• 융합신호처리학회논문지
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• 제7권4호
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• pp.201-206
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• 2006

유전자 알고리즘은 공학 분야에서 필요한 여러 가지 최적화 문제에 대하여 최적에 가까운 해를 제공해주는 반복적 알고리즘으로 알려져 있다. 본 논문에서는 특정 교배방법에서 유전자의 배열순서가 적합도가 높은 스키마의 길이에 미치는 영향을 고찰하였다. 또한 이에 따른 유전자 알고리즘의 성능 변화를 두 개의 예제를 이용한 실험을 통하여 관찰하였다. 예제로 사용된 그래프 분할과 knapsack 문제를 위해 몇 가지 유전자 재배열 방법을 제시하였다. 실험결과에 따르면 유전자 재배열 방법마다 서로 다른 유전자 알고리즘 성능을 보여주었으며, 적합도가 높은 스키마의 길이를 고려한 재배열 방법이 재배열을 하지 않았을 때 보다 유전자 알고리즘의 성능을 향상시켜 주는 것을 관찰하였다. 따라서 주어진 문제에 적합한 유전자 재배열 방법을 찾는 것이 대단히 중요함을 확인하였다.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2003년도 식물바이오벤처 페스티발
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• pp.95-95
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• 2003

• Genomics & Informatics
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• 제4권2호
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• pp.51-56
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• 2006

In planning a genetic association study, it is necessary to determine the number of samples to be collected for the study in order to achieve sufficient power to detect the hypothesized effect. The case-control design is increasingly used for genetic association studies due to the simplicity of its design. We review the methods for the sample size and power calculations in case-control genetic association studies between a marker locus and a disease phenotype.

• Asian-Australasian Journal of Animal Sciences
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• 제25권1호
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• pp.22-27
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• 2012

The experiment involved observations of 2,514 Holstein-Friesian cows to determine the effects of environmental factors (cow's age, calving season, weight and sex of calves, housing system) and genetic factors on gestation length in dairy cattle and the correlation between gestation length and other reproductive traits (calving ease, stillbirth rates and placental expulsion). Genetic parameters were estimated based on the sires of calved cows (indirect effect) and the sires of live-born calves (direct effect). The following factors were found to contribute to prolonged gestation: increasing cow's age, male fetuses and growing fetus weight. Optimal gestation length was determined in the range of 275-277 days based on calving ease and stillbirth rates. The heritability of gestation length was estimated at 0.201-0.210 by the direct effect and 0.055-0.073 by the indirect effect. The resulting genetic correlations suggest that the efforts to optimize (prolong) gestation length could exert an adverse influence on the breeding value of bulls by increasing perinatal mortality and calving difficulty. The standard errors of the investigated parameters were relatively high, suggesting that any attempts to modify gestation length for the purpose of improving calving ease and reducing stillbirth rates should be introduced with great caution.

• 생약학회지
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• 제23권3호
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• pp.142-145
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• 1992

MeOH extract of twenty medicinal herbs were screened for their effects against protein kinase C (PKC) using bleb-forming assay and PKC enzyme assay. Smilax china and Sanguisorba officinalis showed potent anti-PKC activity. Campsis grandiflora and Galla Halepensis showed moderate inhibitory effect on PKC.

• Asian-Australasian Journal of Animal Sciences
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• 제12권5호
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• pp.677-681
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• 1999

Estimates were made of genetic parameters for average daily gain (ADG) and average backfat thickness (ABF), and of the effect of sex on estimates of variance-covariance components for average daily gain of boars (DGM) and gilts (DGF) and average bacfat thickness of boars (BFM) and gilts (BFF) by residual maximum likelihood (REML) under a bivariate animal model. Data included a total of 2233 records (757 for boars and 1476 for gilts) of the Large White breed born between 1981 and 1986 in Miyazaki and Iwate prefectures in Japan. Heritability estimates for ADG and ABF were 0.43 and 0.69, respectively, with a genetic correlation of -0.08. Heritability estimates for DGM and DGF were 0.54 and 0.46, respectively, with a genetic correlation of 0.79, including that the two traits are influenced by similar but not identical genes. Respective estimates for BFM and BFF were 0.71 and 0.72 with a genetic correlation of 0.95, indicating that identical genes influence backfat thickness in boars and gilts.

• Archives of Pharmacal Research
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• 제12권4호
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• pp.269-275
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• 1989

Early embryo development and implantation were arrested in ICR mice which were passively immunized with a mouse monoclonal progesterone amtibody given as a single intraperitoneal injection at 12 hrs or 60 hrs post coitum (p. c.). Unimplanted embryos were recovered from the reproductive tract of the antibody-treated mice and none of these progressed to the blastocyst stage. The most pronounced effect was an arrest of embryonic development at a stage prior to cavitation. The plasma progesterone concentration in the blood taken by carbiac puncture increased greatly after the treatment by virtue of high affinity binding by the antibody in circulation. The result showed that passive immunization against progesterone shortly after mating interfered with early hormone dependent steps which were essential for normal embryonic development.

• The Plant Pathology Journal
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• 제31권2호
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• pp.97-107
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• 2015

Alteration of genetic make-up of the isolates and mono-sporidial strains of Tilletia indica causing Karnal bunt (KB) disease in wheat was analyzed using DNA markers and SDS-PAGE. The generation of new variation with different growth characteristics is not a generalized feature and is not only dependant on the original genetic make up of the base isolate/monosporidial strains but also on interaction with host. Host determinant(s) plays a significant role in the generation of variability and the effect is much pronounced in monosporidial strains with narrow genetic base as compared to broad genetic base. The most plausible explanation of genetic variation in presence of host determinant(s) are the recombination of genetic material from two different mycelial/sporidia through sexual mating as well as through parasexual means. The morphological and development dependent variability further suggests that the variation in T. indica strains predominantly derived through the genetic rearrangements.

• 한국미생물·생명공학회지
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• 제14권2호
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• pp.187-192
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• 1986

대두근류균 접종제 개발을 목적으로 수집 분리되어 우수균주로 선발된 근류균(Rhizobium japonicum)을 대상으로 가기 재배경력이 상이한 3종류의 토양에 장엽콩을 공시 품종으로 하여 접종효과 시험을 실시하였다. 그 결과 근류형성정도 및 질소고정활성을 보면 근류균무접종구에 비하여 근류균을 접종함으로써 3토양 모두 현저한 근류형성 및 질소고정활성의 증가를 보였고 그에 따라 대두의 생육정도도 양호하여 평균 10％의 건물중의 증가를 보였다. 토양별 총질소고정활성의 증가지수는 개간전토양 238％. 미숙전토양 266％, 숙전토땅 157％로 개간전 및 미숙전토양에서 접종효과가 뚜렷하였다. 공시 근류균주별 접종효과는 Rhizobium japonicum R-214, R-138 균주가 우수한 접종효과를 나타냈다.

• Animal Bioscience
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• 제36권6호
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• pp.829-839
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• 2023

Objective: The aim of this study was to clone the mRNA sequence of the Acyl-CoA dehydrogenase long chain (ACADL) gene of goats and explore the effect of ACADL on the differentiation of subcutaneous fat cells on this basis. Methods: We obtained the ACADL gene of goats by cloning and used quantitative real-time polymerase chain reaction (qPCR) to detect the ACADL expression patterns of different goat tissues and subcutaneous fat cells at different lipid induction stages. In addition, we transfect intramuscular and subcutaneous adipocytes separately by constructing overexpressed ACADL vectors and synthesizing Si-ACADL; finally, we observed the changes in oil red stained cell levels under the microscope, and qPCR detected changes in mRNA levels. Results: The results showed goat ACADL gene expressed in sebum fat. During adipocyte differentiation, ACADL gradually increased from 0 to 24 h of culture, and decreased. Overexpression of ACADL promoted differentiation of subcutaneous adipocytes in goat and inhibited their differentiation after interference. Conclusion: So, we infer ACADL may have an important role in positive regulating the differentiation process in goat subcutaneous adipocytes. This study will provide basic data for further study of the role of ACADL in goat subcutaneous adipocyte differentiation and lays the foundation for final elucidating of its molecular mechanisms in regulating subcutaneous fat deposition in goats.