• 한국생산제조학회지
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• 제26권3호
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• pp.292-298
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• 2017

Numerical analysis for various design parameters should be preceded by optimal design of composite materials. Numerous studies have been conducted on the bolting of interconnecting beams. In this study, the response surface method was applied to optimize the design of bolted joints connected by laminated wood composite beams. The response surface was created by combining the FEA code for composite analysis and the algorithm for forming the response surface. Optimization on this response surface was performed with a genetic algorithm to derive the results. The determination of the optimum bolt-hole position for the connection of composite beams is an optimization problem. Tsai-Wu composite failure index, maximum deflection, and simple von Mises stress are set as the objective functions. It has been proved that the design results of the optimized bolt-hole are superior to the design performance of the existing conventional bolt-hole position.

• Steel and Composite Structures
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• 제9권6호
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• pp.535-555
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• 2009

The harmony search method based optimum design algorithm is presented for geometrically non-linear semi-rigid steel frames. Harmony search method is recently developed metaheuristic algorithm which simulates the process of producing a musical performance. The optimum design algorithm aims at obtaining minimum weight steel frames by selecting from standard set of steel sections such as European wide flange beams (HE sections). Strength constraints of Turkish Building Code for Steel Structures (TS648) specification and displacement constraints were used in the optimum design formulation. The optimum design algorithm takes into account both the geometric non-linearity of the frame members and the semi-rigid behaviour of the beam-to-column connections. The Frye-Morris polynomial model is used to calculate the moment-rotation relation of beam-to-column connections. The robustness of harmony search algorithm, in comparison with genetic algorithms, is verified with two benchmark examples. The comparisons revealed that the harmony search algorithm yielded not only minimum weight steel frames but also required less computational effort for the presented examples.

• Advances in environmental research
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• 제8권1호
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• pp.1-21
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• 2019

In the present study, analysis of contaminant transport through one dimensional unsaturated stratified media using element free Galerkin method has been presented. Element free Galerkin method is a meshfree method. A FORTRAN code has been developed for the same. The developed model is compared with the results available in the literature and are found in good agreement. Further a parametric study has been conducted to examine the effects of various parameters like velocity, dispersivity, retardation factor and effect of saturation on the contaminant flow. The results presented conclude that transport of contaminant is retarded in unsaturated zone in comparison with the saturated zone.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2010년도 한국컴퓨터종합학술대회논문집 Vol.37 No.1(B)
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• pp.53-58
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• 2010

코드 난독화 기법 중의 하나인 인라인(Inline)은 코드의 복사를 통하여 함수의 호출 구조를 파괴하여서 코드의 복원과 이해를 어렵게 만든다. 하지만 적절한 전략 없이 인라인 기법을 적용하게 되면, 프로그램 성능이 저하되며 난독화의 결과도 기대 이하일 가능성이 존재한다. 따라서 지나친 성능의 저하를 막으면서 결과적으로 코드의 복원과 이해를 최대한 어렵게 하기 위한 인라인 수행 전략이 필요하다. 이를 위하여 본 논문에서는 정적 함수 호출 그래프를 기반으로 인라인의 적용 여부를 유전 알고리즘을 사용하여 결정하도록 한다. 그리고 인라인 전후의 효용을 보여주기 위하여 정보이론 및 제어 흐름의 복잡도에 기반하여 전체 프로그램의 복잡도를 정의하였다. 마지막으로 해당 기법의 효용을 실험을 통해 보였다.

• Interdisciplinary Bio Central
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• 제5권2호
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• pp.4.1-4.3
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• 2013

A history of discoveries of a gene and DNA was viewed with respect to people, time and places. It started with G. Mendel and J. Meisher, who discovered a gene in a plant species in 1866 and DNA in animals in 1869, respectively. With recognition that DNA was a chemical substance, A. Kossel identified the four chemical components of DNA without knowing their biological function around the turn of the 19th century. On the other hand F. Griffith found a peculiar activity in a bacterial species in 1928, but victimized by the war before understanding what it was. Those discoveries were made in Europe, but they were still fragmentary. Then, in USA, O. T. Avery, A. Hershey, M. Nirenberg and other scientists organized the European discoveries and elucidated their coordinated biological functions in 1950's and 1960'.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 춘계학술대회논문집
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• pp.790-795
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• 2002

The object of this research is limited to the reduction of compression process noise only among the main sources of compressor noise such as motor noise, compression process noise, and valve port flow noise. Thus the research is focused on the wave motion rather than the particle motion of sound wave travels. A muffler is a commonly used device to reduce the compression process noise, generated by the pressure pulsations caused by the cyclic compression process. In this research, the acoustic characteristics of the muffler are analyzed by using the normal gradient integral equation proposed by Wu and Wan. Moreover, a commercial code SYSNOISE developed by indirect variational boundary integral equation is also used to validate the results. For the noise reduction, the topology optimization technique using a genetic algorithm is used. The number, size and position of the muffler holes are considered as design variables. Compared with original design, the optimized design has very improved acoustic characteristics. Both numerical and experimental analyses are used to evaluate new design.

• Molecules and Cells
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• 제42권5호
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• pp.386-396
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• 2019

Labeling of a protein with a specific dye or tag at defined positions is a critical step in tracing the subtle behavior of the protein and assessing its cellular function. Over the last decade, many strategies have been developed to achieve selective labeling of proteins in living cells. In particular, the site-specific unnatural amino acid (UAA) incorporation technique has gained increasing attention since it enables attachment of various organic probes to a specific position of a protein in a more precise way. In this review, we describe how the UAA incorporation technique has expanded our ability to achieve site-specific labeling and visualization of target proteins for functional analyses in live cells.

• Toxicological Research
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• 제32권3호
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• pp.195-205
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• 2016

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index ($F_{ST}$), respectively. The Korean population was genetically similar to the CHB and JPT populations ($F_{ST}$ < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation ($F_{ST}$ > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest $F_{ST}$ value between the Korean and African populations was cystathionine-${\beta}$-synthase rs234709 ($F_{ST}$: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

• Journal of Animal Science and Technology
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• 제50권1호
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• pp.1-8
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• 2008

본 연구는 전자식별칩(RF-ID)를 활용한 생산이력추적 시스템을 도입하여 가축의 생산, 도축, 가공 및 유통단계에 있어 효율성을 증진시키고 소비자들에게 질 좋고 위생적인 한우육을 제공할 수 있도록 발전시키기 위하여 수행하였다. 생산이력추적 시스템의 기본이 되는 새로운 개체식별 바코드, 등록번호 및 농장번호를 고려하여 관리, 자료의 수집과 저장이 용이하도록 설계되었다. 특히 이 시스템은 1) 가축관리를 위하여 표준 전자 식별칩(RF-ID), 표준이표, 마이크로칩 그리고 이표식별 장비를 제공하고, 2) 한우육 상표 보장을 통해 소비자를 보호하고 3) 품질 좋은 한우육을 생산하는 농가에게 인센티브를 제공하고 4) 국가적 개체관리에 있어 획일한 시스템을 제공하는데 그 목적이 있다. 몇몇 농가조합에 적용한 결과와 모 백화점에서 실시한 시범사업 결과 RF-ID 시스템 사용에 대한 가능성을 볼 수 있었다.

• Structural Engineering and Mechanics
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• 제8권2호
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• pp.165-180
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• 1999

The cost effectiveness of using steel roof systems for residential buildings is becoming increasingly apparent with the decrease in manufacturing cost of steel components, reliability and efficiency in construction practices, and the economic and environmental concerns. While steel has been one of the primary materials for structural systems, it is only recently that its use for residential buildings is being explored. A comprehensive system for the design of residential steel roof truss systems is presented. In the first stage of the research the design curves obtained from the AISI-LRFD code for the manufactured cross-sections were verified experimentally. Components of the truss systems were tested in order to determine their member properties when subjected to axial force and bending moments. In addition, the experiments were simulated using finite element analysis to provide an additional source of verification. The second stage of the research involved the development of an integrated design approach that would automatically design a lowest cost roof truss given minimal input. A modified genetic algorithm was used to handle sizing, shape and topology variables in the design problem. The developed methodology was implemented in a software system for the purpose of designing the lowest cost truss that would meet the AISI code provisions and construction requirements given the input parameters. The third stage of the research involved full-scale testing of a typical residential steel roof designed using the developed software system. The full scale testing established the factor of safety while validating the analysis and design procedures. Evaluation of the test results indicates that designs using the present approach provide a structure with enough reserve strength to perform as predicted and are very economical.