• Title/Summary/Keyword: gadolinium

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Utilities and Limitations of Cardiac Magnetic Resonance Imaging in Dilated Cardiomyopathy

  • Min Jae Cha;Yoo Jin Hong;Chan Ho Park;Yoon Jin Cha;Tae Hoon Kim;Cherry Kim;Chul Hwan Park
    • Korean Journal of Radiology
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    • v.24 no.12
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    • pp.1200-1220
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    • 2023
  • Dilated cardiomyopathy (DCM) is one of the most common types of non-ischemic cardiomyopathy. DCM is characterized by left ventricle (LV) dilatation and systolic dysfunction without coronary artery disease or abnormal loading conditions. DCM is not a single disease entity and has a complex historical background of revisions and updates to its definition because of its diverse etiology and clinical manifestations. In cases of LV dilatation and dysfunction, conditions with phenotypic overlap should be excluded before establishing a DCM diagnosis. The differential diagnoses of DCM include ischemic cardiomyopathy, valvular heart disease, burned-out hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, and non-compaction. Cardiac magnetic resonance (CMR) imaging is helpful for evaluating DCM because it provides precise measurements of cardiac size, function, mass, and tissue characterization. Comprehensive analyses using various sequences, including cine imaging, late gadolinium enhancement imaging, and T1 and T2 mapping, may help establish differential diagnoses, etiological work-up, disease stratification, prognostic determination, and follow-up procedures in patients with DCM phenotypes. This article aimed to review the utilities and limitations of CMR in the diagnosis and assessment of DCM.

Supercritical CO2-cooled fast reactor and cold shutdown system for ship propulsion

  • Kwangho Ju;Jaehyun Ryu;Yonghee Kim
    • Nuclear Engineering and Technology
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    • v.56 no.3
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    • pp.1022-1028
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    • 2024
  • A neutronics study of a supercritical CO2-cooled fast reactor core for nuclear propulsion has been performed in this work. The thermal power of the reactor core is 30 MWth and a ceramic UO2 fuel can be used to achieve a 20-year lifetime without refueling. In order to make a compact core with inherent safety features, the drum-type reactivity control system and folding-type shutdown system are adopted. In addition, we suggest a cold shutdown system using gadolinium as a spectral shift absorber (SSA) against flooding. Although there is a penalty of U-235 enrichment for the core embedded with the cold shutdown system, it effectively mitigates the increment of reactivity at the flooding of seawater. In this study, the neutronics analyses have been performed by using the continuous energy Monte Carlo Serpent 2 code with the evaluated nuclear data file ENDF/B-VII.1 Library. The supercritical CO2-cooled fast reactor core is characterized in view of important safety parameters such as the reactivity worth of reactivity control systems, fuel temperature coefficient (FTC), coolant temperature coefficient (CTC), and coolant temperature-density coefficient (CTDC). We can say that the suggested core has inherent safety features and enough flexibility for load-following operation.

Development of a DDA+PGA-combined non-destructive active interrogation system in "Active-N"

  • Kazuyoshi Furutaka;Akira Ohzu;Yosuke Toh
    • Nuclear Engineering and Technology
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    • v.55 no.11
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    • pp.4002-4018
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    • 2023
  • An integrated neutron interrogation system has been developed for non-destructive assay of highly-radioactive special nuclear materials, to accumulate knowledge of the method through developing and using it. The system combines a differential die-away (DDA) measurement system for the quantification of nuclear materials and a prompt gamma-ray analysis (PGA) system for the detection of neutron poisons which disturb the DDA measurements; a common D-T neutron generator is used. A special care has been taken for the selection of materials to reduce the background gamma rays produced by the interrogation neutrons. A series of measurements were performed to test the basic performance of the system. The results show that the DDA system can quantify plutonium of as small as 20 mg and it is not affected by intense neutron background up to 1.57 × 107 s-1 and gamma ray of 4.43 × 1010 s-1. The gamma-ray background counting rate at the PGA detector was reduced down to 3.9 × 103 s-1 even with the use of the D-T neutron generator. The test measurements show that the PGA system is capable of detecting 0.783 g of boron and about 86.8 g of gadolinium in 30 min.

MRI Features of Multiple Cranial Neuropathies in Guillain-Barré Syndrome Occurring after COVID-19 Vaccination: A Case Report (COVID-19 백신 접종 후 발생한 길랑-바레증후군에서 보이는 다발성 뇌신경병증의 MRI 소견: 증례 보고)

  • Youngsoo Soh;Eun Ae Yoo;Eun-Sil Kim;Soo Jung Kim
    • Journal of the Korean Society of Radiology
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    • v.84 no.4
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    • pp.964-969
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    • 2023
  • Guillain-Barré syndrome (GBS) is an immune-mediated demyelinating polyneuropathy characterized by progressive, ascending, and symmetrical paralysis. It is known to be triggered by an antecedent infection or vaccination. Recently, GBS development following coronavirus disease 2019 (COVID-19) vaccination has been reported. Cranial neuropathies in typical GBS patients usually involve the facial and the lower cranial nerves (from IX to XII). We report a rare case of multiple cranial neuropathies involving trigeminal, abducens, and facial nerves in a patient who developed GBS following COVID-19 vaccination on the basis of obvious MRI features.

Feasibility study of spent fuel internal tomography (SFIT) for partial defect detection within PWR spent nuclear fuel

  • Hyung-Joo Choi;Hyojun Park;Bo-Wi Cheon;Hyun Joon Choi;Hakjae Lee;Yong Hyun Chung;Chul Hee Min
    • Nuclear Engineering and Technology
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    • v.56 no.6
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    • pp.2412-2420
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    • 2024
  • The International Atomic Energy Agency (IAEA) mandates safeguards to ensure non-proliferation of nuclear materials. Among inspection techniques used to detect partial defects within spent nuclear fuel (SNF), gamma emission tomography (GET) has been reported to be reliable for detection of partial defects on a pin-by-pin level. Conventional GET, however, is limited by low detection efficiency due to the high density of nuclear fuel rods and self-absorption. This paper proposes a new type of GET named Spent Fuel Internal Tomography (SFIT), which can acquire sinograms at the guide tube. The proposed device consists of the housing, shielding, C-shaped collimator, reflector, and gadolinium aluminum gallium garnet (GAGG) scintillator. For accurate attenuation correction, the source-distinguishable range of the SFIT device was determined using MC simulation to the region away from the proposed device to the second layer. For enhanced inspection accuracy, a proposed specific source-discrimination algorithm was applied. With this, the SFIT device successfully distinguished all source locations. The comparison of images of the existing and proposed inspection methods showed that the proposed method, having successfully distinguished all sources, afforded a 150 % inspection accuracy improvement.

Neutronic examination of the U-Mo accident tolerant fuel for VVER-1200 reactors

  • Semra Daydas;Ali Tiftikci
    • Nuclear Engineering and Technology
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    • v.56 no.7
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    • pp.2625-2632
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    • 2024
  • In this study, we investigated the possibility of employing accident tolerant fuel (ATF) in VVER-1200/V491 assembly without gadolinium-containing fuel rods using the Monte Carlo code Serpent 1.1.7 with ENDF/B-VII cross-section library. The analysis involves assembly design with reflective boundary conditions. To compare the neutronic performances, U-5Mo, U-7.5Mo, U-10Mo, and U-15Mo fuels were chosen in addition to ordinary UO2 fuel. The concentration of 135Xe, 149Sm, fissile and fertile isotopes with burnup, reactivity feedback with fuel temperature variation, and β eff values were calculated. The results indicate that the fuel cycle length increases by 54.27% for U-5Mo, 32.6% for U-7.5Mo, and 13.8% for U-10Mo, while it decreases by 16.4% for U-15Mo fuel. Additionally, the effect of 95Mo content in natural Mo was investigated by reducing the 95Mo concentration. According to the results, each proposed fuel's fuel cycle length extended when the depletion ratio of 95Mo increased. Additionally, the calculations for reactivity feedback guarantee safe operating conditions for all U-xMo fuels.

Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging (KOSCI) - Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mapping

  • Im, Dong Jin;Hong, Su Jin;Park, Eun-Ah;Kim, Eun Young;Jo, Yeseul;Kim, Jeong Jae;Park, Chul Hwan;Yong, Hwan Seok;Lee, Jae Wook;Hur, Jee Hye;Yang, Dong Hyun;Lee, Bae-Young
    • Investigative Magnetic Resonance Imaging
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    • v.24 no.1
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    • pp.1-20
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    • 2020
  • This document is the third part of the guidelines for the interpretation and post-processing of cardiac magnetic resonance (CMR) studies. These consensus recommendations have been developed by a Consensus Committee of the Korean Society of Cardiovascular Imaging (KOSCI) to standardize the requirements for image interpretation and post-processing of CMR. This third part of the recommendations describes tissue characterization modules, including perfusion, late gadolinium enhancement, and T1- and T2 mapping. Additionally, this document provides guidance for visual and quantitative assessment, consisting of "What-to-See," "How-To," and common pitfalls for the analysis of each module. The Consensus Committee hopes that this document will contribute to the standardization of image interpretation and post-processing of CMR studies.

Introduction of a Buffering Layer for the Interfacial Stability of LSGM-Based SOFCs (LSGM계 고체산화물 연료전지의 계면안정성을 위한 완층층의 도입)

  • Kim, Kwang-Nyeon;Moon, Jooho;Son, Ji-Won;Kim, Joosun;Lee, Hae-Weon;Lee, Jong-Ho;Kim, Byung-Kook
    • Journal of the Korean Ceramic Society
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    • v.42 no.9 s.280
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    • pp.637-644
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    • 2005
  • In order to find a proper buffering material which can prohibit an unwanted interfacial reaction between anode and electrolyte of LSGM-based SOFC, we examined a gadolinium doped ceria and scandium doped zirconia as a candidate. For this examination, we investigated the microstructural and phase stability of the interface under different buffering layer conditions. According to the investigation, ceria based material induced a serious La diffusion out of the LSGM electrolyte resulted in the formation of very resistive $LaSrGa_3O_7$ phase at the interface. On the other hand zirconia based material was directly reacted with LSGM electrolyte and thus produced very resistive reaction products such as $La_2Zr_2O_7,\;Sr_2ZrO_4,\;LaSrGaO_4\;and\;LaSrGa_3O_7$. From this study we found that an improper buffering material induced the higher internal cell resistance rather than an interfacial stability.

The Properties of Beam Intensity Scanner(BInS) in IMRT with Phantom for Three Dimensional Dose Verification

  • Young W. Vahc;Park, Kwangyl;Byung Y. Yi;Park, Kyung R.;Lee, Jong Y.;Ohyun Kwon;Park, Kwangyl;Kim, Keun M.
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2003.09a
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    • pp.64-64
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    • 2003
  • Objectives: Patient dose verification is clinically the most important parts in the treatment delivery of radiation therapy. The three dimensional(3D) reconstruction of dose distribution delivered to target volume helps to verify patient dose and determine the physical characteristics of beams used in intensity modulated radiation therapy(IMRT). We present Beam Intensity Scanner(BInS) system for the pre treatment dosimetric verification of two dimensional photon intensity. The BInS is a radiation detector with a custom made software for relative dose conversion of fluorescence signals from scintillator. Methods: This scintillator is fabricated by phosphor Gadolinium Oxysulphide and is used to produce fluorescence from the irradiation of 6MV photons on a Varian Clinac 21EX. The digitized fluoroscopic signals obtained by digital video camera will be processed by our custom made software to reproduce 3D relative dose distribution. For the intensity modulated beam(IMB), the BInS calculates absorbed dose in absolute beam fluence, which are used for the patient dose distribution. Results: Using BInS, we performed various measurements related to IMRT and found the followings: (1) The 3D dose profiles of the IMBs measured by the BInS demonstrate good agreement with radiographic film, pin type ionization chamber and Monte Carlo simulation. (2) The delivered beam intensity is altered by the mechanical and dosimetric properties of the collimating of dynamic and/or static MLC system. This is mostly due to leaf transmission, leaf penumbra, scattered photons from the round edges of leaves, and geometry of leaf. (3) The delivered dose depends on the operational detail of how to make multileaf opening. Conclusions: These phenomena result in a fluence distribution that can be substantially different from the initial and calculative intensity modulation and therefore, should be taken into account by the treatment planing for accurate dose calculations delivered to the target volume in IMRT.

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Vasogenic Edema in Experimental Cerebral Fat Embolism

  • Park Byung-Rae;Koo Bong-Oh
    • Biomedical Science Letters
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    • v.11 no.1
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    • pp.31-36
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    • 2005
  • To evaluate the magnetic resonance imaging and electron microscopic findings of the hyperacute stage of cerebral fat embolism in cats and the time needed for the development of vasogenic edema. Magnetic resonance imaging was performed at 30 minutes (group 1, n=9) and at 30 minutes and 1, 2, 4, and 6 hours after embolization with triolein (group 2, n= 10). As a control for group 2, the same acquisition was obtained after embolization with polyvinyl alcohol particles (group 3, n=5). Electron microscopic examination was done in all cats. In group 1, the lesions were iso- or slightly hyperintense on T2-weighted (T2W) and diffusion-weighted (DWIs) images, hypointense on the apparent diffusion coefficient (ADC) map image, and markedly enhanced on the gadolinium-enhanced T1-weighted images (Gd-T1WIs). In group 2 at 30 minutes, the lesions were similar to those in group 1. Thereafter, the lesions became more hyperintense on T2WIs and DWIs and more hypoinfense on the ADC map image. In group 3, the lesions showed mild hyperintensity on T2WIs at 6 hours but hypointensity on the ADC map image from 30 minutes, with a tendency toward a greater decrease over time. Electron microscopic findings revealed discontinuity of the capillary endothelial wall, perivascular and interstitial edema, and swelling of glial and neuronal cells in groups 1 and 2. The lesions were hyperintense on T2WIs and DWIs, hypointense on the ADC map image, and enhanced on Gd-T1WIs. On electron microscopy, the lesions showed cytotoxic and vasogenic edema with disruption of the blood-brain barrier.

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