous mastectomy was done through semicircular periareolar approach for 26 patients. There were 2 cases of major complications that should be corrected by hematoma evacuation. Circumareolar approach was used for 5 patients, and a case of nipple-areolar complex necrosis was observed. Two cases of another complications which were irregularity of breast and wound disruption could be corrected. Inframammary fold approach was selected for 15 patients. There was a case of wound disruption, so revision surgery whould be done. Four cases of breast irregularity was corrected spontaneously, and 2 cases of partial necrosis of nipple-areolar complex were corrected with secondary healing. Patient satisfaction score for periareolar, cicumareolar, and inframmammary fold approach were 4.5, 4.2 and 4.1, respectively. Some major and minor complications were observed, but satisfactory results could be secured. Conclusion: Semicircular periareolar incision looked adequate for A cup size patient, circumareolar incision was suitable for B cup size with grade A or B ptosis. In B cup size with grade C ptosis patient and C cup patients, inframammary fold incision looked suitable for optimal results.

A retrospective study of single frozen-thawed blastocyst transfer

  • Hur, Yong Soo;Ryu, Eun Kyung;Song, Seung Hyun;Yoon, San Hyun;Lim, Kyung Sil;Lee, Won Don;Lim, Jin Ho
    • Clinical and Experimental Reproductive Medicine
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    • v.43 no.2
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    • pp.106-111
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    • 2016
  • Objective: To study the clinical outcomes of single frozen-thawed blastocyst transfer cycles according to the hatching status of frozen-thawed blastocysts. Methods: Frozen-thawed blastocysts were divided into three groups according to their hatching status as follows: less-than-expanded blastocyst (${\leq}EdB$), hatching blastocyst (HgB), and hatched blastocyst (HdB). The female age and infertility factors of each group were evaluated. The quality of the single frozen-thawed blastocyst was also graded as grade A, tightly packed inner cell mass (ICM) and many cells organized in the trophectoderm epithelium (TE); grade B, several and loose ICM and TE; and grade C, very few ICM and a few cells in the TE. The clinical pregnancy and implantation rate were compared between each group. The data were analyzed by either t-test or chi-square analysis. Results: There were no statistically significant differences in average female ages, infertility factors, or the distribution of blastocyst grades A, B, and C in each group. There was no significant difference in the clinical pregnancy and implantation rate of each group according to their blastocyst grade. However, there was a significant difference in the clinical pregnancy and implantation rate between each group. In the HdB group, the clinical pregnancy and implantation rate were similar regardless of the blastocyst quality. Conclusion: There was an effect on the clinical outcomes depending on whether the blastocyst hatched during single frozen-thawed blastocyst transfer. When performing single frozen-thawed blastocyst transfer, the hatching status of the frozen-thawed blastocyst may be a more important parameter for clinical outcomes than the quality of the frozen-thawed blastocyst.

Percentile-Based Analysis of Non-Gaussian Diffusion Parameters for Improved Glioma Grading

  • Karaman, M. Muge;Zhou, Christopher Y.;Zhang, Jiaxuan;Zhong, Zheng;Wang, Kezhou;Zhu, Wenzhen
    • Investigative Magnetic Resonance Imaging
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    • v.26 no.2
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    • pp.104-116
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    • 2022
  • The purpose of this study is to systematically determine an optimal percentile cut-off in histogram analysis for calculating the mean parameters obtained from a non-Gaussian continuous-time random-walk (CTRW) diffusion model for differentiating individual glioma grades. This retrospective study included 90 patients with histopathologically proven gliomas (42 grade II, 19 grade III, and 29 grade IV). We performed diffusion-weighted imaging using 17 b-values (0-4000 s/mm2) at 3T, and analyzed the images with the CTRW model to produce an anomalous diffusion coefficient (Dm) along with temporal (𝛼) and spatial (𝛽) diffusion heterogeneity parameters. Given the tumor ROIs, we created a histogram of each parameter; computed the P-values (using a Student's t-test) for the statistical differences in the mean Dm, 𝛼, or 𝛽 for differentiating grade II vs. grade III gliomas and grade III vs. grade IV gliomas at different percentiles (1% to 100%); and selected the highest percentile with P < 0.05 as the optimal percentile. We used the mean parameter values calculated from the optimal percentile cut-offs to do a receiver operating characteristic (ROC) analysis based on individual parameters or their combinations. We compared the results with those obtained by averaging data over the entire region of interest (i.e., 100th percentile). We found the optimal percentiles for Dm, 𝛼, and 𝛽 to be 68%, 75%, and 100% for differentiating grade II vs. III and 58%, 19%, and 100% for differentiating grade III vs. IV gliomas, respectively. The optimal percentile cut-offs outperformed the entire-ROI-based analysis in sensitivity (0.761 vs. 0.690), specificity (0.578 vs. 0.526), accuracy (0.704 vs. 0.639), and AUC (0.671 vs. 0.599) for grade II vs. III differentiations and in sensitivity (0.789 vs. 0.578) and AUC (0.637 vs. 0.620) for grade III vs. IV differentiations, respectively. Percentile-based histogram analysis, coupled with the multi-parametric approach enabled by the CTRW diffusion model using high b-values, can improve glioma grading.

Quality Improvement of Strip Loin from Hanwoo with Low Quality Grade by Dry Aging (건조숙성에 따른 저등급 한우 채끝 등심의 품질 증진)

  • Lee, Chul Woo;Lee, Seung Ho;Min, Yejin;Lee, Sookee;Jo, Cheorun;Jung, Samooel
    • The Korean Journal of Food And Nutrition
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    • v.28 no.3
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    • pp.415-421
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    • 2015
  • This study investigated the quality change of strip loin from hanwoo with quality grade 2 produced by dry aging, and compared the quality of dry-aged strip loin with that of strip loin from hanwoo with quality grade $1^+$. Hanwoo strip loins with quality grade $1^+$ (SL1) and 2 (SL2) after a day of slaughter and dry-aged strip loin (DSL2) aged for 21 days at $2^{\circ}C$ with 85% humidity were obtained from local markets. The proximate composition, pH, cooking loss, lipid oxidation, instrumental color (CIE $L^*$, $a^*$ and $b^*$ value) and sensory properties of the strip loins were measured. DSL2 contained low moisture and high protein contents compared with SL2, and low fat, high protein, and high ash contents compared with SL1 (p<0.05). The pH and cooking loss were higher and lower, respectively, in DSL2 compared to SL2 (p<0.05). SL1 had a higher pH than DSL2 (p<0.05). However, the cooking loss was not different between SL1 and DSL2. The TBARS value was the highest in DSL2 and the lowest in SL2 (p<0.05). DSL2 had higher $L^*$ and $b^*$ value compared with SL2 (p<0.05). There were no significant differences of $L^*$, $a^*$ and $b^*$ values between DSL2 and SL1. Sensory properties such as the color, flavor, taste, texture, and acceptability of DSL2 were higher than those of SL2 (p<0.05). There was no significant different in all sensory properties between DSL2 and SL1. According to the results, dry aging can improve the nutritional and sensorial quality of strip loin with quality grade 2 to quality comparable to quality grade $1^+$.

Metallurgical refining study for production of solar grade (SoG) silicon by synthetic slag (태양전지용 실리콘 제조를 위한 슬래그 이용 야금학적 정련연구)

  • Kim, Daesuk;Lee, Sangwook;Park, Dongho;Yu, TaeU;Moon, ByungMoon;Min, DongJoon
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.11a
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    • pp.43.2-43.2
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    • 2010
  • In this study, metallurgical grade (MG) silicon with 99% purity produced by arc furnace process was systematically investigated for slag refining. The most problematic impurities to remove from MG silicon are boron (B) and phosphorus (P). To remove B and P from MG-silicon, we used synthetic slag in the molten state. MG-silicon with synthetic slag of CaO, $SiO_2$, and $CaF_2$ was melted using by high-frequency induction furnace with electrical output of 50kW. Specimens prepared by various refining process conditions(holding time, mixture ratio) were inspected by combined analysis of ICP-MS and XRF. With this approach, B has been reduced to <5ppm, P to <1ppm and other impurities to 0.1~0.2% except for Calcium. Calcium has been increased from 17ppm to 1500ppm. Problem of calcium contamination will be resolved by additional refining processes.

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The Rheological Properties of Castella on the Market (시판 카스테라의 점탄성 계수)

  • 정현숙
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.23 no.2
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    • pp.298-302
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    • 1994
  • This study is carried out in order to investigate to the physical property of Castella. The material is 19 kinds of Castella on the market in Kyushu area.As an result of the sensory evaluation for Castella, it could be classified into 3 types ; a) high grade, C) low grade, and B) midium grade.The results are summarized as follow. The water content of 3 type Castella was most 26-30% but Korea's was more lower . ΔE of A an dB type Castella was similiar , but A and C types was very different. in the Creep test, 3 types are all the 6-element Voigt model, consisting of Hookean body , Newtonian body and two sets of Voigt body. Eo of A type is 13-36% higher than other types. The parts of retardation strain of A type are 21-41% lower than B type, 8-13% higher than C type, respectively.

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Clinical Analysis of Video-assisted Thoracoscopic Spinal Surgery in the Thoracic or Thoracolumbar Spinal Pathologies

  • Kim, Sung-Jin;Sohn, Moon-Jun;Ryoo, Ji-Yoon;Kim, Yeon-Soo;Whang, Choong-Jin
    • Journal of Korean Neurosurgical Society
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    • v.42 no.4
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    • pp.293-299
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    • 2007
  • Objective : Thoracoscopic spinal surgery provides minimally invasive approaches for effective vertebral decompression and reconstruction of the thoracic and thoracolumbar spine, while surgery related morbidity can be significantly lowered. This study analyzes clinical results of thoracoscopic spinal surgery performed at our institute. Methods : Twenty consecutive patients underwent video-assisted thoracosopic surgery (VATS) to treat various thoracic and thoracolumbar pathologies from April 2000 to July 2006. The lesions consisted of spinal trauma (13 cases), thoracic disc herniation (4 cases), tuberculous spondylitis (1 case), post-operative thoracolumbar kyphosis (1 case) and thoracic tumor (1 case). The level of operation included upper thoracic lesions (3 cases), midthoracic lesions (6 cases) and thoracolumbar lesions (11 cases). We classified the procedure into three groups: stand-alone thoracoscopic discectomy (3 cases), thoracoscopic fusion (11 cases) and video assisted mini-thoracotomy (6 cases). Results : Analysis on the Frankel performance scale in spinal trauma patients (13 cases), showed a total of 7 patients who had neurological impairment preoperatively : Grade D (2 cases), Grade C (2 cases), Grade B (1 case), and Grade A (2 cases). Four patients were neurologically improved postoperatively, two patients were improved from C to E, one improved from grade D to E and one improved from grade B to grade D. The preoperative Cobb's and kyphotic angle were measured in spinal trauma patients and were $18.9{\pm}4.4^{\circ}$ and $18.8{\pm}4.6^{\circ}$, respectively. Postoperatively, the angles showed statistically significant improvement, $15.1{\pm}3.7^{\circ}$ and $11.3{\pm}2.4^{\circ}$, respectively(P<0.001). Conclusion : Although VATS requires a steep learning curve, it is an effective and minimally invasive procedure which provides biomechanical stability in terms of anterior column decompression and reconstruction for anterior load bearing, and preservation of intercostal muscles and diaphragm.

Carcass Grading Properties of Imported Beef Cattles Fed in Korea (국내에서 비육한 수입 생우의 도체등급 특성에 관한 연구)

  • Park, B.Y.;Cho, S.H.;Kim, J.H.;Lee, W.S.;Kim, Y.K.;Ahn, C.N.;Kim, J.M.;Yoon, S.G.
    • Journal of Animal Science and Technology
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    • v.45 no.1
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    • pp.151-156
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    • 2003
  • This study was conducted to provide the information for the carcass grading properties of imported beef cattles fed in Korea. The cattles from 4 different breed such as Hereford, Angus, Murray Grey, Hereford${\times}$Angus were imported and slaughtered at 700kg(24 month). The Yield and Quality grading characteristics for 10 cattles from each breed were evaluated. Carcass weight of Murray Grey was lower than the other breed(p<0.05). The thickness of backfat was the lowest for Hereford(13.7mm) and followed by Hereford${\times}$Angus(17.30mm), Angus(18.20mm) and Murray Grey(18.90mm). Hereford had the highest Yield index(64.63%) and Murray Grey had the lowest Yield index(62.43)(p<0.05). The frequency percentages of marbling degree for Angus having the 1++ over degrees were 50% which was the highest among the breed. In the frequencies of final carcass grades, Hereford produced 30% of B grade and 70% of C grade in Yield grade and the 3 grade produced in Quality grade. All carcasses of Angus were graded as the grade C in Yield grade and 20% carcasses of Angus had the 2 grade and 80% carcasses had the 3 grade in Quality grade. Murray Grey produced 10% of grade B and 90% of grade C in Yield grade and produced 10% of the 2 grade and 90% of the 3 grade in Quality grade. The Hereford${\times}$Angus produced 100% of grade C in Yield grade and 100% of the 3 grade in Quality grade.