• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.32 no.1
• /
• pp.21-30
• /
• 2022

Objectives: The purpose of this study is to suggest an optimal method by comparing the analysis methods of work environment measurement datasets including left-censored data where one or more measurements are below the limit of detection (LOD). Methods: A computer program was used to generate left-censored datasets for various combinations of censoring rate (1% to 90%) and sample size (30 to 300). For the analysis of the censored data, the simple substitution method (LOD/2), β-substitution method, maximum likelihood estimation (MLE) method, Bayesian method, and regression on order statistics (ROS)were all compared. Each method was used to estimate four parameters of the log-normal distribution: (1) geometric mean (GM), (2) geometric standard deviation (GSD), (3) 95th percentile (X95), and (4) arithmetic mean (AM) for the censored dataset. The performance of each method was evaluated using relative bias and relative root mean squared error (rMSE). Results: In the case of the largest sample size (n=300), when the censoring rate was less than 40%, the relative bias and rMSE were small for all five methods. When the censoring rate was large (70%, 90%), the simple substitution method was inappropriate because the relative bias was the largest, regardless of the sample size. When the sample size was small and the censoring rate was large, the Bayesian method, the β-substitution method, and the MLE method showed the smallest relative bias. Conclusions: The accuracy and precision of all methods tended to increase as the sample size was larger and the censoring rate was smaller. The simple substitution method was inappropriate when the censoring rate was high, and the β-substitution method, MLE method, and Bayesian method can be widely applied.

• Journal of Environmental Health Sciences
• /
• v.27 no.3
• /
• pp.71-80
• /
• 2001

Blood and urine mercury level of three workers were monitored during 60~80 days after high exposure to mercury at the silver refining plant. Mercury was used to form silver-mercury amalgam from plating sludge. Workers were exposed to mercury about 70 days at the several processes, such as hand held weaving, vibration table, and heating from the furnace. mercury was analysed by atomic absorption spectroscopy-vapor generation technique. Recovery from the biological sample was 95.51% and pooled standard deviation was 0.033. At the time of study, there was no work at the workplace. So, airborne mercury concentration was measured with area sampling 5 days after the work, ranged from 0.1459 to 1.2351 mg/㎥(Arithmatic mean 0.4711 mg/㎥, Geometric mean 0.3566 mg/㎥) at the inside of the plant, that is far above the ACGIH's TLV(0.025 mg/㎥) and ranged from 0.0073 to 0.0330 mg/㎥ at the outdoor. Blood mercury levels at the beginning of the monitoring were 4~14 times greater than the American Conference of Governmental Industrial Hygienists Biological Exposure Index(ACGIH BEI, 15 ug/L). Blood mercury levels were decreased logarithmically, that is, rapidly at the high level and slowly at the low level but sustained above the level of the ACGIH BEI 60~80 days after the work. Urine mercury levels at the beginning of the monitoring were 8~16 times greater than the ACGIH BEI(35 ug/g creatinine). Urine mercury levels were decreased logarithmically, but correlation between urine level and off-days were lower than those of blood. Decreasing pattern of blood mercury levels were little affected than that of urine levels when the chelating agent, D-penicillamine, was administered. There was correlation between blood mercury level and urine mercury level(0.81~0.83) but it didn\`t mean that the highest blood mercury level corresponded the highest urine mercury level. In our study, Case 1 always shows the highest level in urine but case 3 always shows the highest level in blood. Creatinine correction represented better correlations between urine mercury levels and blood levels, and between urine levels and off-days rather than by urine volume. Spot urine sampling had a wide variation than that of whole day urine sampling. So, We recommend spot urine sampling for screening and whole day urine sampling for exact diagnosis.

• Journal of Biomedical Engineering Research
• /
• v.19 no.5
• /
• pp.511-518
• /
• 1998

In order to develop the aerosol bolus technique which is thought to be a potential tool for probing geometries or abnormalities of small airways, an experimental system of measuring fast time variations of particle concentration in the inhaled and exhaled breathing air was developed. The system generates monodisperse sebacic acrid particles of 1 micron size and 1.2 of geometric standard deviation in high concentration of $10^8$ particles/cc, delivers a short pulse of particles at the controlled instant during inhalation using a solenoid valve, and measures the fast change of particle concentration in using the laser light scattering. Successful operation of the generator and the measuring system was confirmed by smooth concentration profiles in inhalation. It was also confirmed that maintaining a constant breathing rate is essential to stable outputs and any disturbance in flow rate near the mode (maximum concentration) induces a large number of spurious peaks in the exhalation. Experimental data without strict control of breathing flow rate showed a substantial amount of scatter. The measured results showed an improvement in scatter over the existing results. When compared with theoretical predictions from 1-D convective diffusion equation and other experiments, general characteristics of dispersion for several penetration depths showed a good agreement, but there exists some difference in absolute values, which is attributed to the difference in body conditions. Improvements are needed in the theory, especially in relation to correcting for the effect of breathing flow rate.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.18 no.1
• /
• pp.110-122
• /
• 1993

When voice is transmitted through packet switching network, there needs a overload control, that is, a control for the congestion which lasts short periods and occurrs in local extents. In this thesis, we analyzed the performance of the statistical packet voice multiplexer using the overload control strategy by bit dropping. We assume that the voice is coded accordng to (4,2) embedded ADPCM and that the voice packet is generated and transmitted according to the procedures in the CCITT recomendation G. 764. For the performance analysis, we must model the superposed packet arrival process to the multiplexer as exactly as possible. It is well known that interarrival times of the packets are highly correlated and for this reason MMPP is more suited for the modelling in the viewpoint of accuracy. Hence the packet arrival process in modeled as MMPP and the matrix geometric method is used for the performance analysis. Performance analysis is similar to the MMPP IG II queueing system. But the overload control makes the service time distribution G dependent on system status or queue length in the multiplexer. Through the performance analysis we derived the probability generating function for the queue length and using this we derived the mean and standard deviation of the queue length and waiting time. The numerical results are verified through the simulation and the results show that the values embedded in the departure times and that in the arbitrary times are almost the same. Results also show bit dropping reduces the mean and the variation of the queue length and those of the waiting time.

• Journal of Korean Society for Geospatial Information Science
• /
• v.23 no.3
• /
• pp.41-47
• /
• 2015

To determine the accurate height, it should be considered geometric height difference obtained by levelling as well as the physical height difference what so called orthometric correction. The orthometric correction amount is small enough to ignore at flatland but the amount is big at high mountains, so it should be considered to obtain accurate height at high mountains. But the calculation process is difficult and complex, not easy to calculate. So, to make the process easy using a user-friendly visual, a orthometric correction calculation program Ortho-Calc. v1.0 was developed in this study. This program was adopted the algorithm of Nassar and Hwang & Hsiao, and Strang Van Hees and it could be to selectivily calculate the correction amount. The inspection result exhibited high accuracy with the standard deviation of 0.024mm by the comparison of previous study. Therefore, This program Ortho-Calc. v1.0 developed in this study, will contribute orthometric correction calculation quickly and easily. And, if this program is widely popular, it could be expected to make a contribution the Benchmark's official height renewal using orthometric correction.

• Journal of Environmental Health Sciences
• /
• v.44 no.1
• /
• pp.55-62
• /
• 2018

Objectives: This study set out to measure the heavy metal concentrations in waste water produced in the casting pickling process at dental technical laboratories and examine the actual state of its treatment. Methods:The investigator measured the concentrations of each heavy metal at 55 dental technical laboratories using an inductively coupled plasma optical emission system. Results: The annual usage of electrolytes was under 10 L in 50 (90.9%), and was 10L or more in five (9.1%) laboratories. Among the laboratories, 15 (27.3%) commissioned the treatment of waste,12 (21.8%) treated the waste with general sewage,and 28 (50.9%) treated the waste in aseptic tank. The arithmetic $mean{\pm}standard$ deviation and the geometric mean of chrome(Cr) were $75.3{\pm}50.9$ and 58.3 mg/L; those of cobalt (Co) were $112.3{\pm}106.7$ and 66.1 mg/L; those of nickel (Ni) were $62.9{\pm}83.5$ and 8.9 mg/L; those of molybdenum (Mo) were $17.1{\pm}13.4$ and 12.0 mg/L; those of iron (Fe) were $31.5{\pm}44.1$ and 6.2 mg/L; those of lead (Pb) were $0.3{\pm}0.3$ and 0.3 mg/L; those of beryllium (Be) were $3.6{\pm}3.6$ and 2.0 mg/L. The hydrogen ion concentration was under pH 2 across all the samples. Conclusions: The findings show that the dental technical laboratories were not doing well with the separation, storage, collection, and treatment of the electrolytes they discarded, and that most of the electrolytes were introduced through the general sewage or aseptic tank. The causes of this include alack of perception among the practitioners at dental technical laboratories and contracted companies avoiding collection for economic reasons. There is a need for education to improve the perceptions of waste water treatment among the practitioners at dental technical laboratories. Environment-related departments should be stricter with legal applications in the central and local governments. It is also required to provide proper management of commissioned treatment.

• Translational and Clinical Pharmacology
• /
• v.25 no.3
• /
• pp.153-156
• /
• 2017

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties of sildenafil citrate chewable tablets (UI14SDF100CW) and conventional sildenafil citrate film-coated tablets ($Viagra^{(R)}$, Pfizer). A randomized, open-label, single dose, two-treatment, two-period, two-way crossover study was conducted in 60 healthy male volunteers. In each period, the subjects received a single oral dose of UI14SDF100CW or $Viagra^{(R)}$ (both tablets contain 140.45 mg of sildenafil citrate, which is equivalent to 100 mg of sildenafil). Serial blood samples were collected up to 24 h post-dose for PK analysis. The plasma concentration of sildenafil was determined using a validated HPLC-MS/MS assay. PK parameters of sildenafil were calculated using non-compartmental methods. The plasma concentration-time profiles of sildenafil in both formulations were similar. For UI14SDF100CW, the $C_{max}$ and $AUC_{last}$ of sildenafil were $1068.69{\pm}458.25$ (mean${\pm}$standard deviation) mg/L and $3580.59{\pm}1680.29h{\cdot}mg/L$, and the corresponding values for $Viagra^{(R)}$ were $1146.84{\pm}501.70mg/L$ and $3406.35{\pm}1452.31h{\cdot}mg/L$, respectively. The geometric mean ratios (90% confidence intervals) of UI14SDF100CW to $Viagra^{(R)}$ for $C_{max}$ and $AUC_{last}$ were 0.933 (0.853-1.021) and 1.034 (0.969-1.108), respectively, which met the bioequivalence criteria of Korean regulatory agency. In conclusion, UI14SDF100CW and $Viagra^{(R)}$ showed similar PK properties. Therefore, UI14SDF100CW can be an alternative to sildenafil for the treatment of erectile dysfunction, providing better compliance.

• Journal of Korean Society of Environmental Engineers
• /
• v.31 no.2
• /
• pp.153-160
• /
• 2009

A PM10 (aerodynamic diameter${\leq}$10 ${\mu}m$) sampler is used to quantify the potential human exposure to suspended particulate matter (PM) and to comply with the governmental regulation. This study was conducted to compare and evaluate the same PM10 cutpoint and different slopes between United States Environmental Protection Agency (USEPA) PM10 sampling criterion and American Conference of Governmental Industrial Hygienists/$Comit\acute{e}$ $Europ\acute{e}en$ de Normalization/International Organization for Standardization thoracic PM10 sampling criterion through theory and experiment. Four PM10 samplers according to the USEPA criterion and one RespiCon sampler in accordance with the thoracic PM10 criterion were used in the present study. In addition, one DustTrak monitor was used to measure real time PM10 mass concentrations. All six aerosol samplers were tested in a PM generation chamber using polydisperse fly ash. Theoretical mass concentrations were calculated by applying the measured particle size distribution characteristics (geometric mean = 6.6 ${\mu}m$, geometric standard deviation = 1.9) of fly ash to each sampling criterion. The measured mass concentrations through a chamber experiment were consistent with theoretical mass concentrations in that a RespiCon sampler with the thoracic PM10 criterion collected less PM than a PM10 sampler with the USEPA criterion. The overall chamber experiment results indicated, when a PM10 sampler was used as a reference sampler, that (1) a RespiCon sampler had a normalizing factor of 1.6, meaning that this sampler underestimated an average 60% of PM10 mass sampled from a PM10 sampler, and (2) a DustTrak real-time monitor using a PM10 inlet had a calibration factor of 2.1.

• The Journal of Korean Society for Radiation Therapy
• /
• v.15 no.1
• /
• pp.29-33
• /
• 2003

I. Purpose Brachytherapy is the main component in treatment of patients with uterine cervical cancer. The reproducibility of applicator position in the same patient at repeated treatments was very important for accurate dose delivery. It was aimed to evaluate the change of applicator location between each high dose rate(HDR) brachytherapy insertion in the patients with uterine cervical cancer. II. Materials and Methods From January 1999 to October 2001, total 52 patients were treated with external beam radiotherapy and HDR brachytherapy (Microselectron, Nucletron). During six to seven times of brachytherapy, all patients had three treatment plans. From the orthogonal radiographs, we measured the following variables; height from upper border of pubic bone to os (HPO), distance from sacral promontory to tip of tandem (DST), distance from coccyx to os (DCO), distance from tip of right ovoid to os (DRO), distance from tip of left ovoid to os (DLO), and distance from center of the first tandem source to ovoid (DTO). To evaluate the reproducibility of applicator position, it was calculated the standard deviation of differences between three insertions for the 7 parameters in each patient. III. Results The ranges of standard deviations of interfractional differences for the variables were as follows. 1)HPO : $0{\sim}0.79cm$ 2)DST : $0{\sim}0.9cm$ 3)DCO : $0.06{\sim}0.76cm$ 4)DRO : $0{\sim}0.53cm$ 5)DLO : $0{\sim}0.45cm$ 6) DTO $0{\sim}0.36cm$ IV. Conclusions There was some change in applicator position on repeated implants in our study. But variation of the interfractional differences was minimal; in all parameters, there were less than 1 cm. We are continued to try for reducing the geometric variation between each procedure.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.39 no.4
• /
• pp.251-261
• /
• 2003

To measure the GPS position accuracy and its distribution according to the length of the baseline, 30 minutes to 24 hours observations at the fixed location were conducted with two GPS receivers (Ll, 12 channels) on May 29 to June 2, 2002. The GPS data received at the reference station, the rover station and the ordinary times GPS observation station operated by the National Geography Institute in Korea were processed in kinematic and static post-processing methods with a post -processing software. The results obtained are summarized as follows: 1. The number of the satellite that could be observed continuously more than six hours was 16 and most of these satellites were positioned at east-west direction on May 31, 2002. The number of the satellite observed and the geometric dilution of precision (GDOP) determined by the average of every 10 minute for the day were 8 and 3.89, respectively. 2. Both the average GPS positions before and after post-processing were shifted (standalone: 1.17 m, post -processing: 0.43m) to the south and west. The twice distance root mean square (2drms) measured with standalone was 6.65m. The 2drms could be reduced to 33.8% (standard deviation 0=17.2) and 5.3% (0=2.2) of standalone by the kinematic and the static post-processing methods, respectively. 3. The relationship between the length of the baseline x (km) and the 2drms y (m) obtained by the static post-processing method was y=0.00l6x+0.006 $(R^2=0.87)$. In the case of the positioning with the static post-processing method using the GPS receiver, it was found that a positioning within 20cm 2drms was possible when the length of the baseline was less than 100km and the receiving time of the GPS is more than 30 minutes.