• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1719-1722
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• 2012

The Wiskott-Aldrich Syndrome Protein family Verprolin - homologous proteins (WAVEs), encoded by a metastasis promoter gene, play considerable roles in adhesion of immune cells, cell proliferation, migration and destruction of foreign agents by reactive oxygen species. These diverse functions have lead to the hypothesis that WAVE proteins have multi-functional roles in regulating cancer invasiveness, metastasis, development of tumor vasculature and angiogenesis. Differentials in expression of WAVE proteins are associated with a number of neoplasms include colorectal cancer, hepatocellular cancer, lung squamous cell carcinoma, human breast adenocarcinoma and prostate cancer. In this review we attempt to unify our knowledge regarding WAVE proteins, focusing on their potentials as diagnostic markers and molecular targets for cancer therapy.

• Plant Biotechnology Reports
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• 제4권1호
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• pp.29-35
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• 2010

NPR1 is a positive regulator of systemic acquired resistance in Arabidopsis and rice. Expression of the rice gene OsNPR1 is induced by salicylic acid (SA). To identify the region of the OsNPR1 promoter involved in response to SA, we carried out deletion mutagenesis of the region 1005 bp upstream of the OsNPR1 start codon. Ciselement analysis revealed that the OsNPR1 promoter contains W-boxes and ASF1 motifs, both of which are known to be functional cis-elements of the WRKY and bZIP proteins, respectively. The deletion constructs 1005:LUC and 752:LUC, were induced by up to 4.3- and 3.8-fold, respectively, following SA treatment, suggesting that W-boxes and ASF1 motifs may play an important role in the strong induction of these constructs by SA. Using mutation analysis, we also showed that both the W-box and ASF1 motif are necessary for SA-induced expression of OsNPR1.

• International Journal of Aeronautical and Space Sciences
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• 제4권1호
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• pp.9-18
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• 2003

In this work, a closed-form analysis is performed for the structural response of coupled composite blades with multi-cell sections. The analytical model includes the effects of shell wall thickness, transverse shear, torsion warping and constrained warping. The mixed beam approach based on Reissner's semi-complementary energy functional is used to derive the beam force-displacement relations. The theory is validated against experimental test data and other analytical results for coupled composite beams and blades with single-cell box-sections and two-cell airfoils. Correlation of the present method with experimental results and detailed finite element results is found to be very good.

• Journal of Applied Biological Chemistry
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• 제43권4호
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• pp.197-206
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• 2000

This paper summarizes recent developments in the field of molecular biology and its application to plant breeding, particularly in rice. Plant breeding in the past mostly depended on the time-consuming crossing of known genomes limited to certain traits. Plant breeding has now benefited from marker-assisted selection and genetic engineering to widen the gene pool, improve plant protection, and increase yield. Future plant breeding will expand based on functional and nutritional genomics, in which gene discovery and high-throughput transformation will accelerate crop design and benefits will accrue to human health, in the form of nutritional food for poor people to reduce malnutrition, or food enriched with antioxidants and with high food value for rich people. Agricultural biotechnology for food is no longer a dream but a reality that will dominate the 21st century for agriculture and human welfare.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1997년도 봄 학술발표회 논문집
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• pp.79-86
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• 1997

In this study, pre-postprocessing toolbox is developed to perform elasto-plastic analyze of underground structures with transient ground water flow. This toolbox is composed of three modules. The first is the data input processor for the structural analysis. The preprocessing Is using GUI (Graphic User Interface), which is consist of dialog box, pull down, and short-cut icon, etc. The second is the structural analysis module. The analysis is based on the elasto-plastic finite element method involving additional options such as ground excavation effect, transient ground water flow, and rock bolts behavior. The last is the postprocessing module. The postprocessing is able to verify the result of the structural analysis by the graphical simulation which visualizes the element mesh, the node displacements, the element stress states, the stress contour, the ground water surface, and the rock bolt stresses. Since various options are considered separately in this toolbox, it is easy to modify the module of each processing, and to update other functional modules for the given analysis conditions.

• Animal cells and systems
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• 제2권2호
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• pp.287-295
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• 1998

The Saccharomyces cerevisiae MGMT gene encodes a O6-methylguanine DNA methyltransferase that protects cells from mutation or death by DNA alkylating agents. Using an in vitro transcription system, we analyzed its promoter region to find regulatory elements for transcription initiation. DNase I footprinting and a transcription assay showed that a functional TATA box, 5'-TGATATAGCA-3', is located in the region spanning from -25 to -34. We also found one upstream repressing sequence (URS), -333 to -213, by promoter deletion and competition analysis. Gel mobility shift assays and Southwestern blot analysis using URS region indicate specific complex formations. These results indicate that several cis-acting and trans-acting elements might be involved in the transcriptional regulation of the S. cerevisiae MGMT gene.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1993년도 Fifth International Fuzzy Systems Association World Congress 93
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• pp.1350-1353
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• 1993

A fuzzy control system typically requires“tuning,”or adjuctment of the parameters defining its linguistic variables. Automating this process amounts to applying a second“metacontrol”layer to drive the controller and plant to desired performance levels. Current methods of automated tuning rely on a single crisp numeric functional to evaluate control system performance. A generalization of Box's complex algorithm allows more realistic tuning based on lexicographic aggregation of multiple ordinal scales of performance, such as effectiveness and efficiency. The method is presented and illustrated using a simple inverted pendulum control system.

• Current Photovoltaic Research
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• 제3권4호
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• pp.116-120
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• 2015

A hybrid transparent conducting layer was applied for Si photodetector. To realize the hybrid transparent conducting layer, a 200 nm-thick ITO layer was deposited onto a Si substrate, following by a solution-processed AgNWs-coating on the ITO. The hybrid transparent conducting layer showed an excellent low electric resistance of $15.9{\Box}/{\Omega}$ with a high optical transparency of 86.89%. Due to these optical and electrical benefits, the hybrid transparent conductor-embedding Si diode provides an extremely high rectifying ratio of 3386. Under light-illumination, the hybrid transparent conductor device provides extremely high photoresponses for broad wavelengths. This implies that a functional design for hybrid transparent conductor is crucial for photoelectric devices and applications.

• International Journal of Internet, Broadcasting and Communication
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• 제16권1호
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• pp.92-98
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• 2024

This meta-analysis systematically reviewed studies on mirror therapy focused on arm and hand function in stroke patients, aiming to comprehensively assess the efficacy of mirror therapy interventions and furnish empirical support for its potential application and future development in the context of stroke rehabilitation. A rigorous search for articles published in international journals up to the year 2022 was conducted. Various assessment tools were employed to calculate effect sizes, evaluating the impact of mirror therapy on arm and hand function in stroke patients. Utilizing a random-effects model, mean effect sizes were determined, yielding a total effect size of 0.545. The effect sizes for the Brunnstrom Recovery Stage (BRS), Box and Block Test (BBT), Modified Barthel Index (MBI), Fugl-Meyer Assessment (FMA), and grip strength test were 0.957, 0.596, 0.490, 0.488, and 0.417, respectively. In summary, we suggest that mirror therapy engenders positive changes in functional recovery among stroke patients, establishing a foundation for its tailored clinical application based on individual subject characteristics.

• 한국작물학회지
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• 제55권2호
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• pp.126-132
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• 2010

천립중이 가벼워 수량은 낮으나 sucrose와 glucose함량이 상대적으로 높아 환자의 이유식 등의 사용을 목적으로 개발된 단미 벼 종자의 발아 및 출아특성과 기계이앙 상자육묘시 적정 파종량을 구명하기 위한 시험결과는 다음과 같다. 1. 단미의 비중별 분포비율은 1.0이하로 가벼운 종자가 97.4%로 대부분이었고 1.12이상인 충실한 종자비율은 2.0% 이하로 낮았다. 반면 일미벼는 단미와 달리 1.12이상 충실한 종자의 비율이 82.3%로 가장 높았고 1.0이하의 충실하지 못한 종자의 비율은 6.4%로 낮았다. 2. 비중별 발아율은 단미의 경우 88-91%로 비중에 관계없이 비슷하였으나 일미벼의 발아율은 단미와 달리 1.0이하는 24%, 1.0～1.12는 61～66%, 1.12이상은 93%로 종자 비중이 무거울수록 발아율이 높았다. 3. 발아속도도 단미 및 일미벼 모두 발아율과 비슷한 경향을 나타냈으나 비중이 1.12이상일 경우 일미벼의 발아속도는 단미보다 빨랐다. 4. 육묘를 위한 단미의 침종기간은 침종온도에 관계없이 일미벼보다 2～4일 더 길었다. 5. 단미는 일미벼에 비해 정상모의 비율이 낮고 비정상모의 비율이 높았는데 비정상모중에서 출아불량이 4.9%, 출아후 shoot의 생육정지는 4.7%, 출아후 생육불량모는 5.3%로 높았다. 6. 기계이앙 육묘시 단미의 적정 파종량은 관행 일미벼 어린모 및 중묘의 상자당 성묘개체수를 기준으로 볼때 관행과 같이 어린모는 220g, 중묘는 130g이었고 부피로는 육묘일수에 관계없이 관행 일미벼의 1.5배량이었다.