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Physiologically Active Fatty Acids their Metabolism and Function (생리활성지방산;그 대사와 기능)

  • Mitsu, Kayama
    • Journal of the Korean Applied Science and Technology
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    • v.13 no.3
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    • pp.15-24
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    • 1996
  • Essentiality was proposed in the field of lipid by Burr and Burr in 1929. When rats were raised on the fat-free diet, their growth retarded and their skin and tails showed the characteristic deficient symptoms, which were relieved by the addition of ${\omega}6(n-6)$ polyunsaturated fatty acids as linoleic(LA) and arachidonic(AA) acids to the basal diet. LA is dehydrogenated to ${\gamma}-linolenic$ acid(GLNA) by ${\Delta}6$ desaturase, then GLNA is 2 carbon chain elongated by elongase to $dihomo-{\gamma}-linolenic$ acid(DGLNA), which is desaturated by ${\Delta}5$ desaturase to AA. These acids are called LA family or ${\omega}6(n-6)$ polyunsaturated fatty acids(PUFA). ${\alpha}-Linolenic$ acid(ALNA) is converted through the series of desaturation and elongation steps to docosahexaenic acid(DHA) via eicosapentaenoic acid(EPA). These acids belong to ALNA family or ${\omega}3(n-3)$PUFA. Human who consume large amounts of EPA and DHA, which are present in fatty fish and fish oils, have increased levels of these two fatty acids in their plasma and tissue lipids at the expense of LA and AA. Alternately, vegetarians, whose intake of LA in high, have more elevated levels of LA and AA and lower levels of EPA and DHA in plasma lipids and in cell membranes than omnivores. AA and EPA are metabolized to substances called eicosanoids. Those derived form AA are known as prostanocids(prostaglandins and prostacyclins) of the 2-types and leukotrienes of the 4-series, whereas those derived from EPA are known as prostanoids of the 3-types and leukotrienes of the 5-series. DGLNA is a precursor of the 1-types of prostaglandins. The metabolites of AA and EPA have competitive functions. Ingestion of EPA from fish or fish oil replaces AA from membrane phospholipids in practically all cells. So this leads to a more physiological state characterized by the production of proatanoids and leukotrienes that have antithrombic, antichemotactic, antivasoconstrictive and antiinflammatory properties. It is evident that ${\omega}3$ fatty acids can affect a number of chronic diseases through eicosanoids alone.

Characteristics of VOCs and Formaldehyde Emitted from Floorings (바닥재로부터 방출되는 휘발성유기화합물과 폼알데하이드 특성)

  • Park, Hyun-Ju;Jang, Seong-Ki;Seo, Soo-Yun;Lim, Jun-Ho
    • Journal of Korean Society for Atmospheric Environment
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    • v.25 no.1
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    • pp.38-45
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    • 2009
  • Since the seventies and the oil crisis, energy-saving measures have led to a reduction in the ventilation of room. The use of synthetic materials which emit various chemical substances had led to an increase in the concentration of indoor pollutants. "Sick building syndrome (SBS)" and "Sick house syndrome (SHS)" are worldwide problems. Also, the number of complaints about indoor air pollution caused by VOCs (Volatile organic compound) and HCHO (Formaldehyde) has increased. It is important that evaluating and understanding emission of indoor air pollutant from building materials. The object of this study was to evaluate emission test method for flooring such as wood based flooring, carpet tile, rubber tile, PVC sheet and tile, and to determine emission of TVOC and form-aldehyde. The quantity of TVOC and carbonyl compounds emission were sampled and measured by Tenax TA and gas chromatography/mass spectrometry (GC/MSD), 2,4-DNPH cartrige with ozone scrubber and high performance liquid from flooring. The TVOC concentration emitted from carpet tile was ($7.419\;mg/m^2 h$) the highest among 5 groups of test materials. In wood based flooring and PVC tile, the emitted concentration of toluene was high. And the dodecane emission was highest in carpet. The concentration of TVOC decreased by an increase in emission test period. After 7 days, the concentration of TVOC from floorings were about 50% below of the concentration at the first day. TVOC emission from wood based flooring, carpet tile, rubber tile, PVC sheet and tile were decreased in 28 days and remained steady after about 15 days. The concentration of formaldehyde emission from floorings showed extremely low.

An Analysis of Economic Effects of Korean Fisheries using Input, Output Analysis (산업연관분석을 이용한 수산업의 경제적 파급효과 추이 분석)

  • Park, Kyoung-Il;Park, Joon-Soon;Seo, Ju-Nam
    • The Journal of Fisheries Business Administration
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    • v.43 no.3
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    • pp.75-87
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    • 2012
  • Today, the Korean fisheries is undergoing significant hardships, both domestically and internationally. While declining amount of catch, ascending international oil prices and others pose a compelling challenge to the fishing sector, the ever strengthening influence of international institutions related to fisheries and international trade organizations also compel to bring about myriad of changes in the realm of fishery products. Against the backdrop, this study attempted to examine the fisheries catch, aquaculture, service, processing fields in terms of its rippling effect and of how the industry has been changed by analyzing the past and present through an input-output analysis. As for research methods, 168 items of the input-output tables in 2000, 2005, 2009, and 2010 were integrated to form and classify 32 sectors (28 basic sectors + catch, aquaculture, fishery service, processed fishery products) so as to generate production inducement coefficient, sensitivity coefficient, and impact coefficient. The analysis results revealed that : though the linkage effect of fishery industry was not very sizable, the impact coefficient of the processed fishery products was high; the consumption and investment coefficient sector among production inducement coefficient was on an upturn trend ; the export coefficient was tended to decline. In the future research, it is necessary to carry out a study based on the integration of detailed classification (404 sector) and a study and analysis of fishery industry by different regions through the inter-regional input-output tables. The fishery industry is one of the crucial industries in Korea. The fishery industry is not only important in its own right but also significant as it exerts influence over other industries. Therefore, it is required that there should be more investment and supports for the development of the fishery industry, and pay efforts to ensure that the investment and development could lead to mutual growth for both the fishery and other various industries.

Conjugation of Cyclohexane Metabolite in Liver Damaged Rats

  • Joh, Hyun-Sung;Yoon, Chong-Guk
    • Biomedical Science Letters
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    • v.12 no.4
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    • pp.361-370
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    • 2006
  • To evaluate an effect of pathological liver damage on the conjugation of cyclohexane metabolites, rats were pretreated with 50% $CCl_4$ dissolved in olive oil (0.1 ml/100 g body weight) 10 or 17 times intraperitoneally at intervals of every other day. On the basis of liver function, the animals pretreated with $CCl_4$ 10 times were identified as acutely liver damaged ones and the animals pretreated with $CCl_4$ 17 times were identified as severly liver damaged ones. To these liver damaged animals, cyclohexane (a single dose of 1.56 g/kg body weight, i.p.) was administered at 48 hr after the last injection of $CCl_4$. The rats were sacrificed at 4 or 8 hr after injection of cyclohexane. The cyclohexane metabolites, cyclohexanol (CH-ol), cyclohexane-1,2-diol (CH-1,2-diol), cyclohexane-1,4-diol (CH-1,4-diol), and their glucuronyl conjugates and cyclohexanone were detected in the urine of cyclohexane treated rats. The urinary concentration of cyclohexane metabolites was generally more increased in liver damaged animals than normal ones, and the increasing rate was higher in $CCl_4$ 17 times injected rats than 10 times injected ones. And liver damaged.ats, especially $CCl_4$ 17 times treated ones, had an enhanced ability of glucuronyl conjugation to CH-ol analogues compared with normal group. Futhermore, CH-1,2 and 1,4-diol were all conjugated with glucuronic acid in $CCl_4$ 17 times injected animals. On the other hand, the increasing rate of activities of hepatic cytochrome P450 dependent aniline hydroxylase, alcohol dehydrogenase and urine diphosphate glucuronyl transferase was higher in 17 times $CCl_4$-treated rats compared with normal and $CCl_4$ 10 times injected animals. Taken all together, it is assumed that an increased urinary excretion amount of cyclohexane metabolites in liver damaged rats might be caused by an increase in the activities of cyclohexane metabolizing enzymes. And enhanced conjugating ability of CH-ol in liver damaged animals and novel finding of conjugating form of CH-1,2 and 1,4-diol might be caused by increase in the activity of hepatic diphosphouridine glucuronyltransferase.

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A Study on Nano-emulsion for Enhanced Transdermal Delivery of Hippophae rhamnoides Leaf Extract (비타민나무 잎 추출물의 피부 흡수 증진을 위한 나노에멀젼 연구)

  • Chae, Kyo Young;Kwon, Soon Sik;Park, Soo Nam
    • Applied Chemistry for Engineering
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    • v.24 no.3
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    • pp.260-265
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    • 2013
  • In this study, nano-emulsions containing 0.01, 0.03, 0.05, and 0.10% ethyl acetate fraction of Hippophae rhamnoides (H. rhamnoides) leaf extracts were prepared. The particle size, particle size distribution and skin permeability of the nano-emulsions were evaluated for five weeks. Nano-emulsion was prepared by the sequential use of homogenizer and microfluidizer. Nano-emulsion containing the ethyl acetate fraction exhibited a monodispersed form. Nano-emulsion containing 0.03% ethyl acetate fraction was the most stable for five weeks. The in vitro skin permeation study of nano-emulsion containing 0.03% ethyl acetate fraction was carried out using Franz diffusion cell. The nano-emulsion showed a better skin permeability than that of O/W emulsion. These results indicate that the nano-emulsion containing the ethyl acetate fraction of H. rhamnoides leaf extract showed a remarkable stability and skin permeability than that of O/W emulsion.

Application Study of Recoil Mechanism using Friction Springs (마찰스프링의 주퇴복좌장치 적용성 연구)

  • Cha, Ki-Up;Gimm, Hak-In;Cho, Chang-Ki
    • Journal of the Korean Society for Precision Engineering
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    • v.29 no.3
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    • pp.324-333
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    • 2012
  • The conventional medium and large caliber gun, in general, utilize the hydro-pneumatic recoil mechanism to control the firing impulse and to return to the battery position. However, this kind of mechanism may cause the problems like the leakages and the property changes in oil and gas due to the temperature variations between low and high temperatures. Accordingly, the friction spring mechanism has recently been researched as an alternative system. The friction spring mechanism consists of a set of closed inner and outer rings with the concentric tapered contact surfaces assembled in the columnar form, and can only be used under the compression load. When the spring column is axially loaded, the tapered surfaces become overlapped, causing the outer rings to expand while the inner rings are being contracted in diameter allowing an axial displacement. Because of friction between tapered contact surfaces, much higher spring stiffness is obtained on the stroke at the increase in load than the stroke at the decrease. In this paper, the dynamic equations regarding the friction spring system and the design approach have been investigated. It is also tried for a dynamic model representing the recoil motion and the friction spring forces. And the model has been proved from firing test using a gun system with friction springs. All the results show that the recoil mechanism using friction springs can substitute for the classic hydro-pneumatic recoil system.

Reduction of Nitrous Oxide Emission by EGR Method on Diesel Engine (디젤엔진에서 배기가스 재순환 방법을 이용한 아산화질소의 배출률 저감)

  • Yoo, Dong-Hoon
    • Journal of Power System Engineering
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    • v.19 no.3
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    • pp.16-21
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    • 2015
  • Nitrous oxide($N_2O$) concentration in the atmosphere has been constantly increased by the human activities with industrial growth after the industrial revolution. One of factors to increase $N_2O$ concentration in the atmosphere is the $N_2O$ emission caused by the combustion of marine fuel. Especially, a sulfur component included in marine fuel oils is known as increasing the $N_2O$ formation in diesel combustion. Form this point of view, $N_2O$ emission from a ship is not negligible. On the other hand, Exhaust gas recirculation(EGR) that have thermal, chemical and dilution effect is effective method for reducing the NOx emission. In this study, an author investigated $N_2O$ reduction by using EGR on a direct injection diesel engine. The test engine was a 4-stroke diesel engine with maximum output of 12 kW at 2600rpm, and operating condition of the engine was a fixed load of 75%. The experimental oil was a blend-fuel that were adjusted with sulfur ratio of 3.5%, and EGR ratio of 0%, 10%, 20% and 30%. In conclusion, diesel fuel that contained 3.5% sulfur component increased $SO_2$ emission in exhaust gas, and increment of EGR ratio reduced NO emission. Moreover, $N_2O$ emission was decreased as over 50% at EGR ratio of 10% and reduced 100% at EGR ratio of 30% compared with $N_2O$ emission of 0% EGR ratio.

Analysis of Genetic Variation of Perilla Germplasm Using RAPD (RAPD를 이용한 들깨 유전자원의 유전적 변이 분석)

  • Kim, Doh-Hoon;Yang, Bo-Kyung;Kim, Hyeon-Kyoung;Kim, Na-Young;Jeong, Soon-Jae;Kim, Ik-Soo;Nam, Jae-Sung;Lee, Jai-Heon;Chung, Dae-Soo
    • Journal of Plant Biotechnology
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    • v.30 no.3
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    • pp.221-226
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    • 2003
  • Genetic variation of Perilla germplasms was investigated using RAPD markers. Forty-two Perilla frutescens lines and cultivars collected form locals were subjected to RAPD analysis using 220 primers. Among them only 13 primers showed polymorphic bands and these 13 primers provided a total of 144 bands, consist of 115 polymorphic and 29 monomorphic ones. The polymorphic bands were subjected to phylogenetic analysis using UPGMA and maximum parsimony (MP) methods. In the UPGMA method, similarity coefficiency of 42 Perilla frutescens lines and cultivars ranged from 0 to 0.7842. The dendrogram of 42 lines and cultivars obtained through UPGMA method resulted in two major groups, and the similar clustering pattern was found by MP method, suggesting Perilla germplasms utilized in this study truly can be divided into two major groups. Although the two major groups were consistent roughly with their phenotypes (under of node, weight of 1,000 grains, and oil content), in detail, much inconsistency also was present.

THD Analysis of a Surface Textured Parallel Thrust Bearing: Effect of Dimple Radius and Depth (Surface Texturing한 평행 스러스트 베어링의 열유체윤활 해석: 딤플 반경과 깊이의 영향)

  • Jeong, YoHan;Park, TaeJo
    • Tribology and Lubricants
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    • v.30 no.5
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    • pp.303-310
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    • 2014
  • In order to reduce friction and improve reliability, researchers have applied various surface texturing methods to highly sliding machine elements such as mechanical seals and piston rings. Despite extensive theoretical research on surface texturing, previous numerical results are only applicable to isothermal and iso-viscous conditions. Because the lubricant flow pattern of textured bearing surfaces is much more complicated than that for non-textured bearings, the Navier?Stokes equation is more suitable than the Reynolds equation for the former. This study carries out a thermohydrodynamic (THD) lubrication analysis to investigate the lubrication characteristics of a single micro-dimpled parallel thrust bearing cell. The analysis involves using the continuity, Navier?Stokes, energy, temperature?viscosity relation, and heat conduction equations with the commercial computational fluid dynamics (CFD) code FLUENT. This study discretizes these equations using the finite volume method and solves them using the SIMPLE algorithm. The results include finding the streamlines, pressure and temperature distributions, and variations in the friction force and leakage for various dimple radii and depths. Increasing the dimple radius and decreasing the depth causes a recirculation flow to form because of a strong vortex, and the oil temperature greatly increases compared with the non-textured case. The present numerical scheme and results are applicable to THD analysis of various surface-textured sliding bearings and can lead to further study.

Structural Response of Offshore Plants to Risk-Based Blast Load

  • Heo, YeongAe
    • Architectural research
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    • v.15 no.3
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    • pp.151-158
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    • 2013
  • Offshore oil and gas process plants are exposed to hazardous accidents such as explosion and fire, so that the structural components should resist such accidental loads. Given the possibilities of thousands of different scenarios for the occurrence of an accidental hazard, the best way to predict a reasonable size of a specific accidental load would be the employment of a probabilistic approach. Having the fact that a specific procedure for probabilistic accidental hazard analysis has not yet been established especially for explosion and fire hazards, it is widely accepted that engineers usually take simple and conservative figures in assuming uncertainties inherent in the procedure, resulting either in underestimation or more likely in overestimation in the topside structural design for offshore plants. The variation in the results of a probabilistic approach is determined by the assumptions accepted in the procedures of explosion probability computation, explosion analysis, and structural analysis. A design overpressure load for a sample offshore plant is determined according to the proposed probabilistic approach in this study. CFD analysis results using a Flame Acceleration Simulator, FLACS_v9.1, are utilized to create an overpressure hazard curve. Moreover, the negative impulse and frequency contents of a blast wave are considerably influencing structural responses, but those are completely ignored in a widely used triangular form of blast wave. An idealistic blast wave profile deploying both negative and positive pulses is proposed in this study. A topside process module and piperack with blast wall are 3D FE modeled for structural analysis using LS-DYNA. Three different types of blast wave profiles are applied, two of typical triangular forms having different impulse and the proposed load profile. In conclusion, it is found that a typical triangular blast load leads to overestimation in structural design.