• Journal of The Korean Astronomical Society
• /
• v.48 no.4
• /
• pp.213-228
• /
• 2015

The Horizon Run 4 is a cosmological N-body simulation designed for the study of coupled evolution between galaxies and large-scale structures of the Universe, and for the test of galaxy formation models. Using 6300³ gravitating particles in a cubic box of L_box = 3150 h⁻¹Mpc, we build a dense forest of halo merger trees to trace the halo merger history with a halo mass resolution scale down to M_s = 2.7 × 10¹¹h⁻¹M_⊙. We build a set of particle and halo data, which can serve as testbeds for comparison of cosmological models and gravitational theories with observations. We find that the FoF halo mass function shows a substantial deviation from the universal form with tangible redshift evolution of amplitude and shape. At higher redshifts, the amplitude of the mass function is lower, and the functional form is shifted toward larger values of ln(1/σ). We also find that the baryonic acoustic oscillation feature in the two-point correlation function of mock galaxies becomes broader with a peak position moving to smaller scales and the peak amplitude decreasing for increasing directional cosine μ compared to the linear predictions. From the halo merger trees built from halo data at 75 redshifts, we measure the half-mass epoch of halos and find that less massive halos tend to reach half of their current mass at higher redshifts. Simulation outputs including snapshot data, past lightcone space data, and halo merger data are available at http://sdss.kias.re.kr/astro/Horizon-Run4.

• BMB Reports
• /
• v.51 no.7
• /
• pp.338-343
• /
• 2018

Transcription termination factor-1 (TTF-I) is an RNA polymerase 1-mediated transcription terminator and consisting of a C-terminal DNA-binding domain, central domain, and N-terminal regulatory domain. This protein binds to a so-called 'Sal box' composed of an 11-base pair motif. The interaction of TTF-I with the 'Sal box' is important for many cellular events, including efficient termination of RNA polymerase-1 activity involved in pre-rRNA synthesis and formation of a chromatin loop. To further understand the role of TTF-I in human immunodeficiency virus (HIV)-I virus production, we generated various TTF-I mutant forms. Through a series of studies of the over-expression of TTF-I and its derivatives along with co-transfection with either proviral DNA or HIV-I long terminal repeat (LTR)-driven reporter vectors, we determined that wild-type TTF-I downregulates HIV-I LTR activity and virus production, while the TTF-I Myb-like domain alone upregulated virus production, suggesting that wild-type TTF-I inhibits virus production and trans-activation of the LTR sequence; the Myb-like domain of TTF-I increased virus production and trans-activated LTR activity.

• Asian-Australasian Journal of Animal Sciences
• /
• v.31 no.2
• /
• pp.157-162
• /
• 2018

Objective: The aim of this study is to identify single nucleotide polymorphisms (SNPs) and genes related to pig IMF and estimate the heritability of intramuscular fat content (IMF). Methods: Genome-wide association study (GWAS) on 704 inbred Berkshires was performed for IMF. To consider the inbreeding among samples, associations of the SNPs with IMF were tested as random effects in a mixed linear model using the genetic relationship matrix by GEMMA. Significant genes were compared with reported pig IMF quantitative trait loci (QTL) regions and functional classification of the identified genes were also performed. Heritability of IMF was estimated by GCTA tool. Results: Total 365 SNPs were found to be significant from a cutoff of p-value <0.01 and the 365 significant SNPs were annotated across 120 genes. Twenty five genes were on pig IMF QTL regions. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, forkhead box protein O1, ectodysplasin A receptor, ring finger protein 149, cluster of differentiation, tyrosine-protein phosphatase non-receptor type 1, SRY (sex determining region Y)-box 9 (SOX9), MYC proto-oncogene, and macrophage migration inhibitory factor were related to mitogen-activated protein kinase pathway, which regulates the differentiation to adipocytes. These genes and the genes mapped on QTLs could be the candidate genes affecting IMF. Heritability of IMF was estimated as 0.52, which was relatively high, suggesting that a considerable portion of the total variance of IMF is explained by the SNP information. Conclusion: Our results can contribute to breeding pigs with better IMF and therefore, producing pork with better sensory qualities.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.15 no.2
• /
• pp.351-365
• /
• 2002

The box system that is composed only of reinforced concrete walls and slabs we adopted on many high-rise apartment buildings recently constructed in Korea. And the framed structure with shear wall core that can effectively resist horizontal forces is frequently adopted for the structural system for high-rise building structures. In these structures, a shear wall may have one or more openings for functional reasons. It is necessary to use subdivided finite elements for accurate analysis of the shear wall with openings. But it would take significant amount of computational time and memory if the entire building structure is subdivided into a finer mesh. An efficient analysis method that can be used regardless of the number, size and location of openings is proposed in this study. The analysis method uses super element, substructure, matrix condensation technique and fictitious beam technique. Three-dimensional analyses of the box system and the framed structure with shear wall core having various types of openings were performed to verify the efficiency of the proposed method. It was confirmed that the proposed method have outstanding accuracy with drastically reduced time and computer memory from the analyses of example structures.

• Proceedings of the Korean Society for Cognitive Science Conference
• /
• 2000.06a
• /
• pp.419-423
• /
• 2000

성공적인 의사소통의 경우에 성(性)이, 이(理)와 명(命)으로 나타난 것이 같다. 진리(aletheia)가, 언어(logos)와 운명(moira)으로 나타난 것들이 일치하는 것이 성공적인 언화행위가 된다. 측정대상(melos)과 본체(ousia)가 구분되는 것은 언어와 운명의 괴리가 있을 수 있기 때문이다. 체계적인 언어처리의 지식기반을 측정대상에 한정한다. (1) 철학의 시작은 더 옳은 언어표현의 정의(definition)로 이전의 잘못 사용된 언어처리를 대체시키는 것으로 소크라테스는 보았다. [R. Crossman] (2)잘못을 지적하는 등에(Tabanidae)의 역할과 옳은 지식의 상기를 돕는 산파법(maieutics)이 소크라테스의 의미분석의 방법이다. [R. Crossman] (3) 언어를 통하여 진리를 추구한다는 입장(via language)에서 한 언어표현이 그 진리의 운명으로 나타남과 어긋날 때, 운명을 택하는 것은 조화 보다 더 안정의 우위를 인정하는 논리적인 입장으로 합리성 보다 실용(pragma)의 우위를 인정하는 것이다. [W. Quine] (4) 공동체의 공통규범의 추구는 그 언어 속의 공통의 형식 또는 법칙의 추구에 기초하는 것이 자연스럽다. 여기에서 그 언어사용은 그 기저의 법칙(underlying rule)에 개입한다는 입장에 기초한다. [J. Searle] (5) 진리의 언어표현과 운명적인 사태들 사이의 괴리를 처리하기 위하여 체계적인 언어표현의 대상(The Young Tableaux)과 실제(The continuum)의 구분을 수용한다. [AMS(2000)]언어표현의 대상은 나타난 것(顯)이고 실제에는 나타나지 않은 것도 있다. [伊川, 明道] (6) 이 나타난 것과 나타나지 않은 것에 간격이 없다는 것(顯微無間)은 그 의사소통이 성공적인 것이라는 것을 말한다. 따라서 그 언어의 표현완전성(functional completeness)은 언화행위가 성공적이라는 것이다. [J. Searle] (7) 수로 쓰인 것(象數)과 시로 쓰인 것(義理)이 하나인 것은 그 나타난 것과 나타나지 않은 것들 사이에 어떠한 틈도 없음을 말한다. [成中英] (8) 공통의 규범의 공통성 속에 규범적인 측면이 벌써 있다. 공통성에서 개인적이 아닌 공적인 규범으로의 전이는 규범, 가치, 규칙, 과정, 제도로의 전이라고 본다. [C. Morrison] (9) 우리의 언어사용에 신비적인 요소를 부인할 수가 없다. 넓은 의미의 발화의미(utterance meaning) 속에 신비적인 요소나 애정표시도 수용된다. 의미분석은 지금 한글을 연구하고, 그 결과에 의존하여서 우리의 실제의 생활에 사용하는 $\boxDr$한국어사전$\boxUl$등을 만드는 과정에서, 어떤 의미에서 실험되었다고 말할 수가 있는 언어과학의 연구의 결과에 의존하여서 수행되는 철학적인 작업이다. 여기에서는 하나의 철학적인 연구의 시작으로 받아들여지는 이 의미분석의 문제를 반성하여 본다.

• Journal of the Korean Solar Energy Society
• /
• v.27 no.2
• /
• pp.111-119
• /
• 2007

The annual mean temperature of South Korea has risen by $1.3^{\circ}C$ for last 100 years by urbanization and industrialization. Especially, the frequency of unusual hot weather in summer increases for a long time and the frequency of unusual cold weather in winter clearly decreases. In recently, The considerable portion of curtain wall system is appled to building skin in domestic. As related to this, the Korea Institute of Construction Technology devised the box typed double skin facade(It is occasionally called as FDFS : Functional Double Facade System) as an alternative that reflects the distinctive local climate and saves cooling energy. Two mock-ups($49m^*4.9m$) applied to single skin(curtain wall) and double skin each were monitored under the outdoor condition. Therefore, the characteristics of natural ventilation and cooling energy consumption of each window had been analyzed in real time. The results of this study are summarized as follow, Analysis of the experiment on an air conditioner: the indoor temperature of the chamber with FDFS is lower than that of the chamber with single skin facades by $3{\sim}6$ degrees(C). A temperature variation of about $1{\sim}2$ degrees between the 0.2m and 1.7m height of the mock-up occurs in FDFS, while that of about maximum 7 degrees occurs in single skin facade at noon with abundant intensity of solar accident. Also, 67 percent of energy consumption for air conditioning has been saved.

• Advances in environmental research
• /
• v.5 no.3
• /
• pp.189-200
• /
• 2016

This study aimed at advanced oxidation of hetero tri-functional reactive dye Acid orange 7 using photo-Fenton conditions in a lab-scale experiment. Decolourisation of Acid Orange 7 dye by Fenton's process was dependent on concentration of Hydrogen peroxide, Ferrous sulphate, pH, and contact time. A $2^3$ factorial design was used to evaluate the effects of these key factors: pH, Fe(II), and $H_2O_2$ concentration, for a dye concentration of 50 mg/L with COD of 340 mg/L at pH 3.0. The response function was removal of colour under optimised conditions; pH 3.0, [Fe(II)] 40.83 mg/L, [$H_2O_2$] 4.97 mmol/L; 13.6 min. of treatment resulting in 100% colour removal. The final COD of treated wastewater was nil suggesting that AOP is a potentially useful process of color removal and dye degradation/mineralisation of effluent having AO7. Minimum contact time for complete decolourisation was at 5 mmol/l $H_2O_2$ concentration. Increase in $FeSO_4$ (mg/l) concentration resulted in decrease of time for complete decolourisation. Box-Behnken Design was used to optimize the process variables. Maximum and minimum levels of pH (3-5), $H_2O_2$ (4-6 mmol/l), $FeSO_4$ (30-46 mg/l) and contact time (5-15 minutes) were used. The statistical analysis revealed a value of 0.88 for coefficient of regression ($R^2$) indicating a good fit of model. Calculated F-value was found higher than the tabulated value confirming to significance of the model. Based on student's t-test, Ferrous sulphate, pH, and contact time have a positive effect on the percent decolourisation of Acid Orange 7.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.49 no.4
• /
• pp.375-383
• /
• 2023

Malic acid-catalyzed transformation has been developed to produce ginsenoside Rg3 which is increasingly in demand as a functional ingredient. The optimization of the conversion of red ginseng saponin (RGS) to ginsenoside Rg3 by acid catalyzed transformation was carried out using Box-Behnken design (BBD) based on Response Surface Analysis (RSM). The main independent variables were malic acid concentration, temperature, and reaction time. Conversion of ginsenoside Rg3 was performed according to BBD model and optimization conditions were analyzed. The concentration of the converted ginsenoside Rg3 ranged from 1.548 mg/L to 4.558 mg/L, and the highest production was obtained under the condition of reacting 1% malic acid, 50 ℃ and 9h. Consequently, The independent variables affecting the production of ginsenoside Rg3 were identified in the following order: malic acid concentration, reaction time and temperature. In addition, it was confirmed that the interaction between malic acid concentration and reaction time had a greater influence than the temperature.

• The Journal of Korean society of community based occupational therapy
• /
• v.4 no.1
• /
• pp.33-45
• /
• 2014

Objective : We tested the effect of mirror treatment on patients with and without unilateral neglect over a period of 4 weeks. We also wanted to know the effect of mirror treatment with regards to improving upper extremity function and dealing with activities of daily living. Methods : Subjects were 10 hemiplegia patients with unilateral neglect and 10 hemiplegia patients without unilateral neglect. They visited the department of occupational therapy. We performed mirror treatment for 30 minutes, 5 times a week for 4 weeks. We used Albert Test to compare our results from before and after the treatment, Fugl-Meyer motor function Assessment(FMA) and Box & Block Test(BBT) for upper extremity function, and Functional Independence Measure(FIM) for activities of daily living. Results : The results showed that mirror treatment had an effect on stroke patients with unilateral neglect. The treatment also had an effect on upper extremity function and activities of daily living regardless of unilateral neglect. Conclusion : The mirror treatment showed improvements on upper extremity function and activities of daily life as well as a reduction in the unilateral neglect after a stroke. In conclusion, the mirror treatment is useful for recovering function and improvement and for helping the patients complete activities of daily living.

• Asian-Australasian Journal of Animal Sciences
• /
• v.29 no.4
• /
• pp.479-486
• /
• 2016

A previous genome-wide association study (GWAS) exposed histone deacetylase 2 (HDAC2) as a possible candidate gene for breast muscle weight in chickens. The present research has examined the possible role of HDAC2 in skeletal muscle development in chickens. Gene expression was measured by quantitative polymerase chain reaction in breast and thigh muscles during both embryonic (four ages) and post-hatch (five ages) development and in cultures of primary myoblasts during both proliferation and differentiation. The expression of HDAC2 increased significantly across embryonic days (ED) in breast (ED 14, 16, 18, and 21) and thigh (ED 14 and 18, and ED 14 and 21) muscles suggesting that it possibly plays a role in myoblast hyperplasia in both breast and thigh muscles. Transcript abundance of HDAC2 identified significantly higher in fast growing muscle than slow growing in chickens at d 90 of age. Expression of HDAC2 during myoblast proliferation in vitro declined between 24 h and 48 h when expression of the marker gene paired box 7 (PAX7) increased and cell numbers increased throughout 72 h of culture. During induced differentiation of myoblasts to myotubes, the abundance of HDAC2 and the marker gene myogenic differentiation 1 (MYOD1), both increased significantly. Taken together, it is suggested that HDAC2 is most likely involved in a suppressive fashion in myoblast proliferation and may play a positive role in myoblast differentiation. The present results confirm the suggestion that HDAC2 is a functional gene for pre-hatch and post-hatch (fast growing muscle) development of chicken skeletal muscle.