• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.178-184
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• 2017

This study was performed on 16 patients diagnosed with tsutsugamushi disease and cerebral infarction from January 2007 to December 2015. An acute cerebral infarction was diagnosed by brain MRI and MRA. Tsutsugamushi disease was diagnosed using a polymerase chain reaction. To distinguish the difference between the generalized cerebral infarction and infarction with tsutsugamushi disease, the blood pressure and body temperature were measured uponadmission. In general, the blood pressure increases during an acute cerebral infarction. Interestingly, in this study, 12 patients showed a systolic blood pressure less than 130 mmHg uponadmission. The location of the cerebral infarction and whether single or multiple cerebral infarction were examined. Thirteen patients had a cerebral infarction in anterior circulation and 3 patients developed in posterior circulation. To evaluate the coagulation disorders, prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer, fibrinogen, fibrin degradation product (FDP). D-dimer, which is generally known to increase in an acute cerebral infarction, showed a significant increase in the 13 patients. Fibrin degradation products (FDP) showed a significant increase in 15 patients. The pathophysiological mechanism of tsutsugamushi disease is known as vasculitis, which may result in an endothelial cell injury and proliferation of the endothelial wall, which may lead to a cerebral infarction accompanied by coagulopathy. Without endothelial cell damage and proliferation, a vasospasm caused by vasculitis may cause vasoconstriction and cerebral infarction.

• Nutrition Research and Practice
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• v.12 no.1
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• pp.69-77
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• 2018

BACKGROUND/OBJECTIVES: Metabolic risk factors should be managed effectively in patients with type 2 diabetes mellitus (T2DM) to prevent or delay diabetic complications. This study aimed to compare the self-management levels of diet and metabolic risk factors in patients with T2DM, according to the duration of illness, and to examine the trends in self-management levels during the recent decades. SUBJECTS/METHODS: Data were collected from the Korea National Health and Nutrition Examination Surveys (KNHANES, 1998-2014). In our analysis, 4,148 patients with T2DM, aged ${\geq}30years$, were categorized according to the duration of their illness (< 5 years, 5-9 years, and ${\geq}10years$). Demographic and lifestyle information was assessed through self-administered questionnaires, and biomarker levels (e.g., fasting glucose level, blood pressure, or lipid level) were obtained from a health examination. Dietary intake was assessed by a 24-recall, and adherence level to dietary guidelines (meal patterns and intake levels of calories, carbohydrates, vegetable/seaweed, sodium, and alcohol) were assessed. Multivariable generalized linear regression and unconditional logistic regression models were used to compare the prevalence rates of hyperglycemia, dyslipidemia, and hypertension according to the duration of patients' illness, accounting for the complex survey design of the KNHANES. RESULTS: In the multivariable adjusted models, patients with a longer duration (${\geq}10years$) of T2DM had a higher prevalence of hyperglycemia than those with a shorter duration of T2DM (< 5 years) (odds ratio 2.20, 95% confidence interval 1.61-3.01, P for trend < 0.001). We did not observe any associations of disease duration with the prevalence of hypertension and dyslipidemia. In addition, the adherence levels to dietary recommendations did not significantly differ according to disease duration, except adherence to moderate alcohol consumption. There were significant decreasing trends in the prevalence of hyperglycemia in patients with a duration of illness ${\geq}10years$ (P for trend = 0.004). CONCLUSION: Although the proportion of patients with adequate control of glucose levels has improved in recent decades, poorer self-management has been found in those with a longer disease duration. These findings suggest the need for well-planned and individualized patient education programs to improve self-management levels and quality of life by preventing or delaying diabetic complications.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.11
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• pp.1818-1827
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• 2018

Objective: The objective of this work was to determine the prevalence of the pathologies that caused the condemnation of pig carcasses in an area of intensive pig farming and Mediterranean climatology and to evaluate their influence in a risk-based inspection procedure for slaughterhouses. Methods: A retrospective observational investigation was carried out from 2002 to 2016 into the pathological processes that caused the condemnation of pig carcasses in a slaughterhouse from South-eastern Spain. The seasonal effect on the causes of condemnation carcass was reported. Negative binomial model was used to evaluate the effect of season on the rate of antemortem rejections and post-mortem condemnations. Histopathological examinations were performed to confirm the diagnosis. Results: The risk of antemortem rejections (0.0564%) was significantly greater in summer (risk ratio [RR] = 1.57). Autumn was associated with higher rate (RR = 1.69) of the total postmortem condemnations (0.1046%). Significantly higher rates of pronounced anaemia (0.0111%) were observed in summer (RR = 3.20). The main causes of anaemia were observed gastroesophageal ulcers and haemorrhagic enteropathies. Significantly highest risk of erysipelas (0.0074%) were observed in autumn (RR = 5.485). About other zoonosis, only eight cases (0.0013%) of carcasses were declared unfit due to tuberculosis lesions. Porcine muscular cysticercosis was not detected. Nevertheless, nonspecific causes such as generalized infections and emaciation represented the half of the condemned carcasses (50.90%). Conclusion: The pathologies leading to the condemnation of carcasses in this study can be considered representative of the pathologies that affect the pig population from a region with a high intensive production and Mediterranean climatology because this slaughterhouse receives a lot of animals from many farms of different size in a high intensive pig production zone (Mediterranean region). Increased knowledge of environmental factors that may foment the appearance of the diseases is essential for implementing inspection programs based on risk assessment in pig's slaughterhouses.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.997-1001
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• 2013

Background: Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor lymphovascular invasion (LVI). It also involves VEGF-C as the most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and require clarification. Aim: To define correlations between VEGF-C expression, LVD and LVI with several clinicopathological parameters from Indonesian breast cancer patients. Materials and Methods: Using a cross-sectional study, a total of 48 paraffin-embedded tissues of breast cancer from Dr. Sardjito General Hospital Indonesia were assessed for VEGF-C expression, LVD and LVI by immunohistochemistry. Correlations of these markers with clinicopathological parameters like patient age, tumor size, lymph node status, grade, ER/PR and Her-2 status, cell proliferation and p-53 expression were investigated by linear analysis. Correlations of VEGF-C expression and LVI with several clinicopathological parameters were analyzed with Coefficient Contingency Chi-Square test. Results: The mean of patients age was 53.0 year, pre and post-menopausal patients accounting for 56.3% and 43.8%, respectively. Some 10.4% were well, 41.7% moderate and 47.9% poorly differentiated. ER positivity was evident in 50% while PR and Her-2 positivity was found in 31.3% and 33.3%, respectively. Breast cancer cells with over-expression of p-53 was 64.6% and with high cell proliferation was 56.3%. Lymph node metastasis was noted in 63.5%, and LVI in 72.9%. Significant correlations were found between LVD and tumor size (p:0.037), grade (p:0.000), lymphnode status (p:0.036), LVI (p:0.003), as well as with p-53 and cell proliferation. There were also significant correlation of VEGF-C (p:0.011) and LVI (p:0.001) with tumor grade. Only ER status was found to have a correlation with tumor size (p:0.027). Conclusions: This study suggested that in Indonesian breast cancer patients, lymphangiogenesis is correlated with tumor size, grade, lymph node status and tumor lymphovascular invasion, the latter also being related with p-53 over expression and high cell proliferation.

• The Journal of Art Theory & Practice
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• no.7
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• pp.165-188
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• 2009

In the development of linear perspective, Brook Taylor's theory has achieved a special position. With his method described in Linear Perspective(1715) and New Principles of Linear Perspective(1719), the subject of linear perspective became a generalized and abstract theory rather than a practical method for painters. He is known to be the first who used the term 'vanishing point'. Although a similar concept has been used form the early stage of Renaissance linear perspective, he developed a new method of British perspective technique of measure points based on the concept of 'vanishing points'. In the 15th and 16th century linear perspective, pictorial space is considered as independent space detached from the outer world. Albertian method of linear perspective is to construct a pavement on the picture in accordance with the centric point where the centric ray of the visual pyramid strikes the picture plane. Comparison to this traditional method, Taylor established the concent of a vanishing point (and a vanishing line), namely, the point (and the line) where a line (and a plane) through the eye point parallel to the considered line (and the plane) meets the picture plane. In the traditional situation like in Albertian method, the picture plane was assumed to be vertical and the center of the picture usually corresponded with the vanishing point. On the other hand, Taylor emphasized the role of vanishing points, and as a result, his method entered the domain of projective geometry rather than Euclidean geometry. For Taylor's theory was highly abstract and difficult to apply for the practitioners, there appeared many perspective treatises based on his theory in England since 1740s. Joshua Kirby's Dr. Brook Taylor's Method of Perspective Made Easy, Both in Theory and Practice(1754) was one of the most popular treatises among these posterior writings. As a well-known painter of the 18th century English society and perspective professor of the St. Martin's Lane Academy, Kirby tried to bridge the gap between the practice of the artists and the mathematical theory of Taylor. Trying to ease the common readers into Taylor's method, Kirby somehow abbreviated and even omitted several crucial parts of Taylor's ideas, especially concerning to the inverse problems of perspective projection. Taylor's theory and Kirby's handbook reveal us that the development of linear perspective in European society entered a transitional phase in the 18th century. In the European tradition, linear perspective means a representational system to indicated the three-dimensional nature of space and the image of objects on the two-dimensional surface, using the central projection method. However, Taylor and following scholars converted linear perspective as a complete mathematical and abstract theory. Such a development was also due to concern and interest of contemporary artists toward new visions of infinite space and kaleidoscopic phenomena of visual perception.

• Investigative Magnetic Resonance Imaging
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• v.14 no.1
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• pp.56-63
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• 2010

Purpose : DIR image is relatively free from susceptibility artifacts therefore, DIR image can make it possible to reliably measure cortical thickness/volume. One drawback of the DIR acquisition is the long scan time to acquire the fully sampled 3D data set. To solve this problem, we applied a parallel imaging method (GRAPPA) and verify the reliability of using the volumetric study. Materials and methods : Six healthy volunteers (3 males and 3 females; age $25.33{\pm}2.25$ years) underwent MRI using the 3D DIR sequence at a 3.0T Siemens Tim Trio MRI scanner. GRAPPA simulation was performed from the fully sampled data set for reduction factor 2. Data reconstruction was performed using MATLAB R2009b. Freesurfer v.4.3.0 was used to evaluate the cortical thickness of the entire brain, and to extract white matter information from the DIR image, Analyze 9.0 was used. The global cortical thickness estimated from the reconstructed image was compared with reference image by using a T-test in SPSS. Results : Although reduced SNR and blurring are observed from the reconstructed image, in terms of segmentation the effect was not so significant. The volumetric result was validated that there were no significant differences in many cortical regions. Conclusion : This study was performed with DIR image for a volumetric MRI study. To solve the long scan time of 3D DIR imaging, we applied GRAPPA algorithm. According to the results, fast imaging can be done with reduction factor 2 with little loss of image quality at 3.0T.

• Journal of the Korean School Mathematics Society
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• v.14 no.3
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• pp.261-275
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• 2011

Seok-Jung Choi's Jisuguimundo mentioned as a brilliant legacy in the history of Korean mathematics had been cloaked in mystery for 300 years. In the meantime there has been some efforts to find solutions, and some particular answers were found, but no one achieved full success mathematically. By the way, H-alternating method showed that to find solutions of Jisuguimundo is possible, even though that method restricted magic number to 88~92 and 94~98. In this paper, $n{\times}n$ Jisuguimundo is defined, and it is showed that finding solutions of it is always possible in case of partition $({\upsilon}+1)+{\upsilon}+({\upsilon}+1)$ & co-partition ${\upsilon}+({\upsilon}+1)+{\upsilon}$, partition $({\upsilon}+1)+({\upsilon}-1)+({\upsilon}+1)$ & co-partition $({\upsilon}-1)+({\upsilon}+1)+({\upsilon}-1)$, partition $({\upsilon}+1)+({\upsilon}+2)+({\upsilon}+1)$ & co-partition $({\upsilon}+2)+({\upsilon}+1)+({\upsilon}+2)$, and partition $({\upsilon}+1)+({\upsilon}+3)+({\upsilon}+1)$ & co-partition $({\upsilon}+3)+({\upsilon}+1)+({\upsilon}+3)$. And It is suggested to find solutions of $n{\times}n$ Jisuguimundo could be used as a task for problem solving.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.29-29
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• 2011

SWAT (Soil and Water Assessment Tool) 모형은 물리적 기반의 준분포형 강우-유출 모형으로서, 대규모의 복잡한 유역에서 장기간에 걸친 다양한 종류의 토양과 토지이용 및 토지관리 상태에 따른 유출과 유사 및 오염물질의 거동에 대한 토지관리 방법의 영향을 예측이 가능하여, 수자원 관리 계획 및 유역관리를 위한 의사결정 지원 등 그 적용 범위가 매우 광범위하다. 이러한 모형의 적용성 검증을 위해서는 매개변수 민감도 분석 및 검 보정, 예측 불확실성 분석을 필요로 한다. 최근 수문 모델의 불확실성을 분석하기 위한 다양한 기법들이 개발 되었는데, 본 연구는 충주댐 유역(6,581.1 m)을 대상으로 유역출구점의 실측 일 유출량 자료(1998~2003)를 바탕으로 SWAT 모형의 유출관련 매개변수(총 18개)에 대한 불확실성 분석을 실시하였다. 이때 사용된 분석 기법으로는 SUFI2 (Sequential Uncertainty FItting algorithm 2), GLUE (Generalized Likelihood Uncertainty Estimation), ParaSol (Parameter Solution)등을 적용 하였다. 이러한 기법은 모두 SWAT-CUP (SWAT-Calibration Uncertainty Program, Abbaspour, 2007) 모형에 탑재되어있으며, 모형의 결과로써 검 보정, 매개변수의 민감도 분석, 각종 목적 함수 및 불확실성의 범위 등이 자동으로 산출 되므로 모형의 사용자가 불확실성 평가 기법의 분석 및 비교를 손쉽게 할 수 있다. 그 결과 대표적인 목적 함수인 결정 계수( $^2$)와 NSE (Nash-Sutcliffe Model Efficiency)는 모두 0.65에서 0.92사이의 값을 나타내어 대체적으로 모의가 잘 이루어졌음을 알 수 있었다. 그러나 불확실성의 범위를 나타내는 지표인 p-factor 및 r-factor에서는 평가 기법 별로 그 차이가 확연하게 드러났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위로 각각 1과 0에 가까울수록 모의 기법의 성능이 우수함을 의미한다. 세 가지 알고리듬 중에서 SUFI2의 p-factor가 약 0.51로 가장 높게 나타났으며, ParaSol의 r-factor가 0.00으로 가장 작게 나타났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위를 의미한다. 본 연구의 결과는 SWAT 모형을 이용한 수문모델링에서 수문분석에 따른 예측결과의 불확실성을 정량적으로 평가함으로서, 모형의 적용성 평가 및 모의결과의 신뢰성 확보에 근거자료로 활용이 가능할 것으로 판단된다.

• The KIPS Transactions:PartD
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• v.13D no.4 s.107
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• pp.513-524
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• 2006

Normalization transform is very useful for finding the overall trend of the time-series data since it enables finding sequences with similar fluctuation patterns. The previous subsequence matching method with normalization transform, however, would incur index overhead both in storage space and in update maintenance since it should build multiple indexes for supporting arbitrary length of query sequences. To solve this problem, we propose a single index approach for the normalization transformed subsequence matching that supports arbitrary length of query sequences. For the single index approach, we first provide the notion of inclusion-normalization transform by generalizing the original definition of normalization transform. The inclusion-normalization transform normalizes a window by using the mean and the standard deviation of a subsequence that includes the window. Next, we formally prove correctness of the proposed method that uses the inclusion-normalization transform for the normalization transformed subsequence matching. We then propose subsequence matching and index building algorithms to implement the proposed method. Experimental results for real stock data show that our method improves performance by up to $2.5{\sim}2.8$ times over the previous method. Our approach has an additional advantage of being generalized to support many sorts of other transforms as well as normalization transform. Therefore, we believe our work will be widely used in many sorts of transform-based subsequence matching methods.

• The KIPS Transactions:PartD
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• v.9D no.6
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• pp.1017-1024
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• 2002

According as mobile computing environment is generalized by development of wireless networking technology and communication device, mobile host uses local cache for extensibility and early response time. and reduction of limited bandwidth. This time, between mobile host and mobile support station cache need consistency interested person of done data accordingly much techniqueses propose. Existent consistency techniques because detection based techniqueses are used mainly and broadcast periodic invalid message considering frequent disconnection. However, these techniqueses increase abort step through increase or delay of transmission message number by accuracy examination of data. Therefore, because mobile host deletes cached data, and extensity are decreased. Techniques that is proposed in this paper did to perform refering update frequency about object that page request or when complete update operation happens to solve these problem. Therefore, have advantage that response is fast because could run write intention declaration or update by update frequency electively asynchronously when update operation consists and abort step decreases. Also, improved extensity running delete or propagation electively according to update frequency about periodic invalid message gone since disconnection.