• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.103-109
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• 2004

The obese population has been increasing over the world wide and obesity became a socioeconomic problems. It is become more serious by the accumulation of the knowledge that the obesity is related directly or indirectly with several diseases like, diabetes, hypertension, etc. With these reasons, many functional food or agents for the purpose of weight loss have been developed. However, most of these remedies are unproven and some have produced even dangerous side effects due to the ephedrine alkaloids contained in Ma-Hang. Because of these reasons, they banned using of these agents in US and regards the antiobesity functional agents as drugs in Europe. Several functional agents are known for weight loss activities like, HCA, L-canitine, CLA, chitosan, calcium supplements and capsaicin containing red pepper, kimchi and kochujang. We describe here about the function, efficacy and mechanism of these antiobesity functional agents. Furthermore, the trial of the mixture of weight loss related herbal ingredients for safe multifunctional antiobesity functional agents are discussed here, as well.

• 펄프종이기술
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• 제35권1호
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• pp.19-26
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• 2003

In recent years, numerous studies have been carried out to find out the possible substitution of PE-coated paperboards used in packaging of watery or oily foods. Accordingly, this study was carried out to obtain the basic data for producing higher functional coating agents for pulp mold by evaluating various kinds of mixed coating agents. At that time, two kinds of synthetic coating agents(AKD, PYA) and three kinds of natural coating agent(CMC, corn starch, oxidized starch) were used for making the mixed coating agents respectively. Physical properties of coated paperboards were tested. Conclusions obtained from this study were as follows. Based on concentrations, the proper mixture ratios were 10:90(AKD:CMC), 10:90(AKD:corn starch), 10:90(AKD:oxidized starch), 40:60(PVA:CMC), 20:80(PVA:corn starch) and 20:80(PYA:oxidized starch). The mixed coating agent of PYA:corn starch(20:80) was the most efficient coating agent. Consequently, water and oil resistance were improved even with much addition of natural coating agents. We consider that they can be suitable for the packaging used in the storage of higher moisture vegetables and other food, and also can be suitable for oily fried food.

• 펄프종이기술
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• 제38권1호통권113호
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• pp.45-53
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• 2006

This study was carried out to produce high functional and biodegradable coating agents for pulp mold by evaluating various kinds of biodegradable polymers. Five kinds of biodegradable polymers were used. In addition, the mixture of the carboxymethylated starch and biodegradable polymers(${\kappa}$-carrageenan, chitosan) were used for mixed coating agents. Physical properties of coated paperboards were evaluated. Conclusions obtained were as follows. 4% ${\kappa}$-carrageenan and 5% chitosan showed higher water and oil resistance. 10% sodium alginate, 4% corn zein and 15% polycaprolactone showed high water resistance while no improvement was found on oil resistance. The optimum mixture ratios for the mixed coating agents were 90:10(carboxymethylated starch : ${\kappa}$-carrageenan) and 50:50(carboxymethylated starch : chitosan). Since these mixed coating agents have excellent biodegradability with higher water and oil resistance, these can be used for the environmental-friendly coating agents.

• 펄프종이기술
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• 제34권4호
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• pp.37-43
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• 2002

In recent years, numerous studies have been carried out to find out the possible substitution of PE-coated paperboards used in packaging of watery or oily foods. Accordingly, this study was carried out to obtain the basic data for producing higher functional coating agents for pulp mold by evaluating various kinds of synthetic and natural coating agents on the market. Physical properties of coated paperboards were tested. Conclusions obtained from this study were as follows. AKD and PVA showed higher functions than the other synthetic coating agents, while functions of CMC, Com starch and Oxidized starch were higher than those of other natural coating agents. Based on concentrations, AKD 0.5%, PVA 10%, CMC 1.5%, corn starch 6% and oxidized starch 8% were appeared as the proper concentrations. W3 consider that AKD may be suitable for the storage of higher moisture vegetables and other food, and PVA may be suitable for higher oily fried food.

• Macromolecular Research
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• 제10권2호
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• pp.127-134
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• 2002

Microporous polypropylene hollow fiber membrane was fabricated from isotactic polypropylene-soybean oil system by melt spinning process. Addition of nucleating agent accelerated the crystallization rate and elevated the crystallization temperature. Nucleating agent increased the number of nuclei and spherulites, which offered more inter-spherulitic amorphous sites for stretching. Benzoic acid, adipic acid, and dibenzylidene sorbitol were selected as nucleating agents, and their characteristics and effects were investigated by thermal and optical analyses. Spherulite growth and micropore formation characteristics were correlated with the kind of nucleating agent. Benzoic acid and adipic acid showed the remarkable nucleating effect, while dibenzylidene sorbitol was less effective than those. Nucleating agents also helped the sample have uniform microporous structure. Increase of nucleating agent composition enhanced the nucleation effect to some extent. Nucleating agents played very important roles in enhancing the membrane porosity and water flux.

• 한국식품영양과학회지
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• 제36권4호
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• pp.503-513
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• 2007

The obese population has been increasing worldwide and obesity has become one of the socioeconomic problems. Obesity raises more concerns as more studies regarding its direct and indirect relativity to several diseases such as type II diabetes, hypertension, etc. are published. Since leptin, an important signal in the chronic control of food intake and energy expenditure, was discovered in 1994, there has been a great accumulation of knowledge on fighting obesity by facilitating pharmacological and nutritional strategies on the molecular level of the body weight control system. In particular, evidences are accumulating that particular food components affect our physiological function and gene expressions which are associated with body weight control. In this study, we review the four mechanisms for weight control and antiobesity functional agents such as HCA, L-carnitine, CLA, chitosan, calcium supplements capsaicin contained in red pepper, and oriental herbal mixture. We also describe about the efficacy and working mechanism of these functional agents on the basis of antiobesity mechanisms.

• 산업공학
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• 제19권1호
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• pp.53-61
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• 2006

We propose a new supply chain planning methodology for both a manufacturer and a distributor in order to find a global supply chain plan for functional product markets. Functional products as opposed to innovative products include the staples that people buy regularly from their nearby places to satisfy basic needs. In the functional product market, the distributor has an initiative of supply chain control and planning with a freedom to request any profit maximizing order quantities until the manufacturer refuses, whereas the manufacturer may not provide more than requested. In this paper, two independent agents on behalf of the manufacturer and the distributor are introduced, and supply chain planning can be conducted by collaboration between them. In addition, mathematical models and a numerical example are presented to show the possibility of the proposed methodology.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.30-37
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• 2008

The knowledge of motility disorders of the gastrointestinal tract has increased over the past decades. The development of newer therapies for bowel motility disorders has been disappointingly slow. Prokinetic agents are medications that enhance coordinated gastrointestinal motility and transit of material in the gastrointestinal tract. These agents are pharmacologically and chemically diverse. However, life-threatening adverse effects of prokinetic agents such as cisapride was present. In this review, pharmacologic effects and use of prokinetic agents in children was introduced.

• 펄프종이기술
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• 제36권4호
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• pp.49-59
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• 2004

This study was carried out to obtain the basic data for producing higher functional coating agents for pulp mold by evaluating various kinds of starch derivatives. At that time, four kinds of starch derivatives were manufactured for making coating agents respectively. Physical properties of coated paperboards were tested. Conclusions obtained from this results were as follows. The water and oil resistance of hydroxypropylated, cyanoethylated and carboxymethy­lated starch were high when degree of molar substitution(DS) of propylene oxide, acrylonitrile and sodium monochloroacetate were 0.18, 0.07 and 0.009, respectively. Also, the those of crosslinked starch were high when degree of crosslinking of epichlorohydrin was 0.02. Consequently, $8\%$ solution of carboxymethylated starch made with DS 0.009 of monochloroacetate was the best among coating agents from starch derivatives men­tioned above.

• BMB Reports
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• 제38권5호
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• pp.619-623
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• 2005

The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p53 and its target genes such as Bcl-2 family members (Bax, Noxa, and PUMA). However, various chemotherapeutic agents can induce cell death in tumor cells that do not express the functional p53, suggesting that some chemotherapeutic agents may induce cell death in a p53-independent pathway. Here we showed that etoposide can induce the similar degree of cell death in p53-deficient HCT 116 cells, whereas 5'-FU-mediated cell death is strongly dependent on the existence of functional p53 in HCT 116 cells. Further, we provide the evidence that etoposide can induce the cytochrome c release from isolated mitochondria, and etoposide-induced cytochrome c release is not accompanied with the large amplitude swelling of mitochondria. These data suggest that etoposide can directly induce the mitochondrial dysfunction irrespective of p53 status, and it may, at least in part, account for the p53-independent pathway in cell death induced by chemotherapeutic agents.