• Communications for Statistical Applications and Methods
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• 제27권6호
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• pp.603-624
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• 2020

There is an emerging interest in brain functional connectivity (FC) based on functional Magnetic Resonance Imaging in Alzheimer's disease (AD) studies. The complex and high-dimensional structure of FC makes it challenging to explore the association between altered connectivity and AD susceptibility. We develop a pipeline to refine FC as proper covariates in a penalized logistic regression model and classify normal and AD susceptible groups. Three different quantification methods are proposed for FC refinement. One of the methods is dimension reduction based on common component analysis (CCA), which is employed to address the limitations of the other methods. We applied the proposed pipeline to the Alzheimer's Disease Neuroimaging Initiative (ADNI) data and deduced pathogenic FC biomarkers associated with AD susceptibility. The refined FC biomarkers were related to brain regions for cognition, stimuli processing, and sensorimotor skills. We also demonstrated that a model using CCA performed better than others in terms of classification performance and goodness-of-fit.

• 정신신체의학
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• 제20권1호
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• pp.22-31
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• 2012

연구목적 : Premenstrual Symptoms Screening Tool(PSST)를 통해서, DSM-IV상의 월경전불쾌장애(premenstrual dysphoric disorder, PMDD)에 대한 진단기준을 사용하여 월경전기증후군(premenstrual syndrome, PMS) 및 PMDD의 빈도, 기능장애, 위험인자들, 월경에 대한 태도, PMS 및 PMDD의 발현 양상 들을 조사하여 보았다. 방 법 : 서울 및 수도권의 중소도시인 수원에 소재하는 대학교에 다니는 여학생들을 대상으로 하여 월경에의 태도 질문지, PSST를 사용한 단면 조사연구를 시행하였다. 결 과 : 총 1410명에게 질문지가 배부되었으며, 그 중 1063부에 대하여 분석하였다. 응답자들은 PSST의 결과에 따라 3군[정상/경도 PMS군(n=759, 71.4%), 심한 PMS군(n=180, 16.9%), PMDD군(n=124, 11.7%)]으로 분류하였다. 각 군별로는 기본적인 역학적 변수 및 위험 인자(음주, 커피 소비, 월경통의 강도, PMS의 가족력)들의 분포에서 유의한 차이가 있었다. 응답자들을 또한 월경에 대한 태도에 따라 3군으로 구분하였다[긍정적 태도군(n=168), 부정적 태도군(n=122), 양가적 태도군(n=773)]. 심각한 월경전기 증상들을 호소하는 이들의 비율은 이 3가지 태도군 간에 유의한 차이가 있어서, 부정적 태도군은 다른 군들에 비해 더 많은 월경전기 증상들을 보고하였다. 결 론 : PMS와 PMDD는 한국의 젊은 여성들에서 널리 발견된다. 일부 응답자들은 그들이 PMDD에 대한 DSM-IV의 진단기준을 완전히 충족시키지 못하였음에도 유의한 기능손상을 보고하였다. 일반적으로, 월경에 대한 부정적인 태도는 더 많은 월경전기 증상들의 경험과 관련이 있었다.

• 한국사회복지학
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• 제59권1호
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• pp.223-249
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• 2007

본 연구는 개인에 대한 직업재활서비스의 적격성이 장애 등급만으로 결정될 수 있는지를 탐색하기 위해 수행되었다. 이론적 검토를 통해 '기능제한(functional limitation)'개념이 이에 대한 대안이 될 수 있음을 확인하였고 변형바델지수(Modified Barthel Index)를 이용하여 기능제한 정도를 측정하였다. 전체 381명의 뇌성마비인을 대상으로 신체적 손상(impairment)과 기능제한 그리고 취업여부의 관계를 파악한 결과, 뇌성마비유형과 부위 등 신체적 손상과 관련된 변인은 취업여부에 직 간접적 영향을 미치지 않았으나 통증문제와 이동능력은 간접적인 경로를 통해, 자기관리능력은 직접적인 경로를 통해 취업여부에 영향을 미침을 알 수 있었다. 이러한 연구결과를 통해 향후 각종 장애관련 연구나 서비스 전달체계의 적격성을 파악하는 과정에서 무엇을 '장애'로 규정할 것인지에 대해 고민해야 하며, 그 대안으로 신체적 '기능제한' 정도를 개념화 하는 것에 대한 추가적인 연구가 수행되어야 함을 알 수 있었다.

• 대한음성학회지:말소리
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• 제51호
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• pp.39-55
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• 2004

Working memory is the term used to refer to the mental workplace in which information can be temporarily stored and manipulated during complex everyday activities such as understanding language. The studies on language and working memory are based on Baddeley's phonological working memory and Daneman and Carpenter's functional working memory. This article reviews two working memory models and the studies on language and working memory based on each model. These are described in the implication of working memory in language development and specific language impairment-evaluation and treatment.

• 한국식품영양과학회지
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• 제41권9호
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• pp.1253-1258
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• 2012

본 연구에서는 복분자 섭취가 노화에 의한 기억력 감퇴에 개선 효과를 나타내는지 조사하기 위해 노화촉진마우스 (SAM)를 사용하여 평가하였다. 28주령 SAMP8 마우스에 복분자 시료를 100 mg/kg body weight/day로 8주간 투여한 후 수동회피시험과 수중미로시험을 실시하여 기억력 개선효과를 평가하였다. 수동회피시험에서 노화 촉진 동물(SAMP8)은 대조동물(SAMR1)에 비해 밝은 방에서 체류시간이 현저히 감소하였다. 복분자를 섭취한 노화 촉진 동물의 밝은 방에서의 체류 시간은 복분자를 섭취하지 않은 동물에 비해 현저히 증가하였다. 수중미로실험에서 대조 동물에 비해 노화 촉진 동물의 평균 탈출잠복기는 길었고, 복분자를 섭취한 경우 평균 탈출잠복기가 유의적으로 감소하였다. 뇌의 대뇌피질과 해마 조직에서 대조군에 비해 노화 촉진 동물의 acetylcholinesterase 활성이 증가하였다. 복분자를 섭취한 노화 촉진 동물의 해마 조직 내 acetylcholinesterase는 복분자를 섭취하지 않은 동물에 비해 유의적으로 감소하였다. 이 결과들은 복분자가 노화촉진마우스에서 노화에 의한 기억력 감퇴에 대한 개선 효과를 나타내며, 이는 콜린성 신경전달에 중요한 역할을 하는 acetylcholinesterase 활성 감소를 통해 이루어짐을 나타낸다. 향후 더 많은 연구가 수행 되어야 하나, 본 연구는 복분자가 노인의 기억력 개선제 개발에 좋은 기능성 소재로 활용할 수 있음을 제시한다.

• 한국치위생학회지
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• 제19권2호
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• pp.161-172
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• 2019

Objectives: This study aimed to analyze the correlation between oral function, oral environment, and brain cognitive function in the elderly. Methods: The subjects were 60 users of senior community center and elderly day care center. The survey was conducted from November to December 2018. Subjects were assessed by oral examination and myofunction test. Oral myofunction was measured using $IOPI^R$ and Lip de $Cum^R$. Survey data were analyzed using the statistical programs of PASW Statistics ver. 18.0. Results: Tongue muscle strength and lips muscle strength was higher in males than in females. The tongue and lip strengths were higher in the <81 years old group than the ${\geq}81$ years old group. Functional tooth analysis showed that there was a ${\geq}15$ teeth group ($40.91{\pm}7.36$) and a <15 teeth group ($32.52{\pm}7.14$). Lip muscle strength analysis showed that the ${\geq}15$ teeth group ($10.54{\pm}3.40$) was higher than the <15 teeth group ($8.20{\pm}2.41$, p<0.05). Tongue muscle strength, lumbar muscle strength, and functional tooth number were lower in the elderly subjects with mild cognitive impairment. Cognitive function was significantly correlated with functional tooth number (r=0.386, p<0.001), tongue strength (r=0.478, p<0.001), and lip strength (r=0.281, p<0.05). Tongue strength was significantly correlated with lip strength (r=0.360, p<0.001) and functional tooth number (r=0.633, p<0.001). Lip strength was significantly correlated with functional tooth number (r=0.376, p<0.001). Conclusions: These results showed that age and functional tooth number influenced oral muscle strength and that the number of functional teeth and oral muscle strength were low in the elderly with mild cognitive impairment. Oral myofunction training and oral care program are suggested to improve the quality of life of the elderly.

• 간호행정학회지
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• 제14권4호
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• pp.421-431
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• 2008

Purpose: Using comprehensive and valid instrument, MDS-HC 2.0, this study aimed to analyze the functional status and to evaluate the care needs of the community-dwelling disabled with cerebral impairment. Method: With a convenient sample of 88 disabled with cerebral impairment, the data were collected at a community health center located in rural area in Choongchung providence in August 2005. Subject's functional status and care needs were evaluated using Minimum Data Set-Home Care version 2.0. Result: Significant proportion of subjects were totally dependent for locomotion-outdoor (26.1%), personal hygiene (24.1%), bathing (24.1%). For IADLs, over 40% of subjects were totally dependent for ordinary house work, managing finances, or shopping. Top five ranked care needs were preventive health care measures (100%), communication disorders (71.6%), visual function (55.7%), health promotion (52.3%), and pressure ulcers (48.9%). The proportion of triggered clinical assessment protocols were significantly higher in disability level I group for the risk of institutionalization (p=<.001), communication disorders (p=.004), cognitive problems (p=.001), pressure ulcers (p=<.001), skin and foot conditions (p=.010), and urinary incontinence and indwelling catheters (p=<.001). Conclusions: It is necessary to provide community based rehabilitation services that are individualized for their service needs thus enhance optimal level of functioning.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.71-77
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• 2019

Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this study is to investigate the effects of spinosin on the improvement of cognitive impairment in model mice with Alzheimer's disease (AD) induced by $A{\beta}_{1-42}$ and determine the underlying mechanism. Spontaneous locomotion assessment and Morris water maze test were performed to investigate the impact of spinosin on behavioral activities, and the pathological changes were assayed by biochemical analyses and histological assay. After 7 days of intracerebroventricular (ICV) administration of spinosin ($100{\mu}g/kg/day$), the cognitive impairment of mice induced by $A{\beta}_{1-42}$ was significantly attenuated. Moreover, spinosin treatment effectively decreased the level of malondialdehyde (MDA) and $A{\beta}_{1-42}$ accumulation in hippocampus. $A{\beta}_{1-42}$ induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment. These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression,suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets.

• 대한물리의학회지
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• 제15권2호
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• pp.65-73
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• 2020

PURPOSE: This study examined the effects of coordinative locomotor training on the physical factors for falls in the elderly with mild cognitive impairment. METHODS: This study examined thirty subjects diagnosed with mild cognitive impairment by the radiologic findings, history, and physical examination. The subjects were assigned to a control group (n = 15) or experimental group (n = 15, coordinative locomotor training). The experimental group underwent coordinative locomotor training for four weeks, with training sessions two times per week. The control group was given a fall-prevention education for 60 minutes without coordinative locomotor training. To evaluate the physical factors for falls, the lower extremity strength and the Korean version of the Fullerton advanced balance scale and biorescue were measured for balance. These tests were conducted before and after training. RESULTS: Significant differences were observed between the two groups after the four weeks of coordinative locomotor training for the elderly with mild cognitive impairment the experimental group had a greater degree of improvement in the physical factors for falls. CONCLUSION: These findings suggest that coordinative locomotor training may have a functional effect on fall-prevention and the mobility of the elderly with mild cognitive impairment. In addition, it is expected to provide systematic and effective data that can be used as a fall prevention program for the elderly with mild cognitive impairment in each institution.

• 대한간호학회지
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• 제49권4호
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• pp.375-385
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• 2019

Purpose: This study aimed to develop and test a structural model for chemotherapy-related cognitive impairment of breast cancer patients based on a literature review and Hess and Insel's chemotherapy-related cognitive change model. Methods: The Participants consisted of 250 patients who were ${\geq}19$ years of age. The assessment tools included the Menopause Rating Scale, Symptom Experience Scale, Hospital Anxiety and Depression Scale, Everyday Cognition, and Functional Assessment of Cancer Therapy-Breast Cancer. Data were analyzed using the SPSS 21.0 and AMOS 21.0 programs. Results: The modified model was a good fit for the data. The model fit indices were ${\chi}^2=423.18$ (p<.001), ${\chi}^2/df=3.38$, CFI=.91, NFI=.91, TLI=.89, SRMR=.05, RMSEA=.09, and AIC=515.18. Chemotherapy-related cognitive impairment was directly influenced by menopausal symptoms (${\beta}=.38$, p=.002), depression and anxiety (${\beta}=.25$, p=.002), and symptom experiences (${\beta}=.19$, p=.012). These predictors explained 47.7% of the variance in chemotherapy-related cognitive impairment. Depression and anxiety mediated the relations among menopausal symptoms, symptom experiences, and with chemotherapy related cognitive impairment. Depression and anxiety (${\beta}=-.51$, p=.001), symptom experiences (${\beta}=-.27$, p=.001), menopausal symptoms (${\beta}=-.22$, p=.008), and chemotherapy-related cognitive impairment (${\beta}=-.15$, p=.024) had direct effects on the quality of life and these variables explained 91.3%. Conclusion: These results suggest that chemotherapy-related toxicity is highly associated with cognitive decline and quality of life in women with breast cancer. Depression and anxiety increased vulnerability to cognitive impairment after chemotherapy. Nursing intervention is needed to relieve chemotherapy-related toxicity and psychological factor as well as cognitive decline for quality of life in patients undergoing chemotherapy.