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Low-frequency Mosaicism of Trisomy 14, Missed by Array CGH

  • Lee, Cha Gon;Yun, Jun-No;Park, Sang-Jin;Sohn, Young Bae
    • Journal of Genetic Medicine
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    • v.10 no.1
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    • pp.52-56
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    • 2013
  • Mosaic trisomy 14 syndrome is a well-known but unusual chromosomal abnormality with a distinct and recognizable phenotype. Array comparative genomic hybridization (CGH) analysis has recently become a widely used method for detecting DNA copy number changes, in place of traditional karyotype analysis. However, the array CGH shows a limitation for detecting the low-level mosaicism. Here, we report the detailed clinical and cytogenetic findings of patient with low-frequency mosaic trisomy 14, initially considered normal based on usual cut-off levels of array CGH, but confirmed by G-banding karyotyping. Our patient had global developmental delay, short stature, congenital heart disease, craniofacial dysmorphic features, and dark skin patches over her whole body. Estimated mosaicism proportion was 23.3% by G-banding karyotyping and 18.0% by array CGH.

Generation of Constant Orientation in Industrial Robots (산업용 로봇의 일정한 방향성 생성)

  • 이승황;양승한;박용국
    • Transactions of the Korean Society of Machine Tool Engineers
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    • v.10 no.2
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    • pp.95-102
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    • 2001
  • In general there are many degrees of freedom(DOFs) in industrial robots. So they have many poses of several special end-effectors positions and orientations. For that reason, industrial robots are used in a wide scope of industrial applica-tions such as welding, spray painting, deburring, and so on. In this research, an off-line continuous path planning method based on linear interpolation with parabolic blend is developed. The method safely maintains the constant orientation for base frame and end-effectors path within allowable error and minimizes the number of segments in path. This algorithm may apply to welding and painting in which the orientation is particularly significant. The simulation study of cartesian curve is carried out to show the performance of this algorithm.

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Development of Simulation Program for Tilt Rotor Aircraft (틸트로터 항공기 비선형 시뮬레이션 프로그램 개발)

  • Yoo, Chang-Sun;Choi, Hyung-Sik;Park, Bum-Jin;Ahn, Sung-Jun;Kang, Young-Shin
    • Journal of Institute of Control, Robotics and Systems
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    • v.11 no.3
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    • pp.193-199
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    • 2005
  • VTOL(Vertical Take-Off and Landing) aircraft is attractive due to the reason that it is not necessary to have long runway. However a rotorcraft has a definite limitation to fly at the high speed due to the stall at the tip of rotor. To solve this problem, tilt rotor, tilt wing and lift fan were researched and developed. It was verified that the tilt rotor aircraft among them was more effective in disk loading. On this basis, the tilt rotor aircraft has been made into XV-15, V-22, BA-609 and Eagle Eye. This paper shows a nonlinear simulation program for general tilt rotor aircraft that was developed in order to validate the flight characteristics of tilt rotor aircraft and verified through the simulation analysis.

An Implementation of I/O Interface System for Power Plant Simulator (발전소 시뮬레이터 I/O 인터페이스 시스템 구축에 관한 연구)

  • 변승현;장태인;조지용;곽귀일
    • Proceedings of the IEEK Conference
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    • 1999.06a
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    • pp.773-776
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    • 1999
  • For providing good quality power steadily, it is required that operators manipulate the control system of power plant with the good knowledge of power plant system and the control strategies, and cope with accidents effectively. With those requirements, it is general to train operators in power plant control room using full-scope simulator. A full scope simulator adopts the I&C instruments in the main cotrol room, so has to include I/O interface system to interface the simulation computer with I&C instruments in main control room. In already developed simulators, most of I/O interface systems are closed. vendor-dependent. proprietary systems. so have the many disadvantages in terms of cost and maintenance. In this paper. we suggest the method to configure I/O interface system for Thermal Power Plant Simulator based on standard technology which gives the advantages of ease-of-use. cost effectiveness, and simplicity of maintenanceuse by using off-the-shelf products for system integration.

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Strategy to Maintain the Smith Predictor Controller in the District Heating System for Apartment Buildings (지역난방 공동주택 시스템에서 Smith Predictor 제어기 적용성 연구)

  • Jung, Sang-Hoon;Moon, Youn-Jin;Ha, Jae-Sun;Cho, Sung-Hwan
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1025-1030
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    • 2009
  • It is known that the classical tuning formula for typical PID controllers in general provides unsatisfactory results for industrial plants where the time delay exceeds the dominant lag time. For this reason, alternative strategies have been studied in order to cope with this problem and the most popular scheme is the Smith Predictor(SP). In this paper, the dynamic model of a unit apartment in the district heating system, which is the control process effected by the dead-time, is developed, and the on/off room temperature control method with the SP simulate using Matlab-Simulink. The simulation results show that the SP works effectively in outdoor temperature variation.

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An Experimental Study on Flexural Repair of Reinforced Concrete Beams with the CFRP Sheet (탄소섬유시트를 사용한 철근콘크리트 구조물의 휨 보강에 관한 실험적 연구)

  • 박정원;박상렬;민창식
    • Proceedings of the Korea Concrete Institute Conference
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    • 2000.04a
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    • pp.781-786
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    • 2000
  • This paper presents the behavior and strenghening effect of reinforced concrete rectangular beams strengthened sing CFRP sheets with different strengthening level. In general, normally strengthened beams are failed by interfacial shear failure (delamination) within concrete, instead of by tensile failure of the CFRP sheets. The delamination occurred suddenly and the concrete cover cracked vertically by flexure was spalled off due to the release energy. The ultimate load considerably increased with an increase of strengthening level, while the ultimate deflection significantly decreased. The tensile force of CFRP sheets and average shear stress of concrete at delamination failure were curvilinearly proportional to the strengthening level. Therefore, the increment of ultimate load obtained by strengthening was curvilinearly proportional to th strengthening level.

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Performance and flow field assessment of settling tanks using experimental and CFD modeling

  • Nouri, Alireza Zamani;Heydari, Mohammad Mehdi
    • Membrane and Water Treatment
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    • v.8 no.5
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    • pp.423-435
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    • 2017
  • Settling Basins are one of the most important and popular methods for removal of suspended sediments irrigation and drainage networks or power canals taking off from an alluvial river and wastewater treatment plant. Improving the performance and so increasing sediment removal efficiency of settling basins by an alternative method is necessary. In the present work, the effect of baffle and its angle of attack with the flow (${\theta}$) on the sediment removal efficiency is investigated by conducting a series of experiments on a straight canal with 8 m length, 0.3 m width and 0.5 m height and 3 m length of basin equipped with an adjustable glass baffle. A numerical analysis has been carried out using ANSYS Fluent 3D software (a general purpose computational fluid dynamics simulation tool) for three Froude numbers from the experiments. The numerical and experimental results were found to match reasonably well.

A study on Adaptive Multi-level Median Filter using Direction Information Scales (방향성 정보 척도를 이용한 적응적 다단 메디안 필터에 관한 연구)

  • 김수겸
    • Journal of Advanced Marine Engineering and Technology
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    • v.28 no.4
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    • pp.611-617
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    • 2004
  • Pixel classification is one of basic image processing issues. The general characteristics of the pixels belonging to various classes are discussed and the radical principles of pixel classification are given. At the same time. a pixel classification scheme based on image direction measure is proposed. As a typical application instance of pixel classification, an adaptive multi-level median filter is presented. An image can be classified into two types of areas by using the direction information measure, that is. smooth area and edge area. Single direction multi-level median filter is used in smooth area. and multi-direction multi-level median filter is taken in the other type of area. What's more. an adaptive mechanism is proposed to adjust the type of the filters and the size of filter window. As a result. we get a better trade-off between preserving details and noise filtering.

Effective Performance Prediction of Axial Flow Compressors Using a Modified Stage-Stacking Method (단축적법의 개선에 의한 축류압축기의 효과적인 성능예측)

  • Song, Tae-Won;Kim, Jae-Hwan;Kim, Tong-Seop;Ro, Sung-Tack
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.24 no.8
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    • pp.1077-1084
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    • 2000
  • In this work, a modified stage-stacking method for the performance prediction of multi-stage axial flow compressors is proposed. The method is based on a simultaneous calculation of all interstage variables (temperature, pressure, flow velocity) instead of the conventional sequential stage-by-stage scheme. The method is also very useful in simulating the effect of changing angles of the inlet guide vane and stator vanes on the compressor operating characteristics. Generalized stage performance curves are used in presenting the performance characteristics of each stage. General assumptions enable determination of flow path data and stage design performance. Performance of various real compressors is predicted and comparison between prediction and field data validates the usefulness of the present method.

A Study on Chinese Special Regulations Concerning the Maritime Claims

  • Fu, Ting-Zhong;Qiu, Jin
    • Journal of the Korean Institute of Navigation
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    • v.21 no.3
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    • pp.39-47
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    • 1997
  • Under Chinese law system, the maritime law is a special branch of the civil law. For this reason, the maritime litigation shall be governed correspondently by the civil prodecure law. However, since the maritime litigation has its own special prodecure which is different from that of general procedure, there must be some special regulations to be a supplement to the civil procedure law. In this paper, a study is made on such regulations which are "The Regulations Relating to the arrest of Ships Before Litigation" and "The Regulations Concerning the Auction of Ships Which Have Been Arrested by Maritime Court for Clearing off the Debts" The aim of this paper is to describe the basic principles established in the regulations mentioned above in order to make the people who are unfamiliar with Chinese maritime legislation to be understood about Chinese special procedure adopted in maritime litigation.maritime litigation.

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