• Korean Journal of Pharmacognosy
• /
• v.52 no.4
• /
• pp.251-256
• /
• 2021

Oat, the seeds of Avena sativa L. (Gramineae), is an important dietary staple for people in many countries. Previous studies reported that A. sativa had various pharmacological effects such as anti-inflammatory, antitumor, neurotonic, and antispasmodic activities. In this study, Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of oat. The ethyl acetate soluble fraction of the oat methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using GFP-expressing transgenic worm. As a result, the ethyl acetate fraction increased SOD and catalase activities, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity compared to the control.

• Korean Journal of Pharmacognosy
• /
• v.53 no.4
• /
• pp.207-212
• /
• 2022

Through the Caenorhabditis elegans model system, the antioxidant activity of methanol extract of Ixeis dentata was investigated. The ethyl acetate soluble fraction of the I. dentata methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using a transgenic strain (CF1553). As a result, the ethyl acetate fraction increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.

• Advances in concrete construction
• /
• v.13 no.5
• /
• pp.367-376
• /
• 2022

Theoretical study of vibration distinctiveness of rotating cylindrical are examined for three volume fraction laws viz.: polynomial, exponential and trigonometric. These laws control functionally graded material composition in the shell radius direction. Functionally graded materials are controlled from two or more materials. In practice functionally graded material comprised of two constituent materials is used to form a cylindrical shell. For the current shell problem stainless steel and nickel are used for the shell structure. A functionally graded cylindrical shell is sanctioned into two types by interchanging order of constituent materials from inner and outer side for Type I and Type II cylindrical shell arrangement. Fabric composition of a functionally graded material in a shell thickness direction is controlled by volume fraction law. Variation of power law exponent brings change in frequency values. Influence of this physical change is investigated to evade future complications. This procedure is capable to cater any boundary condition by changing the axial wave number. But for simplicity, numerical results have been evaluated for clamped- simply supported rotating cylindrical shells. It has been observed from these results that shell frequency is bifurcated into two parts: one is related to the backward wave and other with forward wave. It is concluded that the value of backward frequency is some bit higher than that forward frequency. Influence of volume fraction laws have been examined on shell frequencies. Backward and forward frequency curves for a volume fraction law are upper than those related to two other volume fraction laws. The results generated furnish the evidence regarding applicability of present shell model and also verified by earlier published literature.

• Korean Journal of Pharmacognosy
• /
• v.53 no.2
• /
• pp.96-101
• /
• 2022

Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of Melampyrum roseum (Scrophulariaceae). The ethyl acetate soluble fraction of the M. roseum methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using a transgenic strain. As a result, the ethyl acetate fraction increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.24 no.5
• /
• pp.611-618
• /
• 2018

In this study, numerical analysis of solid-liquid two-phase flow was conducted as a preliminary step to analyze the flow characteristics of drilling fluid using the commercial CFD code, ANSYS CFX 14.5. The homogeneous model and separated flow model were used to simulate solid-liquid two-phase flow phenomena. In the separated flow model, Gidaspow's drag force model was applied with the kinetic theory model was applied for solid particles. The validity of the numerical model used in this study was verified based on the published experimental results. Numerical analysis was carried out for volume fractions of 0.1 to 0.5 and velocities of 1 to 5 m/s in a horizontal tube with a diameter of 54.9 mm and a length of 3 m. The Pressure drop and volume fraction distribution of solid particles were confirmed. The pressure drop was predicted using the homogeneous model and separated flow model within the MAE of 17.04 % and 8.98 %, respectively. A high volume fraction was observed in the lower part of the tube, and the volume fraction decreased toward the upper part. As velocity increased, variations in volume fraction distribution at varying heights were decreased, and the numerical results predicted these flow characteristics well.

• Korean Journal of Food Science and Technology
• /
• v.29 no.5
• /
• pp.1045-1051
• /
• 1997

Three kinds of model melanoidins adjusted to have the same brown color intensity were made from glucose-glycine, glucose-lysine, xylose-arginine and their antioxidative properties were determined. The antioxidative activities of these model melanoidins in linoleic acid emulsion system were determined by ferric thiocyanate method, conjugated diene contents, peroxide value and electron donating ability by DPPH. Xylose-arginine melanoidin showed the strongest antioxidative activity and electron donating ability. The antioxidative effect of melanoidin could be reliably predicted by determining peroxide value and DPPH method. Each melanoidin was separated on Sephadex G-50 column, and brown color intensity, reducing power, ninhydrin positive reaction and antioxidative activity of each fraction were determined. The antioxidative activities of melanoidin fractions showed strong correlation with their brown color intensity and especially to their reducing power. In spite of same brown color intensity, there is no big differences between these model melanoidins, thus xylose-arginine showing strongest antioxidative activity followed by glucose-lysine and glucose-glycine melanoidin. Xylose-arginine melanoidin also showed the strongest electron donating activity and broad range of reducing power when fractionated on Sephadex G-50, which was different tendency from the other model melanoidin.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.15 no.2
• /
• pp.584-595
• /
• 1991

In the direct rolling processes for the mushy state alloy, a mushy state material which simultaneously contains liquid-solid phase is obtained from the exit port of stirring apparatus with a given solid fraction. This solid fraction is dependent on the temperature of within the solid-liquid range which shows to be controlled accurately by the experimental conditions for a given stirring apparatus. Rolling conditions for fabrication the fine surface strip were obtained from direct rolling experiment with mushy state alloys of Sn-75%Pb and aluminum alloy. Influence of solid fraction, rolling speed and initial roller gap on the state of strip surface and solidified structure was observed. We proposed theoretical model for prediction of rolling force, and we compared calculation result and experimental value measured with load cell.

• Korean Journal of Pharmacognosy
• /
• v.29 no.4
• /
• pp.384-390
• /
• 1998

The methanol extract of Torilis Fructus showed potent anti-edematous effect in carrageenan-induced paw edema in rats. Systematic fractionation of the extract with hexane, chloroform, ethyl acetate and butanol resulted in potent anti-edematous action only in hexane fraction at an oral dose of 237 mg/kg which is corresponding to 4.8 g of raw Fructus. This hexane fraction showed inhibitory effects at 77 mg/kg p.o on vascular permeability in mice, at 8mg/pouch on leucocyte emigration in rats, and at 120 mg/kg p.o. on adjuvant arthritis model in rats. These results demonstrate that hexane fraction of the extract possesses potent anti-inflammatory effect which may support its traditional uses.

• Proceedings of the Korean Society of Medical Physics Conference
• /
• 2002.09a
• /
• pp.174-176
• /
• 2002

A total of 134 patients with stage 1 of non-small cell lung cancer treated by carbon ion beam of HIMAC NIRS were investigated for control rate and delivered dose. The delivered dose of every patient was converted to biological effective dose (BED) of LQ model using fraction number, dose per fraction and alpha beta ratio which shows the maximum correlation between BED and tumor control. The BED of every patient was classified to establish a BED response curve for control. Assuming fraction numbers, dose response curves were introduced from BED response curve. The total doses to realize several control rates were obtained for the treatment of small fraction number.

• Biomolecules & Therapeutics
• /
• v.4 no.1
• /
• pp.84-88
• /
• 1996

Alnus japonica cortex has been used as antidiarrhea, antihemorrhage and the remedy of indigestion. This study was performed to investigate the effectiveness of the methanol extracts of the Alnus japonica cortex on the gastric lesion and ulcer. The methanol extract was fractionated with hexane, chloroform and butanol, followed by bioassay on antigastritic and antiulcer activity. The methanol extract showed low acute toxicity with minimum lethal dose of more than 5000 mg/kg, p.o. in mice. The chloroform and the butanol fraction reduced gastric lesion in HCI. ethanol induced gastritic model. On gastric secretion in pylorus ligated rat, the hexane and chloroform fraction decreased the volume and acidity. The butanol fraction had significant inhibitory effects on aspirin and Shay's ulcer. The butanol fraction showed a tendency to inhibit the decrease of mucin secretion due to ingestion of absolute ethanol.