• Biomedical Science Letters
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• v.18 no.3
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• pp.310-312
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• 2012

Cytochrome $b_5$ is involved in the reduction of methemoglobin back to hemoglobin, thereby maintaining normal function of the blood to carry oxygen around. Congenital abnormal condition of this enzyme causes a rare disease called methemoglobinemia. At least 4 different retropseudogenes are reported so far for cytochrome $b_5$. However, type III pseudogene has attracted most attention because it contains open reading frame in its structure. Although there is no evidence yet if this pseudogene is actually expressed in the cell or the blood the possibility of its expression needs to be elucidated. We have isolated type III pseudogene by polymerase chain reaction and cloned into pGEX-4T-1 expression vector followed by SDS-PAGE. Protein was expressed and the size of the expressed protein was 28 kDa as expected in its genetic code. This result also shows that the protein is not harmful for the viability of the microorganism. This study may contribute to the genetic diagnosis of cardiac diseases, possibly caused by cytochrome $b_5$.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.3
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• pp.409-422
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• 2016

A parametric study based on an unsteady mathematical model of a pyrotechnically actuated device was performed for design optimization. The model simulates time histories for the chamber pressure, temperature, mass transfer and pin motion. It is validated through a comparison with experimentally measured pressure and pin displacement. Parametric analyses were conducted to observe the detailed effects of the design parameters using a validated performance analysis code. The detailed effects of the design variables on the performance were evaluated using the one-at-a-time (OAT) method, while the scatter plot method was used to evaluate relative sensitivity. Finally, the design optimization was conducted by employing a genetic algorithm (GA). Six major design parameters for the GA were chosen based on the results of the sensitivity analysis. A fitness function was suggested, which included the following targets: minimum explosive mass for the uniform ignition (small deviation), light casing weight, short operational time, allowable pyrotechnic shock force and finally the designated pin kinetic energy. The propellant mass and cross-sectional area were the first and the second most sensitive parameters, which significantly affected the pin's kinetic energy. Even though the peak chamber pressure decreased, the pin kinetic energy maintained its designated value because the widened pin cross-sectional area induced enough force at low pressure.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.192-192
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• 2008

As the lifetime of nuclear power plants (NPPs) reaches design life, the probability for fatal accidents increases. Most of accidents are known to be caused by degradation of mechanical components. Pressure tubes are the most important components in CANDU reactor. They are subjected to various aging mechanisms such as delayed hydride cracking (DHC), irradiation and corrosion, etc. Therefore, the integrity of pressure tube is key concern in CANDU reactor. Up to recently, conventional deterministic approaches have been utilized to evaluate the integrity of components. However, there are many uncertainties to prevent a rational evaluation. The objective of this paper is to assess the failure probability of pressure tube in CANDU. To do this, probability fracture mechanics (PFM) analysis based on the Genetic Algorithm (GA) is performed. For the verification of the analysis, a comparison of the PFM analysis using a commercial code and mathematical method is carried out.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.7
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• pp.500-511
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• 2007

The Optimal solutions of the design variables in internally finned tubes have been obtained for three-dimensional periodically fully developed turbulent flow and heat transfer. For a trapezoidal fin profile, performances of the heat exchanger are determined by considering the heat transfer rate and pressure drop, simultaneously, that are interdependent quantities. Therefore, Pareto frontier sets of a heat exchanger can be acquired by integrating CFD and a multi-objective optimization technique. The optimal values of fin widths $(d_1,\;d_2)$, fin height(h) and helix angle$(\gamma)$ are numerical1y obtained by minimizing the pressure loss and maximizing the heat transfer rate within ranges of $d_1=0.5\sim1.5mm$, $d_2=0.5\sim1.5mm$, $h=0.5\sim1.5mm$, and $\gamma=0\sim20^{\circ}$. For this, a general CFD code and a global genetic algorithm(GA) are used. The Pareto sets of the optimal solutions can be acquired after $30^{th}$ generation.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2547-2555
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• 2021

The frequency of reactor coolant leakage is expected to increase over the lifetime of a nuclear power plant owing to degradation mechanisms, such as flow-acceleration corrosion and stress corrosion cracking. When loss of coolant accidents (LOCAs) occur, several parameters change rapidly depending on the size and location of the cracks. In this study, leak flow during LOCAs is predicted using a deep fuzzy neural network (DFNN) model. The DFNN model is based on fuzzy neural network (FNN) modules and has a structure where the FNN modules are sequentially connected. Because the DFNN model is based on the FNN modules, the performance factors are the number of FNN modules and the parameters of the FNN module. These parameters are determined by a least-squares method combined with a genetic algorithm; the number of FNN modules is determined automatically by cross checking a fitness function using the verification dataset output to prevent an overfitting problem. To acquire the data of LOCAs, an optimized power reactor-1000 was simulated using a modular accident analysis program code. The predicted results of the DFNN model are found to be superior to those predicted in previous works. The leak flow prediction results obtained in this study will be useful to check the core integrity in nuclear power plant during LOCAs. This information is also expected to reduce the workload of the operators.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.723-730
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• 2019

Acquiring instrumentation signals generated from nuclear power plants (NPPs) is essential to maintain nuclear reactor integrity or to mitigate an abnormal state under normal operating conditions or severe accident circumstances. However, various safety-critical instrumentation signals from NPPs cannot be accurately measured on account of instrument degradation or failure under severe accident circumstances. Reactor vessel (RV) water level, which is an accident monitoring variable directly related to reactor cooling and prevention of core exposure, was predicted by applying a few signals to deep neural networks (DNNs) during severe accidents in NPPs. Signal data were obtained by simulating the postulated loss-of-coolant accidents at hot- and cold-legs, and steam generator tube rupture using modular accident analysis program code as actual NPP accidents rarely happen. To optimize the DNN model for RV water level prediction, a genetic algorithm was used to select the numbers of hidden layers and nodes. The proposed DNN model had a small root mean square error for RV water level prediction, and performed better than the cascaded fuzzy neural network model of the previous study. Consequently, the DNN model is considered to perform well enough to provide supporting information on the RV water level to operators.

• The Journal of Engineering Geology
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• v.24 no.3
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• pp.383-396
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• 2014

The condition, characteristics, and stability of slopes, as well as the consequences of slope failure, need to be understood for the proper stabilization of slopes and preclusion of potential disasters arising from slope failure. Here, a slope code system (SCS) that succinctly and accurately reflects the various conditions of a slope is proposed. The SCS represents the condition, characteristics, and geotechnical stability of slopes, as well as the consequences of slope failure, and the method is quickly and easily applied to a given slope. The SCS comprises five elements: 1) the slope material; 2) the genetic origin (rock type) and geological structure of the slope; 3) the geotechnical stability of the slope; 4) the probability of failure and remedial works made upon the slope; and 5) the consequences of failure. A letter code is selected from each element, and the result of the evaluation and classification of the slope is given as a five-letter code. Because the condition, characteristics, and geotechnical stability of a slope, as well as the consequences of slope failure, are provided by the SCS, this system will provide an effective mechanism for the maintenance and management of slopes, and will also allow more informed decision-making for determining which slopes should be prioritized for remedial measures.

• Food Science of Animal Resources
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• v.24 no.1
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• pp.8-14
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• 2004

Identification of animals has been made with an ear tag with dummy code, and blood typing has been used for paternity and individual identification in live animals. As various genetic markers are for different cattle breeds vary, the discrete genetic markers are necessary to identify Hanwoo. A total of 740 progeny testing Hanwoo were used to identify Hanwoo specific markers. To examine traceability of individuals by using breed specific genetic codes, four animal were randomly sampled, and traced from live animals to post-slaughter processing stages. The candidate genetic makers used in the study were 16 DNA microsatellites which were identified in romosomes 1 and 14. The number of alleles of those DNA microsatellites ranged from a minimum of 3 to maximum of 12. The heterozygote frequency ranged from 0.022 to 0.824. Effective number of alleles for each DNA microsatellites were 3 to 6. Six selected candidate genetic markers were able ti trace individual cattle with an 100% confidence level.

• Composites Research
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• v.21 no.1
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• pp.1-7
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• 2008

Composite vessels for high pressure gas storage are commonly used these days because of their competitive weight reduction ability maintaining strong mechanical properties. To supplement permeability of composite under high pressure, it is usually lined by metal, which is called a Type 3 vessel. However, it has many difficulties to design the Type 3 vessel because of its complex geometry, fabrication process variables, etc. In this study, therefore, GUI (graphic user interface) optimal design code for Type 3 vessels was developed based on semi-geodesic algorithm in which various factors of geometry and fabrication variables are considered and genetic algorithm for optimization. In addition, hydrogen vessels for 350/700 bar that can be applied to FCVs(fuel cell vehicles) were designed using this code for verification.

• Journal of the Korea Society of Computer and Information
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• v.28 no.7
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• pp.85-93
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• 2023

Software birthmark refers to a unique feature inherent in software that can be extracted from program binaries even in the absence of the original source code of the program. Like human genetic information, the similarity between programs can be calculated numerically, so it can be used to determine whether software is stolen or copied. In this paper, we propose a new birthmark technique for Android applications developed using Unity. The source codes of Unity-based Android applications use C# language, and since the core logic of the program is included in the DLL module, it must be approached in a different way from normal Android applications. In this paper, a Unity birthmark extraction and comparison system was implemented, and reliability and resilience were evaluated. The use of the Unity birthmark technique proposed in this paper is expected to be effective in preventing illegal copy or code theft of the Unity-based Android applications.