• 디자인학연구
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• 제16권3호
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• pp.299-308
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• 2003

21세기 지식정보화 시대를 살고있는 지금 Digital 시대가 심화되어감에 따라 기존 시장형태와 사회구조에 큰 변화가 가시화되고 있다. 소비시장의 특징은 힘의 균형이 기업에서 소비자로의 이동이다. 생활수준의 향상에 따른 소비자의 욕구가 다양해지면서 인간의 경험과 감성, 가치에 기반을 둔 다양한 상품들이 히트상품의 양 축을 이루고 있다. 상품의 규격화된 기능과 서비스로는 더 이상 소비자를 사로잡기 어렵다. 소비자가 원하는 것은 감동적인 경험을 제공하는 상품이나 서비스라는 사실에 주목해야 한다. 미래의 상품은 이성이 아니라 소비자의 감성에 호소해야한다. 이제 소비자는 상품자체가 아니라 상품에 담겨있는 스타일과 경험과 이야기를 구매한다. 즉 구매결정의 관건은 감성 가치의 만족인 것이다. 산업디자인의 발전으로 다양해진 사용자의 감성은 사용자들의 새로운 취향을 대변해줄 수 있는 새로운 디자인의 개발이 요구되어지고있다. 사용자중심의 가치관으로의 전환은 자동차에 대한 의식의 변화로 가격, 기능의 물리적 관점에서 개인지 감성과 개성중심으로 변화하여 기능적 형태의 디자인에서 새로운 감성가치를 추구하는 디자인 개념으로 연구되어야한다. 변화의 시대를 맞이하여 디자이너가 주체적이고 합리적인 변화의 방향을 제시해야 할 시점이다.

• 한국발생생물학회지:발생과생식
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• 제17권2호
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• pp.99-109
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• 2013

Trophoblasts, in the placenta, play a role for placental development as well as implantation in the early pregnancy. The characteristics and functions of trophoblast are identified by their localization and potency for proliferation, differentiation, and invasion. Thus, inadequate trophoblast cell death induces trophoblast dysfunction resulting in abnormal placental development and several gynecological diseases. Recently, it was reported that increased immortalization-upregulated protein-2 (IMUP-2) by hypoxia influences trophoblast apoptosis. However, IMUP-2 function on autophagy, which is type II programmed cell death remains unclear. In this study, we analyzed IMUP-2 expression in trophoblast cells (HTR8-SVneo) and compared IMUP-2 effects on cell death including apoptosis and autophagy in trophoblast regardless of IMUP-2 expression. Increased IMUP-2 in trophoblast by IMUP-2 gene transfection induces cell death, especially, apoptosis increases more than autophagy (p<0.05). However, the decreased IMUP-2 in trophoblasts after siRNA treatment decreased apoptosis with the decreased activities of caspase 3 and 7. The expressions of LC3 and MDC as an autophagosome makers and phosphorylated mTOR, which is a negative regulator for autophagy, increased. In addition, the S phase of cell cycle increased in trophoblasts when IMUP-2 expression decreased. Taken together, the alteration of IMUP-2 can control the balance between apoptosis and autophagy of trophoblasts resulting in functional involvement in placental development and in gynecological diseases by regulating the function of trophoblasts.

• 대한후두음성언어의학회지
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• 제23권2호
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• pp.111-118
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• 2012

Botulinum toxin is a potent neurotoxin that is produced by the bacterium Clostridium botulinum. The agent causes muscle paralysis by preventing the release of acetylcholine at the neuromuscular junction of striated muscle. Botulinum toxin A (Botox, AllerganInc., Irvine, California) is the most potent of seven distinct toxin subtypes that are produced by the bacterium. The toxin was initially used clinically in the treatment of strabismus caused by hypertonicity of the extraocular muscles and was sub-sequently described in the treatment of multiple disorders of muscular spasticity and dystonia. In treating patients with Botox for blepharospasm, Carruthers and Carruthers [5] noticed an improvement in glabellar rhytids. This ultimately led to the introduction and development of Botox as a mainstay in the treatment of hyperfunctional facial lines in the upper face. Since its approval by the U.S. Food and Drug Administration for the treatment of facial rhytids (2002), botulinum toxin A has expanded into wide-spread clinical use. Forehead, glabellar, and periocular rhytids are the most frequently treated facial regions. Indications for alternative uses for Botox in facial plastic and reconstructive surgery are expanding. These include a variety of well-established procedures that use Botox as an adjunctive agent to enhance results. In addition, Botox injection is finding increased usefulness as an independent modality for facial rejuvenation and rehabilitation. The agent is used beyond its role in facial rhytids as an effective agent in the management of dynamic disorders of the face and neck. Botox injection allows the physician to precisely manipulate the balance between complex and conflicting muscular interactions, thus resetting their equilibrium state and exerting a clinical effect. This article will address some of the new and unique indications on Botox injection in the face (the lower face and neck, combination with fillers). Important points in terms of its clinical relevance will be stressed, such as an understanding of functional facial anatomy, the importance of precise injections, and correct dosing all are critical to obtaining natural outcomes.

• 대한한방내과학회지
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• 제39권4호
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• pp.802-813
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• 2018

This case report describes a patient with olivopontocerebellar atrophy accompanied by sleep disorder and gait disturbance whose condition was improved by treatment with Korean medicine. The 61-year-old woman, who was diagnosed with olivopontocerebellar atrophy (Multiple Systemic Atrophy-Cerebellum), was admitted to hospital twice and treated with Korean medicine (acupuncture and herbal medicine) and rehabilitation. The Korean medicine was Gwibiondam-tang-gami and Jaeumgeonbi-tang-gami. Clinical symptoms were assessed by the Modified Bathel index, functional independent measurement, Berg balance scale, and Unified Multiple System Atrophy rating scale. A brain MRI at the one-year follow up after onset showed similar progress but clinical symptoms were improved after treatment, and the evaluation index score increased. Multiple system atrophy, a type of degenerative neurological disease, has no targeted treatment. In this situation, although this report describes a single case, Korean medicine treatment could provide a meaningful improvement in the sleep disturbance and gait disorder symptoms of patients with olivopontocerebellar atrophy.

• 대한한방내과학회지
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• 제41권5호
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• pp.777-786
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• 2020

Background: This study is a report on a case of a Wernicke's encephalopathy with quadriplegia, ataxia, and impaired cognition, whose condition was improved by Korean medicine treatment. Case report: A 51-year-old man diagnosed with Wernicke's encephalopathy was treated with acupuncture, Banhabakchulchunma-tang mixed with Ondam-tang-gami (半夏白朮天麻湯合溫膽湯加味), cupping, moxibustion, and rehabilitation. Clinical symptoms were measured with the Manual Muscle Test (MMT), Berg Balance Scale (BBS), Korean Mini Mental Status Exam (K-MMSE), Functional Independence Measure (FIM), Modified Barthel Index (MBI), and a numeric rating scale (NRS). After 22 days of treatment, his clinical symptoms showed improvement. The motor function improved (MMT Rt. side Gr. 4+G/4+G, Lt. side Gr. 4G/4+G → Rt. side Gr. 5-N/4+G, Lt. side Gr. 5-N/4+G), Ataxia was relieved (BBS 3→33), cognition improved (K-MMSE 15→27), ADL scores showed improvement (FIM 58→90, MBI 40→75), and the NRS score decreased for headache (3→0). Conclusion: Korean medicine treatment could be effective in the treatment of patients with Wernicke's encephalopathy.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.254-254
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• 1996

Eosinophils are known to be important effector cells in pathogenesis of asthma. The elucidation of mechanism by which eosinophil survival is regulated in vivo at sites of inflammation is critical tn our understanding of asthma pathogenesis. The maintenance of these cells at site of inflammation depends upon tile balance between its tendency to undergo apoptosis and tile local eosinophil-viability enhancing activity, Qualitative and quantative phenotypic differences have been observed between bronchoalveolar lavage (BAL) and peripheral blood (PB) eosinophils (EOS). We hypothesize that BAL EOS Possess altered functional feature compared to PB EOS. BAL and PB EOS were obtained from ragweed allergic asthmatics after segmental antigen challenge (SAC) at 24 hour or one week, and purified over percoll and CDl6 negative selection. Cells were cultured in duplicate in RPMI, 15% FCS and 1% penicillin/streptomycin without exogenous cytokines. Eosinophil purity and viability was >92%. BAL. EOS viability was 69${\pm}$4.4% versus 39${\pm}$1.6% for PB EOS (p<0.005) at 48 hour time point, and this difference was maintained through day 5 (32${\pm}$7.6% vs. 3.0${\pm}$ 1.4%, p<0.05), Among BAL EOS, those harvested one week after SAC appeared to have an prolonged survival compared to those harvested at 24 hour. Coculture of BAL and PB EOS resulted in significant viability enhancement than expecteed. Direct neutralization of GM-CSF activity, not IL-3 and EL-5, markedly decreased tile survival of BAL EOS in culture, and abrogated tile viability enhancing activity of their culture supernatants in a dose dependent manner. We conclude that BAL EOS activated in vivo possess enhanced viability compared to PB EOS. Mixing and neutralization experiments suggest a role for autocrine production of GM-CSF.

• 대한한의학원전학회지
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• 제25권2호
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• pp.125-139
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• 2012

Objective : This study began with a recognition of the increase in internal disorders caused by functional impairment of the Spleen-Stomach(脾胃) due to modern dietary culture and environment. Method : Way of studying is select and analysis sentences which is include 'Stomach-Yin(胃陰)', 'Stomach-Jin(胃津)', 'Spleen-Stomach-Yin(脾胃陰)', 'Stomach-Yang(胃陽)', 'Spleen-Stomach-Yang (脾胃陽)' in Imjeungjinamuian(臨證指南醫案), and organize relevant paper. Result & Conclusion : In the history of the Spleen-Stomach Theory(脾胃學說), the theoretical mainstream was focused on On-yang(溫養), which was supplemented with methods of sweeten-cool-moisturize(甘凉濡潤) and communication-descent(通降法) by Ye, Tianshi(葉天士). Ye, Tianshi followed the academic theory of Li, Dongyuan(李東垣), putting emphasis on Stomach-gi(胃氣), along with some unique developments of his own. He specifically argued that the Spleen and Stomach be treated separately, and while accepting the methods of Li Dong-yuan in Spleen treatment, asserted that the Stomach-Yin be treated with medicinals with sweet/plain and sweet/cool/moist(甘平與甘凉濡潤) characteristics, and Stomach-Yang be kept firmly, as to prevent obstruction and reflux, by means of medicinals that communicate the Yang softly(通陽柔劑). As a result, the Yin-Yang(陰陽), Dryness-Dampness(燥濕) and Cold-Heat(寒熱) balance of the Yin-Jang (陰臟), Spleen and the Yang-Bu(陽腑), Stomach, the Stomach-Yin and Stomach-Yang was achieved both theoretically and in treatment by means of both communication and supplementation, adding accuracy to clinical application of the Spleen-Stomach Theory.

• 한국한의학연구원논문집
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• 제14권1호
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• pp.49-58
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• 2008

Objective : To provide information about the accessory product of Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent by analyzing old books of oriental medicine, domestic/international papers and related patents Methods : Old books related to the accessory product in the field of oriental medicine were reviewed. Research papers regarding the pharmacological activity of the by-products were reviewed and analyzed. Patents about the residual products were examined and classified by year and subject Results : Seven kinds of by-products from Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent has been used as medicines in oriental medicine. Recently, anti-oxidating, anti-cancer, anti-mutagenic and anti-inflammation activity of the residual product of these plants has been investigated through scientific research. There were 19 patents related with the accessory products of these plants, which were in the subjects of functional cosmetics, anti-inflammation, cleansing goods, hair restorers or improvement of learning ability. Further investigations about the activity of these plants are needed in bone metabolism, water balance and hemostasis in the future. Conclusion : Residual products from these plants is being used in various ways. However, more studies on the efficacy and mechanism, as well as safety, of these plants should be conducted precisely in the future.

• Journal of Power Electronics
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• 제18권5호
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• pp.1595-1607
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• 2018

In this paper, a hierarchical control strategy is introduced to control a new three-port multidirectional DC-DC converter for integrating an energy storage system (ESS) to a bipolar DC microgrid (BPDCMG). The proposed converter provides a voltage-balancing function for the BPDCMG and adjusts the states of charge (SoC) of the ESS. Previous studies tend to balance the voltage of the BPDCMG buses with active sources or by transferring power from one bus to another. Furthermore, the batteries available in BPDCMGs were charged equally by both buses. However, this power sharing method does not guarantee efficient operation of the whole system. In order to achieve a higher efficiency and lower energy losses, a triple-layer hierarchical control strategy, including a primary droop controller, a secondary voltage restoration controller and a tertiary optimization controller are proposed. Thanks to the multi-functional operation of the proposed converter, its conversion stages are reduced. Furthermore, the efficiency and weight of the system are both improved. Therefore, this converter has a significant capability to be used in portable BPDCMGs such as electric DC ships. The converter modes are analyzed and small-signal models of the converter are extracted. Comprehensive simulation studies are carried out and a BPDCMG laboratory setup is implemented in order to validate the effectiveness of the proposed converter and its hierarchical control strategy. Simulation and experimental results show that using the proposed converter mitigates voltage imbalances. As a result, the system efficiency is improved by using the hierarchical optimal power flow control.

• 대한교통학회지
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• 제24권6호
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• pp.55-64
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• 2006

도시 가로에서 보행자와 자동차는 공간 배분 관점에서 상호 경쟁 관계에 있다. 따라서 제한된 시설 한계 범위 내에서 두 이용자의 필요성을 절충할 수 있는 균형적 설계가 필요하다. 본 연구는 가로의 균형적 설계에 대한 실현 방안으로 가로의 계획 및 설계 단계에서 보행자와 자동차의 서비스수준을 동시에 평가하는 방안을 제안하였다. 특히 가로의 기능과 지역 토지이용 특성에 따라 가로의 설계에 있어 보행자와 자동차에 대한 고려 비중에 차이를 반영할 필요성이 있음을 강조하고, 이를 균형적 설계에 반영할 수 있는 방안을 검토하였다. 가로 계획 및 설계 단계에서 보행자 통행 수요가 고려되지 못하여 현 도로용량편람에 제시된 보행자 서비스수준을 이용한 평가가 어려운 현실적 한계를 감안하여, 보행자의 신체적 한계와 이에 따른 쾌적성을 토대로 가로 설계단계에서 활용 가능한 보행자 서비스수준 평가 방안을 제안하였다 아울러, 보도의 균형적 계획 및 설계방안에 대해 헌 설계 방법과의 차이를 설명하고 설계 예제를 토대로 구체적인 적용 방법을 검토하였다.