• 대한두개안면성형외과학회지
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• 제17권3호
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• pp.119-127
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• 2016

Background: Conventional correction of malunioned zygoma requires complete regional exposure through a bicoronal flap combined with a lower eyelid incision and an upper buccal sulcus incision. However, there are many potential complications following bicoronal incisions, such as infection, hematoma, alopecia, scarring and nerve injury. We have adopted a zygomaticofrontal suture osteotomy technique using transconjunctival incision with lateral paracanthal extension. We performed a retrospective review of clinical cases underwent correction of malunioned zygoma with the approach to evaluate outcomes following this method. Methods: Between June 2009 and September 2015, corrective osteotomies were performed in 14 patients with malunioned zygoma by a single surgeon. All 14 patients received both upper gingivobuccal and transconjunctival incisions with lateral paracanthal extension. The mean interval from injury to operation was 16 months (range, 12 months to 4 years), and the mean follow-up was 1 year (range, 4 months to 3 years). Results: Our surgical approach technique allowed excellent access to the infraorbital rim, orbital floor, zygomaticofrontal suture and anterior surface of the maxilla. Of the 14 patients, only 1 patient suffered a complication-oral wound dehiscence. Among the 6 patients who received infraorbital nerve decompression, numbness was gradually relieved in 4 patients. Two patients continued to experience persistent numbness. Conclusion: Transconjunctival incision with lateral paracanthal extension combined with upper gingivobuccal sulcus incision offers excellent exposure of the zygoma-orbit complex, and could be a valid alternative to the bicoronal approach for osteotomy of malunioned zygoma.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.1441-1444
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• 2008

We developed ultra-accelerated quantum chemical molecular dynamics and spectroscopic characterization simulators for development of PDP materials. By combination of these simulators, realistic structure of PDP materials is drawn on the computer. Furthermore, based on the structures, various properties such as cathode luminescence spectrum and secondary electron emission, is successfully evaluated. The strategy of "Experiment integrated Computational Chemistry" using developed simulators will presented that has the potential in being powerful tool for designing the PDP materials.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권1호
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• pp.32-38
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• 2005

The efficacy of bioresorbable fixation has recently been described in the osseosynthesis of the oral & maxillofacial region. However, a liitle data exist regarding the use of biodegradable plates and screws for the internal fixation of human mandible fractures. The purpose of this study is to analyze and compare the treatment of mandibular fractures by using a bioresorbable fixation system with conventional titanium system in human mandible fractures. eighteen patients constituted the bioresorbable fixation group and twenty-five patients constituted the titanium fixation group. Both groups underwent open reduction and internal fixation by use of a bioresorbable system or a titanium fixation system. Panoramic radiograph were obtained preoperatively, immediately postoperatively after reduction, at 6 months and at 12 months postoperatively. In the bioresorbable fixation group, complication(infection) occurred in 1 patient(5.6%) and was resolved by incision & drainage, plate removal and antibiotics without untoward sequelae. 2 patients(8.0%) experienced complications in the titanium fixation group and were treated using conservative treatment. There was no statistical difference in complication rates between two groups. Our data supported the use of bioresorbale plate fixation in mandibular fractures as a means of avoiding the potential and well documented problems with rigid titanium fixation systems. In conclusion, the bioresorbable fixation system provide a reliable and sufficient alternative to conventional titanium plate system.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2003년도 Proceedings of the international symposium on the fusion technology
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• pp.470-475
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• 2003

KIGAM (Korea Institute of Geoscience and Mineral Resources) launched a new project to develop the low-enthalpy geothermal water in the area showing high geothermal anomaly, north of Pohang city, for large-scale space heating from KORP (Korea Research Council of Public Science & Technology) funding. Surface geologic and geophysical surveys including Landsat TM image analysis, gravity, magnetic, Magnetotelluric (MT) and controlled-source audio-frequency MT (CSAMT) and self-potential (SP) methods have been conducted and the possible fracture zone was found that would serve as deeply connected geothermal water conduit. By the end of 2003, two test wells of 1 km depth will be drilled and various kinds of borehole survey along with additional MT measurements and sample analysis will follow and then the detailed subsurface condition is to be characterized. Next step would be drilling the production well of 2 km depth and all further steps remain to be determined depending upon the results of the test well studies.

• Ocean and Polar Research
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• 제25권4호
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• pp.529-543
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• 2003

Deep-sea surface sediments, acquired from 1997 to 2002 in the Clarion-Clipperton fracture zone of the northeast equatorial Pacific, were analyzed for index and geotechnical properties to provide background information for the design of manganese nodule minor. The sediments were classified into 16 types based on the measured properties and evaluated in terms of miner maneuverabillity and potential environmental impacts arising from mining activities. It was found that the middle part of the study area covered with coarse siliceous sediments is more favorable to the commercial production than the northern part of pelagic red clay. In particular, Area B2 in the middle part is considered the best mining site since it shows the highest abundance as well as it consists mostly of normally to over consolidated (types B, C, D) coarse siliceous sediments that are appropriate for effective minor movement and accompany weak environmental impacts. Taking account of all the analyzed core logs, the average shear-strength values are proposed as a practical guideline fur movements of a manganese nodule miner: 6.0 kPa at 10cm and 7.0kPa at 40cm below the seabed.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제13권4호
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• pp.405-411
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• 1991

To determine the sterility of the prepared allogeneic bone of the human, culture of the allografts prior to implantation was performed on fresh-frozen and freeze-dried bone. Before the use of allografts to the patients, it must be confirmed about the sterility, cellular cytotoxicity, immune reaction, and osteoinductive potential as a biomaterials. Oral and maxillofacial surgeons demand for allograft bone will be increased in the future. Wonkwang Bone Bank attempted to meet this demand, has performed series of experimental study on the allograft bone of the Koreans to evaluate the physical and chemical suitability of the bone since the surgeons applications will have broadened from benign cystic lesions to fracture malunions and non-unions, large segmental defects, and whole-bone allorgrafts after tumor surgery. The results obtained were as follows: 1. Freeze-drying(FD) only shoed some bactericidal effects of the normal and osteo bone but in cases of performing EO gas sterilization, the FD effects was not clear. 2. The fact that FD has little effect than the EO gas sterilization on normal bone postulated that the presence of microbiota may be due to an operation and bone processing procedure. 3. FD and EO gas sterilization had a remarkable effect on the osteo bone. 4. The sterilization effect were EO gas, Freeze-drying, Fresh-Frozen with descending order. But all sterilization method were not complete to preserve and implant allograft bone. We are now performing further continuous study on the radiation and chemical sterilization procedure to make safe and complete allograft bone.

• 한국강구조학회 논문집
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• 제16권5호통권72호
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• pp.695-703
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• 2004

본 논문에서는 4개의 철골 해석모델과 1개의 합성보 해석모델에 대한 단조가력 해석의 결과를 나타냈다. 철골 기둥-보 접합부에서 웨브의 모멘트 전달효율과 변형도 집중에 대해서 조사하였다. 해석결과 각형기둥을 가진 모델의 모멘트 전달효율은 각형기둥 플랜지의 면외변형 때문에 H-기둥을 가진 모델에 비해서 빈약했다. 스캘럽과 얇은 각형기둥 두께 및 슬래브도 또한 모멘트 전달효율의 저하를 가져오는 원인으로서, 이는 보-기둥 접합부의 파단을 초래할 가능성이 크다. 해석 결과는 실험결과와 비교하였다. 실험결과를 기초로 하면, 각형기둥 또는 슬래브가 있는 접합부의 변형능력은 빈약한 모멘트 전달효율과 이에 따른 플랜지의 변형도 집중에 의해 감소했다.

• Molecules and Cells
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• 제43권6호
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• pp.517-529
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• 2020

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.

• 한국구조물진단유지관리공학회 논문집
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• 제19권6호
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• pp.55-62
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• 2015

공공시설물의 대형화 및 도심지로의 인구 밀집화에 따라 충돌 또는 폭발과 같은 하중조건 하에서의 구조물 방호성능의 중요성이 대두되고 있다. 그러나 구조물의 방호설계 및 시공에 있어서 필수적이라 할 수 있는 구조 재료 또는 자재에 대한 방호성능 평가기준은 현재 정립되어 있지 않은 실정이다. 따라서 본 연구에서는 구조용 자재의 내충격 성능평가 기준 개발 연구의 일환으로 가스건을 사용한 발사체 충격 파괴시험을 콘크리트 시험체에서 수행함과 동시에, 다양한 접촉식 계측 센서의 적용 가능성을 확인하고자 하였다. 또한, 충격 파괴시험을 통해 일반 콘크리트 및 강섬유가 보강된 초고성능콘크리트의 파괴모드 및 방호성능에 대한 평가를 수행하였다. 실험 수행 결과, 접촉식 계측센서 중 LVDT 변위계의 적용 가능성을 확인하였으며, UHPC의 경우 혼입된 보강섬유의 효과로 인해 일반 콘크리트에 비해 우수한 방호성능을 보여주었다.

• Computers and Concrete
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• 제22권2호
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• pp.227-237
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• 2018

Today, the modeling of concrete as a material within finite element simulations is predominantly done through nonlinear material models of concrete. In current sophisticated computational systems, there are a number of complex concrete material models which are based on theory of plasticity, damage mechanics, linear or nonlinear fracture mechanics or combinations of those theories. These models often include very complex constitutive relations which are suitable for the modeling of practically any continuum mechanics tasks. However, the usability of these models is very often limited by their parameters, whose values must be defined for the proper realization of appropriate constitutive relations. Determination of the material parameter values is very complicated in most material models. This is mainly due to the non-physical nature of most parameters, and also the large number of them that are frequently involved. In such cases, the designer cannot make practical use of the models without having to employ the complex inverse parameter identification process. In continuum mechanics, however, there are also constitutive relations that require the definition of a relatively small number of parameters which are predominantly of a physical nature and which describe the behavior of concrete very well within a particular task. This paper presents an example of such constitutive relations which have the potential for implementation and application in finite element systems. Specifically, constitutive relations for modeling the plane stress state of concrete are presented and subsequently tested and evaluated in this paper. The relations are based on the incremental theory of elastic strain-hardening plasticity in which a non-associated flow rule is used. The calculation result for the case of concrete under uniaxial compression is compared with the experimental data for the purpose of the validation of the constitutive relations used.