• Title/Summary/Keyword: gain schedule

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Effects of Neonatal Footshock Stress on Glucocorticoid and $5-HT_{2A/2C}$ Receptor Bindings and Exploratory Behavior

  • Kim, Dong-Goo;Lee, Seoul;Kang, Dong-Won;Lim, Jong-Su
    • The Korean Journal of Physiology and Pharmacology
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    • v.2 no.6
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    • pp.677-685
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    • 1998
  • To investigate the effects of neonatal stress on behavior and neurochemistry, rats were exposed to the footshock stress on postnatal day (PND) 14 or PNDs 14 and 21. Rats were exposed to uncontrollable electric shocks delivered to the floor with a constant current (0.8 mA) for 5 sec period. Daily sessions consisted of 60 trials on a random time schedule with an average of 55 sec. The first exposure to footshocks on PND 14 decreased body weight gain for 1 day. However, the second exposure to footshocks on PND 21 did not affect body weight gain. Exploratory activity was measured by exposing a rat to a novel environment 24 h after experience of footshocks. Similar to the body weight changes, a decreased activity was noted after the first exposure to footshocks, while no changed activity was noted after the second exposure to footshocks. However, the Bmax value of $5-HT_{2A/2C}$ receptors in the cortex decreased by the second exposure to footshocks, but not by the first exposure to footshocks. Moreover, an autoradiographic study revealed that the density of $[^3H]dexamethasone$ binding in hippocampus decreased in rats exposed to footshocks 4 times during PND $14{\sim}20.$ These results suggest that the uncontrollable footshock stress changes 5-hydroxytryptamine and glucocorticoid receptor systems acutely and that the repeated exposure to the same stress may not elicit behavioral alterations by the compensatory activity of young brain although changes in some neurochemistry exist.

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Fatigue and its Related Factors in Patients on Hemodialysis (혈액투석환자의 피로와 관련 요인에 관한 연구)

  • 김혜령
    • Journal of Korean Academy of Nursing
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    • v.26 no.1
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    • pp.53-72
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    • 1996
  • The Purpose of this study was to identify characteristics of fatigue and the relationship between fatigue and related factors in patients on hemodialysis. This study was a survey study using a cross-sectional design. The subjects for this study were 101 patients on hemodialysis who were registered in the six hemodialysis clinics among a total of eleven clinics in Seoul. The period of data collection was from February 28, 1995 to May 2, 1995. Data were collected through an interview with a structured packet and the physiological data. The tools used in this study were the Visual Analogue Scale-Fatigue developed by Lee et al(1990) and translated by Lee(1991), the fatigue interview schedule developed by this researcher, Zung's self rating depression scale(Zung, 1965), the self-efficacy scale developed by Sherer et al(1982) and the Norbeck Social Support Questionnaire(NSSQ) translated by Oh(1984). The collected data were analyzed using descriptive statistics(mean, standard deviation, frequency, range), Pearson correlation coefficients and Stepwise multiple regression. The results were as follows ; 1. Characteristics of Fatigue of hemodialysis patients : 1) 79 of 101 hemodialysis patients complained fatigue. 2) The mean fatigue score as measured by the VAS-F was 36.2mm. 3) The mean duration of fatigue was 2.9 hours 2. Characteristics of fatigue related factors : 1) The physiologic factor which included Hgb, Hct, BUN, creatinine, potassium and interdialytic weight gain deviated from normal range. 2) The psychological factor which included depression and self-efficacy was about the same level as for patients with other chronic diseases. 3) The environmental factor which included social support had wide variation. 3. The relationship between fatigue and related factors : 1) Interdialytic weight gain in the physiologica factor was the only valuable with fatigue (p<.05) 2) The relationship between fatigue and the psychological factor of depression showed a positive and strong correlation(p<.05). According to the findings of this study, fatigue was highly correlated with the depression. This indicates that nurses should try to assess and control psychological factors when patients complain of fatigue rather than just considering physiological factors. Nursing has to develop effective nursing interventions to reduce fatigue in patients with chronic diseases using the relationship between fatigue and physiological, psychological and environmental factors.

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Influence of (-)-Hydroxycitrate on food Intake, Body Weight and Lipogenesis in Rats ((-)-Hydroxycitrate의 식이 투여가 흰쥐의 식이 섭취량, 체중, 지방대사 및 합성에 미치는 영향)

  • 김상배
    • Journal of Nutrition and Health
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    • v.30 no.2
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    • pp.123-131
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    • 1997
  • The influence of (-0-Hydroxycitrate(HCA), shown to be a competitive inhibitor of adenosine 5-triphosphate(ATP) citrate lyase, on food intake and body weight, serum triglyceride and cholosterol level, in vivo rates of fatty acid and cholesterol synthesis, and fat cell number and size was investigated. 3 groups of female, 5 weeks old Sprague Dawley rats, 8 animals each, were ad libitum meal-fed or pair-fed(3 hours from 10 : 00 to 13 : 00) AIN based high glucose diet for a total period of 8 weeks. Providing normolipidemic rats orally with 400mg of HCA formula containing approximately 20mg of HCA 1 hour prior to daily feeding schedule significantly depressed in vivo hepatic rates of fatty acid and cholesterol synthesis in the liver and adipose tissue. Serum triglyceride and cholesterol levels were significantly reduced by HCA. At the end of treatment period, the rats administered with HCA resulted in a significantly reduction in body weight gain. The reduction in weights was attributable to a significant decrease in fat cell size with a smaller extent, but not significant, reduction in fat cell number. Rats receiving HCA demonstrated less food intake than the controls ; however, this decreased caloric intake was not fully responsible for the HCA induced depression of hepatic and adipocytic lipogenesis, since experiment using pair-fed cojntrol rats showed, less magnitude but similar results. Both a anorectic and an antilipogenic properties of HCA seem to be responsible for this weight reduction activity of HCA. The outcome of this study suggest that metabolic regulation may be a feasible approach to the control of obesity and hyperlipidemia.

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Development of Time-Cost Models for Building Construction Projects in Bangladesh

  • Rahman, MD. Mizanur;Lee, Young Dai;Ha, Duy Khanh;Chun, Yong Hyun
    • Journal of Construction Engineering and Project Management
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    • v.4 no.3
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    • pp.13-20
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    • 2014
  • Estimating time and cost is an important mission in the early phase of a construction project, especially in feasibility study. It provides a foundation for making decision whether or not the project is performed on schedule and within budget. Thus, reliability of this estimate plays a key role in measuring the success of a project. This study was carried out to investigate the time-cost relationship in building construction projects in Bangladesh. The mathematical equation used in this study is based on Bromilow's equation. The research data were collected from sixty-three completed building projects through questionnaire survey. Type of clients, type of projects, and tender methods are the project characteristics considered in this study. The results of analysis indicated that the Bromilow's time-cost (BTC) models developed for each project characteristic are appropriate due to quite high coefficient of determination and relatively small mean percent errors. Among them, the forecasted model for time and cost according to tender methods is the best fit model. It is concluded that the BTC model could be applied in building construction project to predict its time and cost in Bangladesh. Four different regression models were also developed in this study. The results of BTC model between some selected countries were compared to gain the comprehensive view.

An Empirical Study about Assessment of the JIT System: on korean semi-production firm

  • Lee, Eung-Kweon
    • International Commerce and Information Review
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    • v.7 no.2
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    • pp.75-94
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    • 2005
  • This study is focused on evaluating the computer-integrated just-in-time (CI-JIT) production system of a semi-conductor manufacturing firm in Korea. Approaching the mid-1980s, the emphasis was on low price, low-cost operations, and quality, especially in USA. American companies have shifted output to low-wage countries like the Philippines, Korea, Japan, Malaysia and allied countries that can make quality products at low prices. Korea and other Asian countries forego short-term profits to gain a solid foothold in a product market, recognizing that larger market share leads to lower cost and higher profit in the long run. They bring manufacturers and suppliers together to improve material management and operation management, using project teams that investigate topics, such as Just-In-Time(JIT)manufacturing, among others. The "Kanban" word means "card" in Japanese, and is used to indicate the desired final delivery schedule. The operation for a particular item produced is scheduled for a specific time. The same process is extended to the external suppliers. More recently, the cards are gradually being replaced by electronic procedures that follow the same concept. Its capacity must be capable of handling the various transactions required by the JIT coverage as well as some allowances for expanded applications.

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Effects of Controlled Compensatory Growth on Mammary Gland Development and Lactation in Rats

  • Moon, Yang S.;Park, Chung S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.9
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    • pp.1364-1370
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    • 2002
  • The objective of this study was to examine the effect of compensatory growth nutritional regimen on mammary gland growth and lactation. One hundred twenty-two Sprague Dawley female rats (35 days of age) were randomly assigned to either a control or a stair-step compensatory nutrition (SSCN) feeding regimen or an alternating 2-2-3-3-week schedule beginning with 40% energy restriction for 2 weeks followed by re-alimentation (control diet) for 2 weeks. Pup weight gain and milk yield were improved 8% and 8 to 15%, respectively, by the SSCN regimen. The gene expression of $\beta$-casein was 2.3-fold greater in the SSCN group than in the control group during early lactation, but they were greater at all stages of the second lactation. The gene expression of insulin-like growth factor-I was 40% lower in the SSCN group than in the control group during early lactation of the second lactation, but during late lactation it was 80% greater than in the control group. The concentration of serum corticosterone tended to be higher in the SSCN group during the late stage of the first lactation. These results suggest that the stair-step compensatory nutrition regimen improves lactation performance and persistency by modulation of cell differentiation and apoptotic cell death.

Effects of Dietary Nutrient Content, Feeding Period, and Feed Allowance on Juvenile Olive Flounder Paralichthys olivaceus at Different Feeding Period and Ration

  • Kim, Byeng-Hak;Cho, Sung Hwoan
    • Fisheries and Aquatic Sciences
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    • v.17 no.4
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    • pp.441-448
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    • 2014
  • We examined the effects of dietary nutrient content, feeding period, and feed allowance on compensatory growth, food use, chemical composition, and serum chemistry of juvenile olive flounder Paralichthys olivaceus. We placed 720 juvenile fish into 24 400-L flow-through round tanks (30 fish per tank).A $2{\time}2{\time}2$ factorial design (diet: control (C) and high protein and lipid (HPL) ${\time}$ feeding period: 8 and 6 weeks ${\time}$ feed allowance: 100% and 90% of satiation) was applied. Fish were hand-fed twice daily, based on the designated feeding schedule. Weight gain and food consumption were affected by both the feeding period and feed allowance, but not by diet. The food efficiency ratio was not affected by diet, feeding period, or feed allowance, but the protein efficiency ratio and protein retention were affected by diet and feeding period, respectively. We found that the full compensatory growth of fish was not achieved at a restricted feeding allowance.

The effect of supportive periodontal therapy after periodontal treatment : A 1-year follow up. (치주치료 후 유지치주치료의 효과에 관한 평가 : 1년 관찰)

  • Kim, Shin-Young;Kim, Yong-Gun
    • The Journal of the Korean dental association
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    • v.55 no.1
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    • pp.22-29
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    • 2017
  • Purpose : Preservation of the periodontal health of the treated patient requires supportive periodontal therapy for the elimination of periodontal disease. After Phase I therapy is completed, patients are placed on a schedule of periodic recall visits for maintenance care to prevent recurrence of the disease. The amount of tooth loss would be the most relevant criterion in an evaluation of the effect of periodontal treatment, but this would require studies with extremely long follow-up periods. Thus the most commonly used outcome criteria in clinical research have been clinical attachment level change, reduction of pocket depth and bleeding frequency. The purpose of this case study is to identify the effect of supportive periodontal therapy after periodontal flap surgery. Materials & Methods : Following routine hygienic phase of treatment, patients with chronic periodontitis received surgical periodontal treatment. Bleeding on probing, pocket depth and clinical attachment level were measured at baseline, pre-operation and 1 year follow up. All procedures were performed by one operator. Results : One year a total of 28 patients (58sites) to recheck remained, when conducted maintenance program after periodontal flap surgery was observed reduction of bleeding frequency, pocket depth and improvement of clinical attachment level. Conclusion : The results from this study indicate that supportive periodontal therapy after periodontal flap surgery is effective for reduction of bleeding frequency, pocket depth and gain of clinical attachment level.

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Electric power distribution system most suitable investment precedence decision aspect of the reliability side (신뢰도 측면에서 본 배전계통 최적투자 우선순위 결정)

  • Lee, Hee-Tae;Kim, Jae-Chul;Moon, Jong-Fil;Park, Hyun-Taek;Park, Chang-Ho;Park, Sang-Man
    • Proceedings of the KIEE Conference
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    • 2003.07a
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    • pp.384-386
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    • 2003
  • Striking in change that present our country is much by electricity industry reform and the Korea Electric Power Corporation is deciding power distribution system reliability indices every year but power distribution system for reliability evaluation and establishment of investment program are consisting punily. If consider efficient inflection of resources and hereafter power distribution division that is limited for target achievement of schedule level service evaluation and reliability side in operation of the power distribution system, can expect efficient practical use of the power distribution property if gains in electrical side about these change and most suitable investment way consist because there is necessity of electric power plan establishment of area electric power distribution place of business unit. This paper consider proper reliability level and maximum effect through quantitative analysis to gain electrical gains of the power distribution system in reliability side depending on trend DB(Data Base) of data of electric power system composition appliance in this treatise and apply data administration and reliability rate analysis that serve to decide most suitable investment precedence to supply of electric power property to power distribution system present investment algorithm.

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A Nonlinear Observer Design for Estimating State-of-Charge of Lithium Polymer Battery (리튬폴리머 배터리 잔존충전용량 추정을 위한 비선형 관측기 설계)

  • Yoo, Seog-Hwan
    • Journal of the Korean Institute of Intelligent Systems
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    • v.22 no.3
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    • pp.300-304
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    • 2012
  • This paper presents a nonlinear observer design method for SOC(state-of-charge) estimation of Lithium polymer battery cell. The dynamic equation of the battery cell is modeled as a simple RC electrical circuit with a nonlinear voltage source and the parameters are obtained via nonlinear optimization. Using the sum of squares decomposition, the observer gain is designed such that the error dynamics is asymptotically stable and the decay rate is below the prescribed value. In order to illustrate the performance of the observer, a computer simulation is performed using the experimental data with the UDDS(urban dynamometer driving schedule) current profile.