• Title/Summary/Keyword: ginenoside

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Effect of Ginseng Components (Ginsenosides and Fat Soluble Fraction) on Rat Liver Glucokinase Activity (쥐의 간 Glucokinase 활성에 미치는 인삼 성분의 영향)

  • 주충노;김선진
    • Journal of Ginseng Research
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    • v.18 no.1
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    • pp.17-24
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    • 1994
  • Effect of ginsenoside mixture, ginsenoside $Rb_1$,$Rb_2$,$Rg_1$ and the fat soluble fraction of the roots of Panax ginseng C.A. Meyer on the activity of glucokinase (GK) in vitro has been observed and found that GK activity was increased about 15c1c at the concentration of ginsenoside mixture and/or the fat soluble fraction being $10^{-7}$,$10^{-5}$%. It was also observed that glucose uptake by rat liver was increased in the presence of either ginsenoside mixture or the fat soluble fraction by perfusion technique. Ginsenoside mixture stimulated various enzymes related to glucose metabolism, however, both ginsenoside mixture and the fat soluble fraction did not stimulate GK activity as expected. Primary culture of liver cells showed that the ginsenoside mixture and the fat soluble fraction increased GK activity significantly and they stimulated the GK activity synergistically in the co-presence of insulin.

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Effects of the Major Components in Fractions Extracted by Several Solvents on the Growth of Candida parapsilosis (인삼의 유기용매 적출물이 Candidaparapsizosis의 생육에 미치는 영향)

  • 양재원;전병선
    • Journal of Ginseng Research
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    • v.13 no.1
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    • pp.66-70
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    • 1989
  • The specific growth rate was investigated to find the of(emits of major ginseng components in fractions extracted by several solvents on the growth of Candida parapsilosis. The cell proliferation of C. purapsilosis was inhibited by fraction A(hexane soluble components), while enhanced by fraction B(Et2O soluble components), C(AcOEt soluble components), E and F(dialysis outer and inner extract). The additive stimulant effect of cell proliferation was exerted by fraction D(crude saponinE) and B, C or E.

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Metabolic Activities of Ginseng and Its Constituents, Ginsenoside Rb1 and Rg1, by Human Intestinal Microflora

  • Choi, Jong-Ryul;Hong, Sung-Woon;Kim, Yu-Ri;Jang, Se-Eun;Kim, Nam-Jae;Han, Myung-Joo;Kim, Dong-Hyun
    • Journal of Ginseng Research
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    • v.35 no.3
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    • pp.301-307
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    • 2011
  • To evaluate the difference in expressing pharmacological effects of ginseng by intestinal microflora between Koreans, metabolic activities of ginseng, ginsenoside $Rb_1$ and $Rg_1$ by 100 fecal specimens were measured. The ${\beta}$-glucosidase activity for p-nitrophenyl-${\beta}$-D-glucopyranoside was 0 to 0.42 mmol/min/mg and its average activity (mean${\pm}$SD) was $0.10{\pm}0.07$ mmol/min/mg. The metabolic activities of ginsenosides Rb1 and Rg1 were 0.01 to 0.42 and 0.01 to 0.38 pmol/min/mg, respectively. Their average activities were $0.25{\pm}0.08$ and $0.15{\pm}0.09$ pmol/min/mg, respectively. The compound K-forming activities from ginsenoside Rb1 and ginseng extract were 0 to 0.11 and 0 to 0.02 pmol/min/mg, respectively. Their average compound K-forming activities were $0.24{\pm}0.09$ pmol/min/ mg and $2.14{\pm}3.66$ fmol/min/mg, respectively. These activities all were not different between males and females, or between ages. Although compound K-forming activity from the aqueous extract of ginseng was low compared to that from ginenoside $Rb_1$, their profiles were similar to those of isolated compounds. Based on these findings, we believe that the intestinal bacterial metabolic activities of ginseng components are variable in individuals and may be used as selection markers for responders to ginseng.

The Comparative of Growth Characteristics and Ginsenoside Contents in Wild-simulated Ginseng (Panax ginseng C.A. Meyer) on Different Years by Soil Properties of Cultivation Regions

  • Kim, Kiyoon;Huh, Jeong-Hoon;Um, Yurry;Jeon, Kwon Seok;Kim, Hyun-Jun
    • Korean Journal of Plant Resources
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    • v.33 no.6
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    • pp.651-658
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    • 2020
  • The aim of this study was to investigate the comparative growth characteristics and ginenoside contents of wild-simulated ginseng on different years (7 and 13-year-old) by monitoring soil properties of cultivation regions. Plant and soil samples were collected from 6 different cultivation regions. Soil organic matter (OM), total nitrogen (TN) and cation exchangeable capacity (CEC) were significantly higher in 13-year-old wild-simulated ginseng cultivation regions compared to 7-year-old wild-simulated ginseng cultivation regions. Growth characteristics of wild-simulated ginseng had shown significantly higher in 13-year-old wild-simulated ginseng compared to 7-year-old wild-simulated ginseng. Ginsenoside G-Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 were significantly higher in 13-year-old wild-simulated ginseng than 7-year-old wild-simulated ginseng. According to the results of correlation analysis, soil OM, TN and CEC of the cultivated regions were positively correlated with the growth of wild-simulated ginseng. In addition, the root length of wild-simulated ginseng showed positive correlation with ginsenoside content. Hence, this study was able to investigate the correlation between growth and ginsenoside content of wild-simulated ginseng based on soil characteristics of the cultivation regions.

Selection of Preventers for Rusty Ginseng Roots from Natural Resources II (천연자원으로부터 인삼 적변방제물질의 선발 II)

  • Shin, Sun-Hee;Ban, Sunhg-Hee;Woo, Hyun-Jung;Yang, Deok-Cho
    • Journal of Ginseng Research
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    • v.27 no.2
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    • pp.66-71
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    • 2003
  • We screened preventives (preventers) from natural resources to prevent the rust phenomenon in ginseng roots. We examined that how these influence on the rusty phenomenon and the growth of 2 years old ginsengs treated in the preventers. All treats which was compounding preventers & improvers were so excellent of the ginsengs growth. Especially, the growth of 2 years old ginsengs treated with bio-preventer of ICPE-C105 and ICPE-P107R were increased to 73%, 28% compared with nontreatment, respectively. Though rusty ginseng of rate was emerged 58% in control, preventers ICPE-C 105 and ICPE-P107 were emerged of each 16.7%, 20%. It was affirmed effective of preventer. On the other hands, amounts of ginsenoside treated with preventatives showed to be changed. The total ginsenoside was increased to 71% with treatment ICPE-C105R which is the highest among groups compared to control, and ICPE-P$\_$107/R was increased to 50%. To sum up with total results, it is biotic preventatives (ICPE-C$\_$105/R and ICPE-P$\_$107/R) which we created improve both a high yield of ginseng roots and the inhibition of the rusty phenomenon. phenomenon.

Nutritional Composition, Ginsenoside Content and Fundermental Safety Evaluation with Leaf and Stem Extract of Panax ginseng (인삼잎과 줄기 혼합 추출물의 영양성분, Ginsenoside 함량 및 기본적 안전성 평가)

  • 한종현;박성진;안종남;위재준;김기영;박성혜
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.5
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    • pp.778-784
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    • 2004
  • This study was conducted to investigate the application possibility of leaf and stem extract (LSE) from the mixture of leaf and stem of Panax ginseng. This study measured the general nutritional composition, aminoacid minerals contents and fatty acid composition of LSE. We conducted analysis of the ginsenoside content by HPLC and the cell cytotoxicity tests in normal liver and kidney cells. The approximate composition of LSE was 2.51% of carbohydrate 0.53% of crude ash,0.20% of crude fat and 0.15% of crude protein, respectively. LSE contained 102.56 mg/100 g of K ion and high contents of acidic amino acids such as glutamic acid and aspartic acid. In addition to this, it contained all essential amino acids. The major compositions of fatty acids were 39.99% of palmitic acid 14.96% of linoleic acid, 13.31% of docosatetranoic acid and 12.91% of linolenic acid, The total ginsenoside was 0.82 mg/mL, and ratio of PD/PT was 0.68. Negative effects were not found from the results of the cell toxicity respection. These results imply that leaf and stem of Panax gineng could be used as possible food resources and functional food material and feed stuff.