• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.38-38
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• 2003

High iron consumption is associated with an increased risk of cancer possibly via production of reactive oxygen species (ROS) which in turn induces oxidative damage to lipids, proteins and DNA. The aim of the study was to determine whether Fe-NT A causes DNA damage and targets TP 53 in human peripheral lymphocytes. (omitted)

• Journal of Korean Society of societal Security
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• v.3 no.1
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• pp.33-42
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• 2010

This study predicts the stress history for truss bridge with local damages by using global-local model combination method. For this end, the global structure is modeled by 3D frame elements and the selected local details are modeled by shell elements. Then superposition principle enable the global-local model to be combined interactively. Because the frame model cannot consider the rigidity of gusset plate and the interation of structural members due to the complexity of stress distribution in truss connection. The section modification factors are proposed to calibrate the stiffness of global frame element. The global-local model combination is verified by comparing the numerical results with experimental data obtained from the proof loading test to the operating truss bridge. Furthermore, stress histrories of the truss bridge are generated in the consideration of the rigidity of truss connection with local damage by using the combination method.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.4
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• pp.167-172
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• 2006

In the present study, we developed a simple method to predict the neuronal cell death in the mouse hippocampus and striatum following transient global forebrain ischemia by evaluating both cerebral blood flow and the plasticity of the posterior communicating artery (PcomA). Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral occlusion of the common carotid artery (BCCAO) for 30 min. The regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry. The plasticity of PcomA was visualized by intravascular perfusion of India ink solution. When animals had the residual cortical microperfusion less than 15% as well as the smaller PcomA whose diameter was less than one third compared with that of basilar artery, neuronal damage in the hippocampal subfields including CA1, CA2, and CA4, and in the striatum was consistently observed. Especially, when mice met these two criteria, marked neuronal damage was observed in CA2 subfield of the hippocampus. In contrast, after transient BCCAO, neuronal damage was consistently produced in the striatum, dependent more on the degree of rCBF reduction than on the plasticity of PcomA. The present study provided simple and highly reproducible criteria to induce the neuronal cell death in the vulnerable mice brain areas including the hippocampus and striatum after transient global forebrain ischemia.

• Journal of Environmental Science International
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• v.31 no.9
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• pp.735-741
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• 2022

Global warming affects forests and their ecology. Diversity in the forest is a buffer that reduces the damage due to global warming. Mixed forests are ecologically more valuable as versatile habitats and are effective in preventing landslides. In Korea, most forests were created by simple afforestation with trees of evergreen species. Typically, evergreen trees are shallow-rooted, and deciduous trees are deep-rooted. Mixed forest tree roots grip the soil effectively, which reduces the occurrence of landslides. Therefore, improving the distribution of tree types is essential to reduce damage due to global warming. For this improvement, the investigation of tree types of the forest is needed. However, determining the tree type distribution of forests that are spread over wide areas is labor-intensive and time-consuming. This study suggests effective methods for determining the distribution of tree types in a forest that is spread across a relatively wide area. Using normalized difference vegetation index and RGB images from unmanned aerial vehicles, each evergreen and deciduous tree, and grassland area can be distinguished. The distinguished image determines the distribution of tree type. This method is effective compared to directly determining the tree type distribution in the forest by the use of manpower. The data from these methods could be applied to plan a mixed forest or to prepare for future damage due to global warming.

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.53-68
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• 2018

In this paper, an innovative procedure is proposed for the seismic design of reinforced concrete frame structures. The main contribution of the proposed procedure is to minimize the construction cost, considering the uniform damage distribution over the height of structure due to earthquake excitations. As such, this procedure is structured in the framework of an optimization problem, and the initial construction cost is chosen as the objective function. The aim of uniform damage distribution is reached through a design constraint in the optimization problem. Since this aim requires defining allowable degree of damage, a damage pattern based on the concept of global collapse mechanism is presented. To show the efficiency of the proposed procedure, the uniform damage-based optimum seismic design is compared with two other seismic design procedures, which are the strength-based optimum seismic design and the damage-based optimum seismic design. By using the three different seismic design methods, three reinforced concrete frames including six-, nine-, and twelve-story with three bays are designed optimally under a same artificial earthquake. Then, to show the effects of the uniform damage distribution, all three optimized frames are used for seismic damage analysis under a suite of earthquake records. The results show that the uniform damage-based optimum seismic design method renders a design that will suffer less damage under severe earthquakes.

• Journal of Aerospace System Engineering
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• v.6 no.3
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• pp.13-18
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• 2012

Every 3000 hour an aircraft is stricken by a lightning. Also the lightning damage to the aircraft during flight are continually occurred due to extreme weather phenomena such as global warming. Under the airworthiness standards, the aircraft must be designed to protect lightning. To show compliance for lightning, the test should be conducted by the actual lightning current and voltage waveform for the actual aircraft or parts. After test, structure damage is detected via visual inspection or NDI. Structure substantiation for damage is to show retaining limit or near limit load capability. This is conducted by test or analysis based on test. Thus, the aircraft should retain structural strength to land safely, even though the damage of aircraft fuselage from Lightning strike are occurred.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2001.04a
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• pp.454-461
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• 2001

Dynamic responses of a multi-span simply supported bridge are examined under seismic excitations considering damage of bearings. An idealized mechanical model which can consider components such as pounding, friction at the supports, abutment-soil interaction, rotational and translational motions of foundations, and the nonlinear pier motions, is developed to analyze the effects due to damage of bearings. It is assumed that the bearing's response after failure can be expressed with a sliding model with a friction coefficient between the superstructure and the pier top. It is found that the global seismic behaviors are significantly influenced by the damage of bearings and the damage of bearings may lead to unseating failure at unpredicted supports. Therefore, It can be concluded that detailed seismic response analyses of bridge systems considering damage of bearings is required for the purpose of the seismic safety evaluation.

• The Journal of Fisheries Business Administration
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• v.54 no.2
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• pp.91-107
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• 2023

Offshore wind power development has been promoted in countries around the world to cope with global warming. Despite its many advantages, offshore wind power affects the marine environment during construction and operation. As a result, the reduction of fishing areas, changes in the habitat of marine animals, damage to fishing gear, and impeding the safety of fishing activities are occurring. If the offshore wind power generation project is carried out, a fishing damage investigation is nescssary. There are only four fishing damage investigations related to offshore wind power, which are being conducted similarly to the existing fishing damage investigation related to offshore construction. Therefore, this study reviewed and analyzed the report on fisheries damage investigation related to offshore wind power conducted in Korea and suggested problems and improvement measures accordingly.

• Smart Structures and Systems
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• v.25 no.2
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• pp.169-181
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• 2020

Sensor placement is a crucial aspect of bridge health monitoring (BHM) dedicated to accurately estimate and locate structural damages. In addressing this goal, a sensor placement framework based on the deflection influence line (DIL) analysis is here proposed, for the optimal design of damage detection-oriented BHM system. In order to improve damage detection accuracy, we explore the change of global stiffness matrix, damage coefficient matrix and DIL vector caused by structural damage, and thus develop a novel sensor placement framework based on the Fisher information matrix. Our approach seeks to determine the contribution of each sensing node to damage detection, and adopts a distance correction coefficient to eliminate the information redundancy among sensors. The proposed damage detection-oriented optimal sensor placement (OSP) method is verified by two examples: (1) a numerically simulated three-span continuous beam, and (2) the Pinghu bridge which has existing real damage conditions. These two examples verify the performance of the distance corrected damage sensitivity of influence line (DSIL) method in significantly higher contribution to damage detection and lower information redundancy, and demonstrate the proposed OSP framework can be potentially employed in BHM practices.

• The Journal of Korean Medicine
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• v.24 no.1
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• pp.29-40
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• 2003

Object : This research was performed to investigate the protective effect of Aurantii Immaturus Fructus against ischemic damage using PC12 cells and global ischemia in gerbils. Methods : To observe the protective effect of Aurantii Immaturus Fructus on ischemia damage, viability and changes in activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase and production of malondialdehyde (MDA) were observed after treating PC12 cells with Aurantii Immaturus Fructus during ischemic insult. Gerbils were divided into three groups : a normal group, a 5-min two-vessel occlusion (2VO) group, and an Aurantii Immaturus Fructus administered after 2VO group. The CCAs were occluded by microclip for 5 minutes. Aurantii Immaturus Fructus was administered orally for 7 days after 2VO. The histological analysis was performed at 7 days after the surgery. For histological analysis, the brain tissue was stained with 1% cresyl violet solution. Results : The results showed that 1. Aurantii Immaturus Fructus had a protective effect against ischemia in the CAI area of the gerbil hippocampus 7 days after 5-minute occlusion, 2. In the hypoxia/reperfusion model using PC12 cells, the Aurantii Immaturus Fructus had a protective effect against ischemia in the dose of $0.2{\;}\mu\textrm{g}/ml,{\;}2{\;}\mu\textrm{g}/ml{\;}and{\;}20{\;}\mu\textrm{g}/ml$ 3. Aurantii Immaturus Fructus increased the activities of glutathione peroxidase and catalase, 4. The activity of superoxide dismutase (SOD) was increased by ischemic damage, which might represent self protection. This study suggests that Aurantii Immaturus Fructus has some neuroprotective effect against neuronal damage following cerebral ischemia in vivo with a widely used experimental model of cerebral ischemia in Mongolian gerbils, and it also has protective effects on a hypoxia/reperfusion cell culture model using PCq2 cells. Conclusions : Aurantii Immaturus Fructus has protective effects against ischemic brain damage at the early stage of ischemia.