• Journal of Korean Neurosurgical Society
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• v.62 no.5
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• pp.545-550
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• 2019

Objective : Penumbra ACE68 reperfusion catheter is a new large bore aspiration catheter used for reperfusion of large vessel occlusion. The objective of this study was to investigate the efficacy of this catheter in comparison to that of previous Penumbra catheters in patients with acute ischemic stroke related to internal carotid artery (ICA) occlusion. Methods : Data of all eligible patients who received endovascular treatment (EVT) for ICA occlusion using Penumbra aspiration catheters between January 2015 and December 2018 were retrospectively reviewed. After dividing into two groups according to use of penumbra ACE68, baseline characteristics of patients, successful recanalization rate, puncture to recanalization time, and switch to stent base technique rate were assessed. Successful recanalization was defined by a thrombolysis in cerebral infarction (TICI) score ${\geq}2b$ and favorable functional outcome was defined according to modified Rankin scale (score, 0-2). Results : ACE68 reperfusion catheter was used in 29 of 75 eligible patients (39%). The puncture to recanalization time was significantly shorter ($26{\pm}18.2$ minutes vs. $40{\pm}24.9$ minutes, p=0.011) and the rate of switch to stent-based retrieval was significantly lower (3% vs. 20%, p=0.046) in ACE68 catheter group. Moreover, although not statistically significant, the successful recanalization rate was higher (83% vs. 76%, p=0.492) in ACE68 catheter group. Favorable functional outcome was observed in 48% of patients treated with ACE68 reperfusion catheter and in 30% of patients treated using other Penumbra systems (p=0.120). Baseline Alberta Stroke Program Early CT Scores ${\geq}8$ (odds ratio [OR], 9.74; 95% confidence interval [CI], 1.72-54.99; p=0.010) and successful recanalization (OR, 10.20; 95% CI, 1.13-92.46; p=0.039) were independent predictors of favorable outcome. Conclusion : EVT using ACE68 reperfusion catheter can be considered a first-line therapy in patients with acute ICA occlusion as it can achieve rapid recanalization and reduce the frequency of conversion to stent-retrieve therapy.

• Journal of the korean academy of Pediatric Dentistry
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• v.21 no.2
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• pp.540-546
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• 1994

The authors treated three patients who chiefly complained functional anterior crossbite due to premature loss of primary molars by using removable space maintainer and functional appliances. In orthodontic practice, the mandibular rest position and the possibility of taking construction bite have been as the criteria for evaluation of functional factors involved in anterior crossbite. Functional anterior crossbites, if left untreated, may have deleterious effects on the development and function of craniofacial complex and TMJ. Objectives of the treatment were as follows: 1) to recover vertical dimension 2) to eliminate functional disharmony 3) to correct anterior reversed occlusion 4) to attain good facial esthetics 5) to prevent unfavorable growth of jaw & dentition Characterized craniofacial morphology resulting from the premature loss of deciduous molars could be recovered following the correction of crossbite. Therefore, it is recommended that in orthodontic diagnosis of functional anterior crossbite due to premature loss of deciduous molars, the craniofacial abnormality affected by that should be considered.

• Journal of Technologic Dentistry
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• v.24 no.1
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• pp.107-126
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• 2002

The first function of occlusion is mastication. Therefore the functional restoration of occlusal surface is very important. The restoration of occlusal surface is three method as wax bite technique, F.G.P. technique, cone technique. Many dental technician is using compound method. I am using compound method of wax bite technique and cone technique. I have knew common point on each teeth during I have waxing up wax pattern. So I studied on the design waxup technique for mandible molar occlusion. The results of the study were as follows; 1. The dam wax up method can restore axial contour of teeth very easy and make short working time of wax pattern. 2. The height of dam must be same with cusp of adjacent teeth. 3. Automatically the contour of tooth is appeared if the contour of dam is relationship with cuspid line of adjacent teeth. 4. The height of contour of buccal, lingual surface is formed natural curve to add fluid wax by gravitation. 5. The development groove of mandible first premolar is appeared V form. 6. The development groove of mandible second premolar is appeared Y form. 7, The development groove of mandible first molar is appeared M form. 8. The development groove of mandible second molar is W form. 9. The embrasure is formed to carve around contact point area as round convex. It affects to axial form of tooth. 10. The buccal, lingual groove of molar is formed parallel with direction of teeth arrangement.

• Journal of Technologic Dentistry
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• v.21 no.1
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• pp.97-114
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• 1999

The first function of occlusion is mastication. Therefore the functional restoration of occlusal surface is very important. The restoration of occlusal surface is three method as wax bite technique, F.G.P. technique, cone technique. Many dental technician is using compound method. I have knew common point on each teeth during I have waxing up wax pattern. So I studied on the design waxup technique for maxillary molar occlusion. The results of the study were as follows ; 1. The dam wax up method can restore axial contour of teeth very easy and make short working time of wax pattern. 2. The height of dam must be same with cusp of adjacent teeth. 3. Automatically the contour of tooth is appeared if the contour of dam is relationship with cuspid line of adjacent teeth. 4. The height of contour of buccal, lingual surface is formed natural curve to add fluid wax by gravitation. 5. The development groove of Maxillary premolar is appeared V form. 6. The development groove of Maxillary molar is appeared W form. 7. The embrasure is formed to carve around contact point area as round convex. It affects to axial form of tooth. 8. I was knew that the lingual groove and stuart's groove of molar runs parallel with oblique ridge. 9. The buccal groove of molar is formed parallel with direction of teeth arrangement.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.319-328
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• 2024

Lysophosphatidic acid receptor 1 (LPA₁) plays a critical role in brain injury following a transient brain ischemic stroke. However, its role in permanent brain ischemic stroke remains unknown. To address this, we investigated whether LPA₁ could contribute to brain injury of mice challenged by permanent middle cerebral artery occlusion (pMCAO). A selective LPA₁ antagonist (AM152) was used as a pharmacological tool for this investigation. When AM152 was given to pMCAO-challenged mice one hour after occlusion, pMCAO-induced brain damage such as brain infarction, functional neurological deficits, apoptosis, and blood-brain barrier disruption was significantly attenuated. Histological analyses demonstrated that AM152 administration attenuated microglial activation and proliferation in injured brain after pMCAO challenge. AM152 administration also attenuated abnormal neuroinflammatory responses by decreasing expression levels of pro-inflammatory cytokines while increasing expression levels of anti-inflammatory cytokines in the injured brain. As underlying effector pathways, NF-κB, MAPKs (ERK1/2, p38, and JNKs), and PI3K/Akt were found to be involved in LPA₁-dependent pathogenesis. Collectively, these results demonstrate that LPA₁ can contribute to brain injury by permanent ischemic stroke, along with relevant pathogenic events in an injured brain.

• Journal of the korean academy of Pediatric Dentistry
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• v.21 no.2
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• pp.547-554
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• 1994

Posterior crossbites are abnormal buccal, or lingual relationship of a tooth or teeth of the maxilla, the mandible, or both when the teeth of the two arches are in occlusion and involve the molars and premolars. Posterior crossbites are classified as dental, muscular(functional), or skeletal. In an effort to avoid occlusal interferences caused by the inadequate arch width, the patient deviates the mandible laterally upon closure to achieve maximum intercuspation. This is described as functional posterior crossbite. Correction of functional posterior crossbites in the primary & early mixed dentition as early as possible after diagnosis has been recommended, because crossbites do not automatically improve with the eruption of the permanent teeth. Functional posterior crossbites, if left untreated, may have deleterious effects on the development and function of the TMJ. The diagnosis and management of three cases is presented. Each patient with functional posterior crossbites is treated using the bilateral maxillary expansion appliance.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.398-404
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• 1994

Functional recovery after mandibular condyle fracture was a contradictory result of many authors. The treatment goal of condyle fracture has been directed primarily toward restoration of functional movement of the mandible. We selected some patients who requested functional therapy in many cases of condylar fracture, depend on pattern of fracture, patient's demand, occlusion, age. Without intermaxillary fixation, we induced the patients to rapid healing of temporomandibular function and normal mandibular protrusive, lateral movement as a result of early functional therapy by activator. So, the authors report the cases with review of concerned literature.

• The Journal of the Korean dental association
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• v.50 no.2
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• pp.58-63
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• 2012

The fundamental principles and the role of surgeons and orthodontists to produce successful results in orthodontic treatment combined with orthognathic surgery is not different from those of conventional procedures and FOS: surgery-first-orthodontic-treatment-later approach. The communication and cooperation between surgeon and orthodontist is of crucial importance. In FOS, the pre-surgical orthodontic preparation is not carried out in the patient's mouth, but in the mounted stone model and in addition to the simulation of tooth movement, to get a precise surgical occlusion, the entire steps of treatment should be simulated on the articulator as well. Right after the surgery, due to the instability of the occlusion, appropriate post operational care should be given according to the surgical technique applied to the mandible by use of final surgical wafer about 8 weeks.

• IEIE Transactions on Smart Processing and Computing
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• v.1 no.2
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• pp.73-77
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• 2012

This paper reports a combined depth- and model-based face detection and tracking approach. The proposed algorithm consists of four functional modules; i) color-based candidate region extraction, ii) generation of the depth histogram for handling occlusion, iii) rotation-invariant face region detection using ellipse fitting, and iv) face tracking based on motion prediction. This technique solved the occlusion problem under complicated environment by detecting the face candidate region based on the depth-based histogram and skin colors. The angle of rotation was estimated by the ellipse fitting method in the detected candidate regions. The face region was finally determined by inversely rotating the candidate regions by the estimated angle using Haar-like features that were robustly trained robustly by the frontal face.

• The korean journal of orthodontics
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• v.44 no.3
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• pp.143-153
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• 2014

An 8-years old boy with facial asymmetry and unilateral posterior crossbite on the left side received orthopedic and orthodontic treatment. During the first phase of treatment, the narrow maxillary arch was expanded using an acrylic plate. Then, the acrylic plate was used as a bite block with occlusal indentations from the construction bite that was obtained with the incisors in a coincident dental midline. After the position of the mandible was stabilized, the second phase of orthodontic treatment was initiated using fixed appliances for detailing of the occlusion. Skeletal symmetry, ideal occlusion, and coincident dental midlines were thus achieved. Functionally, occlusal force balance and masticatory muscle activity were improved, and the chewing patterns were normalized.