• Journal of the Korean neurological association
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• v.36 no.4
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• pp.325-328
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• 2018

Neovascular glaucoma is a subtype of secondary glaucoma that is characterized by proliferation of fibrovascular tissue in the anterior chamber angle. This condition may be acutely aggravated by carotid revascularization therapies. There have been few previous reports of acute aggravation of neovascular glaucoma following carotid artery stenting. We report the case history of a patient who had acute exacerbation of neovascular glaucoma following carotid artery stenting and required surgical management.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1899-1909
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• 2015

Glaucoma is one of the most common causes of blindness which is caused by increase of fluid pressure in the eye which damages the optic nerve and eventually causing vision loss. An automated technique to diagnose glaucoma disease can reduce the physicians’ effort in screening of Glaucoma in a person through the fundal retinal images. In this paper, optimal hyper analytic wavelet transform for Glaucoma detection technique from fundal retinal images is proposed. The optimal coefficients for transformation process are found out using the hybrid GSO-Cuckoo search algorithm. This technique consists of pre-processing module, optimal transformation module, feature extraction module and classification module. The implementation is carried out with MATLAB and the evaluation metrics employed are accuracy, sensitivity and specificity. Comparative analysis is carried out by comparing the hybrid GSO with the conventional GSO. The results reported in our paper show that the proposed technique has performed well and has achieved good evaluation metric values. Two 10- fold cross validated test runs are performed, yielding an average fitness of 91.13% and 96.2% accuracy with CGD-BPN (Conjugate Gradient Descent- Back Propagation Network) and Support Vector Machines (SVM) respectively. The techniques also gives high sensitivity and specificity values. The attained high evaluation metric values show the efficiency of detecting Glaucoma by the proposed technique.

• International Journal of Computer Science & Network Security
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• v.22 no.9
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• pp.23-30
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• 2022

Glaucoma is a chronic neuropathy that affects the optic nerve which can lead to blindness. The detection and prediction of glaucoma become possible using deep neural networks. However, the detection performance relies on the availability of a large number of data. Therefore, we propose different frameworks, including a hybrid of a generative adversarial network and a convolutional neural network to automate and increase the performance of glaucoma detection. The proposed frameworks are evaluated using five public glaucoma datasets. The framework which uses a Deconvolutional Generative Adversarial Network (DCGAN) and a DenseNet pre-trained model achieves 99.6%, 99.08%, 99.4%, 98.69%, and 92.95% of classification accuracy on RIMONE, Drishti-GS, ACRIMA, ORIGA-light, and HRF datasets respectively. Based on the experimental results and evaluation, the proposed framework closely competes with the state-of-the-art methods using the five public glaucoma datasets without requiring any manually preprocessing step.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.8 no.1
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• pp.143-147
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• 1995

We observed and studied about 14 cases of clinically glaucoma patients. Glaucoma is called NOK PUNG(綠風) in oriental medicine. Generally glaucoma patients, visiting oriental hospital, have a lower intraocular pressure than that of patients, visting western hospital. The weaksight and asthenopia were improved by acupunctural and Medicinal herbal therapy.

• Journal of Yeungnam Medical Science
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• v.19 no.2
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• pp.126-135
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• 2002

Background: Neovascular glaucoma is common secondary glaucoma at high risk for failure of glaucoma filtering surgery. Recently, trabeculectomy with adjunctive mitomycin C trabeculectomy has been tried to improve the surgical success rate of conventional trabeculectomy. But, the long-term effects of mitomycin C trabeculectomy for neovascular glaucoma are unknown. Thus, we evaluated the long-term effects of mitomycin C trabeculectomy and its prognostic factors influencing the outcome. Materials and Methods: Medical records of 62 eyes of 55 neovascular glaucoma who had undergone mitomycin C trabeculectomy were retrospectively reviewed. Surgical success was defined as intraocular pressures of 21 mmHg or less with or without glaucoma medications and no loss of light perception. Surgical failure was defined as postoperative loss of light perception in patients with preoperative vision better than light perception, additional glaucoma surgery, or phthisis bulbi in patients with preoperative vision of no light perception. Results: Postoperative success was obtained in 37 (60%) out of 62 eyes after mean followup period of $23.9{\pm}16.2$ months. Using Kaplan-Meier survival analysis, cumulative success rate at the 6-, 12-, 24- and 36-month intervals were 85%, 71%, 57% and 52%, respectively. Success rate was greater in eyes with diabetic retinopathy than other causes(p=0.005) and in eyes with preoperative panretinal photocoagulation(PRP) than without PRP(p=0.015). However, Cox proportional hazard regression analysis revealed that preoperative PRP was not a significant risk factor for surgical failure. Conclusion: Prognosis of neovascular glaucoma caused by diabetic retinopathy was better than that caused by the other disorders following mitomycin C trabeculectomy. The author would suggest that mitomycin C trabeculectomy could be effective and relatively safe as the first procedure of choice before performing glaucoma drainage device implantation or cyclodestructive procedure.

• Korean Journal of Veterinary Research
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• v.59 no.2
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• pp.109-111
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• 2019

A 10-year-old intact female Jindo dog was presented with a 1-week history of conjunctival redness and ocular discharge in the left eye. There was an absence of menace response, dazzle reflex, and direct pupillary light reflex. Slit-lamp biomicroscopy revealed corneal edema, ciliary flush, and aqueous flare. Intraocular pressure was 68 mmHg. Based on the information available, a diagnosis of glaucoma and uveitis was made. Subsequent histopathologic examination showed the glaucoma was produced by the effects of goniodysgenesis, posterior synechia, and pigment dispersion in the trabecular meshwork. This is the first report of primary glaucoma caused by goniodysgenesis in Jindo dogs.

• Journal of Veterinary Clinics
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• v.40 no.3
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• pp.221-224
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• 2023

A two-year-old spayed female Maltipoo dog was presented with a two-month duration of glaucoma in the right eye. On the first presentation, menace response and dazzle reflex were absent in the right eye, but it was present in the left eye. Slit-lamp biomicroscopy showed buphthalmia, mild corneal edema, and conjunctival and episcleral hyperemia in the right eye. The intraocular pressures were 70 mmHg and 30 mmHg in the right and left eyes, respectively. On the gonioscopic and high-resolution ultrasound examinations, both the iridocorneal angle and ciliary cleft were completely closed in the right eye. However, gonioscopy revealed an opened iridocorneal angle even with some broader base of pectinate ligament fiber, but high-resolution ultrasound showed a narrowed ciliary cleft and increased contact of the iris base with the limbal cornea in the left eye. Based on these results, a diagnosis of primary angle-closure glaucoma was made in both eyes. This case report highlighted the importance of evaluating the ciliary cleft with high-resolution ultrasound as a critical diagnostic and prognostic role in canine glaucoma.

• Journal of Yeungnam Medical Science
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• v.21 no.1
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• pp.12-22
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• 2004

The management of coincident glaucoma and cataract is not only a common clinical challenge but also an important research topic in the ophthalmic surgical field. The purpose of this article is to compare the different surgical options on the basis of their achievable postoperative intraocular pressure (IOP) control, success rates, and complication rates reported in the related literature, and to give advice on how to manage typical situations of patients with both glaucoma and cataract. Main topics were focused on indications and rationale of 3 surgical options (only cataract surgery first and later trabeculectomy, only trabeculectomy first and later cataract surgery, or simultaneous combined surgery). Modern clear corneal cataract extraction techniques resulted in a modest intermediate-term reduction of IOP and has considerably improved the success rates of combined glaucoma and cataract surgery. It also enabled future trabeculectomy to be successfully performed at a later date if necessary. Trabeculectomy alone achieved better IOP regulation than phacotrabeculectomy (combined surgery), but subsequent cataract surgery may compromise preexisting filtering bleb. Combined surgery augmented with mitomycin C achieved a lower IOP than combined surgery alone but had a higher complication rate. In conclusion, the choice of the preferred surgical method should be determined according to the target pressure, the amount of glaucomatous damage, and the grade of visual disturbance caused by the cataract. Phacotrabeculectomy with adjunctive mitomycin C offers visual improvement and achieves the best IOP lowering of all types of combined glaucoma and cataract surgery currently used but is associated with potentially sight-threatening complications.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.1
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• pp.254-267
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• 1999

Based on the research of cataract, glaucoma, bluish glaucoma, we have abtained the following results. 1. Main etiologies of the cataract are deficiency of the liver and kidneys, main symptoms are no nebula, no pain, no tear and sometimes light blue and white vision appear. 2. Main etiologies of glaucoma are receives heat from the liver, stagnation of the liver and gall bladder etc, main symptoms are both forehead corner pull each ether, pain from eye ball to nasal septum, headache, extending pain of the eyes, sometimes red and white flower vision appear, etc. 3. main etiologies of the bluish glaucoma are melancholy, wrath, stagnation of the liver, internal damage, flaming up fire of the phlegm, deficiency of the liver, deficiency of blood, etc, main symptoms are numbness, visual field constriction, blindness, reduce of visual capacity, blue flower vision sometimes appear, etc. 4. Treatments are mainly uses nourish Um(陰) to reduce pathogenic fire, relieve stagnancy of Ki(氣) of the liver, nourish Um(陰) of the liver and kidneys, etc, acupuncture points are mostly contended arounded eyes such as BL10)(天柱), GV16(風府), LR3)(太衝), HT5)(通里) and in the case of nauses and vomitting PC6)(內關, ST36)(足三里) are included in addition to the above.

• Genomics & Informatics
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• v.20 no.3
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• pp.28.1-28.7
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• 2022

We described a clinical, laboratory, and genetic presentation of a pathogenic variant of the CYP1B1 gene through a report of a case of primary congenital glaucoma and a trio analysis of this candidate variant in the family with the Sanger sequencing method and eventually completed our study with the secondary/incidental findings. This study reports a rare case of primary congenital glaucoma, an 8-year-old female child with a negative family history of glaucoma and uncontrolled intraocular pressure. This case's whole-exome sequencing data analysis presents a homozygous pathogenic single nucleotide variant in the CYP1B1 gene (NM_000104:exon3:c.G1103A:p.R368H). At the same time, this pathogenic variant was obtained as a heterozygous state in her unaffected father but not her mother. The diagnosis was made based on molecular findings of whole-exome sequencing data analysis. Therefore, the clinical reports and bioinformatics findings supported the relation between the candidate pathogenic variant and the disease. However, it should not be forgotten that primary congenital glaucoma is not peculiar to the CYP1B1 gene. Since the chance of developing autosomal recessive disorders with low allele frequency and unrelated parents is extraordinary in offspring. However, further data analysis of whole-exome sequencing and Sanger sequencing method were applied to obtain the type of mutation and how it was carried to the offspring.