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A study on skin permeability enhancement of active substances in cosmetics using nanobubble technique (나노버블 기법을 이용한 화장품 내 유효물질의 피부투과성 증가에 관한 연구)

  • Lee, Sung-Joo;Lee, Soon-Hong;Park, Seung-il
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.4
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    • pp.1041-1051
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    • 2020
  • The technology of microbubbles and nanobubbles originated in Japan and Europe is applicable to various applications and its effects are diverse, attracting attention not only from many researchers but also from industry experts. In particular, nanobubbles have the advantage that they can be applied to products in the form of liquids, such as cosmetics, from the study that they can exist for more than several months in water. In this study, it was carried out the production of nanobubbles using bubble encapsulation technique and the experiment of skin permeability enhancement of active substances in cosmetics using nanobubble techniquethree. Nanobubbles were confirmed to affect the skin permeability increase of active substances, and up to 250% increase in skin permeability compared to non-bubbles-free materials(Caffeic acid, at 8 hour). It is expected that research results and industrial ripple effects can be expected not only in the cosmetic field, but also in fields applicable to the improvement of permeability by nanobubble techniques, such as areas related to drug delivery system.

Utilization of Ascidian, Halocynthia roretzi -1. Chemical composition of Ascidian and its seasonal and regional variation- (우렁쉥이 이용에 관한 연구 -1. 계절 및 서식지에 따른 우렁쉥이의 화학성분조성-)

  • LEE Kang-Ho;PARK Chun-Soo;HONG Byeong-Il;JUNG Woo-Jin
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.26 no.1
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    • pp.8-12
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    • 1993
  • Ascidian, Halocynthia roretzi, mainly inhabiting the subtidal rocky bottom as a sessile form, has been favored a tasty sea food in abundance along the east and south coast of Korea. The study was attempted to establish the basic data for evaluating the processing suitability of ascidian. The height, width, total weight, integument weight and edible portion of the ascidian were $9.2{\sim}12.2cm,\;4.7{\sim}6.1cm,\;100.2{\sim}163.0g,\;18.2{\sim}41.4g$ and $20.2{\sim}62.0g$, respectively. The moisture content, which showed a minimum value as low as $80.0\%$ in October. On the contrary, glycogen content of edible portion revealed the maximum value, $3.1{\sim}4.1\%$ from July to August. The protein and fat showed a similar change to glycogen. The level of ash was rather constant throughout the period, being $2.2{\sim}3.8\%$. Among the 7 kinds of mineral analyzed in all the samples of edible portion and integument, Na, K, Mg and Ca contents were predominent in order being more than $96.14{\sim}99.10\%$, of the total ash. In the amino acid composition of ascidian, the predominent ones were asparagine, glutamic acid, taurine, aspartic acid, proline, and lysine in order and the sum of these amino acids occupied $85.0\%$ of the total free amino acid while methionine and arginine were poor.

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An Implementation of Bandwidth Broker Based on COPS for Resource Management in Diffserv Network (차별화 서비스 망에서 COPS 기반 대역 브로커 설계 및 구현)

  • 한태만;김동원;정유현;이준화;김상하
    • Journal of Korea Multimedia Society
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    • v.7 no.4
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    • pp.518-531
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    • 2004
  • This paper discusses a testbed architecture for implementing scalable service differentiation in the Internet. The differentiated services (DiffServ) testbed architecture is based on a model in which a bandwidth broker (BB) can control network resources, and the ALTQ can reserve resources in a router to guarantee a Quality of Service (QoS) for incoming traffic to the testbed. The reservation and releasemessage for the ALTQ is contingent upon a decision message in the BE. The BB has all the information in advance, which is required for a decision message, in the form of PIB. A signaling protocol between the BB and the routers is the COPS protocol proposed at the IETF. In terms of service differentiation, a user should make an SLA in advance, and reserve required bandwidth through an RAR procedure. The SLA and RAR message between a user and the BB has implemented with the COPS extension which was used between a router and the BB. We evaluates the service differentiation for the video streaming in that the EF class traffic shows superb performance than the BE class traffic where is a network congestion. We also present the differentiated service showing a better packet receiving rate, low packet loss, and low delay for the EF class video service.

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A Study of Jazz Piano Techniques about Improvisation (재즈 피아노의 즉흥연주 기법 연구)

  • Sagong, Mi;Cho, Tae-Seon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.2
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    • pp.583-589
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    • 2017
  • The 1900s in New Orleans, the harbor city, was indeed an era of confusion because there were various ethnic groups and races. Songs that had been sung by slaves taken from Africa, Black spiritual music, blues, British folk songs, French folk music, ballet music, Spanish dance music, and the march of military bands were mixed with Rag Time to achieve diversity. This developed the beginning of jazz. While swing jazz was most popular and loved by the public during the 20th century, the bebop preferred the small scale organization of musical instruments and developed as a form of jazz featuring the impromptu musical performances. Later, cool jazz, a new style involving the fast and complicated code progress, emerged with free jazz, which features the fundamental rupture from the tradition of the jazz. Miles Davis, who introduced the rock beat in jazz, started fusion jazz. Although jazz has been named differently depending on the era, the main attraction of jazz lies on improvisation. In other words, despite a small changes in code progress and rhythm, the most important thing the player considers is improvisation. Some famous players who lived in the same era followed the whole atmosphere but each had their own style. So, even when they did play the same song, they revealed their style in solo parts despite the same head.

Efficacy of a Training Program for Long-Term Disease-Free Cancer Survivors as Health Partners: A Randomized Controlled Trial in Korea

  • Yun, Young Ho;Lee, Myung Kyung;Bae, Yeonmin;Shon, Eun-Jung;Shin, Bo-Ram;Ko, Hyonsook;Lee, Eun Sook;Noh, Dong-Young;Lim, Jae-Young;Kim, Sung;Kim, Si-Young;Cho, Chi-Heum;Jung, Kyung Hae;Chun, Mison;Lee, Soon Nam;Park, Kyong Hwa;Chang, Yoon Jung
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7229-7235
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    • 2013
  • Background: To determine whether the Health Partner Program is effective in training long-term cancer survivors to be health coaches. Materials and Methods: We randomly assigned cancer survivors who were selected through a rigorous screening process to either the Health Partner Program or the waiting-list control group. The program consisted of 8 weeks of training in health management, leadership, and coaching. At baseline, 8, and 16 weeks, we measured primary outcomes using the Seven Habit Profile (SHP), the Korean Leadership Coaching Competency Inventory (KCCI), Ed Diner's Satisfaction with Life Scale (SWLS), and the Posttraumatic Growth inventory (PTGI) and secondary outcomes using the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R), and the Medical Outcomes Study (MOS) short form 36-item questionnaire (SF-36). Results: We recruited 70 subjects and randomly assigned 34 to the intervention group. The Sharpen the Saw habit of the SHP increased significantly more in intervention group than in the control group (p=0.049), as did most PTGI factors. The intervention group also showed a significantly greater enhancement of vitality (p=0.015) and mental health (p=0.049) SF-36 scores but no improvement in KCCI, SWLS, HADS, or IES-R scores. The intervention group also showed a greater clinically meaningful improvement in the "Think Win-Win" of SHP (p=0.043) and in the personal strength score (p=0.025) and total score (p=0.015) of the PTGI. Conclusions: Long-term cancer survivors can benefit from the Health Partner Program to become health coaches.

Crystal Structure and Fungicidal Activity of N-[1-(benzotriazol-1-yl)alkyl]aniline Derivatives (N-[1-(benzotriazol-1-yl)alkyl]aniline 유도체의 결정구조와 항균활성)

  • Lim, Chi-Whan;Yi, Kyeong-Joon;Sung, Nack-Do
    • Applied Biological Chemistry
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    • v.38 no.4
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    • pp.359-363
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    • 1995
  • New ten N-[1-(benzotriazol-1-yl)alkyl]aniline(4) derivatives were synthesized and the crystal structure of 4h was shown by X-ray crystallography and the absolute configuration has been assigned as S form. The molecule crystallizes in the monoclinic system, space group $P2_{1}/n$. And the molecules in the crystal are linked with each other through the hydrogen bond $(N_{11}-H_{11}{\cdots}N3)$ with distance $2.300(11){\AA}$ The fungicidal activity($pI_{50}$) in-vitro against Botrytis cineria (BC), Phytophthora casici (PC) and Sclerotium cepinorum (SC) were determined by the agar dilution method. The structure activity ralationships (SAR) between structure of 4 and the activity were studied using a physicochemical parameters of substituents and multiple regression technique. Among these compounds, only the bromo group substituent(4f) showed higher activity, which depend on the hydrophobic(${\pi}$) of substituents. The relative orders of the activity are SC>BC> and PC, respectively. This implies that the activity is affected by the hydrophobic(${\pi}$) nature of the Z group rather than the X group. Linear free energy relationships(LFER) on the fungicidal activity with substituents has been also discussed.

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Lipid Oxidation in Shellfish under the Different Conditions of Drying (패류의 건조조건에 따른 지질산화)

  • LEE Kang-Ho;CHO Tae-Yong;CHO Ho-Sung;LEE Jong-Ho;SHIM Ki-Hwan
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.31 no.2
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    • pp.143-148
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    • 1998
  • This study was carried out in order to investigate oxidative deterioration during dehydration at $40^{\circ}C,\;50^{\circ}C$ and $60^{\circ}C$ of sea mussel and baby clam. Moisture content was decreased with drying temperature and time. Sea mussel was dehydrated more rapidly than baby clam that had Harder muscle tissue. Both samples were not reached to Aw 0.62 in case of 10 hrs drying at $40^{\circ}C$, But it reached within 8 hrs in sea mussel and 10 hrs in baby clam at $50^{\circ}C$, respectively. Even if $60^{\circ}C$ could speed up drying, it caused to form more free fatty acid, peroxide, thiobarbituric acid and brown pigments. Lipophilic brown pigment was 10 times higher than hydrophilic and actively increased in all samples. fluorescence intensity was also increased with drying temperature and time. Particularly, it was higher sea mussel than baby clam more or less.

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Study on Main Factors for Imported Brand launching: Focus on Exclusive Importation Fashion Apparel Brand (수입 브랜드 도입을 위한 주요 요인 연구: 독점 수입 패션 의류 브랜드를 중심으로)

  • LYU, Moon-Sang
    • The Journal of Industrial Distribution & Business
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    • v.10 no.8
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    • pp.45-53
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    • 2019
  • Purpose - The purpose of this study was to clarify the factors to make an exclusive importation contract between foreign fashion brands and local retailers for successful business in Korea. Even though imported fashion brand market shows stead increasing in terms of sales amount, the number of store related study was very rare in fact. Meanwhile, as long as this business is glowing a lot of brands are suffering from bad business performance or getting in ruins thus these problems result in foreign currency loss. The local marketers therefore, strongly expect to know the solution for this matter. Research design, data, and methodology - For the qualitative research, 10 experts who are operating foreign brands with an exclusive contract at a department store or at duty free shop now and who had at least over 10 years of related working experience were included. The factors for the exclusive importation contract with foreign brands were drawn up through the one-to-one in-depth interview method from September 3, 2017 to January 15, 2018. The expert group for the validity analysis includes 2 professors and 5 postgraduate students. Results - As a result of qualitative study on the factors for imported fashion brand's launching with the exclusive importation contract, it turned out that there were 5 factors - safety, profitability, reliability, speed and global retailing. Safety, profitability, and reliability have been mentioned in most related surveys but some details are added and speed and global retailing have been newly highlighted and many unknown legal issues that it was not easy to get form common academic research are included. Speed simply means quick lead time and global retailing means stores where located in other countries. Conclusions - The reason that qualitative research should be done before the quantitative research is due to the scant theoretical background for this matter. Because the market of an imported fashion brand is steadily increasing, determining the factors to make exclusive importation contract is very meaningful from the point of academic and business. After this study, many marketers may get basic conditions to apply for real business and I hope the following quantitative research will give more effective results. The next study also will have extended range concerning industry area, product and distribution channel.

Characteristics of Bacterial-Koji and Doenjang(soybean paste) Made by using Bacillus subtilis DJI (Bacillus subtilis DJI을 이용하여 제조된 세균형 코지와 속성된장의 특성)

  • Chang, Mi;Chang, Rae-Choon
    • Microbiology and Biotechnology Letters
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    • v.35 no.4
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    • pp.325-333
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    • 2007
  • One bacterium with high proteinase production and spore-forming ability was isolated from korean traditional soybean paste(doenjang). The isolated strain was identified as Bacillus subtilis, based on gram-staining, biochemical properties and l6S rRNA gene sequencing, and designated as B. subtilis DJI. Its growth rate was very fast, and it reached its stationary phase within 9 h, and then started to form spores. Bacterial-koji and doenjang were prepared using B. subtilis DJI. Chemical components of the doenjang were determined after 2 months of aging period: amino nitrogen 507 mg%, crude protein 14.3%, crude fat 4.8% and water 54.9%. The composition of total and free amino acids and their ratios of doenjang were changed during the aging period. Among total amino acids in DJI doenjang, glutamic acid, aspartic acid, leucine and arginine were the major amino acids. The fibrinolytic activities of DJI doenjang and traditional doenjangs were 909.7 units/ml and $363.3{\sim}618.6\;units/ml$, respectively. Flavor compounds of DJI doenjang and traditional doenjang were extracted by SDE(simultaneous steam distillation and extraction), and analyzed by GC/MS; DJI doenjang possessed the typically favorable flavor compounds in traditional korean doenjang, with reduced off-flavor compounds.

Numerical Analysis of Resin Filling Process for a Molded Dry-type Potential Transformer (몰드형 건식 계기용 변압기 제작을 위한 수지 충진 해석 연구)

  • Kim, Moosun;Jang, Dong Uk;Kim, Seung Mo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.12
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    • pp.511-517
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    • 2016
  • Current oil-type potential transformers for trains are filled with insulating oil, which could have problems like explosions due to rising inner pressure during train operation. Therefore, mold and dry-type potential transformers are being developed to prevent explosions. One problem in manufacturing mold-type transformers is preventing void formation around the coiled core inside the mold during epoxy filling, which could cause an electrical spark. Micro voids can remain in the resin after filling, and macro voids can occur due to the structure shape. A transformer that is being developed has a cavity at the junction of the core and the coil for better performance, and when highly viscous epoxy flows inside the cavity channel, macro voids can form inside it. Therefore, in this study, the free-surface flow of the mold filling procedure was analyzed numerically by applying the VOF method. The results were used to understand the phenomena of void formation inside the cavity and to modify the process conditions to reduce voids.