• 제목/요약/키워드: genetically modified

검색결과 458건 처리시간 0.029초

Shuffled toluene-o-xylene monooxygenase를 이용한 TCE 측정용 fluorescence biosensor

  • 류두현;김용미;목지예;최상일
    • 한국지하수토양환경학회:학술대회논문집
    • /
    • 한국지하수토양환경학회 2003년도 추계학술발표회
    • /
    • pp.475-478
    • /
    • 2003
  • A sol-gel fiber-optic biosensor with encapsulated pH-sensitive fluorophore and immobilized genetically modified toluene-o-xylene monooxygenase was developed to detect TCE, which is carcinogenic chlorinate organic compounds prevailing in ground water. The sensitivity was characterized for the composition of sol-gel, and manufacturing procedure.

  • PDF

Safety evaluation of gene therapy - a case study of naked DNA product

  • Ahn, Byung-Ok
    • 한국독성학회:학술대회논문집
    • /
    • 한국독성학회 2003년도 추계학술대회
    • /
    • pp.86-86
    • /
    • 2003
  • Gene therapy is a medical intervention based on modification of the genetic material of living cells. Gene transfer usually conducted using bacterial plasmid DNA and/or virus vector to express a specific protein. Gene transfer medicinal products classified as naked nucleic acid, complexed nucleic acid or non-viral vectors, viral vector, and genetically modified cells according to biological origin.(omitted)

  • PDF

Collaborative Study for the Establishment of a National Reference Preparation for Erythropoietin

  • Jin, Jae-Ho;Kim, Gi-Hyun;Shin, Won;Shin, Ji-Soon;Choi, Jong-Yoon;Yoon, Sei-Ung;Kim, Min-Sung;Kim, Yang-Woo;Lee, Seung-Woo
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
    • /
    • pp.253.2-253.2
    • /
    • 2003
  • National regulatory authority have the duty to ensure that available pharmaceutical products are of the required quality. This is particularly difficult for biotechnological products, the quality of which cannot be established entirely by test on the material in the final container. In general biotechnological products are distinguished from other drugs by being derived from genetically modified microorganism to humans, and frequently have a complex molecular structure. (omitted)

  • PDF

Transferrine peptide ligand로 개량된 아데노바이러스를 이용한 신경전구세포로의 유전자 전달 효율 조사 (Modified Adenovirus Mediated Gene Transfer to Neuronal Precursor Cells)

  • 정인실
    • 미생물학회지
    • /
    • 제42권1호
    • /
    • pp.73-76
    • /
    • 2006
  • 신정전구세포를 이용한 퇴행성 뇌질환의 세포치료나 유전자치료에서 효율적인 유전자 전달을 목적으로 개량된 아데노바이러스 벡터의 실용 가능성을 쥐의 해마에서 유래된 신정전구세포를 이용하여 조사하였다. 외피단백질을 조작한 개략 아데노바이러스벡터는 분화전과 후의 신정전구세포로 1세대 아데노바이러스 벡터에 비해 6배 정도 유전자를 효율적으로 전달하였다. 또한 바이러스의 감염은 신정전구세포가 신경세포나 신정 아교세포로 분화하는데 영향을 미치는 않았다. 따라서 신정전구세포를 이용한 신정질환의 세포치료나 유전자 치료에서 개량된 아데노바이러스로 유전자를 전달하면 치료의 효율성을 향상시킬 수 있을 것이다.

서부경남 재래시장을 대상으로한 유전자 재조합 대두의 모니터링 (Monitoring of Genetical Modified Soybean Sold at Local Open Market in Western Gyeongnam)

  • 심원보;남백상;최주미;정순천;정덕화
    • 한국환경보건학회지
    • /
    • 제32권2호
    • /
    • pp.126-131
    • /
    • 2006
  • The objective of this study was monitoring of genetically modified soybean by PCR and ELISA. We collected 60 soybean samples from the open markets located in Western Gyeongnam (Sacheon, Hamyang, Hadong, Sanchung, Uiryung, Geochang, and Hapcheon). A total of 60 soybeans was examined and 14 genetical modified soybean (GMS) were detected by PCR. The GMS rate of selling soybean in Uiryung, Hadong, Sacheon, and Hapcheon was 50.0%, 37.5%, 33.3% and 25%, respectively. The 7 of 14 GMSs were positive by ELISA and most of positive samples were below 3% GMS but 1 (Uiryung 1) of the positive samples was over the 3% which is maximum permit limit in Korea. These results mean that merchants of open market did not express for selling soybean mixed with GMS, so consumers did not recognize GMO. Therefore, we thought that education of GMO for merchant of open market need to recognize about GMO maximum permit limit.