• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.5
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• pp.274-285
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• 2024

Purpose: To evaluate prolonged esomeprazole use in Japanese pediatric patients for reflux esophagitis (RE) maintenance therapy and prevention of gastric (GU) and/or duodenal ulcers (DU) while using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA). Methods: This multicenter, open-label, parallel-group, phase III study (NCT03553563) included patients who were administered esomeprazole according to body weight (10 mg/day [Groups 1 and 3] and up to 20 mg/day [Groups 2 and 4] for patients weighing 10-20 kg and ≥20 kg, respectively). Efficacy outcomes for Groups 1 and 2 (maintenance therapy for healed RE) and Groups 3 and 4 (prevention of long-term NSAID/LDA use-associated GU/DU) were the presence/absence of RE relapse and GU/DU recurrence, respectively. Results: Esomeprazole as maintenance therapy was associated with a low RE recurrence rate, independent of body weight or dosage. Recurrence rates of RE were 0.0% and 5.3% for Groups 1 and 2, respectively. In patients previously diagnosed with GU and/or DU due to long-term NSAID/LDA use, the recurrence rates of GU/DU during weeks 0-32 were 11.1% and 0.0% in Groups 3 and 4, respectively. Conclusion: Long-term use of 10- or 20-mg, once-daily esomeprazole demonstrated a favorable benefit-risk balance in preventing RE and suppressing recurrence of GU and/or DU secondary to NSAID or LDA therapy in Japanese pediatric patients. No new safety concerns were identified. Esomeprazole may be a viable option for managing RE and preventing GU and DU in Japanese pediatric patients.

• Journal of the Korean Geographical Society
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• v.30 no.3
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• pp.242-254
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• 1995

The Hadano Basin is located at a distance of about 70kms and 60kms from Tokyo and Yokohama and lies in the south-west part of the Kanto region in Japan. The basin area, which correspoends to the catchment of the Kaname River, is about areal size of 60.7$\textrm{km}^2$ and extends about length of 8kms in E-W direction and about width of 5kms in N-S direction (Fig.1). The Hadano basin is filled with thick pile of the alluvum from deposits composed of volcanic materials, mostly came from the Hakone Volcano and overlain by Fuji Volcanic ashes. Fluvial deposits form the good aquifer, therefore water resources of Handano City has been largely depending upon the eroundwater. Urbanization and industrialization of the basin has been rapid in the last thirty years, after activation of "Factory Attraction Policy of Hadano City" in 1956. Growth in population and number of factory due to urbanization changed the land-use pattern of the basin rapidly and increased the water demands. Therefore, Hadano City exploited a new source of water supply, and have introduced the prefectureal waterworks since 1976. On the other hand, the rapid urbanization has brought about the pollution of streams in the basin by domestic sewage and industrial waste water. Diffusion rate of sewerage systems in Hadano City is 38% in 1993. In ordcr to examine the impact of anthropogenic factors on river environments, the author took up the change of land-use and diffusion area of sewerage as parameters, and performed field surveys on water discharge and quality. The survey has been made at upstream and downstream of the main stream regularly per month, to get informati ons about the variation of discharge and water quality aiong the stream and its diurnal fluctuation. Annual variation has been analyzed based the data from Hadano City Office. The results are summarized as follows. 1. Stream discharge has been increasing by urbanization (Fig.3). Water quality (C $l^{-10}$ , N $H^{+}$$_{ 4}$-N, BOD) has been improving gradually after the application of sewerage service, yet water pollution load at the lower station has increased than that at the upper one because of the larger anthropogenic discharge volumes (Fig.4). 2. Corrclation coefficient of discharges between upper and lower was 0.81-0.92. Pollutant loads of the R. Kamame after the confluence with R. Kuzuha grew up by 2.4-3.7 times as compared with its upper reaches, and it increased to 3.7-6.9 times after the confluence with the R. Muro (Fig.5). 3. The changes of water quality along the stream can be divided into two groups (Fig.6a). First: water quality of the R. Kaname and R. Shijuhachisse is becoming worse towards the lower reaches because the water from branches are polluted. Second: water quality are improved in the lower where spring and small branch streams supply clear water, for example R. Mizunashi, R. Muro and R. Kuzuha. 4. Measured discharge at the upper station in the R. Shijuhachisse is 0.153㎥/sec, and about 55% of this is recharged until it reaches to the lower point. The R. Mizunashi has a discharge of 1.155㎥/sec at the upper point, is recharged 0.24㎥/sec until the midstream and groundwater spring 0.2㎥/sec at the lower reaches. R. Kuzuha recharged all the mountain runoff (0.2㎥/sec) at the upper reaches. The R. Muro is supplied by many springs and the estimated discharge of spring was 0.47㎥/sec (Fig.6b). 5. Diurmal variations in discharge and water quality are influenced clearly by domestic and industrial waste waters (Fig.7, 8).ed clearly by domestic and industrial waste waters (Fig.7, 8).

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.3
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• pp.498-503
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• 2006

This in vitro study compared the remineralization of incipient interproximal caries in the presence of three glass ionomer cements (highly-filled glass ionomer cement, compomer, resin-modified glass ionomer cement) and a resin composite(control). The long-term changes in remineralization caused by each material were evaluated by microtomography. Proximal restoration was simulated by placing tooth specimens and the various glass ionomer cements in closed containers with artificial saliva at $37^{\circ}C$ and pH 7.0 for 30 days with constant circulation Tomographic images were obtained with a micro CT scanner at 90, 180, and 270 days, and density-measuring software was used to calculate the micro-density of artificial caries lesions in the specimens. The mean density changes were compared between groups in order to evaluate the effects of remineralization. All data were analyzed using one-way ANOVA and the post-HOC Tukey multiple comparison test at p<0.05. While the density of artificial caries lesions increased for all treatments, the increases for the three glass ionomer groups were significantly higher than that for the resin group in each three month period. As time went on, the amount of density increase of the glass ionomer groups decreased, and significant differences were found between the remineralization effects of the glass ionomer groups.

• Horticultural Science & Technology
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• v.31 no.6
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• pp.666-676
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• 2013

The study was carried out to examine the initial point of dormancy, breaking time of internal dormancy, and to find out the accumulated hours of low temperature (under $7.2^{\circ}C$ from $0.0^{\circ}C$ to $7.2^{\circ}C$) for bud-breaking. Over-all, the chilling requirement for breaking of internal dormancy in the commercial apple cultivars ('Fuji' and 'Tsugaru') and apple cultivars bred in Korea ('Hongro', 'Sunhong', 'Honggeum', 'Hongan', 'Hongso', 'Gamhong', 'Summer dream') at the Gunwi region for 4 years (from 2009 to 2012) was investigated. Also, the breaking time of internal dormancy in the field at the Gunwi region and the breaking time of dormancy if air temperature of Gunwi region rises $4^{\circ}C$ higher than the current one were investigated using the same data. The initial point of dormancy was set at the time when the lateral bud breaking did not occurred (when heading back cutting was done in the middle of terminal shoots). The occurrence of the breaking of internal dormancy was decided if the breaking of the terminal bud of bourse shoot occurred within 15 days or not in growth chamber. About 100 bourse shoots were collected by cultivar classification in early December every year and were stored at $5.0^{\circ}C$, and they were placed in growth chamber at one week interval. The chilling requirement of cultivars was expressed in accumulated hours in the field and in the growth chamber under $7.2^{\circ}C$ and $0.0-7.2^{\circ}C$ from the initial point of dormancy to the breaking time of internal dormancy. The results showed that the initial point of dormancy in selected cultivars could occur at the end of September. The breaking time of internal dormancy could occur from the end of January to the early of February. The accumulated hours under $7.2^{\circ}C$ for breaking of internal dormancy were 1,600-2,000 hours, while those of $0.0-7.2^{\circ}C$ were 1,300-1,800 hours. In comparing the different apple cultivars, the chilling requirement of the early flowering cultivars seemed lower than that of the late-flowering cultivars. Based on these results, if the air temperature of Gunwi region rises about $4.0^{\circ}C$ higher than the current one, the breaking time of internal dormancy will be delayed by 2-4 weeks.

• Korean Journal of Agricultural and Forest Meteorology
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• v.11 no.2
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• pp.52-60
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• 2009

This study was conducted to quantify the soil respiratory $CO_2$ emission (SR) in an apple orchard and to determine its relationship with key environmental factors such as air temperature, soil temperature and soil moisture content. Experiment was made over the period from 23 April 2007 to 31 March 2008 in 'Fuji' apple orchard of National Institute of Horticultural and Herbal Science in Suwon, Gyeonggi-do, Korea. The SR was measured by using the automatic opening/closing chamber system based on a closed method. Diurnal variations in SR showed an increase around 0700 hours with increasing soil temperature, its peak between 1400 and 1500 hours, and then a gradual decrease thereafter. Daily variations in SR depended largely on soil and air temperatures over the year, ranging from 0.8 to 13.7 g $CO_2$ $m^{-2}d^{-1}$. During the rainy spell in summer (July$\sim$Autumn) with higher temperature and more precipitation, the SR was lower than that in the spring (May$\sim$June) with moderate temperature. The SR showed a significant exponential relationship with soil temperature ($r^2=0.800$) and air temperature ($r^2=0.805$), but not with soil moisture content ($r^2=0.160$). The $Q_{10}$ values of SR with annual soil temperature and air temperature were 2.0 and 1.9, respectively. The annually integrated SR was 19.6 ton $CO_2$ $ha^{-1}$.

• Journal of Sensor Science and Technology
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• v.11 no.1
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• pp.9-17
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• 2002

The forming conditions of X-ray storage phosrhors $BaFBr_{1-x}I_x:Eu^{2+}$, $Na^+$ have been investigated, and measured the PSL emission spectra and its intensity, fading characteristics and does dependence of the prepared phosphors. These characteristics were compared with those of commercial image plate (ST-III) obtained from Fuji Photo Film Co. The optimal preparing conditions of $BaFBr_{1-x}I_x:Eu^{2+}$, $Na^+$ Phosphor were 0.5 mol% of $EuF_3$, 4.0 mol% of NaF and composition ratio x=0.3, and the sintering temperature were $950^{\circ}C$ in $H_2$ atmosphere. When the composition ratio x was equal to 0, the spectral range of the luminescence of $BaFBr_{1-x}I_x:Eu^{2+}$, $Na^+$ phosphor was $365{\sim}420\;nm$, and its maximum luminescence intensity appeared at 390 nm. When composition ratio x was not equal to 0, the wavelength ranges and peak of the spectra were shifted to the longer wavelength with the growth of composition ratio x. A good linearity was shown between the PSL intensity and X-ray irradiation dose. The phosphor sample with x=0.3 exhibited better fading characteristics than that of other $BaFBr_{1-x}I_x:Eu^{2+}$ phosphor samples, and the fading characteristics of the PSL intensity at room temperature were shown poorer with increasing $I^-$ ion concentration. The lattice constant of the phosphor becomes larger with increasing the $I^-$ ion concentration.

• Food Science and Preservation
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• v.19 no.3
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• pp.413-419
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• 2012

Fermentation of ice apple wine from freeze-concentrated Fuji apple juice to 36 $^{\circ}Brix$ was carried out using Saccharomyces cerevisiae SS89, a sugar-tolerant wine yeast strain. The characteristics of the fermentation and the properties of ice apple wine were compared with those of S. cerevisiae W-3, an industrial wine yeast that was used as a control in this study. During the fermentation, the alcohol content increased more rapidly by S. cerevisiae SS89 together with the decrease of the soluble solid content, compared to S. cerevisiae W-3. It reached 12% (v/v) after 15 days of fermentation by S. cerevisiae SS89 (12.4%, v/v) and 21 days by S. cerevisiae W-3 (12.6%, v/v). The soluble solid contents of the SS89 and W-3 wines were 24.0 and 23.6 $^{\circ}Brix$, respectively. Lactic acid was detected at the highest level, followed by malic aid, among the organic acids in both wines. No big differences in the organic acid contents were observed based on the strains. In the SS89 wine, higher levels of methanol, propanol, butanol, and isoamyl alcohol were detected, together with a lower isobutanol content, compared with the W-3 wine. The SS89 wine showed higher level of intensity as well as higher Hunter's L and b color values compared to the W-3 wine. In the sensory evaluation, similar scores in color, flavor, taste, and overall preference were obtained in the two wines. Therefore, S. cerevisiae SS89 was thought to be useful for the rapid fermentation of ice apple wine.

• Food Science and Preservation
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• v.18 no.4
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• pp.559-566
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• 2011

In this study, the good brewing conditions for the 24 $^{\circ}Brix$ freeze-concentrated apple wine were investigated. The four selected Saccharomyces cerevisiae strains MM10, SS89, SS812, and WW108, could ferment quickly when brewed with high sugar levels. During the fermentation, the reducing sugar contents slowly declined while the total acid in all the yeasts increased and the final alcohol content was 12-13%, a typical wine's alcohol content. The viable counts were shown to be 6-6.8 log cfu/ml. During the fermentation, the organic acid content was shown to be within the range of 2.36-3.11%, and the free sugar content, except for the SS89 and WW108 strains, was shown to consist only of sorbitol, although fructose was somewhat detected in the SS89 and WW108 strains. Methanol was not detected, or only a trace of it was detected, and the aldehyde content was 107.68-114.27 ppm. As for the fusel oil contents, a trace of propanol was detected. Isobutanol and butanol were present in 40.16-54.65 and 25.47-27.73 ppm, respectively. The isoamy1 alcohol content was shown to be the highest (108.88-217.26 ppm). The final total phenolic compounds were shown to be 0.1-0.16%. The final Hue values were shown to be 1.3-3.6, and the final intensity was 0.1-0.45. The lightness (L) was within the range of 91.78-98.51, the redness (a) was at a neutral position at red and green, and the yellowness (b) was within the range of 2.38-7.7. In the sensory evaluation, the SS812 strain was found to be the best in terms of color, the SS89 strain in terms of odor, and the WW108 strain in terms of taste. Overall, SS812 was found to be the best apple wine.

• Korean Journal of Agricultural and Forest Meteorology
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• v.19 no.4
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• pp.252-269
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• 2017

This study was carried out to examine the base temperature to flowering and the average days to flowering by accumulated hours of low temperature ($5.0^{\circ}C$) or changing temperature after bud breaking. Over-all, the prediction of flowering time in the commercial apple cultivars ('Fuji' and 'Tsugaru') and apple cultivars ('Chukwang', 'Gamhong', 'Hongan', 'Honggeum', 'Hongro', 'Hongso', 'Hwahong', 'Summer dream', 'Sunhong') bred in Korea at the Gunwi region for 4 years (from 2009 to 2012) was investigated. Also, this study estimated the flowering time when the air temperature of Gunwi region rises at $5.0^{\circ}C$ was investigated using the same data. The range of accumulated hours of low temperature (chilling requirement) was from 0 hour to 1,671 hours, and the range of high temperature (heat requirements) to flowering after low temperature treatment was from $5.0^{\circ}C$ to $29.0^{\circ}C$. The treatments of changing temperature after bud breaking were classified as constant temperature treatment (control) and $5.0{\sim}10.0^{\circ}C$ elevation or descent treatments. The results show that the average days to flowering was longer with shorter accumulated hours of low temperature, and the average days from bud breaking to flowering of 0 hour treatment was longer about 2~4 weeks than that of 1,335~1,503 hours treatments. In comparing to apple cultivars, the all cultivars were not flowered under $10.0^{\circ}C$ after bud breaking, and the cultivars with low chilling requirements needed low heat requirements for flowering. The average days to flowering of treatments that the air temperature after bud breaking was controlled about $15.0^{\circ}C$ was shorter about 1~3 weeks than that of treatments was controlled about $10.0^{\circ}C$. In the treatment of changing temperature after bud breaking, the average days from bud breaking to flowering of temperature elevation treatment was shorter than that of constant temperature treatment. By use of these results, the base temperature to flowering of main apple cultivars in Korea was seemed to $10.0^{\circ}C$, and if the air temperature of Gunwi region rises about $5.0^{\circ}C$ than that of current, the flowering time was estimated to be delayed by 1 week.

• Korean Journal of Food Science and Technology
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• v.28 no.1
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• pp.90-98
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• 1996

The mineral contents were analyzed for 12 varieties of Korean apples and 9 commercial apple juices by atomic absorption spectrophotometry. On the fresh matter basis, the ash contents of tested apples ranged 0.21-0.48%, Mn 0.20-2.52 ppm, Cu 0.10-1.03 ppm, Fe 0.24-9.88 ppm, Zn 0.09-1.06 ppm, Mg 21.08-99.00 ppm, Ca 15.16-99.56 ppm, K 842.10-1788.10 ppm, Na 10.32-40.53 ppm, P 24.43-90.07 ppm, Pb nd-98.05 ppb, Cd nd-36.08 ppb and Cr 2.25-123.76 ppb. Overally mineral contents of Aori and Jonathan were higher than those of Fuji. The mineral contents of apple cultivated at Wonju, Kangwon and Taegu, $Ky{\check{o}}ngbuk$ were higher than those of the other growing region. The mineral contents of commercial apple juice were ash 0.13-0.36%, Mn 0.24-0.99 ppm, Cu 0.10-0.61 ppm, Fe 0.19-3.70 ppm. Zn 0.20-1.77 ppm, Mg 18.16-49.56 ppm, Ca 14.42-42.30 ppm, K 785.07-1440.30 ppm, Na 14.71-52.58 ppm, P 16.57-63.56 ppm, Pb nd-95.55 ppb, Cd nd-17.65 ppb and Cr 8.60-110.98 ppb, respectively. Comparing mineral contents of apples and commercial apple juices, Cu, Mg, K, Ca and Fe contents of apples were higher and Zn, Na contents were lower than those of apple Juices.