• 생약학회지
• /
• 제14권1호
• /
• pp.1-3
• /
• 1983

한국에 자생하는 ${\ulcorner}$좀물푸레나무${\lrcorner}$의 수피에서 fraxin, fraxetin-8-glucoside $(mp.\;204{\sim}5^{\circ})$를 달리 확인하였다.

• 생약학회지
• /
• 제24권3호
• /
• pp.197-202
• /
• 1993

Three components, fraxetin-8-glucoside, esculetin-6-glucoside and mannitol, were isolated from the stem bark of Fraxinus chiisanensis var. stenophylla, F. japonica var. intermedia and F. densata. The MeOH extract of the cortex of F. densata had the antiinflammatory activity on the carrageenin-induced paw edema in rat. The MeOH extracts of the cortex of all three Fraxinus spp. have the potent analgesic activity on the HOAc-induced writhing syndrome in mouse and the hepatoprotective activity on the $CCl_4-induced$ fatty liver in rat: protection of ballooning formation and inhibition of sGPT and sGOT increased by $CCl_4$.

• 생약학회지
• /
• 제12권3호
• /
• pp.143-145
• /
• 1981

The methanol extract of the rootbark of Fraxinus sieboldiana Blume(Oleaceae) gave two coumarin glycosides, fraxin (fraxetin-8-glucoside), $C_{16}H_{18}O_{10},\;mp\;204^{\circ}\;and\;esculin\;(esculetin-6-glucoside),\;C_{15}H_{16}O_{9},\;mp\;204{\sim}205^{\circ}$. Beside, the methanol extract of the root bark was found to contain mannitol. ${\beta}-sitosterol$ is confirmed by massspectrometry.

• Natural Product Sciences
• /
• 제19권3호
• /
• pp.236-241
• /
• 2013

A high-performance liquid chromatography-diode array detector (HPLC-DAD) method was established for quantitative evaluation of nine constituents of Fraxinus rhynchophylla such as four coumarins, esculin (1), fraxin (2), esculetin (3), fraxetin (4), three lignans, syringaresinol 4,4'-O-${\beta}$-diglucoside (5), pinoresinol 4-O-${\beta}$-glucoside (6), pinoresinol (9), one secoiridoid, oleuropein (7), and one coumarinolignan, cleomiscosin C (8). The preferred chromatographic condition was obtained on Phenomenex Gemini-NX (3 ${\mu}m$, C18 110A, $150{\times}4.60$ mm) and the mobile phase was composed of water and acetonitrile using a gradient elution. The wavelength was set at 220 nm. Extraction condition of these constituents in F. rhynchophylla was also optimized through extraction time, extraction solvent and extraction method using established method. From this study, extraction at $70^{\circ}C$ with the mixture of ethanol and water for more than 12 h was suggested to be good extraction condition for these constituents. Quantitation of nine constituents in different F. rhynchophylla samples was also successfully accomplished with the newly established method.