• 한국노년학
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• v.29 no.4
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• pp.1577-1589
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• 2009

The purpose of this study was to compare the health status, functional status, and home environment hazards by the fear of falling and explore the factors that contribute to the fear of falling. This was a descriptive study. Data were collected for two years with 973 older adults who enrolled in a health center at A city. Trained nurses visited subjects' home and collected data using Resident Assessment Instrument MDS-HC. The average age of the subjects was 76.8 (±7.6) and female was 74.8%. 20.7% of subjects reported fear of falling. In terms of the fear of falling, two groups were compared. There were significant differences in vision, urinary incontinence, pain that interrupts daily activity, unstable gait, comorbidities, frequency of depressive or anxious sign. The greater the age, IADL and ADL dependency, comorbidities, unstabled gait, the more fear of falling. In conclusion, this study reassured the importance of assessing the major factors related to fear of falling such as age, IADL and ADL, comorbities, gait among older adults. This study will contribute to establish strategies for preventing fall. Reducing the fear of falling through the comprehensive nursing intervention will ultimately improve the quality of life in the elderly.

• Journal of the Korean Geographical Society
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• v.37 no.4
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• pp.317-336
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• 2002

Dongrae-bu, the administrative central area in Busan in Chosun-dynasty(1392-1910), performed the large parts of diplomatic and trading functions with Japan because of its geographical conditions. Because of his location, landscape of Dongrae city-wall is the mirror of political and military meaning in Chosun-dynasty period. Elements of landscape, such as site of city-wall, location and morphology of gates, government official buildings and the road systems can be interpreted by the functional and socio-cultural terms. The changes of landscape during Japanese colonial period(1910-1945) show that destruction of city-walt went on for the purpose of imperialism. Especially, the landscape which had political meaning in Chosun-dynasty had erased in terms of modem urban planning. Cates of city-wall, official guest house, fortress which symbolize the governing and political power of Chosun-dynasty were destructed almost perfectively. New road system was imported Urban planning was effective instrument through which city-wall could be destroyed for the Japanese colonialism. Under those processes, traditional structure was changed towards the dependency on Japan. Those relict landscape are remained in present urban landscape such as road system, cul-de sac, house and cornerstones. Those results of this study show that city-wall in Korea should be studied in terms of socio-cultural aspects in each periods.

• The Korean Journal of Pharmacology
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• v.23 no.1
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• pp.25-31
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• 1987

The present study examines firstly, the inhibition of collagen gelation to explore the possible involvement of $Cu^{++}$-catalyzed peroxidation in rheumatoid arthritis and secondly, the effect of sodium salicylate on this peroxidative reaction to provide a possible explanation for its mechanism of anti-inflammatory action. Incubation of collagen obtained from rat skin with $Cu^{++}$ and $H_2O_2$ resulted in the inhibition of gelation in terms of maximal turbidity and lag phase, but either $Cu^{++}$ or $H_2O_2$ alone essentially gave no effect in the collagen gelation. In the presence of sodium salicylate the inhibited gelation of collagen induced by $Cu^{++}$ and $H_2O_2$ was reversed with the dependency of the concentration of sodium salicylate. Moreover, the rate of $H_2O_2$ decomposition by $Cu^{++}$ was accelerated by sodium salicylate and this decomposition of $H_2O_2$ was found to be saturable in terms of concentration of this drugs. Thus it can be expected that $Cu^{++}$ -catalyzed peroxidation attacks collagen resulting in change of structural or functional integrity of collagen, and sodium salicylate may act on this peroxidative process, possibly through the enhancement of catalatic action of $Cu^{++}$. From these results $Cu^{++}$-catalyzed peroxidation can be in part responsible for degradation of joint tissue in rheumatoid arthritis and sodium salicylate may exert its anti-inflammatory action by this peroxidative reaction.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.1
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• pp.102-109
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• 2008

The aims of this study were to evaluate dental caries status and to analyze the dental caries related factors which could explain the relationship between dental caries and disabled type, severity of handicap, and oral health behaviors among disabled children and adolescent in Korea. A total of 677 subjects aged from 6 to 18 were finally selected by stratified cluster sampling. They were examined by 13 trained dentists and interviewed with questionnaire. For the crude and adjusted associations, bivariate and multivariate analysis were performed using SPSS program(SPSS Inc, Chicago, USA). DMFT index were 0.90(ages 6-8), 2.32(ages 9-11), 3.63(ages 12-14) and 4.93(ages 15-17), respectively. The DMFT index was significantly related to age, frequency and dependency of toothbrushing, and mastication and functional disorder. Specialized preventive care program which accounted the age and toothbrushing instruction be developed and adapted to promote oral health status and behaviors of disabled children and adolescent in Korea.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.4
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• pp.15-25
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• 2012

The research on the FPGA CAD tools in academia has been lacking practicality due to the underlying FPGA fabric architecture which is too simple and inefficient to be applied for commercial FPGAs. Recently, the database of placement positions and routing graphs on commercial FPGA architectures has been built, and provided for enabling the academic development of placement and routing tools. To extend the limit of academic CAD tools even further, we have developed the evaluation toolkit for the K-FPGA architecture which is under development. By providing interface for exchanging data with a commercial FPGA toolkit at every step of mapping, packing, placement and routing in the tool chain, the toolkit enables individual tools to be developed without waiting for the results of the preceding step, and with no dependency on the quality of the results, and compared in detail with commercial tools at any step. Also, the fabric primitive library is developed by extracting the prototype from a reporting file of a commercial FPGA, restructuring it, and modeling the behavior of basic gates. This library can be used as the benchmarking target, and a reference design for new FPGA architectures. Since the architecture is described in a standard HDL which is familiar with hardware designers, and read in the tools rather than hard coded, the tools are "data-driven", and tolerable with the architectural changes due to the design space exploration. The experiments confirm that the developed library is correct, and the functional correctness of applications implemented on the FPGA fabric can be validated by simulation. The placement and routing tools are under development. The completion of the toolkit will enable the development of practical FPGA architectures which, in return, will synergically animate the research on optimization CAD tools.

• Journal of Dairy Science and Biotechnology
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• v.34 no.2
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• pp.137-144
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• 2016

The ultimate research goal of the current study was a development of hydrolyzed whey protein powder (7%-GNANA) manufactured with normal content of sialic acid, a marker compound, that is naturally occurring at 7% concentration in GMP obtained from the milk protein. GMP is a safe food, used worldwide in infant and baby foods, etc. The test substance was prepared using (7% sialic acid containing) GMP as a raw material, and then using alcalase, an enzyme approved as a food additive, after separation of sialic acid with 100% efficiency and 7%-GNANA (containing 7% sialic acid and protein; product name: HELICOBACTROL-7) provided by MEDINUTROL Inc. (Korea). Bacterial reverse mutation (Ames) test was conducted in accordance with GLP Guideline using the test substance specified above. To identify its mutagenic potential against microorganisms, histidine auxotrophic strains of Salmonella Typhimurium, TA98, TA100, TA1535, and TA1537, and tryptophan auxotrophic strain of Escherichia coli, WP2uvrA, were used. The bacterial reverse mutation (Ames) test was performed by dividing the test substances into five different concentration groups (0, 61.7, 185, 556, 1,670, $5,000{\mu}g/plate$). Results of this experiment did not reveal repetitive increase of colony generating values or positive criteria for reverse mutagenicity for any concentration of test substances in any of the five strains, regardless of the presence of a metabolic activation system, and no dose-dependency was identified. In conclusion, the safety of 7%-GNANA test substance was verified by bacterial reverse mutation test conducted before registration of 7%-GNANA as a food additive.

• Journal of KIISE
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• v.43 no.10
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• pp.1115-1123
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• 2016

Assumption-based truth maintenance system (ATMS) is a tool that maintains the reasoning process of inference engine. It also supports non-monotonic reasoning based on dependency-directed backtracking. Bookkeeping all the reasoning processes allows it to quickly check and retract beliefs and efficiently provide solutions for problems with large search space. However, the amount of data has been exponentially grown recently, making it impossible to use a single machine for solving large-scale problems. The maintaining process for solving such problems can lead to high computation cost due to large memory overhead. To overcome this drawback, this paper presents an approach towards incrementally maintaining the reasoning process of inference engine on cluster using Spark. It maintains data dependencies such as assumption, label, environment and justification on a cluster of machines in parallel and efficiently updates changes in a large amount of inferred datasets. We deployed the proposed ATMS on a cluster with 5 machines, conducted OWL/RDFS reasoning over University benchmark data (LUBM) and evaluated our system in terms of its performance and functionalities such as assertion, explanation and retraction. In our experiments, the proposed system performed the operations in a reasonably short period of time for over 80GB inferred LUBM2000 dataset.

• Journal of the Korean Society of Radiology
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• v.18 no.1
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• pp.37-44
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• 2024

Even though MR can reveal excellent soft-tissue contrast and functional information, CT is also required for electron density information for accurate dose calculation in Radiotherapy. For the fusion of MRI and CT images in RT treatment planning workflow, patients are normally scanned on both MRI and CT imaging modalities. Recently deep-learning-based generations of CT images from MR images became possible owing to machine learning technology. This eliminated CT scanning work. This study implemented a CycleGan deep-learning-based CT image generation from MR images. Three CT generators whose learning is based on T1- , T2- , or T1-&T2-weighted MR images were created, respectively. We found that the T1-weighted MR image-based generator can generate better than other CT generators when T1-weighted MR images are input. In contrast, a T2-weighted MR image-based generator can generate better than other CT generators do when T2-weighted MR images are input. The results say that the CT generator from MR images is just outside the practical clinics and the specific weight MR image-based machine-learning generator can generate better CT images than other sequence MR image-based generators do.

• Journal of Chest Surgery
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• v.57 no.2
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• pp.160-168
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• 2024

Background: Data on perioperative outcomes of emergent versus elective resection in esophageal cancer patients requiring esophagectomy are lacking. We investigated whether emergent resection was associated with increased risks of morbidity and mortality. Methods: Data on patients with esophageal malignancy who underwent esophagectomy from 2005 to 2020 were retrospectively analyzed from the American College of Surgeons National Surgical Quality Improvement Program database. Thirty-day complication and mortality rates were compared between emergent esophagectomy (EE) and non-emergent esophagectomy. Logistic regression assessed factors associated with complications and mortality. Results: Of 10,067 patients with malignancy who underwent esophagectomy, 181 (1.8%) had EE, 64% had preoperative systemic inflammatory response syndrome, sepsis, or septic shock, and 44% had bleeding requiring transfusion. The EE group had higher American Society of Anesthesiologists (ASA) class and functional dependency. More transhiatal esophagectomies and diversions were performed in the EE group. After EE, the rates of 30-day mortality (6.1% vs. 2.8%), overall complications (65.2% vs. 44.2%), bleeding, pneumonia, prolonged intubation, and positive margin (17.7% vs. 7.4%) were higher, while that of anastomotic leak was similar. On adjusted logistic regression, older age, lower albumin, higher ASA class, and fragility were associated with increased complications and mortality. McKeown esophagectomy and esophageal diversion were associated with a higher risk of postoperative complications. EE was associated with 30-day postoperative complications (odds ratio, 2.39; 95% confidence interval, 1.66-3.43; p<0.0001). Conclusion: EE was associated with a more than 2-fold increase in complications compared to elective procedures, but no independent increase in short-term mortality. These findings may help guide data-driven critical decision-making for surgery in select cases of complicated esophageal malignancy.

• Journal of Dairy Science and Biotechnology
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• v.34 no.2
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• pp.99-116
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• 2016

We herein performed animal safety assessment in accordance with Good Laboratory Practice (GLP) regulations with the aim of developing sialic acid from glycomacropeptide (hereafter referred to as "GMP") as an index ingredient and functional component in functional foods. GMP is a type of whey protein derived from milk and a safe food, with multiple functions, such as antiviral activity. A test substance was produced containing 7% (w/w) sialic acid and mostly-hydrolyzed whey protein (hereafter referred to as "7%-GNANA") by enzymatic treatment of substrate GMP. The maximum intake test dose level was selected based on 5,000 mg/kg/day dose set for male NOEL (no-observed-effect-level) and female NOAEL (no-observed-adverse-effect-level) determined by a dose-range finding (DRF) test (GLP Center of Catholic University of Daegu, Report No. 15-NREO-001) that was previously conducted with the same test substance. To evaluate the toxicity of a repeated oral dose of the test substance in connection with the previous DRF study, 1,250, 2,500, and 5,000 mg/kg of the substance were administered by a probe into the stomachs of 6-week-old SPF Sprague-Dawley male and female rats for 90 d. Each test group consisted of 10 male and 10 female rats. To determine the toxicity index, all parameters, such as observation of common signs; measurements of body weight and food consumption; ophthalmic examination; urinalysis, electrolyte, hematological, and serum biochemical examination; measurement of organ weights during autopsy; and visual and histopathological examinations were conducted according to GLP standards. After evaluating the results based on the test toxicity assessment criteria, it was determined that NOAEL of the test substance, 7%-GNANA, was 5,000 mg/kg/day, for both male and female rats. No animal death was noted in any of the test groups, including the control group, during the study period, and there was no significant difference associated with test substance, as compared with the control group, with respect to general symptoms, body weight changes, food consumption, ophthalmic examination, urinalysis, hematological and serum biochemical examination, and electrolyte and blood coagulation tests during the administration period (P<0.05). As assessed by the effects of the test substance on organ weights, food consumption, autopsy, and histopathological safety, change in kidney weight as an indicator of male NOAEL revealed up to 20% kidney weight increase in the high-dose group (5,000 mg/kg/day) compared with the change in the control group. However, it was concluded that this effect of the test substance was minor. In the case of female rats, reduction of food consumption, increase of kidney weight, and decrease of thymus weight were observed in the high-dose group. The kidney weight increased by 10.2% (left) and 8.9% (right) in the high-dose group, with a slight dose-dependency compared with that of the control group. It was observed that the thymus weight decreased by 25.3% in the high-dose group, but it was a minor test substance-associated effect. During the autopsy, botryoid tumor was detected on the ribs of one subject in the high-dose group, but we concluded that the tumor has been caused by a naturally occurring (non-test) substance. Histopathological examination revealed lesions on the kidney, liver, spleen, and other organs in the low-dose test group. Since these lesions were considered a separate phenomenon, or naturally occurring and associated with aging, it was checked whether any target organ showed clear symptoms caused by the test substance. In conclusion, different concentrations of the test substance were fed to rats and, consequently, it was verified that only a minor effect was associated with the test substance in the high-dose (5,000 mg/kg/day) group of both male and female rats, without any other significant effects associated with the test substance. Therefore, it was concluded that NOAEL of 7%-GNANA (product name: Helicobactrol) with male and female rats as test animals was 5,000 mg/kg/day, and it thus was determined that the substance is safe for the ultimate use as an ingredient of health functional foods.