• Proceedings of the KOSOMBE Conference
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• v.1992 no.05
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• pp.155-160
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• 1992

Liver function test is one of the most common tests for diagnosis and follow-up of patients and for heal th screening. Automatic interpretation and suggestions on the diagnostic possibilities contribute to shorten the interpretation time of the test results and help to provide qualified health care. Fuzzy logic has been recently introduced and being spread for these purposes. The present study aims at model Ins the foray rule-based laboratory diagnosis system. The fuzzy rule-based laboratory diagnosis system was applied to the diagnosis regarding liver function test. The system was evaluated by comparing with the stepwise multivariate discriminant function analysis, which showed similar results, and the overall accuracy of the fuzzy diagnosis system was about 80%.

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.3
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• pp.150-154
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• 2002

Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders. An indication of the emerging significance of antibody-based therapeutics is that over a third of the proteins currently undergoing clinical trials in the United States are antibodies. Until the late 1980's, antibody technology relied primarily on animal immunization and the expression of engineered antibodies. However, the development of methods for the expression of antibody fragments in bacteria and powerful techniques for screening combinatorial libraries, together with the accumulating structure-function data base of antibodies, have opened unlimited opportunities for the engineering of antibodies with tailor-made properties for specific applications. Antibodies of low immunogenicity, suitable for human therapy and in vivo diagnosis, can now be developed with relative ease. Here, antibody structure-function and antibody engineering technologies are described.

• Animal cells and systems
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• v.5 no.1
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• pp.65-69
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• 2001

Obtaining mutant animals is important for studying the function of a particular gene. A chemical mutagenesis was first carried out to generate mutations in C. elegans. In this study, we used ultraviolet-activated 4,5',8-trimethylpsoralen to induce small deletion mutations. A library of mutagenized worms was prepared for recovery of candidate animals and stored at $15^{\circ}C$ during screening instead of being made into a frozen stock library. In order to isolate deletion mutations in target genes, a polymerase chain reaction (PCR)-based screening method was used. As a result, two independent mutants with deletions of approximately 1.0 kb and 1.3 kb were isolated. This modified and improved reverse genetic approach was proven to be effective and practical for isolating mutant animals to study gene function at the organismal level.

• Journal of Electrical Engineering and Technology
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• v.5 no.2
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• pp.209-219
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• 2010

In this paper, a novel dynamic available transfer capability (DATC) has been computed for real time applications using three different intelligent techniques viz. i) back propagation algorithm (BPA), ii) radial basis function (RBF), and iii) adaptive neuro fuzzy inference system (ANFIS) for the first time. The conventional method of DATC is tedious and time consuming. DATC is concerned with calculating the maximum increase in point to point transfer such that the transient response remains stable and viable. The ATC information is to be continuously updated in real time and made available to market participants through an internet based Open Access Same time Information System (OASIS). The independent system operator (ISO) evaluates the transaction in real time on the basis of DATC information. The dynamic contingency screening method [1] has been utilized and critical contingencies are selected for the computation of DATC using the energy function based potential energy boundary surface (PEBS) method. The PEBS based DATC has been utilized to generate patterns for the intelligent techniques. The three different intelligent methods are tested on New England 68-bus 16 machine and 39-bus 10 machine systems and results are compared with the conventional PEBS method.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.55.4-55.4
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• 2017

For modified gravity models with screening mechanisms, the signal of modified gravity is larger at low density areas. We could add a density weighted mark to galaxy correlation function and increase the signal to noise of modified gravity detection. Based on mock galaxy catalogs from modified gravity simulations, we try different mark functions and parameters to find the best choices for discreminating modified gravity from GR. In this talk I will present our marked correlation funciton results and discuss its advantages and disadvantages.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.34D no.3
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• pp.93-104
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• 1997

Steady-state I-V characteristics of a resonant tunneling diode (RTD) is calculated by numerical analysis using quantum liouville equation based on wigner function which is derived from density operator. Modifications to the conventional discrete model are made to calculate more accurate quantum correlations. It is pointed out that we must include inelastic processes and the resistivity of the contacting layers to get a much more credible potential which can be theoretically obtained from the simple screening theory. The effects of spatially-varying effective mass is also checked briefly.

• Therapeutic Science for Rehabilitation
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• v.9 no.4
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• pp.69-81
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• 2020

Objective : The purpose of this study was to develop a Yonsei dual task cognitive screening test (Y-DuCog) for the elderly. Methods : The reliability and validity test of Y-DuCog (Yonsei Dual Task Cognitive Screening Test) was developed by 229 elderly people aged over 60 years from community organizations at Gyeonggi-do and Chungcheong-do from May 2019 to August 2019. In addition, the criteria for classifying elderly with cognitive impairment were presented. Results : The correlation analysis between MMSE-K, MoCA-K and Y-DuCog were a correlation between the DTE and CRR of Y-DuCog. As a result of internal consistency, Cronbach's-α values of DTE and CRR showed .848 (p<.01) and .916 (p<.01), respectively. The test-retest reliability was high. The screening point showed 88.7% sensitivity and 83.5% specificity at 31.76 seconds in total DTE, and 84.5% sensitivity and 76.6% specificity at 0.38 in total dual-task CRR. Conclusion : This study verified the reliability and validity of Y-DuCog. It was found that the level of education was not a barrier to the undertaking of this test. Furthermore, the test could be performed easily and quickly. It is also expected to be used to evaluate the effectiveness of cognitive function assessment and intervention methods in the elderly.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2655-2659
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• 2014

Dual specificity protein phosphatase 4 (DUSP4) has been considered a promising target for the development of therapeutics for various human cancers. Here, we report the first example for a successful application of the structure-based virtual screening to identify the novel small-molecule DUSP4 inhibitors. As a consequence of the virtual screening with the modified scoring function to include an effective molecular solvation free energy term, five micromolar DUSP4 inhibitors are found with the associated $IC_{50}$ values ranging from 3.5 to $10.8{\mu}M$. Because these newly identified inhibitors were also screened for having desirable physicochemical properties as a drug candidate, they may serve as a starting point of the structure-activity relationship study to optimize the medical efficacy. Structural features relevant to the stabilization of the new inhibitors in the active site of DUSP4 are discussed in detail.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.1
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• pp.14-20
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• 2018

Mucopolysaccharidoses (MPSs) are a group of rare inherited metabolic disorders caused by specific lysosomal enzyme deficiencies leading to the sequential degradation of glycosaminoglycans, causing substrate accumulation in various cells and tissues and progressive multiple organ dysfunction. The rare disease medical care team at Mackay Memorial Hospital in Taiwan has been dedicated to the study of MPSs for more than 20 years. Since 1999, more than 50 academic papers focusing on MPSs have been published in international medical journals. Topics of research include the following items regarding MPSs: incidence, natural history, clinical manifestations, gene mutation characteristics, cardiac function, bone mineral density, sleep studies, pulmonary function tests, hearing assessments, percutaneous endoscopic gastrostomy, anesthetic experience, imaging analysis, special biochemical tests, laboratory diagnostics, global expert consensus conferences, prenatal diagnosis, new drug clinical trials, newborn screening, and treatment outcomes. Of these published academic research papers, more than half were cross-domain, cross-industry, and international studies with results in cooperation with experts from European, American and other Asian countries. A cross-specialty collaboration platform was established based on high-risk population screening criteria with the acronym "BECARE" (Bone and joints, Eyes, Cardiac and central nervous system, Abdomen and appearance, Respiratory system, and Ear, nose, and throat involvement). Through this platform, orthopedic surgeons, rheumatologists, ophthalmologists, cardiologists, rehabilitation physicians, gastroenterologists, otorhinolaryngologists, and medical geneticists have been educated with regards to awareness of suspected cases of MPSs patients to allow for a further confirmative diagnosis of MPSs. Because of the progressive nature of the disease, an early diagnosis and early multidisciplinary therapeutic interventions including surgery, rehabilitation programs, symptom-based treatments, hematopoietic stem cell transplantation, and enzyme replacement therapy, are very important.