• 한국도서관정보학회지
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• 제35권3호
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• pp.293-319
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• 2004

이 연구는 우리나라 최초의 관립도서관이며 국립중앙도서관의 전신인 조선총독부도서관에서 사용한 분류표에 관한 것이다. 조선총독부 도서관 분류표는 신서부, 고서부, 양서부의 세 개 분류표를 편찬하여 사용하였다. 이에 이 연구는 일제강점기 당시 관립도서관이었던 조선총독부도서관분류표의 특징에 대해 분석하였다. 또한 조선총독부 도서관 분류표와 관련 있는 분류표를 비교 분석하여 그 영향관계를 파악하였다.

• 한국발생생물학회지:발생과생식
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• 제15권1호
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• pp.61-69
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• 2011

Previously, we have shown that Bcl2l10 as a member of Bcl-2 family, key regulators of the apoptotic process, is dominantly expressed in oocytes of ovary but several member of the Bcl-2 family are not expressed in oocytes. Recent our studies had been processed about roles and regulatory mechanisms of Bcl2l10 in oocytes. Microinjection of Bcl2l10 RNAi into the cytoplasm of germinal vesicle oocytes resulted in metaphase I (MI) arrest and exhibited abnormalities in their spindles and chromosome configurations (Yoon et al., 2009). The present study was conducted to elucidate the downstream genes regulated by Bcl2l10 and signaling networks in Bcl2l10 RNAi microinjected oocytes by using microarray analysis. Surprisingly, we found that a large proportion of genes regulated by Bcl2l10 RNAi were involved in the cell cycle and actin skeletal system regulation as important upstream genes of Bcl2l10. Among the transcripts with highly significant fold changes more than 2-fold, Tpx2 and Cep192 are 16.1- and 8.2-fold down regulated respectively by Bcl2l10 RNAi. Tpx2 and Cep192 are known as cofactors that control Aurora A kinase activity and localization. Therefore, we concluded that Bcl2l10 may have important roles during oocyte meiosis as functional upstream regulator of Tpx2 and Cep192.

• 한국과학교육학회지
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• 제32권5호
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• pp.866-878
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• 2012

자연과학고는 자연과학과 관련된 직업 교육을 특성화한 고등학교이며 자연과학고 학생들은 높은 수준의 과학 동기가 요구된다. 이 연구는 자연과학고 학생들과 일반 고등학교의 학생들의 과학 동기의 수준과 구조를 비교 분석하기 위해 진행되었다. 이 연구를 위해서 자연과학고 학생 193명, 일반고 학생들은 208명이 참여하였다. 참여 학생을 대상으로 직업적 관심, 학습내용의 관련성 인식, 과학 점수 동기, 과학 수업의 필요성, 과학 수업에 대한 자기 의지, 자아 효능감, 과학수업의 즐거움의 7개 변인의 수준과 구조를 비교하였다. 연구 결과 자연과학고 학생들은 일반 고등학교 학생들에 비하여 7개 동기 요소 모두 낮은 수준을 보였다. 특히 과학 점수 동기와 과학 수업의 즐거움에서 가장 큰 차이가 나타났다. 7개 변인간 경로 분석의 결과는 자연과학고 학생들의 일반 고등학교 학생들에 비하여 직업에 대한 관심이 수업에 대한 자기 의지에 대한 영향력이 더 높았으며, 과학 점수에 대한 동기가 수업의 대한 의지와 자아 효능감에 미치는 영향력이 더 높았다. 자연과학고 학생들의 수업에 대한 자기 의지와 자아 효능감에 관련된 변인의 설명력은 일반 고등학교에 비하여 약 30%가 높았다. 이 결과는 자연과학고 학생들의 과학 동기 구조는 일반 학생들에 비하여 상대적으로 보다 명확하며, 직업에 대한 관심과 과학 점수동기와 같은 외적 동기 요소에 큰 영향력이 있었다.

• Journal of the Korean Data and Information Science Society
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• 제25권3호
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• pp.623-632
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• 2014

We shall consider the estimation for the parameter and the right tail probability in a general exponential distribution. We also shall consider the estimation of the reliability P(X < Y ) and the skewness trends of the density function of the ratio X=(X+Y) for two independent general exponential variables each having different shape parameters and known scale parameter. We then shall consider the estimation of the failure rate average and the hazard function for a general exponential variable having the density function with the unknown shape and known scale parameters, and for a bivariate density induced by the general exponential density.

• 지역연구
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• 제14권2호
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• pp.77-83
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• 1998

• 한국지구과학회지
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• 제28권3호
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• pp.289-297
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• 2007

본 연구의 목적은 과학영재아의 기질특성을 분석하고 이 기질 특성이 시험불안과 어떤 관계가 있는가를 알아보는 것이다. 연구대상은 대학부설과학영재교육원에서 교육받고 있는 92명의 중학생 과학영재아들과 97명의 전주시내에 소재한 중학교 1학년 일반아들이다. 측정도구는 개정판기질차원척도(Revised Dimensions of Temperament Survey: DOTS-R)를 사용하였다. 연구결과 과학영재아는 일반아에 비하여 집중성, 지속성 및 접근성 기질이 높게 나타났다. 이에 비하여 일반집단은 활동성, 융통성, 긍정성 기질이 높게 나타났다. 또한 영재아와 일반아의 우세기질에 대한 검증 결과 기질 특성에 유의한 차이가 있었는데 과학영재집단은 지속성 기질이, 일반집단은 융통성 기질이 우세기질로 나타났다. 과학영재아와 일반아의 기질 특성과 시험불안의 상관관계분석에서 과학영재아는 접근성, 지속성이 부적상관을 보였고, 일반집단은 집중성이 부적상관을 보였으며, 활동성은 두 집단 모두에서 정적상관을 보였다. 즉 활동성 기질은 시험불안을 높이는 요인으로 작용하고 있는 것으로 나타났다. 연구결과는 과학영재아를 판별하기 위한 목적보다는 그들의 기질적 특성을 최대한 파악하여 과학영재의 기질특성에 맞는 학습활동을 제공하는데 활용되어져야 할 것이며 연구결과의 일반화를 위하여 대상범위를 확대할 필요가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6351-6356
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• 2013

Background: Goshajinkigan (GJG) is used for the treatment of several neurological symptoms. We investigated the efficacy of GJG and mecobalamin (B12) against neurotoxicity associated with docetaxel (DOC) in breast cancer patients. Materials and Methods: Sixty breast cancer patients were treated with DOC. Thirty-three patients (GJG group) received oral administration of 7.5 g/day GJG and 27 patients (B12 group) received oral administration of 1500 ${\mu}g/day$ B12. Neuropathy was evaluated according to DEB-NTC (Neurotoxicity Criteria of Debiopharm), Common Terminology Criteria for Adverse Events (NCI-CTC) ver. 3.0, and a visual analogue scale (VAS). This study employed a randomized open design. Results: The incidence of neuropathy was 39.3% in the GJG group, and 88.9% in the B12 group (p<0.01). In the GJG group, grade 1 DEB-NTC was observed in 2 cases, grade 2 in 5 cases and grade 3 in 5 cases. Grade 1 NCI-CTC was observed in 7 cases, grade 2 in 6 cases, and VAS was $2.7{\pm}2.2$. In the B12 group, grades 1, 2 and 3 DEB-NTC were observed in one case, 12 cases and 12 cases, respectively; and grades 1, 2 and 3 NCI-CTC were observed in 11 cases, 12 cases and one case, and VAS was $4.9{\pm}2.4$. Conclusions: Concomitant administration of GJG is useful in preventing neuropathy in breast cancer patients treated with a DOC regimen.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4835-4838
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• 2013

Background: We compared treatment completion rates and safety of docetaxel and cyclophosphamide sixcycle therapy (TC6) with docetaxel followed by 5FU, epirubicin and cyclophosphamide (T-FEC) therapy in Japanese patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Materials and Methods: We administered TC6 q3w or T-FEC q3w to HER2-negative breast cancer patients. The primary endpoint of this trial was toxicity. As second endpoints, the treatment completion rate and relative dose intensity were evaluated. Results: The TC6 and T-FEC group consisted of 22 and 21 patients, respectively. Concerning hematological toxicity, grade 3 or higher adverse reactions included neutropenia and febrile neutropenia. As non-hematological adverse events, exanthema and peripheral neuropathy were frequently reported in the TC6 group, whereas more patients of the T-FEC group reported nausea and vomiting. In TC6, the treatment completion rate was 86.4% and the relative dose intensity of docetaxel was 93.2%. In T-FEC, the values were 95.2% and 98.9%, respectively. Conclusions: These results suggest that TC6 is tolerable in Japanese, and that this regimen can also be performed in outpatient clinics. However, with the TC6 regimen, the compliance was slightly lower than with the T-FEC regimen, and supportive therapy needs to be managed appropriately.

• Journal of Korean Biological Nursing Science
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• 제26권1호
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• pp.60-69
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• 2024

Purpose: This descriptive research study attempted to determine how general hospital nurses' awareness of the importance of patient safety management and patient safety competency affected patient safety management activities. Methods: From September 13 to 26, 2022, a survey was administered to 230 ward nurses who provided direct care to patients at five non-accredited general hospitals being evaluated for accreditation located in metropolitan cities. The collected data were analyzed with descriptive statistics, the t-test, one-way analysis, the Scheffé test, Pearson correlation coefficients, and hierarchical regression using SPSS for Windows version 26.0. Results: In total, 221 (96.1%) respondents were female. The average age was 32.2 years, and the average clinical experience was 3.5 years; 196 participants (85.2%) were general nurses. Patient safety competency (β = .44, p < .001), awareness of the importance of safety management (β = .31, p < .001), and medication error experience (β = -.15, p = .002) all had statistically significant associations with patient safety management activities. The explanatory power of these variables for patient safety management activities was 50.7%. Conclusion: This study confirmed that patient safety competency, awareness of the importance of patient safety management, and experience with medication errors significantly influenced patient safety management activities.

• Journal of Computing Science and Engineering
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• 제2권2호
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• pp.162-179
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• 2008

We have developed a tool for annotation of electronic health record (EHR) data. Currently we are in the process of manually annotating a corpus of Norwegian general practitioners' EHRs with mainly linguistic information. The purpose of this project is to attain a linguistically annotated corpus of patient histories from general practice. This corpus will be put to future use in medical language processing and information extraction applications. The paper outlines some of our practical experiences from developing such a corpus and, in particular, the effects of semi-automated annotation. We have also done some preliminary experiments with part-of-speech tagging based on our corpus. The results indicated that relevant training data from the clinical domain gives better results for the tagging task in this domain than training the tagger on a corpus form a more general domain. We are planning to expand the corpus annotations with medical information at a later stage.