• Title/Summary/Keyword: genotoxicological safety

Search Result 33, Processing Time 0.017 seconds

Genotoxicological Safety Evaluation of Imported Oranges Irradiated with Ionizing Energy (이온화 에너지를 조사한 수입 오렌지의 유전독성학적 안전성 평가)

  • Huang, Yu-Hua;Jung, Da-Woon;Kang, Il-Jun
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.43 no.6
    • /
    • pp.909-915
    • /
    • 2014
  • This study was carried out to evaluate the genotoxicity of imported oranges irradiated with ionizing energy (0.5 and 1 kGy). In bacterial reversion assays with Salmonella Typhimurium TA98, TA100, TA1535, and TA1537, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no significant increase in the number of revertant colonies in both the absence and presence of the S9 metabolic activation system. In chromosomal aberration tests with Chinese hamster ovary (CHO) cells, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no increase in the frequency of chromosomal aberrations. In in vivo mouse micronucleus assay, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no increase in the frequency of polychromatic erythrocytes with micronucleus. These results indicate that imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no genotoxic effects under these experimental conditions.

Genotoxicological Safety of High-Dose Gamma-Irradiated Cereal Powders (고선량 감마선조사 곡류 분말의 유전독성학적 안전성평가)

  • Han Sag-Myung;Kim Hye-Mi;Jeung Seung-Kyoung;Lee Ju-Woon;Byun Myung-Woo;Kang Il-Jun
    • Food Science and Preservation
    • /
    • v.13 no.4
    • /
    • pp.524-529
    • /
    • 2006
  • Gamma irradiation at 30 kGy was applied to cereal powders to evaluate their possible genotoxicity. The genotoxicity of 30 kGy-irradiated cereal powders was evaluated by Salmonella typhimurium reversion assay, chromosomal aberration test and in vivo micronucleus assay. The result were negative in the bacterial reversion assay with S. typhimurium TA98, IA100, TA1535 and TA1537. No mutagenicity was detected in the assay with and without metabolic activation. In chromosomal aberration tests with CHL cells and in vivo mouse micronucleus assay, no significant difference in the incidences of chromosomal aberration and micronuclei was observed between non-irradiated and 30 kGy-irradiated cereal powders. These result indicate that cereal powders irradiated at 30 kGy did not show any genotoxic effect under these experimental conditions.

Genotoxicological Safety of the Ethanol Extract from Seafood Cooking Drips by Gamma Irradiation (감마선 조사한 수산 자숙액 에탄올 추출물의 유전독성학적 안전성 평가)

  • Kim, Hyun-Joo;Choi, Jong-il;Lee, Hee-Sub;Kim, Jae-Hun;Byun, Myung-Woo;Chun, Byung-Soo;Ahn, Dong-Hyun;Yook, Hong-Sun;Kim, Keehyuk;Lee, Ju-Woon
    • Journal of Radiation Industry
    • /
    • v.2 no.1
    • /
    • pp.21-26
    • /
    • 2008
  • Although seafood cooking drips were the byproducts from the fishery industry it was known that the cooking drips had many nutrients and could be used as functional materials. Previously, the physiological properties of cooking drips were shown to be increased by a gamma irradiation. But, there was no report on the safe for the genotoxicity on the irradiation. In this study, the genotoxicity of the cooking drips from Hizikia fusiformis, Enteroctopus dofleni and Thunnus thynnus was evaluated by the Ames test (Salmonella typhimurium reversion assay) and the SOS chromotest. The results from all samples were negative in the bacterial reversion assay with S. typhimurium TA98, TA100. No mutagenicity was detected in the assay, both with and without metabolic activation. The SOS chromotest also indicated that the gamma-irradiated seafood cooking drips did not show any mutagenicity. Therefore, this study indicated that gamma irradiation could be used for the hygiene, functional properties and processibility of seafood cooking drips.