• 모자간호학회지
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• 제1권
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• pp.34-44
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• 1991

The purposes of this study were to predict newborn birthweight by use of gestational period and fundal height and to identify growth curve of fundal height according to gestational period and growth curve of newborn birthweight according to fundal height. The subjects for the study were 802 women who delivered the normal newborn babies at Seoul National University Hospital from Sep. 1, 1981 to Aug.31, 1986. The data were collected bit chart review and analyzed nth SPSS program. The results of study were as follows : 1. The multiple regression equation ($R^2$=0.416) used for the prediction of newborn birthweight was y=(newborn birthweight, kg)=-4.421+0.075$x_1$(fundal height, cm)+0.053$x_2$(gestational period, weeks)+0.016$x_3$(abdominal girth, cm)+0.010$x_4$(maternal height, cm) 2. The growth curve of fundal height according to gestational period was obtained by polynomial regression. The regression equation was Y(fundal height, cm)=-36.78+18.58$log_ex$(gestational period, weeks) The growth curve of newborn birth weight according to fundal height was obtained by polynomial regression. The regression equation was Y(newborn birthweight, kg)=-8.09+3.27$log_ex$ (Fundal Height, cm) 3. In the following subgroups no significant difference was found in fundal height : engaged vs. nonengaged presentation, and nulliparous vs. multiparous women.

• 한국수정란이식학회지
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• 제29권4호
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• pp.369-373
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• 2014

This study was performed to establish a new parameter for estimating gestational age and predicting parturition day by ultrasonographic measurement of deep portion of telencephalic vesicle (DPTV) diameter in small dogs. Fetal head diameter (HD) and DPTV diameter were measured in 15 pregnant Pekingese bitches, from Day 15 to the parturition day, and evaluated the correlation between gestational age. HD was measured from day 29 of pregnancy to parturition day and increased from $4.9{\pm}2mm$ to $25.5{\pm}0.7mm$. Especially, from day 38 of pregnancy to parturition day, HD uniformly increased about 0.6 mm per day and was significantly and linearly relative to gestational age during this period ($r^2$ >0.99). DPTV diameter was measured from day 35 to day 60 of pregnancy and increased from $3.2{\pm}0.9mm$ to $11.5{\pm}0.7mm$. Especially from day 38 to day 60 of pregnancy, DPTV diameter uniformly increased about 1 mm per 3 days and was significantly and linearly relative to gestational age during this period ($r^2$ >0.99). In conclusion, DPTV diameter could to be a useful parameter for the estimation of gestational age and the prediction of parturition day when used alone or in combination with HD during the second half of pregnancy.

• 한국임상수의학회지
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• 제16권1호
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• pp.128-137
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• 1999

Plasma progesterone (P$_4$) concentrations were measured for confirming the estrus observation and for the early pregnancy diagnosis in 130 cows of small farmers. Ultrasonographic examinations were performed from day 30 after artificial insemination to establish the characteristic ultrasonographic appearances of gestational structures in each pregnant stages. Of the 130 cows inseminated, 111 cows (85.4%) were an ovulatory estrus, 12 cows (9.2%) were an unovulatory estrus, and 7 cows (5.4%) were the error of estrus detection, respectively. The accuracy for early pregnancy diagnosis in 111 ovulatory estrus cows achieved when the discriminatory concentration at day 21 after artificial insemination was placed at 3.0 ng-/ml in plasma, was 86.7 % for positive diagnosis and 100% for negative diagnosis, respectively. Pregnancy diagnosis by ultrasonography were performed to evaluate gestational structures from day 30 after artificial insemination in 83 cows. Pregnant cows were 72 of 83 cows. The characteristic ultrasonography of gestational structures in each gestational stages was as follows. The embryo proper was observed within anechoic fetal fluid between 28 and 40 days after insemination, and amnion and embryonic heartbeat was also detected in this period. Between days 41 and 50, embryo proper was detected as an discriminated from head and body, and forelimb buds and hindlimb buds were also observed in this period. Between days 51 and 60, an embryo proper was clearly discriminated from head and body, and fetal movement, forelimb buds and hindlimb buds were observed in this period. Between days 61 and 70, fetus was completely developed, and fetal skeleton, organs and cotyledon were observed. After day 71, each organs of fetus were rapidly developed and a fetus was partially observed in screen because fetus was too big and larger, These results indicate that plasma P$_4$ determination at days 0,6 and 21 after artificial insemination can be utilized for confirming the estrus observation and for early pregnancy diagnosis. Also, ultrasonography was reliable method for early pregnancy diagnosis at day 30 after artificial insemination.

• Clinical and Experimental Pediatrics
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• 제46권12호
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• pp.1194-1199
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• 2003

목 적 : 본 연구는 서울에 소재한 삼성서울병원 신생아중환자실에서의 시기에 따른 태아 영아의 생존 한계의 변화를 알아보기 위해서 시행되었다. 방 법 : 1994년 11월부터 2002년 12월까지 삼성서울병원 신생아중환자실에 입원하였던 출생체중 800 g 미만의 초극소미숙아 73명, 재태연령 27주 미만의 초극소미숙아 117명이 연구대상이었다. 연구대상 초극소미숙아들의 의무기록을 생존여부와 만성폐질환, 미숙아 망막증, 뇌실내 출혈와 뇌실주위 백질연화증을 포함하는 주요 합병증들의 발생유무를 중심으로 조사하였다. 태아 영아의 생존 한계는 생존율이 50%에 도달하는 시점으로 정의하였고 총 연구기간을 1998년 이전(제 1기)과 1999년 이후(제 2기)의 두 시기로 나누어 태아 영아의 생존 한계와 주요 합병증의 발생빈도를 비교하였다. 결 과 : 태아 영아의 생존 한계는 제 1기에는 출생체중 800 g대, 재태연령으로는 26주 대에서 제 2기에는 출생체중 600 g대, 재태연령으로는 24주 대로 현저히 낮아졌다. 제 2기에서의 이 한계 출생체중 대와 재태연령 대에서의 주요 합병증들의 발생빈도는 50% 미만이었다. 주요 합병증들의 발생빈도는 출생체중이나 재태연령이 감소함에 따라서 반드시 증가하지는 않았다. 결 론 : 본 연구의 결과, 본원에서는 출생체중이 600 g 이상이거나 재태연령이 24주 이상인 초극소미숙아들에게는 적극적으로 소생술을 시행해야 할 것으로 생각된다. 이 출생체중과 재태연령의 초극소미숙아에서 주요 합병증이 발생할 위험은 그보다 조금 더 큰 출생체중, 더 많은 재태연령의 그것보다 크지 않은 것으로 보인다.

• 지역사회간호학회지
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• 제31권4호
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• pp.427-435
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• 2020

Purpose: The purpose of this study was to assess the knowledge and health beliefs about gestational diabetes and to identify the influence on breastfeeding intention of women those who have been diagnosed with gestational diabetes. Methods: A cross-sectional descriptive study was designed. A questionnaire survey was conducted on 270 women who were pregnant and currently diagnosed with gestational diabetes. Data collection was conducted at Internet cafes and breastfeeding clinics where pregnant women were able to participate actively. The data collection period was from November 5 to November 27, 2019 and analyzed using descriptive statistics, independent t-test, χ2 test and multiple logistic regression. Results: The average age of the participants was 34.21±3.73 years. There were 221 women who had breastfeeding intention, and 49 women who did not intend to breastfeed. The higher the perceived susceptibility (OR=2.49, p=.032), benefits (OR=2.62 p=.009), and the self-efficacy, the higher the intention to perform breastfeeding (OR=2.97, p=.004). On the other hand, the higher the perceived severity, the lower the intention to perform breastfeeding (OR=0.35, p=.007). Conclusion: Health beliefs such as perceived susceptibility, perceived benefits, self-efficacy and perceived severity have been shown to affect the breastfeeding intention. Based on these results, we suggest developing a breastfeeding promotion intervention program that improves self-efficacy in gestational diabetics.

• 한국발생생물학회지:발생과생식
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• 제27권4호
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• pp.195-203
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• 2023

Exposure to environmental chemicals, including endocrine-disrupting chemicals, during the gestational period can have profound adverse effects on several organs in offspring. Bisphenol A (BPA) can infiltrate the human body through food and drinks, and its metabolites can cross both the placental and the blood-brain barriers. In this study, we investigate the effect of gestational exposure to BPA on epigenetic, biochemical, and histological modifications in the uterine tissues of F1 adult offspring rats. Pregnant rats were exposed to BPA from gestational day 8-15, and changes in global DNA methylation in uterine tissues obtained from adult offspring born to the exposed mothers were analyzed. Global DNA methylation analysis revealed that gestational exposure to BPA resulted in DNA hypomethylation in the uterus. Progesterone receptor (PR) protein expression in uterine tissues was monitored using western blot analysis, which revealed that the PR protein content was considerably higher in all BPA-exposed groups than in the control. Immunohistochemical examination for the PR revealed that intense PR-positive cells were more frequently observed in the BPA-exposed group than in the control group. To date, the evidence that the upregulation of PRs observed in the present study was caused by the non-methylation of specific PR promoter regions is lacking. Conclusively, these results indicate that exposure to BPA during gestation induces epigenetic alterations in the uteri of adult female offspring. We speculate that the global DNA hypomethylation and upregulation of the PR observed simultaneously in this study might be associated with the uterus.

• 한국정보통신학회논문지
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• 제21권2호
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• pp.259-264
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• 2017

신생아의 출생체중은 자궁내발육부전이나 과체중출생아를 진단하는 데 사용되는 등, 의학적으로 여러 가지 중요한 정보를 제공한다. 본 논문에서는 2011년부터 2013년까지 한국에서 태어난 신생아의 출생체중 데이터를 분석하고, 생물학적으로 부자연스러운 체중 분포를 관찰할 수 있음을 보인다. 이러한 비상식적인 체중 분포는 데이터 수집과정 등에서 오류가 존재함을 의미하는데, 특히 임신주수가 28주에서 32주인 신생아들의 체중 데이터에서 현저한 오류 데이터를 관찰할 수 있다. 이를 보정하기 위해, 본 논문은 가우시안 혼합 모델을 사용하여 오류 데이터와 정상 데이터를 예측하고, 오류 데이터로 예측된 자료들을 삭제하는 과정을 제안한다. 제안된 보정 과정을 통하여 보다 자연스럽고 의학적으로 의미 있는 출생체중 백분율을 구할 수 있음을 보인다.

• 대한간호학회지
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• 제13권3호
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• pp.51-60
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• 1983

Currently changing trends of child health care is demand total health assessment of child including growth and development. This study concentrates on the growth & developmental status of low birth weight infant for help their growth & development. Thus it can be provide a direction for scientific health education and counseling materials by investigating factor of growth & development. The subjects for this study were made up of 40 low birth weight infant who attended the well baby clinic of E university Hospital. The study method used was a questionnaire ＆ anthropometric assessment and DDST for normative data of development. The period for data collection was from July 1st to August 31th, 1982. Analysis of the data was done using percentages, $\chi$$^2$-test Stepwise Multiple Regression. The results of study were as follows. 1. The mean weight of birth was 2,068gm and mean of gestational period was 35.65 weeks. 2. The age at which weight ; 32.5%, head circumference : 67,5% chest circumference : 55.0%, height : 50. 0％ was normal range of physical growth. 3. The reverse age at which social development ; 87.5%, fine motor & adaptive development ; 70.0%, gross motor development ; 72.5% of children Passed by DDST to determine of normal range of development. 4. In the among variables, it was found that the infant who were the higher emotional & verbal response of mother and stimulus environment was the more normal range of weight & development than who was not. 5. The stepwise Multiple Regression between developmental status and predictors-birth order, weight at birth, sex, antenatal care, gestational period-are accounts for 34.1%.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권6호
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• pp.531-538
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• 2020

Purpose: Our aim was the longitudinal assessment of cyst size in fetuses with biliary cystic malformation (BCM) to explore its etiology and the possibility of antenatal differentiation between biliary atresia (BA) and congenital biliary dilatation (CBD). Methods: We conducted a retrospective review of all patients diagnosed antenatally with BCM from 1994 to 2014 at our institutions. Results: The study cohort comprised of three patients with BA and six with CBD. There were no significant differences in the gestational age and cyst size at the first detection of BCM between the two groups. In fetuses with CBD, the cyst size steadily increased as the gestational age advanced, while it fluctuated around 1.5 cm and remained below 2.1 cm in those with BA. However, the ratio of cystic area to fetal trunk area was approximately constant due to linear fetal growth in fetuses with CBD. Conclusion: Fetuses with BCM <2.1 cm in the late gestation period were more likely to have BA than CBD. Our observation of cyst enlargement with advancing gestational age in the CBD group was attributed solely to fetal growth. Biliary dilatation in fetuses with CBD and BA might be completed at the onset of BCM.

• Child Health Nursing Research
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• 제21권4호
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• pp.302-310
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• 2015

Purpose: The purpose of this study was to compare the rate of breastfeeding and factors which affect late preterm infants' (LPIs) breastfeeding according to gestational age. Methods: Participants were LPIs of 34 weeks (n=70), 35 weeks (n=75), and 36 weeks (n=88). Data were collected from July to December, 2011 from four university hospitals in D city. Descriptive statistics and odds ratio were used to compare three groups. Results: The rate of breastfeeding at 1 week after LPIs' discharge was 32.9%, 37.3%, 23.9% at 34, 35 and 36 weeks, respectively. The tendency to breastfeed in LPIs of 34 weeks was lower for LPIs born by Cesarean-section, while it was higher for LPIs with a longer period of breastfeeding during hospitalization and higher body weight at the first day of feeding. The prevalence of breastfeeding in LPIs of 35 weeks and 36 weeks was higher for infants with a history of more frequent breastfeeding during hospitalization. Conclusion: The rate of breastfeeding in LPIs of 36 weeks was the lowest. This study suggests that nurses should give more customized education to mothers with LPIs of 36 weeks during their stay in hospitals.