• 대한치과보철학회지
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• 제57권4호
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• pp.467-474
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• 2019

최근 들어 치아의 심미적인 개선을 위해 전치부 보철 치료를 하는 경우가 많다. 하지만 전치부 심미 보철치료이후 환자가 발음, 저작 등 기능적으로 불만족스럽게 생각하는 경우가 종종 있다. 전치부는 심미적으로 중요할 뿐만 아니라 교합과 관련하여서도 중심위 다음으로 중요한 전방유도가 성립되는 부분으로, 잘못된 전방유도 설정으로 인해 구치부의 교합간섭을 초래할 수 있다. 또한 새롭게 설정된 전치부 보철물의 전방유도가 환자의 기능로(envelope of function)과 조화를 이루지 않을 시 환자가 불편감을 나타낼 수 있다. 본 증례는 전치부 심미 보철 이후 부정확한 발음 및 안정적인 접촉이 없어서 불안정한 교합, 전반적인 불편감을 호소하는 환자에서 체계적인 진단과 치료과정을 통해 보철물을 재수복하여 환자와 술자 모두에게서 심미적으로, 그리고 기능적으로 만족스러운 결과를 얻었기에 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.346-351
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• 2016

Objective : Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI. Methods : We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institutes of Health Stroke Scale increment ${\geq}2$ points during 24 hours despite receiving standard treatment. Regional parameter ratios, such as cerebral blood flow and volume (rCBV) ratio (ipsilateral value/contralateral value) on perfusion MRI were analyzed to investigate the association with EPI. Results : Sixty-four patients were enrolled in total. EPI was present in 18 (28%) subjects and all EPI occurred within 3 days after hospitalization. Diabetes mellitus, rCBV ratio and regional time to peak (rTTP) ratio showed statically significant differences in both groups. Multi-variate analysis indicated that history of diabetes mellitus [odds ratio (OR), 6.13; 95% confidence interval (CI), 1.55-24.24] and a low rCBV ratio (rCBV, <0.85; OR, 6.57; 95% CI, 1.4-30.27) was significantly correlated with EPI. Conclusion : The incidence of EPI is considerable in patients with acute MCA territory infarction caused by MCA occlusion. We suggest that rCBV ratio is a useful neuro-imaging parameter to predict EPI.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.545-550
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• 2019

Objective : Penumbra ACE68 reperfusion catheter is a new large bore aspiration catheter used for reperfusion of large vessel occlusion. The objective of this study was to investigate the efficacy of this catheter in comparison to that of previous Penumbra catheters in patients with acute ischemic stroke related to internal carotid artery (ICA) occlusion. Methods : Data of all eligible patients who received endovascular treatment (EVT) for ICA occlusion using Penumbra aspiration catheters between January 2015 and December 2018 were retrospectively reviewed. After dividing into two groups according to use of penumbra ACE68, baseline characteristics of patients, successful recanalization rate, puncture to recanalization time, and switch to stent base technique rate were assessed. Successful recanalization was defined by a thrombolysis in cerebral infarction (TICI) score ${\geq}2b$ and favorable functional outcome was defined according to modified Rankin scale (score, 0-2). Results : ACE68 reperfusion catheter was used in 29 of 75 eligible patients (39%). The puncture to recanalization time was significantly shorter ($26{\pm}18.2$ minutes vs. $40{\pm}24.9$ minutes, p=0.011) and the rate of switch to stent-based retrieval was significantly lower (3% vs. 20%, p=0.046) in ACE68 catheter group. Moreover, although not statistically significant, the successful recanalization rate was higher (83% vs. 76%, p=0.492) in ACE68 catheter group. Favorable functional outcome was observed in 48% of patients treated with ACE68 reperfusion catheter and in 30% of patients treated using other Penumbra systems (p=0.120). Baseline Alberta Stroke Program Early CT Scores ${\geq}8$ (odds ratio [OR], 9.74; 95% confidence interval [CI], 1.72-54.99; p=0.010) and successful recanalization (OR, 10.20; 95% CI, 1.13-92.46; p=0.039) were independent predictors of favorable outcome. Conclusion : EVT using ACE68 reperfusion catheter can be considered a first-line therapy in patients with acute ICA occlusion as it can achieve rapid recanalization and reduce the frequency of conversion to stent-retrieve therapy.

• 대한소아치과학회지
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• 제21권2호
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• pp.540-546
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• 1994

The authors treated three patients who chiefly complained functional anterior crossbite due to premature loss of primary molars by using removable space maintainer and functional appliances. In orthodontic practice, the mandibular rest position and the possibility of taking construction bite have been as the criteria for evaluation of functional factors involved in anterior crossbite. Functional anterior crossbites, if left untreated, may have deleterious effects on the development and function of craniofacial complex and TMJ. Objectives of the treatment were as follows: 1) to recover vertical dimension 2) to eliminate functional disharmony 3) to correct anterior reversed occlusion 4) to attain good facial esthetics 5) to prevent unfavorable growth of jaw & dentition Characterized craniofacial morphology resulting from the premature loss of deciduous molars could be recovered following the correction of crossbite. Therefore, it is recommended that in orthodontic diagnosis of functional anterior crossbite due to premature loss of deciduous molars, the craniofacial abnormality affected by that should be considered.

• 대한치과기공학회지
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• 제24권1호
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• pp.107-126
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• 2002

The first function of occlusion is mastication. Therefore the functional restoration of occlusal surface is very important. The restoration of occlusal surface is three method as wax bite technique, F.G.P. technique, cone technique. Many dental technician is using compound method. I am using compound method of wax bite technique and cone technique. I have knew common point on each teeth during I have waxing up wax pattern. So I studied on the design waxup technique for mandible molar occlusion. The results of the study were as follows; 1. The dam wax up method can restore axial contour of teeth very easy and make short working time of wax pattern. 2. The height of dam must be same with cusp of adjacent teeth. 3. Automatically the contour of tooth is appeared if the contour of dam is relationship with cuspid line of adjacent teeth. 4. The height of contour of buccal, lingual surface is formed natural curve to add fluid wax by gravitation. 5. The development groove of mandible first premolar is appeared V form. 6. The development groove of mandible second premolar is appeared Y form. 7, The development groove of mandible first molar is appeared M form. 8. The development groove of mandible second molar is W form. 9. The embrasure is formed to carve around contact point area as round convex. It affects to axial form of tooth. 10. The buccal, lingual groove of molar is formed parallel with direction of teeth arrangement.

• 대한치과기공학회지
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• 제21권1호
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• pp.97-114
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• 1999

The first function of occlusion is mastication. Therefore the functional restoration of occlusal surface is very important. The restoration of occlusal surface is three method as wax bite technique, F.G.P. technique, cone technique. Many dental technician is using compound method. I have knew common point on each teeth during I have waxing up wax pattern. So I studied on the design waxup technique for maxillary molar occlusion. The results of the study were as follows ; 1. The dam wax up method can restore axial contour of teeth very easy and make short working time of wax pattern. 2. The height of dam must be same with cusp of adjacent teeth. 3. Automatically the contour of tooth is appeared if the contour of dam is relationship with cuspid line of adjacent teeth. 4. The height of contour of buccal, lingual surface is formed natural curve to add fluid wax by gravitation. 5. The development groove of Maxillary premolar is appeared V form. 6. The development groove of Maxillary molar is appeared W form. 7. The embrasure is formed to carve around contact point area as round convex. It affects to axial form of tooth. 8. I was knew that the lingual groove and stuart's groove of molar runs parallel with oblique ridge. 9. The buccal groove of molar is formed parallel with direction of teeth arrangement.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.319-328
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• 2024

Lysophosphatidic acid receptor 1 (LPA₁) plays a critical role in brain injury following a transient brain ischemic stroke. However, its role in permanent brain ischemic stroke remains unknown. To address this, we investigated whether LPA₁ could contribute to brain injury of mice challenged by permanent middle cerebral artery occlusion (pMCAO). A selective LPA₁ antagonist (AM152) was used as a pharmacological tool for this investigation. When AM152 was given to pMCAO-challenged mice one hour after occlusion, pMCAO-induced brain damage such as brain infarction, functional neurological deficits, apoptosis, and blood-brain barrier disruption was significantly attenuated. Histological analyses demonstrated that AM152 administration attenuated microglial activation and proliferation in injured brain after pMCAO challenge. AM152 administration also attenuated abnormal neuroinflammatory responses by decreasing expression levels of pro-inflammatory cytokines while increasing expression levels of anti-inflammatory cytokines in the injured brain. As underlying effector pathways, NF-κB, MAPKs (ERK1/2, p38, and JNKs), and PI3K/Akt were found to be involved in LPA₁-dependent pathogenesis. Collectively, these results demonstrate that LPA₁ can contribute to brain injury by permanent ischemic stroke, along with relevant pathogenic events in an injured brain.

• 대한소아치과학회지
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• 제21권2호
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• pp.547-554
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• 1994

Posterior crossbites are abnormal buccal, or lingual relationship of a tooth or teeth of the maxilla, the mandible, or both when the teeth of the two arches are in occlusion and involve the molars and premolars. Posterior crossbites are classified as dental, muscular(functional), or skeletal. In an effort to avoid occlusal interferences caused by the inadequate arch width, the patient deviates the mandible laterally upon closure to achieve maximum intercuspation. This is described as functional posterior crossbite. Correction of functional posterior crossbites in the primary & early mixed dentition as early as possible after diagnosis has been recommended, because crossbites do not automatically improve with the eruption of the permanent teeth. Functional posterior crossbites, if left untreated, may have deleterious effects on the development and function of the TMJ. The diagnosis and management of three cases is presented. Each patient with functional posterior crossbites is treated using the bilateral maxillary expansion appliance.

• Journal of Yeungnam Medical Science
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• 제11권2호
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• pp.398-404
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• 1994

저자등은 하악 과두 골절에 있어 골절의 양상, 환자의 요구, 교합의 상태, 한자의 나이등을 고려하여 기능적 처지가 필요하다고 판단된 환자들에 있어 악간 고정기간 없이 activator를 이용한 기능적 치료를 한 결과, 빠른 악관절 기능의 회복을 관찰하고 정상적인 하악의 전, 측방 기능운동을 유도할 수 있었기에 문헌 고찰과 함께 보고하는 바이다.

• 대한치과의사협회지
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• 제50권2호
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• pp.58-63
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• 2012

The fundamental principles and the role of surgeons and orthodontists to produce successful results in orthodontic treatment combined with orthognathic surgery is not different from those of conventional procedures and FOS: surgery-first-orthodontic-treatment-later approach. The communication and cooperation between surgeon and orthodontist is of crucial importance. In FOS, the pre-surgical orthodontic preparation is not carried out in the patient's mouth, but in the mounted stone model and in addition to the simulation of tooth movement, to get a precise surgical occlusion, the entire steps of treatment should be simulated on the articulator as well. Right after the surgery, due to the instability of the occlusion, appropriate post operational care should be given according to the surgical technique applied to the mandible by use of final surgical wafer about 8 weeks.