• The Korean Journal of Physiology and Pharmacology
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• v.12 no.2
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• pp.83-87
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• 2008

The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin. To investigate the genetic association between FRK polymorphisms and the risk of obesity in Korean population, single nucleotide polymorphisms (SNPs) in the FRK gene region were selected and analyzed. The body mass index (BMI) was calculated, and biochemical data (systolic blood pressure, diastolic blood pressure, hemoglobin A1C, triglyceride, total cholesterol, high density lipoprotein, and low density lipoprotein) of blood sample from each subject were also measured. One hundred fifty five healthy control and 204 overweight/obesity subjects were recruited. Genotype frequencies of six SNPs [rs6568920 (+8391G>A), rs3756772 (+56780A>G), rs3798234 (+75687C>T), rs9384970 (+68506G>A), rs1933739 (+72978G>A), and rs9400883 (+75809A>G)] in the FRK gene were determined by Affymetrix Targeted Genotyping Chip data. According to the classification of Korean Society for the Study of Obesity, control (BMI 18 to < 23) and overweight/obesity (BMI$\geq$23) subjects were recruited. For the analysis of genetic data, EM algorithm, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis (codominant, dominant, and recessive models) was performed. Age and gender as covariates were adjusted. For biochemical data, Student's t test was used. The mean value of BMI in the control and overweigh/obesity groups was 21.1${\pm}$1.2 (mean${\pm}$SD) and 25.6${\pm}$2.0, respectively. All biochemical data of the overweight/obesity group were statistically significance, compared with the control group. Among six SNPs, two linkage disequilibrium (LD) blocks were discovered. One block consisted of rs1933739 and rs9400883, and the other comprised rs3756772 and rs3798234. One SNP (rs9384970, +68506G>A) showed an association with overweight/obesity in the codominant model (p=0.03). Interestingly, the AA genotype distribution in the overweight/obesity group (n=7, 3.5%) was higher than those in the control group (n=1, 0.6%), which is not found in either Japanese or Chinese subjects. Therefore, the AA genotype of rs9384970 may be a risk factor for development of obesity in Korean population. The results suggest that FRK may be associated with overweight/obesity in Korean population.

• Molecules and Cells
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• v.38 no.7
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• pp.587-596
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• 2015

Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized.

• Journal of Korean Medicine for Obesity Research
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• v.2 no.1
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• pp.53-61
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• 2002

Objective: Obesity is closely related to several factors such as genetic factors, energy intake and energy expenditure. It was said that alcohol & food habits were important to formation of obesity. The purpose of this study are to find out the alcohol & food habitual characteristic of obese adult men and to promote the health of these men. Method: From May, 2000 to November, 2001, We collected 75 eases obese patients, who visited to the Health Examination Center Dept. of Kangnam oriental medicine hospital, Dongguk University who took the health examination, and control group who were matched by age and sex. We investigated the alcohol & food habits by questionnaire. Results and Conclusions: 1. The patients over BMI 25 were in excess of the standard of obesity such as Modified Broca $^{\circ}{{\O}}s$ Index. Percent Body Fat, Abdominal Fat Distribution. But, the patients below BMI 20 were normal range of obesity degree. 2. Abdominal Fat Distribution was increased according to age and physical activity was decreased in obese group. 3. The mean of total calory by alcohol in a month was 4324.6kcal in obese group while control group was 2206.8kcal. 4. In the comparison of food habit, obese group is higher than control group in 7 articles of the 13 articles which influenced obesity.

• The Journal of Korean Medicine
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• v.40 no.1
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• pp.24-33
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• 2019

Objectives: The purpose of this study is to analyze the causes of short stature through a clinical review of factors related to childhood height growth. So we can find the way to meet the needs of the heightism which is widely spread among modern people. Methods: Among 160 patients who came to Andong B oriental clinic for the purpose of growth therapy, 112 children whose height was smaller than other normal children were analyzed. When the children first came to the clinic, we checked their height and weight. The parents' height was recorded through a questionnaire. The relationship between obesity index and height growth was examined through growth plate test and Inbody test. We want to identify the genetic factors related to parental factors based on the data of the parent height. Results: For short stature children, weight was often normal or low. When we examined the relationship between parental genetic factors and child growth, we found that they were more influenced by father's height rather than mother's. We investigated the correlation between skeletal maturity and the five viscera. There was no apparent correlation between skeletal maturity and the five viscera but we found that there was some degree of relevance. Conclusions: For short stature children, the weight was often normal or low and parental genetic factors were more influenced by father than by mother. In the case of bone maturity it did not show a direct correlation between the five viscera.

• The Journal of Korean Society for School & Community Health Education
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• v.9 no.1
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• pp.33-46
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• 2008

Objectives: The aim of this study was to investigate the correlation between the obesity rate in elementary school students in Daejeon and the relevant factors such as social-demographical factors, genetic factors, birth factors, diet factors and intelligence factors. Methods: For the research, 443 fourth grade students, 405 fifth grade students and 417 sixth grade students from six elementary schools in Daejeon Metropolitan City Participated in this study and classified into three groups: normal-weight group, mild obesity group, and moderate or severe obesity group. Results: The total obesity rate of the elementary school students in the school district of Daejeon Metropolitan City was 14.2%; the rate of mild obesity was 7.2%; the rate of moderate obesity was 5.5%; and the rate of severe obesity was 1.5%. The obesity rate of surveyed boys was 16.9%, and the obesity rate of girls was 11.1%. The significant factors for girls' obesity were fathers' EMI, mothers' EMI, living standards, constant demand of foods, preference for greasy foods, frequency of eating snacks, and daily walking hours. It was found that students' subjective mind and objective health index were related to obesity. In the case of obese students, they had more concern about their health and more stress from the dissatisfaction of their physical appearance than normal students. Conclusions: From the above evidences, it is apparent that the obesity of elementary school students has strong relations with eating habits rather than physical activities. It is to be hoped that obesity prevention programs such as effective meal guidance. parental guidance for watching TV, and intense physical activities will be included in the curriculums of health education for elementary school students.

• Genomics & Informatics
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• v.8 no.3
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• pp.116-121
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• 2010

The association between adiponectin concentration and obesity have been reported and genetic variations of the ADIPOQ gene are known to influence the plasmatic concentration of adiponectin. Therefore, we investigated the effect of AIPOQ single nucleotide polymorphism (SNP) on obesity-related variables, and their modulation by dietary intakes in Korean women. The subjects consisted of 3,217 Korean women aged 40-59 years participating in the Korean Genome Epidemiology Study (KoGES). The general characteristics, anthropometric variables, serum blood profiles were measured. Dietary intake was analyzed using the Food Frequency Questionnaire. Subjects with the T allele of AIPOQ rs182052 showed significantly higher obesity-related variables such as weight (p=0.005), BMI (p<0.000), fat body mass (p=0.005), and waist-hip ratio (p=0.007) than those with the C allele. Moreover, the rs182052 T allele was associated with an increased risk of obesity prevalence (p=0.019). However, there were not any significant interactions observed between the genotype of ADIPOQ rs182052 and dietary intake on BMI and fat body mass. These findings suggest that the obesity-related variables may be more dominantly affected by the genotype of ADIPOQ rs182052 than dietary intake in middle aged Korean women.

• Nutrition Research and Practice
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• v.5 no.3
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• pp.253-259
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• 2011

The rapid rise in the incidence of obesity has emerged as one of the most pressing global public health issues in recent years. The underlying etiological causes of obesity, whether behavioral, environmental, genetic, or a combination of several of them, have not been completely elucidated. The obesity epidemic has been attributed to the ready availability, abundance, and overconsumption of high-energy content food. We determined here by Pearson's correlation the relationship between food type consumption and rising obesity using the loss-adjusted food availability data from the United States Department of Agriculture (USDA) Economic Research Services (ERS) as well as the obesity prevalence data from the Behavioral Risk Factor Surveillance System (BRFSS) and the National Health and Nutrition Examination Survey (NHANES) at the Centers for Disease Control and Prevention (CDC). Our analysis showed that total calorie intake and consumption of high fructose com syrup (HFCS) did not correlate with rising obesity trends. Intake of other major food types, including chicken, dairy fats, salad and cooking oils, and cheese also did not correlate with obesity trends. However, our results surprisingly revealed that consumption of com products correlated with rising obesity and was independent of gender and race/ethnicity among population dynamics in the U.S. Therefore, we were able to demonstrate a novel link between the consumption of com products and rising obesity trends that has not been previously attributed to the obesity epidemic. This correlation coincides with the introduction of bioengineered corns into the human food chain, thus raising a new hypothesis that should be tested in molecular and animal models of obesity.

• Genomics & Informatics
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• v.10 no.2
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• pp.99-105
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• 2012

Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between childhood obesity and CVD risk, it would be worthwhile to evaluate whether previously identified lipid-related variants in adult subjects are associated with lipid variations in a childhood obesity study (n = 482). In an association analysis for 16 genome-wide association study (GWAS)-based candidate loci, we confirmed significant associations of a genetic predisposition to lipoprotein concentrations in a childhood obesity study. Having two loci (rs10503669 at LPL and rs16940212 at LIPC) that showed the strongest association with blood levels of TG and HDL-C, we calculated a genetic risk score (GRS), representing the sum of the risk alleles. It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, $-1.13{\pm}0.07$) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, $10.89{\pm}0.84$). These two loci yielded consistent associations in our previous meta-analysis. Taken together, our findings demonstrate that the genetic architecture of circulating lipid levels (TG and HDL-C) overlap to a large extent in childhood as well as in adulthood. Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.

• Journal of Korean Medicine for Obesity Research
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• v.3 no.1
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• pp.75-84
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• 2003

Objective : In Western medicine, the cause of obesity include overeating, lack of exercise, genetic factor, endocrinal impediment and psychological factor. Since the society becomes more complexed and the tensions among social members gets intensified, psychological factor getting more important. In Oriental medicine, Seven Emotion(七情, in oriental medical term) as an emotional stressor was thought to be a factor of obesity. Therefore the purpose of this study is to examine the relationship between Seven Emotion and obesity in detail. Methods : overview the stress with the view of Oriental medicine and research the relationship between Seven Emotion as an emotional stressor and obesity. Results : 1. Seven Emotion can be understood as an emotional stress in Western medicine. If Seven Emotion is excessive, its extreme mental stimulation causes physical illness. 2. Having influence upon the function of internal organs, excessive Seven Emotion causes obesity. Since it hinders normal flow of Gangi(肝氣), Seven Emotion disturbs healthy function of Bi-Wi(脾胃) and normal fluctuation of Qi. Consequently, obesity is resulted from the accumulation of fat since normal metabolism of body is disrupted. 3. In Seven Emotion-Anger(怒), Joy(喜), Anxiety(憂), Thought(思), Sorrow(悲), Fear(恐), Surprise(驚)-give rise to Gan-bi-bul-wha(肝脾不和), Sim-hi-yang-huh(心脾兩虛), Bi-qi-huh(碑氣虛), Dam-sup-jeo-po(痰濕沮胞) and Wi-wha-sang-youm(胃火上炎) in type of symptom in obesity and therefore, cause obesity.

• Mycobiology
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• v.38 no.1
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• pp.58-61
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• 2010

In an effort to develop novel mushroom-derived anti-obesity nutraceuticals, water and ethanol extracts containing the lipaseinhibitory compound from Phellinus linteus were prepared, and their nutritional components were determined. The optimal conditions for the extraction of P. linteus lipase inhibitor involved the treatment of the fruiting bodies with distilled water at $80^{\circ}C$ for 72 hr and 80% ethanol at $100^{\circ}C$ for 60 hr, respectively. The distilled water extract and ethanol extract contained 10.9% and 6.11% of crude protein, and 0.96% and 15.86% of crude fat, respectively. Additionally, the distilled water extract contained a large quantity of minerals, including 239.5 mg of K, 39.3 mg of Mg, and 39.3 mg of Na. The free amino acid content of the distilled water extracts was also higher than that of the ethanol extracts, and in particular, the distilled water extracts contained 5,139 mg of asparagine, 3,891 mg of tryptophan, 2,598 mg of alanine, and 2,066 mg of serine in 100 g of the distilled water extracts. 100 g of the distilled water and ethanol extracts were found to contain 12.31 g and 8.16 g of malic acid, respectively.