• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.2968-2976
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• 2021

This paper introduces a method to reconstruct the three-dimensional (3D) microstructure of two-phase materials, e.g., porous materials such as highly irradiated nuclear fuel, from two-dimensional (2D) sections via a multi-objective optimization genetic algorithm. The optimization is based on the comparison between the reference and reconstructed 2D sections on specific target properties, i.e., 2D pore number, and mean value and standard deviation of the pore-size distribution. This represents a multi-objective fitness function subject to weaker hypotheses compared to state-of-the-art methods based on n-points correlations, allowing for a broader range of application. The effectiveness of the proposed method is demonstrated on synthetic data and compared with state-of-the-art methods adopting a fitness based on 2D correlations. The method here developed can be used as a cost-effective tool to reconstruct the pore structure in highly irradiated materials using 2D experimental data.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.11
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• pp.1631-1635
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• 2007

Japanese Brown cattle, one of the four domestic beef breeds in Japan, are suffering from numerical reduction due to economic pressure from profitable breeds. In this study, all the reproductive cows in the Kouchi sub-breed of the Japanese Brown cattle that were alive in July 2005 were investigated by pedigree analysis to clarify genetic structure and composition of genetic variability. In addition, genetically important individuals for the maintenance of genetic variability of the sub-breed were also identified through the core set method. The number of cows analyzed was 1,349. Their pedigrees were traced back to ancestors born around 1940, and pedigree records of 13,157 animals were used for the analysis. Principal component analysis was performed on the relationship matrix of the cows, and their factor loadings were plotted on a three-dimensional diagram. According to their spatial positions in the diagram, all the cows were subdivided into five genetically distinctive subpopulations of 131 to 437 animals. Genetic diversity of the whole sub-breed, which is estimated to be 0.901, was decomposed into 0.856 and 0.045 of within-subpopulation and between-subpopulation components. Recalculation of genetic diversity after removal of one or several subpopulations from the five subpopulations suggested that three of them were genetically important for the maintenance of genetic variability of the sub-breed. Applying the core set method to all the cows, maximum attainable genetic diversity was estimated to be 0.949, and optimal genetic contributions assigned to each cow supported the previous results indicating relative importance of the three subpopulations as useful genetic materials.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.38-43
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• 2021

Purpose: Demand for genetic counseling on cancer predisposition syndrome is increasing. We evaluated the psychological effect on counselees after genetic counseling at a clinic in a single center. Materials and Methods: We surveyed a total of 72 enrolled participants who visited a genetic counseling clinic at the Samsung Medical Center (SMC). The initial survey was conducted before the first genetic counseling session, and the second survey was conducted after the second genetic counseling session. A total of 43 participants completed both the initial and second surveys. Results: The initial survey of 72 participants indicated higher feelings of guilt in the group with religion, higher depression and anxiety in the group with a diagnosis of self, and higher anxiety in the group on self-referral to the genetic counseling clinic. In the completed survey of 43 participants, overall decreased depression was observed after the second genetic counseling session (P=0.013). Risk perception and anxiety decreased in the group diagnosed with benign variant/variant of uncertain significance (BV/VUS, 25/3) and increased in the group diagnosed with pathogenic variant (PV, 15). Risk perception and anxiety differed between the BV/VUS and PV groups (P<0.001 and P=0.03, respectively). Conclusion: The genetic counseling clinic at the SMC was effective in ameliorating the depression score. Assessment of survey results revealed different depression scores, feelings of guilt and anxiety, and different effects of the genetic counseling clinic, depending on the subgroups. Understanding the needs and psychological characteristics of different groups is necessary for improving genetic counseling services.

• International Journal of Industrial Entomology and Biomaterials
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• v.31 no.2
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• pp.56-61
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• 2015

Rutin is an important bioflavonoid that is consumed in the daily diet. This study compared the functional components of rutin from various silkworm species using a gene database with those of rutin produced by silkworms selectively bred through cross-combinations. We made comparisons between the geographical origin and species of silkworm using a gene database and discovered that rutin activity was ranked in the following order by species, Chinese (C5)> miscellaneous varieties (Jamsaeng 1 Ho) >Japanese (Jam 115) > European (E58) >Korean (Sun 3 ho). However, rutin levels with respect to various genetic traits (blood color, silk color, and egg color) were consistent. In order to study rutin changes that occurred during the cross breeding of the silkworm gene, we bred cross-combinations utilizing Jam 115 and the 4051 silkworms. In conclusion, in order to provide information about the constituents of functional materials contained in silkworm powder, it is imperative that silkworm cross breeding occurs so that the database of functional materials extracted from silkworms will expand.

• International Journal of Industrial Entomology and Biomaterials
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• v.29 no.2
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• pp.162-168
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• 2014

1-Deoxynojirimycin(1-DNJ or DNJ), a component in silkworm powder, prevents glucose from being absorbed into the bloodstream from the small intestine by inhibiting ${\alpha}$-glucosidase activity. This study compared the functional components of 1-DNJ from various silkworm species using a gene database with those of 1-DNJ produced by silkworms bred through cross-combinations. We utilized comparisons of geographical origins and species of silkworms using a gene database and discovered that 1-DNJ activity was ranked in the following order by species, Japanese (SK-1) > Chinese (C48) > European (Rock191). 1-DNJ constituted varying percentages of silkworm organs in the following order, blood > epithelial tissue > body fat > silk glands. With regard to sex, 1-DNJ, levels were higher in males than females. However, 1-DNJ levels with respect to various genetic traits (blood color, silk color, and egg color) were consistent. In order to study 1-DNJ changes that occurred during cross breeding of the silkworm gene, we bred cross-combinations utilizing SK-1 and C48 silkworms. In conclusion, in order to provide information about the constituents of functional materials contained in silkworm powder, it is imperative that silkworm cross breeding occurs so that the database of functional materials extracted from silkworms will expand.

• Korean Journal of Breeding Science
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• v.40 no.3
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• pp.250-257
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• 2008

Knowledge of genetic diversity and of the genetic relationships among elite breeding materials has had a significant impact on the improvement of crops. In maize, this information is particularly useful in i) planning crosses for hybrid and line development, ii) in assigning lines to heterotic groups and iii) in plant variety protection. We have used the SSR technique to study the genetic diversity and genetic relationships among 76 Korean waxy corn accessions, representing a diverse collection from throughout Korea. Assessment of genetic diversity among members of this group was conducted using 30 microsatellite markers. Among these 30 microsatellite markers, we identified a total of 127 alleles (with an average of 4.2 and a range of between 2 and 9 alleles per locus). Gene diversity at these 30 microsatellite loci varied from 0.125 to 0.795 with an average of 0.507. The cluster tree generated with the described microsatellite markers recognized two major groups with 36.5% genetic similarity. Group I includes 63 inbred lines, with similarity coefficients of between 0.365 and 0.99. Group II includes 13 inbred lines, with similarity coefficients of between 0.45 and 0.85. The present study indicates that the 30 microsatellite loci chosen for this analysis are effective molecular markers for the assessment of genetic diversity and genetic relationships between Korean waxy corn accessions. Specifically, this study's assessment of genetic diversity and relationships between a set of 76 Korean waxy corn inbred lines will be helpful for such activities as planning crosses for hybrid and line development and association mapping analyses of maize breeding programs in Korea.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.05a
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• pp.155-158
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• 2001

The layup optimization by genetic algorithm (GA) for the strength of laminated composites with free-edge is presented. For the calculation of interlaminar stresses of composite laminates with free edges, extended Kantorovich method is applied. In the formulation of GA, repair strategy is adopted for the satisfaction of given constraints. In order to consider the bounded uncertainty of material properties, convex modeling is used. Results of GA optimization with scattered properties are compared with those of optimization with nominal properties. The GA combined with convex modeling can work as a practical tool for light weight design of laminated composite structures since uncertainties are always encountered in composite materials.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.70-73
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• 2001

The layup optimization by genetic algorithm (GA) for the interlaminar strength of laminated composites with free edge is presented. For the calculation of interlaminar stresses of composite laminates with free edges, extended Kantorovich method is applied. In the formulation of GA, repair strategy is adopted for the satisfaction of given constraints. In order to consider the bounded uncertainty of material properties, convex modeling is used. Results of GA optimization with scattered properties are compared with those of optimization with nominal properties. The GA combined with convex modeling can work as a practical tool for maximum interlaminar strength design of laminated composite structures, since uncertainties are always encountered in composite materials and the optimal results can be changed.

• Food Science and Industry
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• v.52 no.2
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• pp.171-187
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• 2019

Novel food materials can be produced based on biotechnology such as genetic recombination, microbial fermentation, and enzymatic engineering by utilizing living organisms such as animal, plant, and microorganism or by applying the enzymes isolated from them. Especially, exploration and development of novel prebiotics and probiotics attracted great attention worldwide in the food industry, of which the research and industrial trends in food biotechnology field are promoting the production of next generation sweeteners and proliferation of beneficial bacteria in gastrointestinal tract. Development and commercialization of novel food materials by domestic bioprocessing technology have been sluggish due to the GMO/LMO food safety issues. Meanwhile, the US and EU do not perceive badly about gene manipulation technology, and the research is most active in the fields of crops and GMMs, respectively. Genetic scissors, which are considered as next generation technology, are notable since foreign genes do not remain in final products.

• Structural Engineering and Mechanics
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• v.80 no.5
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• pp.539-551
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• 2021

With the continuous increase of computational capacity, more and more complex nonlinear elastoplastic constitutive models were developed to study the mechanical behavior of elastoplastic materials. These constitutive models generally contain a large amount of physical and phenomenological parameters, which often require a large amount of computational costs to determine. In this paper, an inverse parameter determination method is proposed to identify the constitutive parameters of elastoplastic materials, with the consideration of both strain rate effect and temperature effect. To carry out an efficient design, a hybrid optimization algorithm that combines the genetic algorithm and the Nelder-Mead simplex algorithm is proposed and developed. The proposed inverse method was employed to determine the parameters for an elasto-viscoplastic constitutive model and Johnson-cook model, which demonstrates the capability of this method in considering strain rate and temperature effect, simultaneously. This hybrid optimization algorithm shows a better accuracy and efficiency than using a single algorithm. Finally, the predictability analysis using partial experimental data is completed to further demonstrate the feasibility of the proposed method.