• 한국임상수의학회지
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• 제29권1호
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• pp.38-42
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• 2012

To determine the prevalence of the primary glaucoma (PG) and occurrence of primary glaucoma in initially non-affected normal eye. Medical records of 7751 dogs presented to the Veterinary Medical Teaching Hospital (VMTH) of Seoul National University (SNU) between January 2006 and December 2009 were examined. Among 7751 dogs, forty three dogs (0.55%) developed PG. The following breeds were included in the study: 18 American Cocker Spaniels, 17 Shih Tzus, 3 Mixed Breeds, 2 Malteses, 2 Pekingeses, and 1 Chow Chow. The mean onset age of PG in the first eyes was $7.1{\pm}2.3$ years in the all breeds. Compared with Mixed Breed (0.54%), American Cocker Spaniel (3.16%, p = 0.004) and Chow Chow (20%, p = 0.001) had a higher risk of developing glaucoma. Twenty six of 43 dogs (60.1%) were females with male-to-female ratio of 1:1.53. Twenty nine of 33 eyes (87.9%) developed glaucoma in the fellow eye within mean ${\pm}SD$ time of $17.5{\pm}2.7$ months. From this study, American Cocker Spaniel and Shih Tzu were the most frequent PG breed in Korea. Also, unilateral PG dogs developed glaucoma in the non-affected normal eye within approximately 17 months. The results indicate that prophylactic medical therapy with antiglaucoma agents should be considered to delay or prevent developing glaucoma in non-affected normal eye.

• International journal of advanced smart convergence
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• 제8권3호
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• pp.7-12
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• 2019

This study aimed that certain risk factors are linked to the risk of developing depression and decreasing quality of life. This study was implemented using data from the 6th and 7th Korea National Health and Nutritional Examination Survey. The National Health and Nutrition Survey consist of health surveys, screenings, and nutrition surveys. Among the risk factors, data on adult diseases such as depression, hypertension, arthritis, diabetes, cataract, glaucoma, and macular degeneration were used. In total, 12,768 adults over 20 years of age were selected, of whom 520 were diagnosed with depression. The most common risk factors in adults over 20 years of age were hypertension, arthritis, cataract, diabetes, depression, glaucoma, and macular degeneration. Their risk factors were analyzed if these were associated with depression and quality of life. The results revealed that hypertension, arthritis, diabetes, cataract, glaucoma, and macular degeneration were predictors for the occurrence of depression in adults. The factors associated with the highest risk for depression were arthritis and glaucoma. Furthermore, the study investigated the effect of certain factors on the quality of life; the factor associated with the greatest impact on quality of life was arthritis. This study verified that the aforementioned factors were related to the risk of developing depression and decreasing quality of life.

• 한국임상수의학회지
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• 제32권1호
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• pp.108-111
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• 2015

7개월령 수컷 말티즈견이 1.5개월 동안 오른쪽 눈의 녹내장으로 치료를 받던 중에 내원하였다. 안검사에서 우안, 각막 천공, 홍채 탈출, 각막부종 및 혈관화가 관찰되었다. 안압은 오른쪽 눈이 33 mmHg, 왼쪽 눈이 19 mmHg이었다. 오른쪽 눈은 만성 녹내장, 각막 천공 및 홍채 탈출로 진단되었다. 그 눈은 실명하였으며 안구를 보존하기 위해 안내 보철물 삽입과 결막 플랩을 함께 적용하기로 하였다. 수술 후에 결막 플랩은 각막 천공 부위를 막고 안내 보철물을 적절하게 유지하였다. 수술 15개월 후에도 아무런 합병증 없었으며 보호자는 매우 만족하였다. 그러므로 안내 보철물과 결막 플랩의 병용 적용은 각막 천공으로 인한 녹내장의 치료에 이용될 수 있을 것이다.

• 대한기계학회논문집A
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• 제25권5호
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• pp.805-815
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• 2001

Glaucoma is an eye disease which is caused by abnormal high IOP (Intra Ocular Pressure). High IOP is caused by the aqueous humor which is produced consistently but not drained due to malfunction of the trabecular system which has a role of draining the aqueous humor into the venous system. Currently, there are three methods to treat glaucoma-using medicines, surgical operation, and using implant device. The first and second methods are not long acting, so the use of implants is increasing in these days in order to drain out the aqueous humor compulsory. However, though conventional implants have a capability of pressure regulation, they cannot maintain IOPs desired for different patients, and too much aqueous humor are usually drained, to cause hypotony. To solve these problems, it is needed to develop a new implant which is capable of controling the IOP actively and copes with personal difference of patients. An active glaucoma implant consists of the valve actuator, pressure sensor, controller, and power supply. In this paper, firstly, we make an analysis of the operation of a conventional implant using a bond graph and show defects and limitations of the conventional valve analytically. Secondly, we design and analyze a valve actuator considering actuation principles, resistance elements, control methods, and energy sources focused on power saving problem. Finally, using simulations the possibility of the proposed valve actuator is investigated.

• Journal of Ginseng Research
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• 제39권1호
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• pp.7-13
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• 2015

Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops. Methods: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment. Results: Almost all patients displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean Red Ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01). Conclusion: Korean Red Ginseng supplementation may provide an additional treatment option for dry eye and patients with glaucoma using antiglaucoma eye drops.

• 대한한의학방제학회지
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• 제29권2호
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• pp.93-103
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• 2021

Objectives : This study was conducted to evaluate the Intraocular pressure (IOP) and retina neuroprotective effect of Acer palmatum thumb. extract in glaucoma of DBA2/J mice vivo model. Methods : The amount of change in intraocular pressure(IOP) was measured every two weeks for 30 weeks in the DBA2/J glaucoma animal model. The increased IOP were regrouping into drug treatment groups. EW and EE (1, 2 mg/㎖)extract was eye drop administered twice per day for 8 weeks. After administration of the extract, IOP was measured every 1 week at a fixed time for 8 weeks, and protein expression levels and serological changes related to retinal function were investigated. Results : The DBA2/J mice were IOP increased as time dependent, resulting in damage to the retinal function protein related in glaucoma animal model. However, administration of extracts from Leaves of Acer palmatum thumb. prevented an increase IOP, increased for Brn3α, PKCα, and OPN1SW. Additionally, the experssion of Aterocyte maker, GFAP was decreased in DBA2/J mice. Conclusions : These results demonstrate that both IOP and age can be considered in studies using DBA2/J mice and suggest that the extracts from Leaves of Acer palmatum thumb. regulating of IOP and expression of proteins related to retinal function.

• Journal of Ginseng Research
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• 제45권6호
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• pp.676-682
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• 2021

Background: Red ginseng has been found to improve ocular perfusion and dry eye syndrome in glaucomatous eyes; however, its effects on visual function and vision-related quality of life have not been investigated. This study sought to evaluate the effects of red ginseng on visual function and vision-related quality of life in glaucoma patients using contrast sensitivity and a questionnaire. Methods: Participants were randomly assigned to two groups in this prospective, randomized, double-blind study: in one group, red ginseng was taken first, followed by a placebo, and in the other, placebo was taken first, followed by red ginseng. We measured and compared changes in contrast sensitivity and vision-related quality of life between the two groups. Contrast sensitivity was measured using OPTEC® 6500P, and vision-related quality of life was evaluated using the 25-item National Eye Institute Visual Function Questionnaire. One-way and two-way repeated measure analyses of variance were used for the comparison. Relationships between respective changes in dry eye syndrome and contrast sensitivity were also analyzed. Results: Daytime contrast sensitivity and ocular pain improved after the administration of red ginseng. Nighttime contrast sensitivity was improved in early or moderate glaucoma. Improved contrast sensitivity was not associated with improvement in dry eye syndrome. Conclusion: Red ginseng could improve contrast sensitivity and ocular pain in patients with glaucoma. The mechanism underlying improvement in contrast sensitivity appears to be associated with enhanced retinal perfusion or retinal ganglion cell function, but not dry eye syndrome.

• 대한수의학회지
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• 제62권3호
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• pp.26.1-26.7
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• 2022

This study was aimed to evaluate the prophylactic anti-glaucoma effect of topical 5% betaxolol (BTX) and 2% dorzolamide (DRZ) on the second eye in dogs with unilateral primary angle closure glaucoma (PACG). Medical records of 60 dogs with unilateral PACG who received prophylactic anti-glaucoma eyedrops in the second eye, from 2016 to 2021, were reviewed. The prophylactic effects of BTX were maintained on 28/60 (46.7%) eyes until last visit and BTX failure was observed on median 510 (range, 53-1,927) days in 32/60 (53.3%) eyes. After DRZ instillation in BTX failure eyes, the prophylactic effects were extended at median 610 (range, 157-2,270) days in 21/32 (65.6%) eyes. DRZ failure eyes (17/21, 81.0%) eyes required chemical ablation or surgical intervention due to uncontrolled intraocular pressure. The duration of prophylactic effects was decreased with aging (R² = 0.334, p = 0.006). The predominant breeds were Shih-Tzu (41.9%) and American Cocker Spaniel (30.6%) with no significant differences in survival curves (p = 0.210). The average prophylactic effects of BTX persisted more than 1.5 year and could be selected the first prophylactic eye drop in unilateral PACG. Also, early surgical intervention should be considered in prophylactic medications failure cases.

• 한국안광학회지
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• 제17권2호
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• pp.241-247
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• 2012

목적: 본 연구는 녹내장과 대사증후군, 그리고 구성요소간의 상관성을 평가하기 위해 수행되었다. 방법: 제 3기(2005), 4기(2007-9), 5기(2010) 국민건강영양조사 자료에서 40세 이상 19,162 명을 대상으로 녹내장과 대사증후군, 그리고 구성요소(복부비만, 공복혈당장애, 높은 혈압, 이상지질혈증) 간의 연관성을 조사하였다. 로지스틱회귀분석을 통하여 인구학적, 생활방식 그리고 사회경제적 요인을 보정한 후 연관성을 평가하였으며, 녹내장의 위험과 대사약물복용간의 연관성을 평가하였다. 결과: 성별 및 연령을 보정한 로지스틱 회귀분석에서, 공복혈당장애(odds ratio (95% Confidence Interval): 1.78 (1.25, 2.53)) 및 대사증후군(1.45 (1.01, 2.08))이 있는 연구대상자가 그렇지 않은 연구대상자에 비해 유의하게 높은 녹내장 교차비를 보였고, 추가적으로 흡연, 음주, 규칙적 운동, 소득, 교육수준을 보정하였을 때 교차비는 더욱 증가하는 것으로 나타났다(공복혈당장애: 1.89 (1.29, 2.77), 대사증후군: 1.52 (1.03, 2.25)). 또한, 연구대상자가 가지고 있는 이상 대사증후군 요소의 수에 따른 녹내장의 유병률 증가는 경계적 유의성(borderline significant: age and sex adjusted p for trend = 0.055)을 보였다. 고혈압 치료제의 사용 역시 녹내장의 위험과 유의한 상관관계가 있었다. 결론: 대사증후군 및 공복혈당장애는 녹내장과 유의한 상관관계가 있었고, 고혈압 치료제 사용 역시 녹내장과 유의한 상관관계가 있었다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제2권4호
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• pp.253-258
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• 2002

This paper reports the design, modeling, fabrication and measurement of passive microvalves, which are applicable to glaucoma implants. The proposed microvalves were designed using fluidic theory. The microvalves consisted of microchannels and chambers. The microchannels had a constant fluidic resistance generating a pressure difference. Six kinds of microvalves were designed using fluidic equations for laminar flow and fabricated to examine the influences of chamber size, channel length and the shape of channel cross section. The pressure difference between the designed microvalve and the fabricated microvalve was measured to be less than 4%.