• Animal Bioscience
• /
• v.34 no.11
• /
• pp.1739-1748
• /
• 2021

Objective: In recent years, long noncoding RNAs (lncRNAs) have been identified in many species, and some of them have been shown to play important roles in muscle development and myogenesis. However, the differences in lncRNAs between Kazakh cattle and Xinjiang brown cattle remain undefined; therefore, we aimed to confirm whether lncRNAs are differentially expressed in the longissimus dorsi between these two types of cattle and whether differentially expressed lncRNAs regulate muscle differentiation. Methods: We used RNA-seq technology to identify lncRNAs in longissimus muscles from these cattle. The expression of lncRNAs were analyzed using StringTie (1.3.1) in terms of the fragments per kilobase of transcript per million mapped reads values of the encoding genes. The differential expression of the transcripts in the two samples were analyzed using the DESeq R software package. The resulting false discovery rate was controlled by the Benjamini and Hochberg's approach. KOBAS software was utilized to measure the expression of different genes in Kyoto encyclopedia of genes and genomes pathways. We randomly selected eight lncRNA genes and validated them by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Results: We found that 182 lncRNA transcripts, including 102 upregulated and 80 downregulated transcripts, were differentially expressed between Kazakh cattle and Xinjiang brown cattle. The results of RT-qPCR were consistent with the sequencing results. Enrichment analysis and functional annotation of the target genes revealed that the differentially expressed lncRNAs were associated with the mitogen-activated protein kinase, Ras, and phosphatidylinositol 3-kinase (PI3k)/Akt signaling pathways. We also constructed a lncRNA/mRNA coexpression network for the PI3k/Akt signaling pathway. Conclusion: Our study provides insights into cattle muscle-associated lncRNAs and will contribute to a more thorough understanding of the molecular mechanism underlying muscle growth and development in cattle.

• Knowledge Management Research
• /
• v.21 no.4
• /
• pp.211-225
• /
• 2020

We investigate factors affecting chatbot use intention of online shopping mall users. We identify theoretical foundations from the literature and postulate that accuracy, personalization level, intelligence, intimacy, social presence, and piracy concern should affect intention to use more or negative intention to use. Based on 300 responses from online shopping mall chatbot users in Korea, we run the statistical analysis to assure the reliability and validity of the measurements. From the multiple regression analysis, we find that personalization level, intelligence, social presence, and privacy concerns significantly affect intention to use more. In contrast, we find that accuracy and privacy concerns significantly affect negative intention to use. This work will present pragmatic implications upon the design and management of chatbot in order to not only incent customers to use more but reduce factors that may cause negative use intention. Among functional factors, personalization and intelligence increases the intention to use more while accuracy decreases negative intention to use. Among emotional factors such as intimacy and social presence, we find that only social presence significantly increases intention to use more. Privacy concerns is found to decrease intention to use and increase negative intention to use.

• Journal of Legislation Research
• /
• no.41
• /
• pp.7-42
• /
• 2011

The social welfare law concerning the children, the elderly and the disabled has been sufficiently in the center of the discussion in the academic as well as practical arena. One can find however rarely academic proposals about the way of understanding, spheres affiliated with this legal system, and systematic characteristics. So these problems stay now vague. This article aims to approach to these points of issue. First, it tries to reveal the physical, psychological and psychic characteristics of these group of people. These situation are not to be effectively protected by norms and measures provided by other instruments of social security, i.e. social insurances and social assistances. Second, based upon these functional limits inherent to these instruments of social security the own system of the social welfare law is explored in this article. The discussing points are as follows; 1. the concept of social welfare law, 2. as core principles; realization of the personality and freedom based upon self-determination right, universalism and equality. 3. rearrangements of the legal provisions to bring harmony with the legal purpose and function of social welfare law. Finally, it is pointed that the evaluation of the relevant legislation is essential, since in this area the difference between the norm purpose and the reality could be immense.

• Journal of the Korean Applied Science and Technology
• /
• v.37 no.6
• /
• pp.1528-1534
• /
• 2020

This study examines the trends of the domestic age-friendly industry, examines the ingredients notified by the Ministry of Food and Drug Safety of aging cosmetics, and analyzes the research trends of raw materials other than the notices, and prepares data for the aged-friendly industry to quickly cope with changes in the cosmetics industry environment and aging people. I wanted to. In addition to the ingredients notified by the Ministry of Food and Drug Safety, research trends on the development of ingredients for anti-aging cosmetics are examined, and the anti-aging effects of each ingredient are examined. Through this, 'aging' and 'cosmetics', 'Anti-Aging', 'Anti-Aging', etc. In order to lead the development of anti-aging cosmetics related to the aging industry, research activities on products that are effective in preventing aging by strengthening the skin in addition to the four ingredients notified by the Ministry of Food and Drug Safety are constantly being conducted. In the functional cosmetics field notified by the Minister of Food and Drug Safety, it is believed that various basic research activities should be conducted so that research on anti-aging can be scientifically supported rather than a single research.

• Korean Journal of Food Science and Technology
• /
• v.53 no.1
• /
• pp.99-103
• /
• 2021

The purpose of this study was to investigate how microwave drying, a method to minimize the scent and physicochemical changes of the final products, affects the quality characteristics of various herbs according to treatment intensity (pulse and continuous waves) and time. In the current study, different physicochemical qualities, such as weight change, moisture content, water activity, color, and microbial growth, of five different Korean herbs were analyzed after microwave drying. The results clearly showed that the pulse wave method was a more effective approach than the continuous wave method for maintaining the physicochemical properties of herbs. Furthermore, pulse wave drying lead to efficient microbial death in various herbs after a short time. Thus, microwave drying with a pulse wave can be applied to herb processing and packaging technology while minimizing the quality changes of herbs.

• International Journal of Oral Biology
• /
• v.46 no.2
• /
• pp.67-73
• /
• 2021

This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

• The Journal of Korean Academy of Sensory Integration
• /
• v.19 no.1
• /
• pp.39-53
• /
• 2021

Objective : The purpose of this study was to systematically review dysphagia rehabilitation treatment for children with feeding disorders. Methods : The articles evaluated in this study were collected from the PubMed, Medline Complete, and CINAHL databases and subsequently reviewed using the PRISMA flow chart and PICOS approach. A total of 13 papers were analyzed for study quality, disease groups, evaluation tools, interventions, and post-intervention effects. Results : Of the reviewed papers, six (46.15%) related to autism spectrum disorder (ASD) and seven (53.85%) to cerebral palsy (CP) with age ranges of between 2 and 8 years for the ASD studies and between 12 months and 18 years for CP. In evaluating the types of feeding disorder involved, the ASD group exhibited predominantly behavioral conditions while the CP subjects had a larger number of functional oral and swallowing issues. In terms of interventions, behavior modifications were used most frequently with ASD while oral-sensory motor, texture modifications, and electrical stimulation were applied at the same frequency with children with CP. All interventions were found to be effective. Conclusion : In this study, research into children with feeding disorders was reviewed according to condition, evaluation tool, and method of intervention. It is expected that this review can be used as basic data for developing a protocol that will allow clinicians to efficiently apply condition-specific interventions for eating disorders without resorting to trial and error.

• The Journal of Korean Academy of Prosthodontics
• /
• v.60 no.3
• /
• pp.283-292
• /
• 2022

For fixed prosthetic treatment using implants, implants must be placed in a suitable location for prosthetic treatment. During surgery, minimally invasive prosthetic restoration is possible using a flapless method using a surgical guide. The patient in this case was an 86-year-old male patient who wanted treatment due to discomfort when using conventional dentures. Due to systemic disease, the patient had difficulty using removable local dentures, so full dentures for the maxilla and fixed implants for the mandible were restored. Because there is a high risk of bleeding due to systemic disease, the implant was placed in a flapless method using a surgical guide. Finally, prostheses were fabricated with maxillary full denture and mandibular screw-retained zirconia, and this report shows satisfactory esthetic and functional recovery.

• The Journal of Korean Academy of Prosthodontics
• /
• v.60 no.4
• /
• pp.420-430
• /
• 2022

Open bite is accompanied by decrease in tooth contact and overbite, and causes collapse of occlusal plane, mastication difficulties, speech disorders, changes in appearance, and lower occlusal force than normal. Open bite caused by temporomandibular joint disorder in adults with complete occlusion must be corrected after removal or stabilization of the causative factors. Orthodontic treatment, occlusal adjustment, prosthetic treatment, and surgical treatment can be the option of occlusal correction. This report describes about estimating the cause of occlusion change in two patients who developed an open bite due to mandibular displacement in adults with complete occlusion and different treatment approaches accordingly. In one patient, satisfactory result was obtained in functional and esthetic aspects through occlusal adjustment after stabilization of the temporomandibular joint.

• Journal of Korea Entertainment Industry Association
• /
• v.14 no.4
• /
• pp.155-167
• /
• 2020

The stage manager role of "Our Town"(1938), a representative work of Thornton Wilder(1897-1975), is a unique theatrical device that presents a wide range of interesting and diverse perspectives in the actor's acting approach, the director's stage-shape methodology, and the audience's theater experience. Why did Wilder call stage manager role a stage manager, not just a simple narrator? Because "Our Town" intentionally lacks the basic elements that dramas must have, it needed a more self-reliant and omnipotent role in creating the margins of dramatic writing, including boldly omitted time and space, with infinite imagination. For this reason, stage manager role plays a much more complex and multi-functional role than a narrator. In response, this paper accurately articulates the concept of theatrical style and theatrical convention on the premise of the stage manager role in "Our Town," followed by making theatrical convention, the director of scene progress and scene change, the messenger of the writer's thoughts, and dramatic rhythm control.