• 대한본초학회지
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• 제28권6호
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• pp.129-133
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• 2013

Objectives : The purpose of this study was to investigate the effects of Angelicae acutilobae Radix Water Extract (AA) on the production of cytokines in RAW 264.7 cell stimulated with lipopolysaccharide (LPS). Method : RAW 264.7 cells were cotreated with AA (50 and $100{\mu}g/mL$) and lipopolysaccharide (LPS; $1{\mu}g/mL$) for 24 hours. After 24 hours treatment, using bead-based multiplex cytokine assay, concentrations of various cytokines such as interleukin(IL)-6, tumor necrosis factor-alpha(TNF-${\alpha}$) granulocyte colony-stimulating factor(G-CSF), granulocyte macrophage colony-stimulating factor(GM-CSF), and macrophage inflammatory protein(MIP)-$1{\alpha}$ were measured. Result : AA significantly inhibited LPS-induced production of IL-6 and MIP-$1{\alpha}$ from LPS-stimulated RAW 264.7 cells at the concentration of $50{\mu}g/mL$. AA significantly inhibited LPS-induced production of TNF-${\alpha}$ from LPS-stimulated RAW 264.7 cells at the concentration of $100{\mu}g/mL$. AA significantly inhibited LPS-induced production of G-CSF and GM-CSF in RAW 264.7 cells at the concentrations of 50 and $100{\mu}g/mL$. Conclusion : These results suggest that AA has anti-inflammatory effect related with its inhibition of proinflammatory cytokines such as IL-6, TNF-${\alpha}$, G-CSF, GM-CSF, and MIP-$1{\alpha}$ in LPS-induced macrophages.

• 대한수학회보
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• 제53권1호
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• pp.91-102
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• 2016

A chief factor H/K of G is called F-central in G provided $(H/K){\rtimes}(G/C_G(H/K)){\in}{\mathfrak{F}}$. A normal subgroup N of G is said to be ${\pi}{\mathfrak{F}}$-hypercentral in G if either N = 1 or $N{\neq}1$ and every chief factor of G below N of order divisible by at least one prime in ${\pi}$ is $\mathfrak{F}$-central in G. The symbol $Z_{{\pi}{\mathfrak{F}}}(G)$ denotes the ${\pi}{\mathfrak{F}}$-hypercentre of G, that is, the product of all the normal ${\pi}{\mathfrak{F}}$-hypercentral subgroups of G. We say that a subgroup H of G is ${\pi}{\mathfrak{F}}$-embedded in G if there exists a normal subgroup T of G such that HT is s-quasinormal in G and $(H{\cap}T)H_G/H_G{\leq}Z_{{\pi}{\mathfrak{F}}}(G/H_G)$, where $H_G$ is the maximal normal subgroup of G contained in H. In this paper, we use the ${\pi}{\mathfrak{F}}$-embedded subgroups to determine the structures of finite groups. In particular, we give some new characterizations of p-nilpotency and supersolvability of a group.

• 방사성폐기물학회지
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• 제11권3호
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• pp.245-251
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• 2013

NaI(Tl) 섬광검출기로 측정한 에너지 스펙트럼으로부터 공간 감마 선량률을 계산하기 위하여 에너지밴드 방법과 G-factor 방법의 결과를 비교 검토하였다. 먼저 한국원자력연구원 내 운영 중인 환경방사선감시기 EFRD 3300에 장착된 3"${\Phi}X3$" NaI(Tl) 검출기의 G-factor를 MCNP 모델링을 통하여 입사 방사선의 방향에 따라 각각 구하였으며, 이로부터 계산된 선량률과 에너지밴드 방법으로 계산된 결과의 차이를 비교 검토함으로써 EFRD 3300에 적용 가능한 최적의 G-factor 값을 유도하였다. 그리고 EFRD 3300 방사선감시기가 운영되고 있는 지역 주변에 위치한 HPIC 방사선감시기의 선량률과 비교 검토를 수행하였으며, 3"${\Phi}X3$" NaI(Tl) 검출기 기반의 EFRD 3300에서 $7.7{\mu}R/h$의 측정값을 얻어 약 $3{\mu}R/h$ 정도의 차이를 보였다. 일반적으로 HPIC 방사선감시기는 고에너지 우주방사선량도 측정할 수 있는 것으로 알려져 있으므로, 이 차이는 3"${\Phi}X3$" NaI 계측기로 측정되지 못하는 고에너지 영역의 우주방사선에 의한 영향으로 평가할 수 있었다.

• 한국재료학회지
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• 제2권3호
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• pp.220-227
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• 1992

전기유변유체(electrorheological fluid : ERF)는 크기가 $10^{-6}m$정도를 가진 분극성이 강한 입자 분말을 유전유체속에 혼합하여 만든 콜로이드용액으로서 외부전기 장에 의하여 액체상태로부터 겔(gel)상태로 상태변환을 한다. 상태변환과정은 가역과정이며 $10^{-3}$초 정도의 빠른 시간내에 이루어진다. 본 논문에서는 주기적응력이나 주기적 변형이 가해지는 강제진동실험을 통하여 ERF의 점탄성 특성을 조사하였다. 점탄성은 복소수로서 실수부인 동적전단탄성율(storage shear modulus, G')과 허수부인 동적손실율(loss modulus, G")의 합으로 표현된다. 동적전단탄성율은 강제진동의 진폭과 주파수의 함수로 외부전기장에 의하여 크게 변화되었으나 손실계수(loss factor, ${\eta}=G"/G'$)는 진동의 진폭, 진동수 및 외부전기 장에 거의 독립적이었다. 실험(1)은 강제진동의 진폭을 고정하고 진동수를 변화하는 방법(frequency sweep)과 실험(2)는 진동 진폭을 변화시키는 방법(amplitude sweep)으로 실행했다. 본 실험에서는 cornstarch입자를 corn oil에 혼합한 것과 zeolite입자를 silicone oil에 흔합한 콜로이드 용액이 ERF로서 사용되었으며 인가된 전기장은 약$(1~3){\times}10^6V/m$의 직류전기장이 가하여졌다.기장이 가하여졌다.

• Tuberculosis and Respiratory Diseases
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• 제87권1호
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• pp.22-30
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• 2024

Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.

• Biomolecules & Therapeutics
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• 제2권4호
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• pp.310-315
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• 1994

The pharmacokinetics and tissue distribution of DA-3030 (recombinant human granulocyte colony-stimulating factor, rhG-CSF, recently manufactured by Dong-A research laboratory of Dong-A Pharmaceutical Company) were compared with reported data in the literature. After intravenous(i.v.) administration of DA-3030, at dose of 5, 10 and 100 $\mu\textrm{g}$/kg to rats, some pharmacokinetic parameters, such as terminal half-lives(1.05, 1.19 and 1.83 hr, respectively) and clearance (84.0, 54.8 and 45.5 mι/hr/kg, repectively), were dose-dependent. This could be due to the saturable metabolism of DA-3030 in rats. Similar results were also reported. After subcutaneous(s.c.) and intramuscular(i.m.) administrations of DA-3030, 10 $\mu\textrm{g}$/kg to rats, the extent of bioavailability(absolute bioavailability) were incomplete; the values were 23.3 and 18.2% after s.c. and i.m. injections, respectively, due to the degradation of DA-3030 by protease. After 7-consecutive day i.v. administrations of DA-3030, 10 $\mu\textrm{g}$/kg/day, to rats, the plasma concentrations and pharmacokinetic parameters of DA-3030 were not significantly different from those in single administration. In mice and dogs at DA-3030 dose of 10 $\mu\textrm{g}$/kg, the plasma concentrations of DA-3030 were also declined rapidly with terminal half-lives of 1.31 and 1.15 hr, respectively. DA-3030 was highly concentrated in the kidney after i.v. administration of DA-3030, 10 $\mu\textrm{g}$/kg, to rats, and the results were similar to those obtained using radiolabelled rhG-CSF in the literature. Above data indicate that DA-3030 has similar properties to rhG-CSF manufactured by other companies in view of pharmacokinetics.

• 대한방사선치료학회지
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• 제25권2호
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• pp.107-113
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• 2013

목 적: 호흡동조 시스템을 이용한 양성자치료 시 생성되는 양성자빔을 측정하고 분석함으로써 호흡동조 양성자치료의 정확성을 검증하고자 한다. 대상 및 방법: 호흡동조 양성자치료를 실시한 환자 세 명의 치료계획을 이용하여 양성자 치료 시스템에서 양성자빔을 생성했다. 이때 자체 제작한 구동 팬톰을 사용하여 호흡동조 시스템을 적용해 분할 조사되는 양성자빔을 재현하였다. 양성자빔의 중요특성인 Range, Spread-Out Bragg Peak (SOBP), Output factor를 각 5회씩 측정하였으며 호흡동조 시스템을 적용하지 않은 연속 양성자빔에서도 동일한 항목들을 측정했다. Range와 SOBP 측정에는 Multi-Layer Ionization Chamber, Output factor 측정에는 Scanditronix Wellhofer와 Farmer chamber를 사용했다. 결 과: 호흡동조 시스템을 적용한 경우 세 환자의 평균 Range는 7.226, 12.216, 19.918 $g/cm^2$, SOBP는 4.950, 6.496, 8.486 $g/cm^2$, Output factor는 0.985, 1.026, 1.138 cGy/MU였으며, 적용하지 않은 경우 평균 Range는 7.230, 12.220, 19.920 $g/cm^2$, SOBP는 4.940, 6.512, 8.490 $g/cm^2$, Output factor는 0.984, 1.027, 1.136 cGy/MU로 측정됐다. 평균 Range의 차는 -0.004, -0.004, -0.002 $g/cm^2$, SOBP는 0.010, -0.016, -0.004 $g/cm^2$, Output factor는 0.001, -0.001, 0.002 cGy/MU로 나타났다. 결 론: 호흡동조 양성자치료 시 분할 조사된 양성자빔과 연속 조사된 양성자빔의 Range, SOBP 및 Output factor 모두 차이가 미미했다. 따라서 본 연구를 통해 호흡동조 시 발생된 양성자빔의 선질을 검증하였고 이를 이용한 양성자치료의 정확성 또한 확인할 수 있었다.

• Biomolecules & Therapeutics
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• 제5권3호
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• pp.316-322
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• 1997

CJ-50001 is a recombinant granulocyte-colony stimulating factor (rG-CSF) synthesized by recombi-nant DNA technology using E. coli as an expression system. The general pharmacological properties of CJ-50001 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses are 100, 300 and 1, 0007g/kg, i.v. for mice and rats, 1, 10 and 100$\mu$g/kg, 1.v. for dogs and 1 and 10$\mu$g/ml for isolated guinea pig ileum. Intravenous administration of CJ-50001 at this dose range did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electro-lytes excretion. In summary, CJ-50001 had no harmful pharmacological erect in these studies even up to the 200-fold expected clinical dose, 2507g/man.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2004년도 춘계학술대회
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• pp.48-56
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• 2004

To perform R&D program, it is necessary to invest input factor(I/F). And these factor are converted to output factors(O/F) at the end of R&D program. Pee. reviewers evaluate output factors and produce evaluation grades(E/G). This paper try to analyze the relationship to I/F, O/F and E/G, According to the analysis results, the relation between I/F and E/G is as weak as the relation between O/F and E/G. The strength of relationship is relatively very strong in the relation between I/F and O/F

• 한국결정성장학회지
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• 제22권1호
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• pp.29-35
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• 2012

Special attention in the role of convection in vapor crystal growth has been paid since some single crystals under high gravity acceleration of $10g_0$ appear considerably larger than those under normal gravity acceleration ($1g_0$). With increasing the gravity acceleration from $1g_0$ up to $10g_0$, the total molar flux for ${\Delta}T$ = 30 K increases by a factor of 4, while for ${\Delta}T$ = 90, by a factor of 3. The maximum molar fluxes for three different gravity levels of $1g_0$, $4g_0$ and $10g_0$, appear approximately in the neighborhood of y = 0.5 cm, and the molar fluxes show asymmetrical patterns, which indicate the occurrence of either one single or more than one convective cell. As the gravitational level is enhanced form $1g_0$ up to $10g_0$, the intensity of convection is increased significantly through the maximum molar fluxes for ${\Delta}T$ = 30 K and 90 K. At $10g_0$, the maximum total molar flux is nearly invariant for for ${\Delta}T$ = 30 K and 90 K. The total molar flux increases with increasing the gravity acceleration, for $1g_0{\leq}g_y{\leq}10g_0$, and decreases with increasing the partial pressure of component B, a noble gas called as Kr (Krypton), $P_B$. The ${{\mid}U{\mid}}_{max}$ is directly proportional to the gravity acceleration for 20 Torr $P_B{\leq}300$ Torr. As the partial pressure of $P_B$ (Torr) decreases from 300 Torr to 20 Torr, the slopes of the ${{\mid}U{\mid}}_{max}s$ versus the gravity accelerations increase from 0.29 sec to 0.54 sec, i.e. by a factor of 2. The total molar flux of $Hg_2Cl_2$ is first order exponentially decayed with increasing the partial pressure of component B, $P_B$ (Torr) from 20 Torr up to 300 Torr.