• Molecules and Cells
• /
• v.28 no.6
• /
• pp.501-507
• /
• 2009

Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein synthesis and other signaling pathways. Previous studies have mostly focused on the roles of FMRP within the hippocampus - a key structure for spatial memory. However, recent studies indicate that FMRP may have a more general contribution to brain functions, including synaptic plasticity and modulation within the prefrontal cortex. In this brief review, we will focus on recent studies reported in the prefrontal cortex, including the anterior cingulate cortex (ACC). We hypothesize that alterations in ACC-related plasticity and synaptic modulation may contribute to various forms of cognitive deficits associated with FXS.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2008.04a
• /
• pp.393-399
• /
• 2008

A modeling method for the modal analysis of a pre-twisted multi-packet blade system undergoing rotational motion is presented in this paper. Blades are idealized as pre-twisted cantilever beams that are fixed to a rotating disc. The stiffness coupling effects between blades due to the flexibilities of the disc and the shroud are modeled with discrete springs. The coupling effect between chordwise and flapwise bending deflection is also considered. Hybrid deformation variables are employed to derive the equations of motion. To obtain more general information, the equations of motion are transformed into dimensionless forms in which dimensionless parameters are identified. The effects of the dimensionless parameters and the number of packets as well as blades on the modal characteristics of the rotating multi-packet pre-twisted blade system are investigated with some numerical examples.

• The Research Journal of the Costume Culture
• /
• v.9 no.2
• /
• pp.207-222
• /
• 2001

This study investigates the chulik of Soo Buen's, Heymjo Kim's, Sooncheon Kim's grave in early Chosun Dynasty. The purpose of this study is to revise concretely the relation to Mongolian costume, Zilsun and Chulik, of the distintion of sex to wearer. This paper reviews the general construction form the excavated graves of them. This paper finds that there exist different Chulik forms according to the ratios between upper portion and lower portion in Early Chosun Dynasty. Eventhough they were a kind of Mongolian costume, in relation to Zilsun(質孫) and Chulik(帖 ) they are different form each other. They have a lot of pleats coat( 積袍), but they are different clothes, and also, even if Chulik were excavated in womens grave, because their husbands presented them to their wives, Chuliks were not women's, and they were used for men.

• The International Journal of Costume Culture
• /
• v.5 no.2
• /
• pp.1-14
• /
• 2002

The first purpose of this research is to investigate the functionalistic concept through the general consideration of Functionalism, and to study the art's aesthetic value of functionalistic expressionist artists implication and form in terms of architecture and product design. Secondly, it analyzes the implication and shape of Functionalism towards 'Art to Wear', which can be explained as a mixture of fashion and art. The results are as follows; First, functionalistic 'Art to Wear' of Mechanical Analogy appears to have futuristic inclination stressing the significance of geometric shapes and machine aesthetics. It uses new materials, and reduce an unnecessary work of art to convey more accurate, concrete and effective character of form. Secondly, functionalistic 'Art to Wear' of Organic Analogy regards natural elements as important to pursue the warm human nature. Also, it appears to be free and comforting forms of Functionalism through an organic silhouette. Thirdly, functionalistic 'Art to Wear' of Moral Analogy excludes excessive ornaments, and includes the implication of appropriate and purposive purity which serves for practical function.

• Journal of Institute of Control, Robotics and Systems
• /
• v.6 no.4
• /
• pp.276-284
• /
• 2000

In this paper, the genetic algorithm is used to design a mixed H₂/ H/sub ∞/ controller Two kinds of controller forms, Youla's form and the general form, are considered to design a mixed H₂/ H/sub ∞/ controller. Efficient searching methods are sought to minimize the given H₂cost function under the H∞ constraint. It is verified by an example that the developed algorithm can provide stable results in the region where unstable results are shown by the conventional gradient method.

• Journal of the Korea Furniture Society
• /
• v.26 no.4
• /
• pp.301-313
• /
• 2015

This study purposes on continuing experimental research of furniture form creation focused on the importance and necessity for a-formal concept for designers to drift away from general acknowledgement and practice routine to design more radical forms for meeting various needs of late industrialized society, which have not been satisfied with formal and universal designs. This study covers presenting new points of view on research for designers to look for different solutions to widen their consideration in the process of furniture form development and to set up academic data base with the case studies of designers in anti-construction concept to define their experimental challenges for new design form creation, on the basis of overall research on the effects and roles of a-formal approach in the furniture design form creation.

• Journal of the Korean Society for Precision Engineering
• /
• v.6 no.4
• /
• pp.84-93
• /
• 1989

This paper describes some development of Computer-Aided Process Planning System for cold-forging of rotationally symmetric parts(soild shape and solid-can combined shape) produced by the presses or formers. Using the developed system, forming sequences for producing final product are generated as graphic forms and process names, preform dimensions and process parameters(load, punch pressure, die pressure) are generated as routing sheets. Konwledges for forming sequence and process parameters are extracted from process limitations, plasticity theories, handbooks, relevent refferences and empirical know-how of experts in cold forging companies. Among extracted knowldeges, general and consistent knowledges are represented as design rules and are constructed as knowledge base. The developed system provides more powerful tool for through checking the producibilities of design, conformation of appropriate forming sequences and discoveries of new possibility. The results of the developed system are in good agreement with the practical data.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 1999.03b
• /
• pp.45-48
• /
• 1999

A program for initial blank design in sheet forming which contains the capabilities of forward loading simulation by the finite element method and backward tracking simulation has been developed and proved the effectiveness by applying to a square cup stamping process. In the blank design of square cup stamping the backward tracing program can produce an optimum blank configuration which forms a sound net-shape cup produce without machining after forming. Another general application appears in the blank design of a cup stamping with protruding flanges one of typical automobile components. The blank configurations derived by backward tracing simulation have been confirmed by a series of loading simulations. The approach for decision of an initial blank configuration presented in this study will be a milestone in fields of sheet forming process design.

• 한국데이터정보과학회:학술대회논문집
• /
• 2006.04a
• /
• pp.121-129
• /
• 2006

Two color or cDNA microarrays are extensively used to study relative expression levels of thousands of genes simultaneously. 0かy two tissue samples can be hybridized on a single microarray slide. Thus, a microarray slide necessarily forms an incomplete block design with block size two when more than two tissue samples are under study. We also need to control for variability in gene expression values due to the two dyes. Thus, red and green dyes form the second blocking factor in addition to slides. General design problem for these microarray experiments is discussed in this paper. Designs for factorial cDNA microarrays are also discussed.

• International Journal of Costume and Fashion
• /
• v.8 no.1
• /
• pp.75-84
• /
• 2008

This paper starts with the assumption that in order for hanbok to be made known to the world as a cultural code representing Korean beauty, it must first be made familiar among Koreans with opportunities for widespread use of hanbok in a way which forms an understanding with the fashion sense of young generations, and that wearing hanbok must be promoted. We observe the contents and problems of past hanbok festivals and provide methods to promote the wearing of hanbok among the population, creating an occasion for mingling with various cultures in hanbok events which may be experienced by the general population, and developing hanbok as a tourist item and promoting the hanbok industry through standardized hanbok festivals. Globalization of hanbok most occur through a combination of related academic fields, division of roles in fields of expertise, and a scientific understanding of hanbok. The re-creating of traditional hanbok will allow for affirmation of Korean image, a rediscovery of the value of Korean culture, and the establishment of cultural identity. The development of such global designs will form a foundation for hallyu wave culture within popular culture.