• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.110.2-110.2
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• 2007

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• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.110.1-110.1
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• 2007

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• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2002.10a
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• pp.40-44
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• 2002

선박 설계시 최적화에 있어 종래에는 Random search Parametric study, Hook&Jeeves Method등이 사용되어져 왔으나 1960년대 Genetic algorithm이 소개되고 꾸준히 발전함과 함께 선박 설계에서도 Genetic algorithm이 사용되기 시작하였다. 본 논문에서는 이러한 Genetic algorithm 중 Simple Genetic algorithm(SGA), Micro Genetic algorithm(MGA), Threshold Genetic algorithm(TGA), Hybrid Genetic algorithm(HGA)을 선박 설계에 적용하여 그 성능을 비교 검토해 보았다. MGA는 계산 부담을 줄이기 위해 작은 개체로 효율적인 탐색을 하며, TGA는 local optimum에서 쉽게 벗어나게 할 수 있는 특징이 있다. HGA는 Hook&Jeeves Method를 Genetic algorithm과 병합되어 있다. 이를 바탕으로 본 논문에서 망간단괴 수송선의 경제성을 평가한다. 평가 방법은 연간 300만톤을 생산한다고 가정하여 연간 운송 용적을 동호제약으로 해서 최적화를 한 뒤, 이를 이용하여 몇가지 Case로 나누어서 초기 자본, 연간 비용, 20년간 총 비용을 계산하여 가장 경제적인 선박을 선택한다.

• Proceedings of the KAIS Fall Conference
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• 2003.11a
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• pp.80-83
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• 2003

A Genetic algorithm is a searching algorithm that based on the law of the survival of the fittest. Multi-population Genetic Algorithms are a modified form of genetic algorithm. Therefore, experience with fuzzy logic and genetic algorithm has proven to be that a combination of them can efficiently make up for their own deficiency. The Multi-population Genetic Algorithms independently evolve subpopulations. In this paper, we suggest a new coding method that independently evolves subpopulations using the fuzzy logic controller. The fuzzy logic controller has applied two fuzzy logic controllers that are implemented to adaptively adjust the crossover rate and mutation rate during the optimization process. The migration scheme in the multi-population genetic algorithms using fuzzy logic controllers is tested for a function optimization problem, and compared with other group migration schemes, therefore the groups migration scheme is then performed. The results demonstrate that the migration scheme in the multi-population genetic algorithms using fuzzy logic controller has a much better performance.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.165.1-165.1
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• 2000

• Childhood Kidney Diseases
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• v.25 no.1
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• pp.14-21
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• 2021

Chronic kidney disease, the presence of structural and functional abnormalities in the kidneys, is associated with a lower quality of life and increased morbidity and mortality in children. Genetic etiologies account for a substantial proportion of pediatric chronic kidney disease. With recent advances in genetic testing techniques, an increasing number of genetic causes of kidney disease continue to be found. Genetic testing is recommended in children with steroid-resistant nephrotic syndrome, congenital malformations of the kidney and urinary tract, cystic disease, or kidney disease with extrarenal manifestations. Diagnostic yields differ according to the category of clinical diagnosis and the choice of test. Here, we review the characteristics of genetic testing modalities and the implications of genetic testing in clinical genetic diagnostics.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.1
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• pp.1-6
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• 2009

Genetic variability is an important component in the ability of populations to adapt in the face of environmental change. Severe human impacts reduced Muzzafarnagri sheep of India from 500,000 in 1972 to 10,989 in 1973-74. Here we report for the first time the effect of this population decline on levels of genetic variability at 13 FAO recommended ovine microsatellite loci and contrast levels of variability to that in a breed from the same geographical region, which differed in numbers, by an order of magnitude (Marwari sheep). Of the 13 loci, 100% were polymorphic in both breeds. A high degree of genetic variation was observed within populations in terms of both allele diversity (number of alleles per locus, >4) and gene diversity (expected heterozygosity, >0.5), which implied that there is still a substantial amount of genetic diversity at the nuclear loci in a declining population. Nevertheless, overall low number of alleles per locus and relatively less abundance of low frequency alleles in Muzzafarnagri sheep suggested that genetic variability has been comparatively reduced in this population. Bottleneck analysis indicated that a genetic bottleneck did not occur during the most recent decline. In addition, we found that the differentiation among populations was moderate ($F_{ST}$= 11.8%). This study on assessment of genetic effects of the population declines in ovines is a step towards identification of genetically impoverished or healthy populations, which could prove to be a useful tool to facilitate conservation planning in this important species of small ruminants.

• Journal of Life Science
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• v.18 no.2
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• pp.175-179
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• 2008

Cornus controversa is a long-lived woody species mostly distributed in East Asia. Random amplified polymorphic DNA (RAPD) markers were used to investigate the genetic diversity and population structure of Korean populations of this species. A high level of genetic variation was found in seven populations of C. controversa. The mean genetic diversity (H) was 0.222 across populations, varying from 0.200 to 0.238. Eighty of the 93 loci (86.0%) showed detectable polymorphism in at least one population. Total genetic diversity values ($H_T$) varied between 0.192 and 0.231, giving an average overall polymorphic loci of 0.212. The interlocus variation of genetic diversity within populations ($H_S$) was high (0.167). Mean of genetic diversity in C. controversa was higher than average values for species with similar life history traits. The sexual reproduction, perennial habitat, and longevity are proposed as possible factors contributing to high genetic diversity. On a per locus basis, the proportion of total genetic variation due to differences among populations ($G_{ST}$) ranged from 0.169 to 0.278 with a mean of 0.216, indicating that about 21.6% of the total genetic variation was among populations. An indirect estimate of the number of migrants per generation (Nm=1.893) indicated that gene flow was extensive among Korean populations of C. controversa.

• The Journal of Korean Academic Society of Nursing Education
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• v.12 no.1
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• pp.104-114
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• 2006

Genetic knowledge for oncology nurses is important in Korea because oncologists are incorporating genetic counseling and genetic testing into their practice. The purpose of this paper is to describe our method of developing the first academic cancer genetic risk assessment and counseling course for Korean nurses. A one-week (non-credit) cancer genetics counseling program was constructed for master's level Korean oncology nurses. The course emphasized basic genetic concepts and principles the genetics of cancer; hereditary cancer syndromes; family history assessments; pedigree construction; risk calculation; surveillance recommendations and treatment options ethical, legal, social, and psychological issues inherent in genetic testing. The goals of this program are to: 1) provide a comprehensive knowledge base for nurses who are currently expanding their scope of practice into the genetic counseling role 2) introduce this knowledge to nurses who want to use it in their practice; and 3) provide cancer genetic knowledge and resources to Korean nursing faculty who plan to incorporate this knowledge into existing master's courses. This academically-based course is recognized as valuable by nurses, nursing faculty, and physicians. With this new knowledge nurses can begin toexpand their role in delivering comprehensive cancer care services.

• Asian Oncology Nursing
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• v.12 no.4
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• pp.267-273
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• 2012

Purpose: The purpose of this review article is to introduce how the Korean Society of Genetic Nursing (KSGN) has evolved and tried to translate genomic knowledge to nursing practice, and then to suggest the future role of genetic nurses in Korea. Methods: A literature review was performed and the current status of genetic counselling in Korea was explored. Then the educational and clinical experiences of the authors were incorporated. Finally, the main activities of Korean nursing for genetics were identified. Results: Two types of genetic counsellor certification have been issued in Korea: one is issued by the Korean Society of Genetic Medicine, another by the Korean Society of Breast Cancer since June 2011. A few Korean nursing researchers have continuously performed research related to genetic nursing and undertook several research projects funded by the government since 2003. In February 2011, KSGN was established and is now trying to establish further international networks. Conclusion: Nursing genetic experts should be trained to integrate all specialties for genetic counselling, so they can provide holistic genetic services including ethical, legal, and social issues (ELSI).