• The Korean Journal of Physiology and Pharmacology
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• v.17 no.6
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• pp.479-484
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• 2013

Given the CYP3A4 and CYP3A5's impact on the efficacy of drugs, the genetic backgrounds of individuals and populations are regarded as an important factor to be considered in the prescription of personalized medicine. However, genetic studies with Korean population are relatively scarce compared to those with other populations. In this study, we aimed to identify CYP3A4/5 polymorphisms and compare the genotype distributions among five ethnicities. To identify CYP3A4/5 SNPs, we first performed direct sequencing with 288 DNA samples which consisted of 96 Koreans, 48 European-Americans, 48 African-Americans, 48 Han Chinese, and 48 Japanese. The direct sequencing identified 15 novel SNPs, as well as 42 known polymorphisms. We defined the genotype distributions, and compared the allele frequencies among five ethnicities. The results showed that minor allele frequencies of Korean population were similar with those of the Japanese and Han Chinese populations, whereas there were distinct differences from European-Americans or African-Americans. Among the pharmacogenetic markers, frequencies of $CYP3A4^*1B$ (rs2740574) and $CYP3A5^*3C$ (rs776742) in Asian groups were different from those in other populations. In addition, minor allele frequency of $CYP3A4^*18$ (rs28371759) was the highest in Korean population. Additional in silico analysis predicted that two novel non-synonymous SNPs in CYP3A5 (+27256C>T, P389S and +31546T>G, I488S) could alter protein structure. The frequency distributions of the identified polymorphisms in the present study may contribute to the expansion of pharmacogenetic knowledge.

• Korean Journal of Agricultural Science
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• v.50 no.4
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• pp.869-881
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• 2023

A genetic improvement program in Korea was implemented to improve the performance of Hanwoo cattle by generating livestock with genetically desirable economic characteristics. In particular, in response to external changes, such as the expansion of Free Trade Agreement (FTA), the livestock genetic improvement program has increased farm income by improving the productivity and quality of Hanwoo cattle. Using production cost data from Statistics Korea, the total input and output indices of Hanwoo feeding cattle from 2008 - 2021 were estimated and the growth and productivity changes were analyzed. The productivity change measures results were used to estimate the cumulative effects of the Hanwoo genetic improvement program on quality improvement, another purpose of the program, using a finite distributed lag model. The average annual increase in output (market weight) of Hanwoo was 0.9%. However, total input increased by 1.6%, resulting in a 0.6% decline in total factor productivity. In contrast, the Hanwoo genetic improvement program contributed significantly to the production of high quality beef, rather than contributing to improved productivity of the cattle. Hanwoo carcass weight, which is used as a performance indicator for the livestock genetic improvement program, has significantly improved and is projected to increase at a slower rate. The collective findings indicate the need for new performance indicators that can comprehensively indicate the performance of the genetic improvement of Hanwoo.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.579-589
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• 2017

This paper deals with the optimum cost design of partially prestressed concrete I crosssectioned beams by using Genetic Algorithms. For this purpose, the optimum cost design of two selected example problems that have different characteristics in behavior are performed via Genetic Algorithms by determining their objective functions, design variables and constraints. The results obtained from the technical literature are compared with the ones obtained from this study. The interpretation of the results show that the design of partially prestressed concrete I crossectioned beams from cost point of view by using Genetic Algorithms is 35~50 % more economical than the traditional ones (technical literature) without conceding safety.

• Current Research on Agriculture and Life Sciences
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• v.31 no.2
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• pp.124-130
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• 2013

The significance of environment change and genetic safety has been recently recognized by many genetically modified (GM) plants. This study was to evaluate the safety of drought-tolerant rice and to identify the environment variance. The GM rice of drought-tolerant rice and four check cultivars were analyzed the data on agronomic characters and principal component in large-GM crop field. There was no significant difference in agronomic characters between the drought-tolerant rice and donor plant, 'Ilmi'. Grain yield showed the standard deviation of the difference, did not significant statistically. Related to grain characters, grain appearance were similar to the drought-tolerant rice and donor plant, 'Ilmi'. In Chemical characters, brown rice of the drought-tolerant rice and a donor plant, 'Ilmi' did difference in starch and protein, however, was similar as 'Ilpum'. These results indicated that drought-tolerant rice may perform to detect genetic safety in GM plants progeny.

• Journal of the Korean Society of Safety
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• v.33 no.2
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• pp.61-67
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• 2018

This study proposes a new vibration control approach for adjacent twin structures, which is termed as viscous damper asymmetric coupling system in this paper. The proposed system takes a concept that the diagonal bracing viscous dampers are asymmetrically distributed in two buildings to break the behavior symmetry of the twin buildings and then the coupling viscous damper is additionally installed at the top floor of the two buildings to couple both buildings and interactively transfer the asymmetric behavior-caused damping forces into both buildings. These asymmetric damping distributions and interacting damping forces of the connection damper efficiently suppress the overall vibration of the damper-coupled adjacent twin buildings efficiently. Genetic algorithm (GA) based multi-objective optimization technique is adopted for optimal design of the proposed system. In the numerical example of adjacent twin 10-story building structures, the conventional control approach, that is, uniform damping distribution system (UDS) is also taken into account for comparison purpose. The optimization results verify that the proposed system either can improve the control performance over the UDS with the same damping capacity, or can save the damping capacity significantly while maintaining the similar level of control performance to the UDS.

• Smart Structures and Systems
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• v.22 no.4
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• pp.469-479
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• 2018

The present research study utilizes a multi-objective optimization method for Pareto optimization of an eight-degree of freedom full vehicle vibration model, adopting a non-dominated sorting genetic algorithm II (NSGA-II). In this research, a full set of ride comfort as well as ride safety parameters are considered as objective functions. These objective functions are divided in to two groups (ride comfort group and ride safety group) where the ones in one group are in conflict with those in the other. Also, in this research, a special optimizing technique and combinational method consisting of weighted sum method and Pareto optimization are applied to transform Pareto double-objective optimization to Pareto full-objective optimization which can simultaneously minimize all objectives. Using this technique, the full set of ride parameters of three dimensional vehicle model are minimizing simultaneously. In derived Pareto front, unique trade-off design points can selected which are non-dominated solutions of optimizing the weighted sum comfort parameters versus weighted sum safety parameters. The comparison of the obtained results with those reported in the literature, demonstrates the distinction and comprehensiveness of the results arrived in the present study.

• Journal of Science and Technology Studies
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• v.14 no.1
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• pp.59-85
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• 2014

This study aims to highlight the social aspects of genetic discrimination as another shadow that biotechnology can influence on social life. To do so, the definition of "genetic discrimination" and three perspectives (exceptionalism, expressivism, and human right discourse) were reviewed. In addition, the Genetic Information Nondiscrimination Act (GINA) of the United States and the Bioethics and Safety Act of Korea were analyzed. Several social implications for establishing the research and policies of genetic discrimination based on the existing research results of perceived genetic discrimination (the experiences, fears, and coping strategies of genetic discrimination) were suggested. These included public consensus on the definition of genetic discrimination and emphasis on a human rights approach against genetic discrimination; concerns regarding genetic discrimination in both the personal and public domains; raising the consciousness of both health care providers and the public regarding genetic discrimination; and developing psycho-social coping strategies for decreasing the fear of discrimination of asymptomatic people (hereditary carriers).

• The Korea Journal of Herbology
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• v.20 no.2
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• pp.1-6
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• 2005

Objectives : The purpose of this study is to investigate genetic toxicity of Cervi pantotrichum Cornu herbal acupuncture solution(CPCHA). Methods : In this study, a series of investigation have been carried out to analyze the effects of Cervi pantotrichum Cornu herball acupuncture solution(CPCHA) on colony forming ability of NIH3T3cells, Hela cells and adrenorectal coloncell for genetic toxicity test. Results and Conclusions : From the above results, it is suggested that Cervi pantotrichum Cornu herball acupuncture solution(CPCHA) was limited 0.5-10ug/ml by test. Cervi pantotrichum Cornu herball acupuncture solution(CPCHA) did not exert the protective role to the genetic toxicity in kinds of cell lines used in this study. From these results, Cervi pantotrichum Cornu herbal aqua-acupuncture solution needs further study to prove it's function in cell culture system.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.299-299
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• 2000

In this paper, a determination method of number of AGVs fer introducing to the multi-path material handling systems is presented by using genetic algorithm. For serving the raw material to each work stations automatically, there needs to introduce a AGVs for transfer the raw martial. To reduce the overall production cost in the material handling systems, however, a trade off exists between the amount of inventory hold on the shop floor and the number of AGVs needed to provide adequate service. In this paper, firstly a objective function which included the net present fixed costs of each stations and each purchased AGVs, delivering cost. stock inventory cost, and safety stock inventory cost is presented. Secondly by using genetic algorithm, the optimal reorder quantity at each stations is decided, where the number of AGVs is increased step by step. From a simulation with different GA parameters, we can determine a optimal number of AGVs to reduce the overall production cost. Thus, the effectiveness of GA for determining the number of AGVs is verified in automated material handling systems.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.25 no.4
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• pp.247-254
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• 2015

Ride comfort is one of the major factors in evaluating the performance of the vehicle. Tire is closely related to the ride comfort of the vehicle as the only parts in contact with the road surface directly. Vertical stiffness which is one of the parameters to evaluate the tire performance is great influence on the ride comfort. In general, the lower the vertical stiffness, the ride comfort is improved. Research for improving the ride comfort has been mainly carried out by optimizing the shape of the pneumatic tire. However, demand for safety of the vehicle has been increased recently such as a run-flat tire which is effective in safety improvement. But a run-flat tire have trouble in practical use because of poor ride comfort than general tire. Therefore, In this paper, the research was carried out for improving the ride comfort through the optimization of the SIR shape inside a run-flat tire. Meta-model was generated by using the design of experiment and it was able to reduce the time for the finite element analysis of optimization. In addition, Shape optimization for improving the ride comfort was performed by using the genetic algorithm which is one of the global optimization techniques.