• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.203-217
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• 2019

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide dismutase [SOD] and glutathione [GSH]), and expression of heat shock protein (Hsp) 70 and connexin 43 (Cx-43) in myocardial muscles in isoproterenol (ISO) induced myocardial infarction (MI). Thirty two adult male Sprague Dawely rats were divided into 4 groups (each 8 rats): normal control (NC) group, ISO group: received ISO at dose of 150 mg/kg body weight intraperitoneally (i.p.) for 2 successive days; ISO + Trizma group: received (ISO) and Trizma (solvent of CoPP) at dose of 5 mg/kg i.p. injection 2 days before injection of ISO, with ISO at day 0 and at day 2 after ISO injections; and ISO + CoPP group: received ISO and CoPP at a dose of 5 mg/kg dissolved in Trizma i.p. injection as Trizma. We found that, administration of ISO caused significant increase in heart rate, corrected QT interval, ST segment, cardiac enzymes (lactate dehydrogenase, creatine kinase-muscle/brain), cardiac HO-1, Hsp70 with significant attenuation in myocardial GSH, SOD, and Cx-43. On the other hand, administration of CoPP caused significant improvement in ECG parameters, cardiac enzymes, cardiac morphology; antioxidants induced by ISO with significant increase in HO-1, Cx-43, and Hsp70 expression in myocardium. In conclusions, we concluded that induction of HO-1 by CoPP ameliorates ISO-induced myocardial injury, which might be due to up-regulation of Hsp70 and gap junction protein (Cx-43).

• 문화기술의 융합
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• 제7권2호
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• pp.389-394
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• 2021

본 연구에서는 알콕시-아민-알루미늄 유도체인 DPHMP-AlH와 프로피오페논, 부티로페논과의 분자구조 및 경계궤도함수의 특성을 알아보았다. 또한, 전이상태의 입체구조 및 열역학적 파라미터를 계산하여 최종 생성물인 (R),(S)-페닐프로판올과 (R),(S)-페닐부탄올의 선택적 환원에 미치는 영향을 조사하였다. 그 결과 입체 분자구조적 안정성을 고려해 볼 때 (S)형 DPHMP-AlH와 알킬페논의 전이상태가 더 안정한 것으로 나타났으며, 이 결과로부터 DPHMP-AlH와 알킬페논의 선택적 환원으로 얻어진 최종 결과물은 (S)-(1)-페닐프로판올과 (S)-(1)-페닐부탄올의 형성이 유리한 것을 확인하였다.

• 한국융합학회논문지
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• 제12권2호
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• pp.29-34
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• 2021

본 논문에서는 중심에 동공을 갖는 원통형태 광결정 도파로가 제안되어지고, 이 전송로의 도파 특성에 대한 분석이 수행되어진다. 여기서 동공은 일반적인 공기이거나 임의의 액체나 고체 물질들에 의한 저지수 유전체로써 형성되게 된다. 베셀 함수를 이용한 분석적 방법으로 전자장에 대한 엄밀한 해를 구하기 위하여, 행렬 기법이 고유치 방정식의 유도에 사용되고, 실효 굴절률, 분산, 전자장 분포 등의 기본 모드의 중요한 전송 성질들이 조사된다. 또한 분석 결과 정확도의 검증을 위하여 엄밀한 완전 벡터 유한 차분법을 적용해보고, 광결정 도파로의 설계와 제조 상의 문제를 해결하는데 용이하게 활용하고자 한다. 설계된 중심-동공 광도파관의 실효 모드 면적이 2.6056 ㎛2에서 5.9673 ㎛2까지 동작 파장에 따라 다양하게 변하며, 일반적으로 광도파로의 중심으로부터 바깥쪽으로 원통형의 층수가 적을수록 그리고 굴절률 n1이 약간 큰 저지수일수록 실효 면적은 작아지므로, 비선형 소자 응용의 관점에서 훨씬 더 최적화된 결과를 나타낸다.

• 인간식물환경학회지
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• 제23권1호
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• pp.47-53
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• 2020

This study conducted a horticultural therapy program for trainees entrusted to the Juvenile Classification Review Center in order to fill the educational gap while providing emotional stability during the one-month period of commissioned education. The effects of horticultural therapy were examined by the pretest and posttest changes of the emotional items such as anxiety, self-esteem, self-efficacy and stress index. As the research method, this study used the one-group pretest-posttest experimental design on 16 female trainees of commissioned education staying at the Juvenile Classification Review Center in the juvenile reformatory located in A city. The horticultural therapy program was carried out in four sessions: two on flower arrangement and two on planting. The scores before and after the horticultural therapy program were measured using the Revised Children's Manifest Anxiety Scale (RCMAS) to examine the effects of horticultural therapy on the reduction of anxiety for the adolescents staying in the Juvenile Classification Review Center. The results show that there was significant decrease in the mean of anxiety from 62.5 (SD = 6.8) to 57.6 (SD = 8.1) points after the program (p = .002). There was no significant change in self-esteem, which was 76.9 (SD = 11.2) before the horticultural therapy and 78.3 (SD = 8.7) after the therapy (p = .420). In self-efficacy, there was no significant change from 72.9 (SD = 10.9) before and 75.1 (SD = 11.0) after horticultural therapy (p = .178). In order to examine the physiological changes in such emotional functions, this study measured the stress index using the uBioMacpa as the tool. The result of the measurement showed that there was a significant change in the mean from 33.8 (SD = 2.3) before to 31.1 (SD = 2.2) after the horticultural therapy (p < .001).

• 디지털융복합연구
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• 제19권8호
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• pp.173-184
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• 2021

현대 조직에서 고위급 임원들의 이직이 점차 증가하고 있음에도, 대부분의 기존 연구들에서는 임원들의 비자발적 이직/퇴직의 함의에 대한 연구에 치중해있는 실정이다. 본 연구에서는 기존 연구의 한계를 탈피하기 위해, 조직원 이동과 창업자 연구에 기반하여 임원들의 자발적 이직에 관한 이론적 모형을 제언한다. 첫째, 최고경영자로 창업자가 된 경우 기존 기업에 부정적 영향을 줄 것이나, 두 기업이 협력적 관계가 형성될수록 부정적 관계는 줄어들 것이다. 둘째, 스핀오프의 경우 기존 기업에 긍정적 영향을 줄 것이나, 스핀오프 기업의 성과가 저조할수록 긍정적 관계는 약화될 것이다. 마지막으로, 경쟁사로 이직하는 경우에는 부정적, 협력사로 이직하는 경우에는 긍정적 영향을 기존 기업의 성과에 줄 것이다. 본 연구에서는 임원들의 자발적 이직이 기존 기업의 성과에 미치는 영향력이 임원들의 향후 활동 양태에 따라 달라질 것이라 주장한다.

• Steel and Composite Structures
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• 제45권3호
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• pp.389-408
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• 2022

Residual capacity is defined as the load carrying capacity of an RC column after undergoing severe damage. Evaluation of residual capacity of RC columns is necessary to avoid damage initiation in RC structures. The central aspect of the current research is to propose an empirical formula to estimate the residual capacity of RC columns after undergoing severe damage. This formula facilitates decision making of whether a replacement or a repair of the damaged column is adequate for further use. Available literature mainly focused on the simulation of explosion loads by using simplified pressure time histories to develop residual capacity of RC columns and rarely simulated the actual explosive. Therefore, there is a gap in the literature concerning general relation between blast damage of columns with different explosive loading conditions for a reliable and quick evaluation of column behavior subjected to blast loading. In this paper, the Arbitrary Lagrangian Eulerian (ALE) technique is implemented to simulate high fidelity blast pressure propagations. LS-DYNA software is utilized to solve the finite element (FE) model. The FE model is validated against the practical blast tests, and outcomes are in good agreement with test results. Multivariate linear regression (MLR) method is utilized to derive an analytical formula. The analytical formula predicts the residual capacity of RC columns as functions of structural element parameters. Based on intensive numerical simulation data, it is found that column depth, longitudinal reinforcement ratio, concrete strength and column width have significant effects on the residual axial load carrying capacity of reinforced concrete column under blast loads. Increasing column depth and longitudinal reinforcement ratio that provides better confinement to concrete are very effective in the residual capacity of RC column subjected to blast loads. Data obtained with this study can broaden the knowledge of structural response to blast and improve FE models to simulate the blast performance of concrete structures.

• 한국재난정보학회 논문집
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• 제19권2호
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• pp.254-261
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• 2023

연구목적: 이 연구는 탐정제도를 합법화하기 위하여 현재 대치 중인 문제에 대하여 살펴보고 해결방안을 제시하기 위한 목적을 가진 연구이다. 연구방법: 이 연구의 목적을 달성하기 위하여 탐정분야의 선행연구 및 통계자료 등을 분석하고 대치중인 문제에 대하여 논리적으로 해결방안을 제시하였다. 연구결과: 신뢰를 해결하기 위해서 불법적인 수단을 가리지 않는 민간조사업체가 늘어나면서 이에 대해 관리·감독하고 더불어 공권력의 공백을 보충해줄 공인탐정제도를 도입하고자 하는 시도가 생겨났다. 그러나, 공인탐정제도의 입법공인탐정업의 성격상 변호사, 신용조사업 등 기존의 직역을 담보하는 근거법률과의 상충문제와 공인탐정제도를 관리·감독하여야 하는 주무관청의 선정문제에서 경찰청과 법무부가 대립하는 등 입법시도 중 여러 문제를 수반하면서 입법이 진전되지 않은 상태이다. 결론: 이에 본 연구에서는 공인탐정 제도에 대해 그동안 국회에 제출되었던 공인탐정업 관련 법안에 대해 분석한 후 공인탐정업의 업무범위, 관리·감독 주무관청 선정 등 주요쟁점에 대해 살펴보고 공인탐정제도의 성공적 안착을 위한 개선방안을 제시해보고자 한다.

• 영어영문학
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• 제53권2호
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• pp.219-241
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• 2007

This study takes its point of departure from Lacanian psychoanalysis and explores the point that an irremediable gap in the human subject can be illuminated in terms of the Lacanian categories, fantasy, symptom, gaze or voice as cause of desire of the Other. With respect to the category of the symptom, Lacan claims that the Other is always already there in the constitution of the subject, that is, the relation of the subject to the Other that is overwhelming as well as attracting the subject. Chapter II deals with the unthought, excessive ground of the conscious that borders on the subject, as is the case of self-excentric aspect of the man. Indeed, in Lacan's early work, the subject is essentially a relationship to the Other as desire(objet petit a), and there is no such thing as a symptom or fantasy without some subjective involvement. Lacanian unknown real, perpetual excess as the cause of desire animates the subject even as it threatens to blast it apart. The structures that establish the lines of desire in every individual are derived from an ineluctably intersubjective field. The Other is always already there in the constitution of the subject. In the final years of Lacan's teaching we find a kind of universalization of the symptom and almost everything that is becomes in a way symptom. Symptom, embodied in Laura in "Goblin Market," is her only substance, the only positive support of her being. By looking at the Laura's symptom in chapter III we gain an insight into the forbidden domain, into a real space that should be left unseen and unthought. The voice of goblin men therefore functions as a sublime object that is animating as well as dominating element even as it threatens to disintegrate the subject. Objet petit a as a sublime object that must be excluded in reality returns in the real, taking on a certain materiality which has an effect on Laura, that is, animates Laura's desire. Objet petit a is a real object, signifying nothing. In conclusion, the theoretical importance of Lacanian psychoanalysis is the relation between a subject and an Other as Objet petit a.

• Membrane and Water Treatment
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• 제14권4호
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• pp.155-162
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• 2023

Global climate change and urbanization have various demerits, such as water pollution, flood damage, and deterioration of water circulation. Thus, attention is drawn to Nature-based Solution (NbS) that solve environmental problems in ways that imitate nature. Among the NbS, urban wetlands are facilities that perform functions, such as removing pollutants from a city, improving water circulation, and providing ecological habitats, by strengthening original natural wetland pillars. Frequent monitoring and maintenance are essential for urban wetlands to maintain their performance; therefore, there is a need to apply the Internet of Things (IoT) technology to wetland monitoring. Therefore, in this study, we attempted to develop a real-time wetland monitoring device and interface. Temperature, water temperature, humidity, soil humidity, PM1, PM2.5, and PM10 were measured, and the measurements were taken at 10-minute intervals for three days in both indoor and wetland. Sensors suitable for conditions that needed to be measured and an Arduino MEGA 2560 were connected to enable sensing, and communication modules were connected to transmit data to real-time databases. The transmitted data were displayed on a developed web page. The data measured to verify the monitoring device were compared with data from the Korea meteorological administration and the Korea environment corporation, and the output and upward or downward trend were similar. Moreover, findings from a related patent search indicated that there are a minimal number of instances where information and communication technology (ICT) has been applied in wetland contexts. Hence, it is essential to consider further research, development, and implementation of ICT to address this gap. The results of this study could be the basis for time-series data analysis research using automation, machine learning, or deep learning in urban wetland maintenance.

• 한국발생생물학회지:발생과생식
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• 제27권4호
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• pp.205-211
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• 2023

INTS14/VWA9, a component of the integrator complex subunits, plays a pivotal role in regulating the fate of numerous nascent RNAs transcribed by RNA polymerase II, particularly in the biogenesis of small nuclear RNAs and enhancer RNAs. Despite its significance, a comprehensive mutation model for developmental research has been lacking. To address this gap, we aimed to investigate the expression patterns of INTS14 during zebrafish embryonic development. We generated ints14 mutant strains using the CRISPR/Cas9 system. We validated the gRNA activity by co-injecting Cas9 protein and a single guide RNA into fertilized zebrafish eggs, subsequently confirming the presence of a 6- or 9-bp deletion in the ints14 gene. In addition, we examined the two mutant alleles through PCR analysis, T7E1 assay, TA-cloning, and sequencing. For the first time, we used the CRISPR/Cas9 system to create a model in which some sequences of the ints14 gene were removed. This breakthrough opens new avenues for in-depth exploration of the role of ints14 in animal diseases. The mutant strains generated in this study can provide a valuable resource for further investigations into the specific consequences of ints14 gene deletion during zebrafish development. This research establishes a foundation for future studies exploring the molecular mechanisms underlying the functions of ints14, its interactions with other genes or proteins, and its broader implications for biological processes.